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1. 发明授权

US06784314B2 Process for producing amine derivatives 失效
标题翻译：制备胺衍生物的方法
公开(公告)号：US06784314B2
公开(公告)日：2004-08-31
申请号：US10240574
申请日：2002-10-01
申请人： Makoto Yamashita , Kaneyoshi Kato , Hiroyuki Tawada
发明人： Makoto Yamashita , Kaneyoshi Kato , Hiroyuki Tawada
IPC分类号： C07C23305
CPC分类号： C07C235/34 , C07B2200/07 , C07C217/74 , C07C2602/10
摘要： This invention provides a convenient and industrially advantageous process producing amine derivatives having the action of inhibiting the secretion and accumulation of amyloid &bgr; protein. In Compound (I), the ether linkage is selectively cleaved without cleaving the amide linkage present in the same molecule and tertiary amines are not converted into quaternary salts, and thus Amine Derivative (V) with good qualities having the action of inhibiting the secretion and accumulation of amyloid &bgr; protein can be obtained in high yield.
摘要翻译：本发明提供了方便和工业上有利的方法，产生具有抑制淀粉样蛋白β蛋白分泌和积累作用的胺衍生物。在化合物（I）中，醚键被选择性地切割而不裂解同一分子中存在的酰胺键和叔胺不会转化为季盐，因此可以高产率获得具有抑制淀粉样β蛋白分泌和积累作用的具有良好品质的胺衍生物（V）。

2. 发明授权

US07420070B2 Process for preparing optically active 2,3-dihydrobenzofuran compounds 失效
标题翻译：光学活性2,3-二氢苯并呋喃化合物的制备方法
公开(公告)号：US07420070B2
公开(公告)日：2008-09-02
申请号：US11054371
申请日：2005-02-09
申请人： Isao Aoki , Mari Adachi , Hiroyuki Tawada , Makoto Yamashita , Misayo Sera
发明人： Isao Aoki , Mari Adachi , Hiroyuki Tawada , Makoto Yamashita , Misayo Sera
IPC分类号： C07D405/00 , C07D307/00
CPC分类号： C07D307/79 , C07B2200/07 , C07D405/04 , C07F9/65742
摘要： A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: [wherein R1 and R2 are each hydrogen or an optionally substituted hydrocarbon group; R3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.
摘要翻译：一种制备光学活性2,3-二氢苯并呋喃化合物的方法，其包括用光学活性酸化合物对其进行光学拆分的2,3-二氢苯并呋喃化合物或其盐进行光学拆分：其中R 1， SUP>和R 2各自为氢或任选取代的烃基; R 3是任选取代的芳族基团; 并且C是除了氨基之外还可以具有取代基的苯环]。该方法可以在工业上有利地生产用于合成可用作神经变性疾病等的预防和/或治疗药物的光学活性2,3-二氢苯并呋喃化合物的中间体。

3. 发明授权

US07034166B2 Process for producing benzofuran derivative 失效
标题翻译：苯并呋喃衍生物的制备方法
公开(公告)号：US07034166B2
公开(公告)日：2006-04-25
申请号：US10483089
申请日：2002-07-11
申请人： Hiroyuki Tawada , Makoto Yamashita , Yujiro Ono
发明人： Hiroyuki Tawada , Makoto Yamashita , Yujiro Ono
IPC分类号： C07D307/79 , C07C49/76 , C07C43/23
CPC分类号： C07D307/79 , Y02P20/55
摘要： A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a salt thereof; which comprises reacting a compound represented by the formula: wherein R1 and R2 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y is a halogen atom, ring A is a benzene ring that may be optionally further substituted in addition to the group represented by Y and ring B is an optionally substituted benzene ring, or a salt thereof, with a compound represented by the formula: WH wherein W is wherein ring C is an optionally substituted benzene ring, ring D is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R3 is a hydrogen atom, an aliphatic hydrocarbon group containing an aromatic group or an acyl group, and R4 is a hydrogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof and thereafter, if necessary, deprotecting the resultant product, which is suitable for industrial production.
摘要翻译：一种用于有效且容易地制备由下式表示的化合物的新方法：其中环A是可以任选进一步被W代表的基团进一步取代的苯环或其盐; 其包括使下式表示的化合物：其中R 1和R 2彼此相同或不同，并且各自为氢原子，任选取代的烃基或任选地取代的杂环基，Y是卤素原子，环A是可以任选地进一步被Y代表的基团进一步取代的苯环，并且环B是任选取代的苯环或其盐与由公式：<？in-line-formula description =“In-line Formulas”end =“lead”？> WH <？in-line-formula description =“In-line Formulas”end =“tail”？>其中W 其中环C是任选取代的苯环，环D是任选取代的5-至7-元含氮杂环，R 3是氢原子，含有芳族的脂族烃基基团或酰基，R 4是氢原子，任选取代的烃基或酰基，或其盐，此后，如果需要，将所得产物脱保护，其适用于工业生产。

4. 发明授权

US06878831B2 Process for preparing optically active 2,3-dihydrobenzofuran compounds 失效
标题翻译：光学活性2,3-二氢苯并呋喃化合物的制备方法
公开(公告)号：US06878831B2
公开(公告)日：2005-04-12
申请号：US10451723
申请日：2001-12-27
申请人： Isao Aoki , Mari Adachi , Hiroyuki Tawada , Makoto Yamashita , Misayo Sera
发明人： Isao Aoki , Mari Adachi , Hiroyuki Tawada , Makoto Yamashita , Misayo Sera
IPC分类号： C07D307/79 , C07D405/04 , C07F9/6574 , C07D307/78
CPC分类号： C07D307/79 , C07B2200/07 , C07D405/04 , C07F9/65742
摘要： A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: [wherein R1 and R2 are each hydrogen or an optionally substituted hydrocarbon group; R3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.
摘要翻译：一种制备光学活性2,3-二氢苯并呋喃化合物的方法，其包括用光学活性酸化合物使其由通式或其盐表示的2,3-二氢苯并呋喃化合物进行光学拆分：[其中R 1和R 2' 2>各自为氢或任选取代的烃基; R 3是任选取代的芳基; 并且C是除了氨基之外还可以具有取代基的苯环]。该方法可以在工业上有利地生产用于合成可用作神经变性疾病等的预防和/或治疗药物的光学活性2,3-二氢苯并呋喃化合物的中间体。

5. 发明申请

US20050014813A1 Process for production of pyrazole compounds 审中-公开
标题翻译：吡唑化合物的制备方法
公开(公告)号：US20050014813A1
公开(公告)日：2005-01-20
申请号：US10495173
申请日：2002-11-12
申请人： Hiroyuki Tawada , Makoto Yamashita , Tomomi Ikemoto , Atsuko Nishiguchi
发明人： Hiroyuki Tawada , Makoto Yamashita , Tomomi Ikemoto , Atsuko Nishiguchi
IPC分类号： C07D231/20 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D231/04 , A61K31/4152
CPC分类号： C07D401/12 , C07D231/20 , C07D413/12 , C07D413/14 , C07D417/12
摘要： As a method capable of conveniently producing a pyrazole compound in a high yield, which is useful as a synthetic intermediate for a pharmaceutical agent such as a therapeutic agent for diabetes and the like, a production method of a compound represented by the formula (I) wherein n is an integer of 1 to 4 and R1 is a. hydrocarbon group optionally having substituents, or a salt thereof, is provided, which includes reacting a compound represented by the formula, (II) wherein Q is a hydroxy group optionally having substituents or an amino group optionally having substituents, R is a hydrocarbon group optionally having substituents and other symbols are as defined above, or a salt thereof, with hydrazine or a salt thereof.
摘要翻译：作为能够以高收率制备吡唑化合物的方法，作为糖尿病治疗剂等药剂的合成中间体是有用的，由式（I）表示的化合物的制造方法，其中n为1〜4的整数，R 1为a。提供任选具有取代基的烃基或其盐，其包括使式（II）表示的化合物，其中Q是任选具有取代基的羟基或任选具有取代基的氨基，R是任选的烃基具有取代基和其它符号如上所定义，或其盐与肼或其盐反应。

6. 发明申请

US20060142598A1 Process for producing benzofuran derivative 失效
标题翻译：苯并呋喃衍生物的制备方法
公开(公告)号：US20060142598A1
公开(公告)日：2006-06-29
申请号：US11359023
申请日：2006-02-22
申请人： Hiroyuki Tawada , Makoto Yamashita , Yujiro Ono
发明人： Hiroyuki Tawada , Makoto Yamashita , Yujiro Ono
IPC分类号： C07D493/00
CPC分类号： C07D307/79 , Y02P20/55
摘要： A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a salt thereof; which comprises reacting a compound represented by the formula: wherein R1 and R2 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y is a halogen atom, ring A is a benzene ring that may be optionally further substituted in addition to the group represented by Y and ring B is an optionally substituted benzene ring, or a salt thereof, with a compound represented by the formula: WH wherein W is wherein ring C is an optionally substituted benzene ring, ring D is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R3 is a hydrogen atom, an aliphatic hydrocarbon group containing an aromatic group or an acyl group, and R4 is a hydrogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof and thereafter, if necessary, deprotecting the resultant product, which is suitable for industrial production.
摘要翻译：一种用于有效且容易地制备由下式表示的化合物的新方法：其中环A是可以任选进一步被W代表的基团进一步取代的苯环或其盐; 其包括使下式表示的化合物：其中R 1和R 2彼此相同或不同，并且各自为氢原子，任选取代的烃基或任选地取代的杂环基，Y是卤素原子，环A是可以任选地进一步被Y代表的基团进一步取代的苯环，并且环B是任选取代的苯环或其盐与由式中W为W，其中环C为任选取代的苯环，环D为任选取代的5至7元含氮杂环，R 3为氢原子，含有芳基或酰基的脂族烃基，R 4为氢原子，任选取代的烃基或酰基，或其盐，然后如果需要，将所得物产品，适用于工业产品说明。

7. 发明申请

US20050171184A1 Process for preparing optically active 2,3-dihydrobenzofuran compounds 失效
标题翻译：光学活性2,3-二氢苯并呋喃化合物的制备方法
公开(公告)号：US20050171184A1
公开(公告)日：2005-08-04
申请号：US11054371
申请日：2005-02-09
申请人： Isao Aoki , Mari Adachi , Hiroyuki Tawada , Makoto Yamashita , Misayo Sera
发明人： Isao Aoki , Mari Adachi , Hiroyuki Tawada , Makoto Yamashita , Misayo Sera
IPC分类号： C07D307/79 , C07D405/04 , C07F9/6574 , A61K31/4035 , C07D45/02
CPC分类号： C07D307/79 , C07B2200/07 , C07D405/04 , C07F9/65742
摘要： A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: [wherein R1 and R2 are each hydrogen or an optionally substituted hydrocarbon group; R3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.
摘要翻译：一种制备光学活性2,3-二氢苯并呋喃化合物的方法，其包括用光学活性酸化合物对其进行光学拆分的2,3-二氢苯并呋喃化合物或其盐进行光学拆分：其中R 1， SUP>和R 2各自为氢或任选取代的烃基; R 3是任选取代的芳族基团; 并且C是除了氨基之外还可以具有取代基的苯环]。该方法可以在工业上有利地生产用于合成可用作神经变性疾病等的预防和/或治疗药物的光学活性2,3-二氢苯并呋喃化合物的中间体。

8. 发明申请

US20080146602A1 Thienopyridine Derivatives, Production Method and Use Thereof 审中-公开
标题翻译：噻吩并吡啶衍生物，其生产方法和用途
公开(公告)号：US20080146602A1
公开(公告)日：2008-06-19
申请号：US11596634
申请日：2005-05-13
申请人： Atsuo Baba , Tsuneo Yasuma , Hiroyuki Tawada , Makoto Yamashita
发明人： Atsuo Baba , Tsuneo Yasuma , Hiroyuki Tawada , Makoto Yamashita
IPC分类号： A61K31/4365 , C07D471/04 , A61P19/02
CPC分类号： C07D495/04
摘要： A compound represented by the formula (I) wherein R is a hydrogen atom or a C1-4 alkyl group, and X is CH2, O or S, or a salt thereof. The present invention provides a novel thienopyridine derivative having an anti-inflammatory effect, a bone resorption suppressing effect, an immune cytokine production suppressing effect and the like, and useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of arthritis such as rheumatoid arthritis and the like, and the like, and the like.
摘要翻译：由式（I）表示的化合物，其中R是氢原子或C 1-4烷基，X是CH 2，O或S，或的盐。本发明提供具有抗炎作用，骨吸收抑制作用，免疫细胞因子产生抑制作用等的新颖的噻吩并吡啶衍生物，可用作预防或治疗关节炎的药剂如类风湿关节炎等，类似物等。

9. 发明授权

US07323577B2 Process for producing benzofuran derivative 失效
标题翻译：苯并呋喃衍生物的制备方法
公开(公告)号：US07323577B2
公开(公告)日：2008-01-29
申请号：US11359023
申请日：2006-02-22
申请人： Hiroyuki Tawada , Makoto Yamashita , Yujiro Ono
发明人： Hiroyuki Tawada , Makoto Yamashita , Yujiro Ono
IPC分类号： C07D493/00
CPC分类号： C07D307/79 , Y02P20/55
摘要： A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a salt thereof; which comprises reacting a compound represented by the formula: wherein R1 and R2 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y is a halogen atom, ring A is a benzene ring that may be optionally further substituted in addition to the group represented by Y and ring B is an optionally substituted benzene ring, or a salt thereof, with a compound represented by the formula: WH wherein W is wherein ring C is an optionally substituted benzene ring, ring D is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R3 is a hydrogen atom, an aliphatic hydrocarbon group containing an aromatic group or an acyl group, and R4 is a hydrogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof and thereafter, if necessary, deprotecting the resultant product, which is suitable for industrial production.
摘要翻译：一种用于有效且容易地制备由下式表示的化合物的新方法：其中环A是可以任选进一步被W代表的基团进一步取代的苯环或其盐; 其包括使下式表示的化合物：其中R 1和R 2彼此相同或不同，并且各自为氢原子，任选取代的烃基或任选地取代的杂环基，Y是卤素原子，环A是可以任选地进一步被Y代表的基团进一步取代的苯环，并且环B是任选取代的苯环或其盐与由公式：<？in-line-formula description =“In-line Formulas”end =“lead”？> WH <？in-line-formula description =“In-line Formulas”end =“tail”？>其中W 其中环C是任选取代的苯环，环D是任选取代的5-至7-元含氮杂环，R 3是氢原子，含有芳族的脂族烃基基团或酰基，R 4是氢原子，任选取代的烃基或酰基，或其盐，此后，如果需要，将所得产物脱保护，其适用于工业生产。

10. 发明授权

US08003219B2 Coating liquid, conductive film formed by coating liquid, and forming method thereof 有权
标题翻译：涂布液，通过涂布液形成的导电膜及其形成方法
公开(公告)号：US08003219B2
公开(公告)日：2011-08-23
申请号：US12226827
申请日：2007-01-31
申请人： Christopher Cordonier , Tetsuya Shichi , Takafumi Numata , Kenichi Katsumata , Akimasa Nakamura , Yasuhiro Katsumata , Teruo Komine , Kenichirou Amemiya , Makoto Yamashita , Akira Fujishima
发明人： Christopher Cordonier , Tetsuya Shichi , Takafumi Numata , Kenichi Katsumata , Akimasa Nakamura , Yasuhiro Katsumata , Teruo Komine , Kenichirou Amemiya , Makoto Yamashita , Akira Fujishima
IPC分类号： B32B17/06 , B05D3/02
CPC分类号： C01G23/053 , B01J21/066 , B01J37/0219 , C01P2002/84 , C09C1/3607 , C23C18/1216 , C23C18/1225 , C23C18/1279 , Y10T428/31678
摘要： The present invention provides a technology related to a conductive film which is high in transparency, conductivity, and adhesiveness to a base plate. The present invention also provides a coating liquid including metal materials reacting with a ligand represented by a particular Chemical Formula and including indium (In), tin (Sn), or both thereof.
摘要翻译：本发明提供了与基板的透明性，导电性和粘合性高的导电膜相关的技术。本发明还提供了包含与特定化学式表示的配体反应的金属材料，包括铟（In），锡（Sn）或其二者的涂布液。

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