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1. 发明授权

US5578708A Bone-associated transcription control factor-like protein 失效
标题翻译：骨相关转录调控因子样蛋白
公开(公告)号：US5578708A
公开(公告)日：1996-11-26
申请号：US208108
申请日：1994-03-08
申请人： Makoto Okazaki , Sunao Takeshita , Shinji Kawai , Reiko Kikuno , Egon Amann
发明人： Makoto Okazaki , Sunao Takeshita , Shinji Kawai , Reiko Kikuno , Egon Amann
IPC分类号： A61K38/00 , A61K39/395 , A61K49/00 , A61P3/00 , A61P19/10 , A61P43/00 , C07K14/47 , C07K14/51 , C07K16/00 , C12N15/09 , C12N15/12 , C12P21/00 , C12P21/08 , G01N33/50 , G01N33/53
CPC分类号： C07K14/51 , C07K14/4702 , A61K38/00 , C07K2319/02
摘要： Bone-associated proteins derived from bone of mammals, including mice and human beings, named OSF-6. The protein is the novel natural type mammal protein, which can play an important role in bone formation, and belongs to a group of transcription control factors.OSF-6 can be used as a therapeutic agent for bone metabolic diseases, and also as a diagnostic agent for bone metabolic diseases, since it may demonstrate a high organ specificity to bone.
摘要翻译：衍生自哺乳动物骨骼的骨相关蛋白，包括小鼠和人类，称为OSF-6。该蛋白是新型天然型哺乳动物蛋白，可在骨形成中起重要作用，属于一组转录调控因子。 OSF-6可用作骨代谢疾病的治疗剂，也可用作骨代谢疾病的诊断剂，因为它可能对骨骼具有高的器官特异性。

2. 发明授权

US5756664A Protein with bone formation ability and process for its production 失效
标题翻译：具有骨形成能力的蛋白质及其生产过程
公开(公告)号：US5756664A
公开(公告)日：1998-05-26
申请号：US426627
申请日：1995-04-21
申请人： Egon Amann , Yoko Otawara-Hamamoto , Reiko Kikuno , Sunao Takeshita , Kenichi Tezuka
发明人： Egon Amann , Yoko Otawara-Hamamoto , Reiko Kikuno , Sunao Takeshita , Kenichi Tezuka
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , A61K49/00 , A61P3/00 , A61P43/00 , C07K14/475 , C07K16/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/865 , C12R1/91 , G01N33/53 , C07K14/435 , C07K7/08 , C07K14/51
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/02
摘要： The present invention provides the sequence of the novel bone-related protein OSF-2 which can be obtained from mammalian bone tissues. The invention further provides a method of production of OSF-2 by recombinant techniques.
摘要翻译：本发明提供可从哺乳动物骨组织获得的新型骨相关蛋白OSF-2的序列。本发明还提供了通过重组技术生产OSF-2的方法。

3. 发明申请

US20060275302A1 Novel cancer-associated gene 有权
标题翻译：新型癌症相关基因
公开(公告)号：US20060275302A1
公开(公告)日：2006-12-07
申请号：US10535733
申请日：2003-11-20
申请人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno , Shin-ichi Funahashi
发明人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno , Shin-ichi Funahashi
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C12N9/1048 , C07K14/4748
摘要： The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having biological activity substantially equivalent to the functions of the polypeptide (a).
摘要翻译：本发明提供：新型DNA，包含DNA的癌相关基因，由DNA编码的重组蛋白，与蛋白结合的抗体，包含抗体的抗癌剂，结合蛋白质和筛选系统。这样的新型DNA的实例是包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）多肽，由与氨基酸序列相同或基本相同的氨基酸序列组成， SEQ ID NO：2; 或（b）通过缺失，取代或添加一个或多个氨基酸并具有与功能基本相同的生物学活性的由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的多肽的多肽（a）。

4. 发明授权

US5908828A Synthetic peptide derivatives and the salts thereof 失效
标题翻译：合成肽衍生物及其盐
公开(公告)号：US5908828A
公开(公告)日：1999-06-01
申请号：US497599
申请日：1995-06-30
申请人： Takashi Kurita , Tomoaki Matsumoto , Reiko Kikuno , Yoko Otawara-Hamamoto , Gerhard Breipohl
发明人： Takashi Kurita , Tomoaki Matsumoto , Reiko Kikuno , Yoko Otawara-Hamamoto , Gerhard Breipohl
IPC分类号： A61K38/00 , C07K14/51 , A61K38/16 , C07K14/00
CPC分类号： C07K14/51 , A61K38/00
摘要： The present invention provides synthetic peptide derivatives represented by the formulaP.sup.1 -R.sup.1 -P.sup.2wherein P.sup.1 is a peptide having an amino acid sequence in the SEQ ID NO.:1 of the Sequence Listing, or analogues thereof; P.sup.2 is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R.sup.1 denotes a linker with a property that does not interfere with the activity of the each peptide P.sup.1 and P.sup.2 to bind N-terminal end of the peptides P.sup.1 and P.sup.2.The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier.The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof.
摘要翻译：本发明提供由式P1-R1-P2表示的合成肽衍生物，其中P1是具有序列表SEQ ID NO：1中的氨基酸序列的肽或其类似物; P2是具有序列表的SEQ ID NO：2中的氨基酸序列的肽或其类似物; R1表示具有不影响各肽P1和P2与肽P1和P2的N末端结合的活性的性质的连接体。本发明还提供了用于治疗骨相关疾病的药物组合物，其包含所述肽衍生物或其治疗上可接受的盐和药学上可接受的载体。本发明还提供了治疗哺乳动物中骨相关疾病的方法，其包括向其施用有效量的所述肽衍生物或其可治疗可接受的盐。

5. 发明授权

US07790866B2 Cancer-associated gene 有权
标题翻译：癌症相关基因
公开(公告)号：US07790866B2
公开(公告)日：2010-09-07
申请号：US10535733
申请日：2003-11-20
申请人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno , Shin-ichi Funahashi
发明人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno , Shin-ichi Funahashi
IPC分类号： C07H21/02 , C07H21/04 , C07K14/00 , C07K17/00 , C12P21/06 , C12P19/34 , C12N15/64
CPC分类号： C12N9/1048 , C07K14/4748
摘要： The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having biological activity substantially equivalent to the functions of the polypeptide (a).
摘要翻译：本发明提供：新型DNA，包含DNA的癌相关基因，由DNA编码的重组蛋白，与蛋白结合的抗体，包含抗体的抗癌剂，结合蛋白质和筛选系统。这样的新型DNA的实例是包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）多肽，由与氨基酸序列相同或基本相同的氨基酸序列组成， SEQ ID NO：2; 或（b）通过缺失，取代或添加一个或多个氨基酸并具有与功能基本相同的生物学活性的由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的多肽的多肽（a）。

6. 发明申请

US20060160082A1 Novel genes and proteins encoded thereby 审中-公开
标题翻译：由此编码的新型基因和蛋白质
公开(公告)号：US20060160082A1
公开(公告)日：2006-07-20
申请号：US10530880
申请日：2003-10-16
申请人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno
发明人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno
IPC分类号： C12Q1/68 , C07H21/02 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47
摘要： A novel DNA comprising a protein-encoding region is directly cloned from cDNA library originating from human adult whole brain and human fetal whole brain, the base sequence thereof is determined, and the functions thereof are identified. A DNA comprising a base sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with the amino acid sequence represented by SEQ ID No.1, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No.1 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a), recombinant polypeptide encoded by the above DNAs, and protein comprising the polypeptide.
摘要翻译：从源自人成人全脑和人胎儿全脑的cDNA文库直接克隆包含蛋白质编码区的新型DNA，确定其碱基序列，鉴定其功能。包含编码以下多肽（a）或（b）的碱基序列的DNA：（a）由与SEQ ID No.1所代表的氨基酸序列相同或基本相同的氨基酸序列组成的多肽）由SEQ ID No.1所示的氨基酸序列组成的多肽，其中部分氨基酸缺失，取代或添加，并且具有与多肽（a）的功能基本上相同的生物学活性，由上述DNA和包含该多肽的蛋白质。

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