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    • 2. 发明授权
    • Carbamoyl-2-pyrrolidinone compounds
    • 卡巴酸-2-吡咯烷酮化合物
    • US5229402A
    • 1993-07-20
    • US449923
    • 1989-12-13
    • Makoto KajitaniEtsuo HasegawaAkihiro KawaguchiJunji YamamotoKatsuo ToideTakaji HonnaMitsugi YasumotoNobuo Kasahara
    • Makoto KajitaniEtsuo HasegawaAkihiro KawaguchiJunji YamamotoKatsuo ToideTakaji HonnaMitsugi YasumotoNobuo Kasahara
    • C07D207/26C07D207/263C07D207/273C07D401/12C07D417/12
    • C07D207/27C07D207/26C07D207/273C07D401/12C07D417/12
    • The present invention provides a carbamoyl-2-pyrrolidinone compound which has the following formula (2) and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents and cerebral metabolism activators or anoxic brain damage protectives ##STR1## wherein R.sup.1 is a hydrogen atom, hydroxyl or lower alkyl substituted or unsubstituted with hydroxyl, and R.sup.3 is phenyl, tetrahydronaphthyl, pyridyl or thiazolyl having or not having lower alkoxyl, lower alkylamino, a halogen atom or halogenomethyl as a substituent.Further, the present invention provides novel carbamoyl-2-pyrrolidinone compounds represented by the formula ##STR2## wherein R.sup.1 is a hydrogen atom, hydroxyl or lower alkyl substituted or unsubstituted with hydroxyl, and R.sup.2 is phenyl, tetrahydronaphthyl, pyridyl or thiazolyl having or not having methoxy or lower alkylamino as a substituent, provided that when R.sup.1 is a hydrogen atom or unsubstituted lower alkyl, R.sup.2 is not unsubstituted phenyl.
    • PCT No.PCT / JP89 / 00401 Sec。 371日期1989年12月13日第 102(e)日期1989年12月13日PCT提交1989年4月12日PCT公布。 公开号WO89 / 09767 本发明提供具有下式(2)的氨基甲酰基-2-吡咯烷酮化合物,可用作治疗老年痴呆的药物,即作为脑功能改善剂和脑代谢激活剂或缺氧性脑 (2)其中R1是氢原子,羟基或被羟基取代或未取代的低级烷基,R3是具有或没有低级烷氧基,低级烷基氨基,卤原子或卤代甲基的苯基,四氢萘基,吡啶基或噻唑基 作为取代基。 此外,本发明提供由式(1)表示的新型氨基甲酰基-2-吡咯烷酮化合物,其中R 1是氢原子,羟基或被羟基取代或未取代的低级烷基,R 2是苯基,四氢萘基,吡啶基或噻唑基 具有或不具有甲氧基或低级烷基氨基作为取代基,条件是当R 1为氢原子或未取代的低级烷基时,R 2为未取代的苯基。