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1. 发明申请

US20050113397A1 Imidazo[1,2-a]pyridine derivative 审中-公开
标题翻译：咪唑并[1,2-a]吡啶衍生物
公开(公告)号：US20050113397A1
公开(公告)日：2005-05-26
申请号：US10502971
申请日：2003-01-30
申请人： Makoto Takemura , Hisashi Takahashi , Katsuhiro Kawakami , Hiroshi Takeshita , Youichi Kimura , Jun Watanabe , Yuichi Sugimoto , Akihiro Kitamura , Ryohei Nakajima , Kazuo Kanai , Tetsunori Fujisawa
发明人： Makoto Takemura , Hisashi Takahashi , Katsuhiro Kawakami , Hiroshi Takeshita , Youichi Kimura , Jun Watanabe , Yuichi Sugimoto , Akihiro Kitamura , Ryohei Nakajima , Kazuo Kanai , Tetsunori Fujisawa
IPC分类号： A61K31/437 , A61K31/4375 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P31/00 , A61P31/10 , C07D471/04 , C07D471/14 , C07D491/14 , C07D519/00 , A61K31/4745 , A61K31/519 , C07D487/14
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/14 , C07D491/14
摘要： A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.
摘要翻译：基于其1,6-β-葡聚糖合成抑制的新机理，通过下式（I）表示的化合物，其能够在宽谱中特异性或选择性表达抗真菌活性的盐或其溶剂化物，以及抗真菌剂包含它们中的任何一个。

2. 发明申请

US20050069965A1 Method for screening agent acting on cell wall 失效
标题翻译：筛选剂作用于细胞壁的方法
公开(公告)号：US20050069965A1
公开(公告)日：2005-03-31
申请号：US10492202
申请日：2002-10-22
申请人： Akihiro Kitamura , Ryohei Nakajima
发明人： Akihiro Kitamura , Ryohei Nakajima
IPC分类号： A61P31/10 , C12Q1/02 , C12Q1/18 , G01N33/50 , G01N33/53 , G01N33/569
CPC分类号： G01N33/5014 , C12Q1/025 , C12Q1/18 , G01N33/5008 , G01N2400/00 , G01N2500/00
摘要： A method for screening an agent acting on a cell wall, which comprises the following steps of: (1) culturing a microorganism having a reporter protein fixed on a cell wall as a GPI-anchored protein in the presence of a test agent acting on a cell wall; (2) analyzing a saccharide chain of a substance derived from the reporter protein released in a culture fluid of the microorganism; and (3) estimating a targeting site of the test agent on the cell wall on the basis of information of the saccharide chain of the substance derived from the reporter protein obtained in the step (2). An agent acting on a cell wall directed to a particular targeting site can be efficiently screened by conveniently and suitably determining a targeting site of an agent having an inhibitory action on a cell wall.
摘要翻译：一种筛选作用在细胞壁上的试剂的方法，其包括以下步骤：（1）在作用于细胞壁上的试验剂存在下培养具有作为GPI锚定蛋白固定在细胞壁上的报道蛋白的微生物细胞壁; （2）分析来自微生物培养液中释放的报道蛋白质的物质的糖链; （3）基于来自步骤（2）中获得的报道蛋白的物质的糖链的信息，估计细胞壁上测试剂的靶向位点。通过方便和适当地确定对细胞壁具有抑制作用的试剂的靶向位点，可以有效地筛选作用在指向特定靶位点的细胞壁上的试剂。

3. 发明授权

US07459268B2 Method for screening agent acting on cell wall 失效
标题翻译：筛选剂作用于细胞壁的方法
公开(公告)号：US07459268B2
公开(公告)日：2008-12-02
申请号：US10492202
申请日：2002-10-22
申请人： Akihiro Kitamura , Ryohei Nakajima
发明人： Akihiro Kitamura , Ryohei Nakajima
IPC分类号： C12Q1/00
CPC分类号： G01N33/5014 , C12Q1/025 , C12Q1/18 , G01N33/5008 , G01N2400/00 , G01N2500/00
摘要： A method for screening an agent acting on a cell wall, which comprises the following steps of: (1) culturing a microorganism having a reporter protein fixed on a cell wall as a GPI-anchored protein in the presence of a test agent acting on a cell wall; (2) analyzing a saccharide chain of a substance derived from the reporter protein released in a culture fluid of the microorganism; and (3) estimating a targeting site of the test agent on the cell wall on the basis of information of the saccharide chain of the substance derived from the reporter protein obtained in the step (2). An agent acting on a cell wall directed to a particular targeting site can be efficiently screened by conveniently and suitably determining a targeting site of an agent having an inhibitory action on a cell wall.
摘要翻译：一种筛选作用在细胞壁上的试剂的方法，其包括以下步骤：（1）在作用于细胞壁上的试验剂存在下培养具有作为GPI锚定蛋白固定在细胞壁上的报道蛋白的微生物细胞壁; （2）分析来自微生物培养液中释放的报道蛋白质的物质的糖链; （3）基于来自步骤（2）中获得的报道蛋白的物质的糖链的信息，估计细胞壁上测试剂的靶向位点。通过方便和适当地确定对细胞壁具有抑制作用的试剂的靶向位点，可以有效地筛选作用在指向特定靶位点的细胞壁上的试剂。

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