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1. 发明授权

US07745604B2 Upstream control elements of the proopiomelanocortin gene and their use 有权
标题翻译： proopiomelanocortin基因的上游控制元件及其用途
公开(公告)号：US07745604B2
公开(公告)日：2010-06-29
申请号：US11503426
申请日：2006-08-10
申请人： Malcolm J. Low , Marcelo Rubinstein , Flavio Silva Junqueira de Souza
发明人： Malcolm J. Low , Marcelo Rubinstein , Flavio Silva Junqueira de Souza
IPC分类号： C07H21/04 , C12N15/00 , C12N5/00
CPC分类号： G01N33/5082 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/665 , C07K2319/60 , C12N2830/008 , C12Q1/6897 , G01N33/5058 , G01N33/5088 , G01N2333/665 , G01N2333/70571
摘要： The nucleic acid sequence of the POMC enhancer is disclosed herein. Sequences from the human, rat, rabbit, hamster, mouse, and cow POMC enhancer are disclosed. Hybrid transgenes, comprising a POMC transcriptional control element operably linked to a nucleic acid sequence encoding a marker are also enclosed. In addition, transgenic mice carrying a hybrid transgene including a POMC control element operably linked to a marker are disclosed herein.
摘要翻译：本文公开了POMC增强子的核酸序列。公开了来自人，大鼠，兔，仓鼠，小鼠和牛POMC增强子的序列。包含可操作地连接到编码标记的核酸序列的POMC转录控制元件的杂交转基因也被封闭。此外，本文公开了携带包含可操作地连接到标记物的POMC对照元件的杂交转基因的转基因小鼠。

2. 发明授权

US07125979B2 Upstream control elements of the proopiomelanocortin gene and their use 有权
标题翻译： proopiomelanocortin基因的上游控制元件及其用途
公开(公告)号：US07125979B2
公开(公告)日：2006-10-24
申请号：US10336091
申请日：2003-01-03
申请人： Malcolm J. Low , Marcelo Rubinstein , Flavio Silva Junqueira de Souza
发明人： Malcolm J. Low , Marcelo Rubinstein , Flavio Silva Junqueira de Souza
IPC分类号： C07H21/04 , C12N15/85
CPC分类号： G01N33/5082 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/665 , C07K2319/60 , C12N2830/008 , C12Q1/6897 , G01N33/5058 , G01N33/5088 , G01N2333/665 , G01N2333/70571
摘要： The nucleic acid sequence of the POMC enhancer is disclosed herein. Sequences from the human, rat, rabbit, hamster, mouse, and cow POMC enhancer are disclosed. Hybrid transgenes, comprising a POMC transcriptional control element operably linked to a nucleic acid sequence encoding a marker are also enclosed. In addition, transgenic mice carrying a hybrid transgene including a POMC control element operably linked to a marker are disclosed herein.
摘要翻译：本文公开了POMC增强子的核酸序列。公开了来自人，大鼠，兔，仓鼠，小鼠和牛POMC增强子的序列。包含可操作地连接到编码标记的核酸序列的POMC转录控制元件的杂交转基因也被封闭。此外，本文公开了携带包含可操作地连接到标记物的POMC对照元件的杂交转基因的转基因小鼠。

3. 发明授权

US06278038B1 Mammalian melanocortin receptors and uses 失效
标题翻译：哺乳动物黑皮质素受体和用途
公开(公告)号：US06278038B1
公开(公告)日：2001-08-21
申请号：US09097231
申请日：1998-06-12
申请人： Roger D. Cone , Wenbiao Chen , Malcolm J. Low
发明人： Roger D. Cone , Wenbiao Chen , Malcolm J. Low
IPC分类号： A01K6700
CPC分类号： C12Q1/6897 , A01K2217/075 , A61K38/00 , C07K7/56 , C07K14/4711 , C07K14/723 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/68 , G01N2333/695 , G01N2333/72 , G01N2333/726 , G01N2500/00
摘要： This invention provides methods and reagents for developing naturally-occurring and synthetic agonists and antagonists specific for a mammalian melanocortin receptor, and the use of such agonists and antagonists for treatment and alleviation of dysfunction and disease. The invention specifically provides reagents and methods for developing naturally-occurring and synthetic agonists and antagonists specific for a mammalian melanocortin receptor termed MC5-R. The naturally-occurring and synthetic agonists and antagonists specific for the MC5-R receptor are provided by the invention for the treatment, control, amelioration and alleviation of diseases, and dysfunctional and abnormal states related to thermoregulatory disorders, as well as other diseases relating to exocrine gland disorders, including lacrimal gland dysfunction and sebaceous gland disorders including acne and other skin problems. Also provided by the invention are nucleic acids, constructs, vectors and methods for producing an animal bearing a genetically-disrupted endogenous MC5-R melanocortin receptor, in both the heterozygous and homozygous condition, preferably a rodent and most preferably a mouse. Rodents bearing genetically disrupted MC5-R genes homozygously, termed “gene knockout”rodents in the art, are also advantageously provided.
摘要翻译：本发明提供用于开发天然存在的和合成的哺乳动物黑皮质素受体特异的激动剂和拮抗剂的方法和试剂，以及这些激动剂和拮抗剂用于治疗和减轻功能障碍和疾病的用途。本发明特别提供了用于开发天然存在的和合成的激动剂和特异于哺乳动物黑皮质素受体MC5-R的拮抗剂的试剂和方法。本发明提供了针对MC5-R受体特异性的天然存在和合成的激动剂和拮抗剂，用于治疗，控制，改善和缓解疾病，以及与体温调节性疾病有关的功能障碍和异常状态以及与外分泌腺疾病，包括泪腺功能障碍和皮脂腺疾病，包括痤疮和其他皮肤问题。本发明还提供了在杂合和纯合条件下产生具有遗传破坏的内源性MC5-R黑皮质素受体的动物的核酸，构建体，载体和方法，优选啮齿动物，最优选小鼠。也有利地提供了在本领域中遗传上破坏的基因破坏的MC5-R基因，称为“基因敲除”啮齿动物。

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