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1. 发明申请

US20090205979A1 Electrolyte-Containing Sheet For Use In Specific Detection Of Analyte Using Photocurrent 审中-公开
标题翻译：用于特定检测使用光电流的分析物的含电解质片
公开(公告)号：US20090205979A1
公开(公告)日：2009-08-20
申请号：US12348993
申请日：2009-01-06
申请人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Yoshimasa Yamana
发明人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Yoshimasa Yamana
IPC分类号： G01N27/26 , G01F1/64 , C25B11/00 , C25B9/00
CPC分类号： G01N27/305
摘要： There is disclosed an electrolyte medium which makes it possible to significantly simplify device structure and detection procedure as well as to detect photocurrent with high sensitivity and accuracy, in specific detection of an analyte with use of photocurrent generated by photo-excitation of a sensitizing dye. The electrolyte-containing sheet comprises a hydrous substrate; and an electrolyte contained in the hydrous substrate. The electrolyte-containing sheet is used as an electrolyte medium in specific detection of an analyte with use of photocurrent generated by photo-excitation of a sensitizing dye. A gel matrix or a water-absorbent substrate can be used as the hydrous substrate.
摘要翻译：公开了一种电解质介质，其可以通过使用通过感光染料的光激发产生的光电流来特异性检测分析物，从而显着简化器件结构和检测过程以及以高灵敏度和精确度检测光电流。含电解质的片材包含含水基材; 以及包含在含水基材中的电解质。含电解质的片材用作特定检测分析物的电解质介质，其使用通过感光染料的光激发产生的光电流。可以使用凝胶基质或吸水性基质作为含水底物。

2. 发明申请

US20110220517A1 METHOD FOR SPECIFICALLY DETECTING TEST SUBSTANCE USING PHOTOCURRENT, SENSOR UNIT USED THEREFOR, AND MEASURING DEVICE 审中-公开
标题翻译：使用光电特定检测测试物质的方法，其使用的传感器单元和测量装置
公开(公告)号：US20110220517A1
公开(公告)日：2011-09-15
申请号：US12811956
申请日：2009-01-09
申请人： Makoto Bekki , Masako Ajimi , Hitoshi Ohara , Shuji Sonezaki , Yoshimasa Yamana
发明人： Makoto Bekki , Masako Ajimi , Hitoshi Ohara , Shuji Sonezaki , Yoshimasa Yamana
IPC分类号： G01N27/49 , G01N27/413
CPC分类号： G01N27/305 , G01N27/3276 , G01N33/5438
摘要： This invention provides a method for detecting an analyte, which, in specific detection of an analyte using photocurrent that is generated by photoexcitation of a sensitizing dye, can significantly simplify the structure and a detection procedure of a sensor unit and a device using the sensor unit and can realize detection with high accuracy, and also provides a sensor unit and a device using the sensor unit. According to the method, an analyte-containing sample solution and a sensitizing dye are brought into contact with the surface of a working electrode to immobilize the sensitizing dye onto the working electrode through specific binding. Subsequently, an electrolyte is supplied in situ while allowing the sample solution to be held without being removed to bring the working electrode and a counter electrode into contact with the electrolyte. The working electrode is irradiated with light to photoexcite the sensitizing dye and thus to detect photocurrent that flows across the working electrode and the counter electrode.
摘要翻译：本发明提供了一种用于检测分析物的方法，其特征在于使用通过光敏染料的光激发产生的光电流来特异性检测分析物，可以显着简化传感器单元和使用传感器单元的装置的结构和检测程序并且可以高精度地实现检测，并且还提供使用传感器单元的传感器单元和设备。根据该方法，使含分析物的样品溶液和敏化染料与工作电极的表面接触，通过特异性结合将致敏染料固定在工作电极上。随后，在原位提供电解质，同时允许样品溶液被保持而不被除去以使工作电极和对电极与电解质接触。用光照射工作电极，使感光染料发光，从而检测流过工作电极和对电极的光电流。

3. 发明申请

US20110193187A1 ELECTRODE MEMBER FOR SPECIFIC DETECTION OF ANALYTE USING PHOTOCURRENT 审中-公开
标题翻译：使用光电特定检测分析仪的电极部件
公开(公告)号：US20110193187A1
公开(公告)日：2011-08-11
申请号：US13061244
申请日：2009-09-01
申请人： Masako Nakamura , Makoto Bekki , Jyunya Narita , Shuji Sonezaki , Hitoshi Ohara
发明人： Masako Nakamura , Makoto Bekki , Jyunya Narita , Shuji Sonezaki , Hitoshi Ohara
IPC分类号： H01L31/0224 , H01L31/18 , B82Y99/00
CPC分类号： H01G9/2027 , Y02E10/542 , Y02P70/521
摘要： Disclosed is an electrode member for specific detection of an analyte using a photocurrent. The electrode member has at least a conductive substrate and an electron-accepting substance provided on said conductive substrate. The aforementioned electron-accepting substance consists at least of a first substance layer that is made of a semiconductor and a second substance that is made of a semiconductor of a kind different from that of the aforementioned semiconductor, a metal or a metal oxide, and is carried on the surface of said first substance layer. With the electrode member, improved detection sensitivity for the test substance and improved measurement precision can be achieved with specific detection of an analyte using a photocurrent.
摘要翻译：公开了一种用于使用光电流特异性检测分析物的电极部件。所述电极构件至少具有导电性基板和设置在所述导电性基板上的电子接受性物质。上述受电子物质至少由半导体形成的第一物质层和由与上述半导体不同的半导体制成的第二物质，金属或金属氧化物构成，并且为承载在所述第一物质层的表面上。利用电极构件，可以通过使用光电流的分析物的特异性检测来实现测试物质的改进的检测灵敏度和改善的测量精度。

4. 发明授权

US08092670B2 Method for specifically detecting analyte using photocurrent, and electrode, measuring cell and measuring device for use therein 有权
标题翻译：使用光电流专门检测分析物的方法，以及用于其中的电极，测量元件和测量装置
公开(公告)号：US08092670B2
公开(公告)日：2012-01-10
申请号：US11992858
申请日：2006-09-28
申请人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
发明人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
IPC分类号： G01N27/26 , G01N33/48 , G01N33/487 , G01N33/49 , G01N33/493 , G01N33/50 , G01N33/53 , G01N33/533
CPC分类号： G01N33/5438
摘要： A method, an electrode, a measuring cell, and a measuring device are disclosed which can detect and quantitatively determine an analyte having specific bonding properties, in a highly sensitive, simple and accurate manner using photocurrent. This method comprises contacting a working electrode and a counter electrode with an electrolyte medium, wherein the working electrode has an analyte immobilized thereon through a probe substance and wherein the analyte is bonded to a sensitizing dye; irradiating the working electrode with light to photoexcite the sensitizing dye; and detecting photocurrent flowing between the working electrode and the counter electrode, wherein the photocurrent is generated by transfer of electrons from the photoexcited sensitizing dye to the working electrode. The working electrode comprises an electron accepting layer comprising an electron accepting substance capable of accepting electrons released from the sensitizing dye in response to photoexcitation, wherein the probe substance is supported on a surface of the electron accepting layer. The electron accepting substance is an oxide semiconductor having an energy level lower than that of a lowest unoccupied molecular orbit (LUMO) of the sensitizing dye. The electrolyte medium comprises an electrolyte and at least one solvent selected from an aprotic solvent and a protic solvent, wherein the electrolyte comprises a salt capable of providing an oxidized sensitizing dye with electrons.
摘要翻译：公开了一种方法，电极，测量单元和测量装置，其可以使用光电流以高灵敏度，简单和准确的方式检测和定量地确定具有特定粘合特性的分析物。该方法包括使工作电极和对电极与电解质介质接触，其中工作电极通过探针物质固定在其上的分析物，并且其中分析物与致敏染料结合; 用光照射工作电极对光敏染料进行光刺激; 并且检测在工作电极和对电极之间流动的光电流，其中通过将电子从光激发敏化染料转移到工作电极而产生光电流。工作电极包括电子接受层，其包含能够响应于光激发而接受从感光染料释放的电子的电子接受物质，其中探针物质被负载在电子接受层的表面上。电子接受物质是具有比敏化染料的最低未占据分子轨道（LUMO）的能级更低的氧化物半导体。电解质介质包括电解质和至少一种选自非质子溶剂和质子溶剂的溶剂，其中电解质包含能够提供氧化的致敏染料与电子的盐。

5. 发明申请

US20090294305A1 Method for Specifically Detecting Analyte Using Photocurrent, and Electrode, Measuring Cell and Measuring Device for Use Therein 有权
标题翻译：使用光电流特异性检测分析物的方法，电极，测量单元及其使用的测量装置
公开(公告)号：US20090294305A1
公开(公告)日：2009-12-03
申请号：US11992858
申请日：2006-09-28
申请人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
发明人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
IPC分类号： G01N27/26 , G01F1/64
CPC分类号： G01N33/5438
摘要： A method, an electrode, a measuring cell, and a measuring device are disclosed which can detect and quantitatively determine an analyte having specific bonding properties, in a highly sensitive, simple and accurate manner using photocurrent. This method comprises contacting a working electrode and a counter electrode with an electrolyte medium, wherein the working electrode has an analyte immobilized thereon through a probe substance and wherein the analyte is bonded to a sensitizing dye; irradiating the working electrode with light to photoexcite the sensitizing dye; and detecting photocurrent flowing between the working electrode and the counter electrode, wherein the photocurrent is generated by transfer of electrons from the photoexcited sensitizing dye to the working electrode. The working electrode comprises an electron accepting layer comprising an electron accepting substance capable of accepting electrons released from the sensitizing dye in response to photoexcitation, wherein the probe substance is supported on a surface of the electron accepting layer. The electron accepting substance is an oxide semiconductor having an energy level lower than that of a lowest unoccupied molecular orbit (LUMO) of the sensitizing dye. The electrolyte medium comprises an electrolyte and at least one solvent selected from an aprotic solvent and a protic solvent, wherein the electrolyte comprises a salt capable of providing an oxidized sensitizing dye with electrons.
摘要翻译：公开了一种方法，电极，测量单元和测量装置，其可以使用光电流以高灵敏度，简单和准确的方式检测和定量地确定具有特定粘合特性的分析物。该方法包括使工作电极和对电极与电解质介质接触，其中工作电极通过探针物质固定在其上的分析物，并且其中分析物与致敏染料结合; 用光照射工作电极对光敏染料进行光刺激; 并且检测在工作电极和对电极之间流动的光电流，其中通过将电子从光激发敏化染料转移到工作电极而产生光电流。工作电极包括电子接受层，其包含能够响应于光激发而从感光染料中释放的电子的受电子物质，其中探针物质被负载在电子接受层的表面上。电子接受物质是具有比敏化染料的最低未占据分子轨道（LUMO）的能级更低的氧化物半导体。电解质介质包括电解质和至少一种选自非质子溶剂和质子溶剂的溶剂，其中电解质包含能够提供氧化的致敏染料与电子的盐。

6. 发明申请

US20120270264A1 DNA CONSTRUCT, AND PROCESS FOR PRODUCTION OF RECOMBINANT CHO CELL USING SAME 审中-公开
标题翻译： DNA构建及使用该方法生产重组CHO细胞的方法
公开(公告)号：US20120270264A1
公开(公告)日：2012-10-25
申请号：US13498006
申请日：2010-09-21
申请人： Shuji Sonezaki , Yumi Ogami , Yoshimasa Yamana , Junya Narita
发明人： Shuji Sonezaki , Yumi Ogami , Yoshimasa Yamana , Junya Narita
IPC分类号： C12N15/85 , C12P21/00 , C12N5/10 , C12N15/86 , C12N15/90
CPC分类号： C07K16/00 , C12N15/85 , C12N15/907 , C12N2830/46 , C12N2830/85 , C12P21/02
摘要： Disclosed is a DNA construct that is useful for efficient production of recombinant CHO cells useful for the production of target proteins. The DNA construct is a construct comprising, from a 5′ end toward a 3′ end, a first homologous DNA fragment, a target protein gene, and a second homologous DNA fragment. The first and second homologous DNA fragments have homology allowing for homologous recombination with a part of a hypoxanthine-phosphoribosyltransferase enzyme (hprt) locus in a CHO cell genome and have a chain length of not less than 1 kbp.
摘要翻译：公开了可用于有效生产可用于产生靶蛋白的重组CHO细胞的DNA构建体。 DNA构建体是包含从5'端到3'端的第一同源DNA片段，靶蛋白基因和第二同源DNA片段的构建体。第一和第二同源DNA片段具有允许与CHO细胞基因组中的一部分次黄嘌呤 - 磷酸核糖基转移酶（hprt）基因座同源重组并且链长不小于1kbp的同源性。

7. 发明申请

US20120100627A1 MEASUREMENT DEVICE USED FOR SPECIFICALLY DETECTING SUBSTANCE TO BE EXAMINED USING PHOTOCURRENT, SENSOR UNIT USED FOR SAME, AND METHOD FOR SPECIFICALLY DETECTING SUBSTANCE TO BE EXAMINED USING PHOTOCURRENT 失效
标题翻译：用于特异性检测使用光电流检测的物质的测量装置，用于相同的传感器单元以及使用光电检测物质进行特定检测的方法
公开(公告)号：US20120100627A1
公开(公告)日：2012-04-26
申请号：US13256713
申请日：2010-03-18
申请人： Makoto Bekki , Shuji Sonezaki
发明人： Makoto Bekki , Shuji Sonezaki
IPC分类号： G01N27/00 , G01N30/96
CPC分类号： G01N27/305
摘要： In utilizing photocurrent generated in the photoexcitation of a dye in specific detection of an analyte, highly accurate detection can be realized by discharging charged current generated in the formation of a sensor unit and, in the detection of photocurrent of a plurality of detection spots provided on a working electrode, discharging photocurrent which is derived from a detection spot subjected to the latest photocurrent measurement and becomes noise current. The present invention provides a measuring apparatus comprising a sensor unit comprising a working electrode, a counter electrode, and an electrolyte-containing substance, a single or plurality of light sources that apply light to the working electrode, an XY moving device provided when the light source is moved relatively in an XY direction relative to the working electrode, an ammeter that measures current which flows across the working electrode and the counter electrode, and a discharge device that discharges charged current and photocurrent derived from a detection spot subjected to the latest photocurrent measurement. The specific detection method using the measuring apparatus is carried out by controlling the timing of light irradiation and the timing of connection to the ammeter and the discharge device.
摘要翻译：利用在特定检测分析物中对染料的光激发产生的光电流，可以通过放电在传感器单元的形成中产生的充电电流来放电，并且在检测到多个检测点的光电流时，能够实现高精度的检测工作电极，从经受最新光电流测量的检测点导出的放电光电流成为噪声电流。本发明提供了一种测量装置，包括：传感器单元，包括工作电极，对电极和含电解质的物质;对工作电极施加光的单个或多个光源;当所述光源相对于工作电极相对于XY方向移动，测量流过工作电极和对电极的电流的电流表;以及放电装置，其对充电电流进行放电，并从经受最新光电流的检测点导出光电流测量。通过控制光照射的定时和与电流表和放电装置的连接的定时来进行使用测定装置的具体的检测方法。

8. 发明授权

US08501492B2 Measurement device used for specifically detecting substance to be examined using photocurrent, sensor unit used for same, and method for specifically detecting substance to be examined using photocurrent 失效
标题翻译：用于使用光电流特异性检测待检测物质的测量装置，用于其的传感器单元以及使用光电流专门检测待检测物质的方法
公开(公告)号：US08501492B2
公开(公告)日：2013-08-06
申请号：US13256713
申请日：2010-03-18
申请人： Makoto Bekki , Shuji Sonezaki
发明人： Makoto Bekki , Shuji Sonezaki
IPC分类号： G01N27/00 , G01N30/96 , G01N30/00
CPC分类号： G01N27/305
摘要： In utilizing photocurrent generated in the photoexcitation of a dye in specific detection of an analyte, highly accurate detection can be realized by discharging charged current generated in the formation of a sensor unit and, in the detection of photocurrent of a plurality of detection spots provided on a working electrode, discharging photocurrent which is derived from a detection spot subjected to the latest photocurrent measurement and becomes noise current. The present invention provides a measuring apparatus comprising a sensor unit comprising a working electrode, a counter electrode, and an electrolyte-containing substance, a single or plurality of light sources that apply light to the working electrode, an XY moving device provided when the light source is moved relatively in an XY direction relative to the working electrode, an ammeter that measures current which flows across the working electrode and the counter electrode, and a discharge device that discharges charged current and photocurrent derived from a detection spot subjected to the latest photocurrent measurement. The specific detection method using the measuring apparatus is carried out by controlling the timing of light irradiation and the timing of connection to the ammeter and the discharge device.
摘要翻译：利用在特定检测分析物中对染料的光激发产生的光电流，可以通过放电在传感器单元的形成中产生的充电电流来放电，并且在检测到多个检测点的光电流的检测中可以实现高精度的检测工作电极，从经受最新光电流测量的检测点导出的放电光电流成为噪声电流。本发明提供了一种测量装置，包括：传感器单元，包括工作电极，对电极和含电解质的物质;对工作电极施加光的单个或多个光源;当所述光源相对于工作电极相对于XY方向移动，测量流过工作电极和对电极的电流的电流表;以及放电装置，其对充电电流进行放电，并从经受最新光电流的检测点导出光电流测量。通过控制光照射的定时和与电流表和放电装置的连接的定时来进行使用测定装置的具体的检测方法。

9. 发明申请

US20100136115A1 Pharmaceutical Titanium Dioxide Composite Allowing Disappearance of Drug Efficacy By Light Irradiation 审中-公开
标题翻译：药物二氧化钛复合物允许通过光照射消除药物功效
公开(公告)号：US20100136115A1
公开(公告)日：2010-06-03
申请号：US11990040
申请日：2006-08-04
申请人： Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Toshiaki Banzai , Yoshinobu Kubota
发明人： Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Toshiaki Banzai , Yoshinobu Kubota
IPC分类号： A61K9/14 , A61K31/704 , A61K38/14 , A61P35/00
CPC分类号： A61K41/0028 , A61K9/0019 , A61K31/704 , A61K47/58 , A61K47/6923 , A61K47/6929 , B82Y5/00
摘要： Disclosed is a titanium dioxide composite material which can be dispersed in an aqueous solvent stably and can be administered to a living body in a simple manner and in which the pharmacological effect of a therapeutic compound carried on the composite material can be eliminated by irradiation with light. Also disclosed is a dispersion product of the composite material. The composite material comprises titanium dioxide which has a photocatalytic activity and a therapeutic compound attached to the titanium dioxide through a hydrophilic polymer. The composite material is stable in an aqueous solvent and can be administered to a living body in a simple manner. After the composite material is administered to a living body, a site on the living body where the pharmacological effect of the therapeutic compound is not needed to be developed can be irradiated with light to induce the light excitation of titanium dioxide at the site, thereby decomposing the therapeutic compound to reduce any adverse side effect of the therapeutic compound.
摘要翻译：公开了一种二氧化钛复合材料，其可以稳定地分散在水性溶剂中，并且可以简单的方式施用于生物体，并且通过照射光可以消除携带在复合材料上的治疗化合物的药理作用。还公开了复合材料的分散体。复合材料包括具有光催化活性的二氧化钛和通过亲水性聚合物连接到二氧化钛上的治疗化合物。复合材料在水性溶剂中稳定，可以以简单的方式施用于生物体。在将复合材料施用于生物体后，可以用光照射生物体上不需要开发治疗化合物的药理作用的部位，从而在该部位诱导二氧化钛的光激发，从而分解该治疗化合物用于减少治疗化合物的任何副作用。

10. 发明申请

US20060281087A1 Titanium dioxide complex having molecule distinguishability 审中-公开
标题翻译：具有分子识别性的二氧化钛络合物
公开(公告)号：US20060281087A1
公开(公告)日：2006-12-14
申请号：US10551164
申请日：2004-03-31
申请人： Shuji Sonezaki , Koki Kanehira , Shinichi Yagi , Yumi Ogami
发明人： Shuji Sonezaki , Koki Kanehira , Shinichi Yagi , Yumi Ogami
IPC分类号： C12Q1/68 , C09C1/36 , G01N33/555
CPC分类号： A61K41/0019 , A61K9/0014 , A61K33/24 , A61K41/0042 , A61K47/02 , A61K47/6883 , A61K47/6923 , A61K47/6929 , A61L2/16 , B82Y5/00 , C07K17/14 , G01N33/554
摘要： A titanium dioxide composite having a molecular recognition capacity is obtained by modifying the surface of a fine titanium dioxide particle with a hydrophilic polymer in such a manner that titanium dioxide is bonded via an ester bond to a carboxyl group of the hydrophilic polymer and immobilizing a molecule having an ability to specifically bind to a target molecule to the carboxyl residue of the hydrophilic polymer. Due to the molecule distinguishability, this titanium dioxide complex can bind specifically to an endocrine disrupting chemical, a pathogenic factor, a cancer cell and the like and decompose the same by a photocatalytic function.
摘要翻译：具有分子识别能力的二氧化钛复合体是通过用亲水性聚合物的羧基与二氧化钛键合而使亲水性聚合物的表面进行改性而得到的，具有将特异性结合到亲水性聚合物的羧基残基的靶分子的能力。由于分子的可区分性，这种二氧化钛络合物可以特异性结合内分泌干扰物，致病因子，癌细胞等，并通过光催化功能分解。

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