专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08154796B2 Microscope apparatus 有权
标题翻译：显微镜装置
公开(公告)号：US08154796B2
公开(公告)日：2012-04-10
申请号：US11593842
申请日：2006-11-07
申请人： Makoto Araki , Hiroshi Sasaki , Tatsuo Nakata , Makio Ueno
发明人： Makoto Araki , Hiroshi Sasaki , Tatsuo Nakata , Makio Ueno
IPC分类号： G02B21/06
CPC分类号： G02B21/0032 , G01N21/6458 , G01N2021/6439 , G02B21/0044 , G02B21/0076 , G02B21/0084 , G02B21/16 , G02B21/32
摘要： A microscope apparatus that can observe into the interior of a specimen and that can apply an optical stimulus over a wide area within a short period of time is provided. The microscope apparatus comprises at least one observation scanning optical system including a laser light source for emitting observation laser light, an objective lens, and a scanning optical system for two-dimensionally scanning the observation laser light in a predetermined examination plane of the specimen via the objective lens; and at least one stimulus optical system which includes a lamp light source for emitting light having a wavelength used for optical stimulation and which irradiates the specimen with the light emitted from the lamp light source.
摘要翻译：提供了可以观察到样本内部并且可以在短时间内在广泛区域上施加光学刺激的显微镜装置。显微镜装置包括至少一个观察扫描光学系统，其包括用于发射观察激光的激光光源，物镜和用于在样本的预定检查平面中二维扫描观察激光的扫描光学系统物镜; 以及至少一个刺激光学系统，其包括用于发射具有用于光学刺激的波长的光的灯光源，并且从灯光源发射的光照射样本。

2. 发明申请

US20070109634A1 Microscope apparatus 有权
标题翻译：显微镜装置
公开(公告)号：US20070109634A1
公开(公告)日：2007-05-17
申请号：US11593842
申请日：2006-11-07
申请人： Makoto Araki , Hiroshi Sasaki , Tatsuo Nakata , Makio Ueno
发明人： Makoto Araki , Hiroshi Sasaki , Tatsuo Nakata , Makio Ueno
IPC分类号： G02B21/06
CPC分类号： G02B21/0032 , G01N21/6458 , G01N2021/6439 , G02B21/0044 , G02B21/0076 , G02B21/0084 , G02B21/16 , G02B21/32
摘要： A microscope apparatus that can observe into the interior of a specimen and that can apply an optical stimulus over a wide area within a short period of time is provided. The microscope apparatus comprises at least one observation scanning optical system including a laser light source for emitting observation laser light, an objective lens, and a scanning optical system for two-dimensionally scanning the observation laser light in a predetermined examination plane of the specimen via the objective lens; and at least one stimulus optical system which includes a lamp light source for emitting light having a wavelength used for optical stimulation and which irradiates the specimen with the light emitted from the lamp light source.
摘要翻译：提供了可以观察到样本内部并且可以在短时间内在广泛区域上施加光学刺激的显微镜装置。显微镜装置包括至少一个观察扫描光学系统，其包括用于发射观察激光的激光光源，物镜和用于在样本的预定检查平面中二维扫描观察激光的扫描光学系统物镜; 以及至少一个刺激光学系统，其包括用于发射具有用于光学刺激的波长的光的灯光源，并且从灯光源发射的光照射样本。

3. 发明授权

US07889341B2 Multiphoton-excitation laser scanning microscope 有权
标题翻译：多光子激发扫描显微镜
公开(公告)号：US07889341B2
公开(公告)日：2011-02-15
申请号：US12148671
申请日：2008-04-21
申请人： Makoto Araki , Yasunari Matsukawa , Hiroshi Sasaki , Makio Ueno
发明人： Makoto Araki , Yasunari Matsukawa , Hiroshi Sasaki , Makio Ueno
IPC分类号： G01N21/25
CPC分类号： G02B21/0076 , G01N21/6458 , G02B21/0064 , G02B21/008
摘要： A multiphoton-excitation laser scanning microscope capable of efficiently collecting fluorescence emitted from a specimen to acquire a brighter multiphoton-excitation fluorescence image is provided. This multiphoton-excitation laser scanning microscope includes a multiphoton-excitation laser light source for emitting ultrashort pulsed laser light, a light-scanning unit configured to scan a specimen with the ultrashort pulsed laser light emitted from the multiphoton-excitation laser light source in two dimensions, an objective lens configured to focus the ultrashort pulsed laser light scanned by the light-scanning unit on the specimen, a collector lens disposed opposite the objective lens, with the light-scanning unit disposed therebetween, to collect fluorescence emitted from the specimen, and a light detector configured to detect the fluorescence collected by the collector lens. The collector lens has a higher numerical aperture and a larger field number than the objective lens.
摘要翻译：提供能够有效地收集从样本发出的荧光以获得更明亮的多光子激发荧光图像的多光子激发激光扫描显微镜。该多光子激发激光扫描显微镜包括用于发射超短脉冲激光的多光子激发激光光源，被配置为使用从多光子激发激光光源发射的超短脉冲激光二维扫描样本的光扫描单元配置为将由所述光扫描单元扫描的超短脉冲激光对准在所述检体上的物镜，与所述物镜相对设置的集光透镜，其间设置有所述光扫描单元，以收集从所述检体发出的荧光，以及光检测器，被配置为检测由所述收集透镜收集的荧光。收集透镜具有比物镜更高的数值孔径和更大的场数。

4. 发明申请

US20080266551A1 Multiphoton-excitation laser scanning microscope 有权
标题翻译：多光子激发扫描显微镜
公开(公告)号：US20080266551A1
公开(公告)日：2008-10-30
申请号：US12148671
申请日：2008-04-21
申请人： Makoto Araki , Yasunari Matsukawa , Hiroshi Sasaki , Makio Ueno
发明人： Makoto Araki , Yasunari Matsukawa , Hiroshi Sasaki , Makio Ueno
IPC分类号： G01N21/00 , G01J3/30
CPC分类号： G02B21/0076 , G01N21/6458 , G02B21/0064 , G02B21/008
摘要： A multiphoton-excitation laser scanning microscope capable of efficiently collecting fluorescence emitted from a specimen to acquire a brighter multiphoton-excitation fluorescence image is provided. This multiphoton-excitation laser scanning microscope includes a multiphoton-excitation laser light source for emitting ultrashort pulsed laser light, a light-scanning unit configured to scan a specimen with the ultrashort pulsed laser light emitted from the multiphoton-excitation laser light source in two dimensions, an objective lens configured to focus the ultrashort pulsed laser light scanned by the light-scanning unit on the specimen, a collector lens disposed opposite the objective lens, with the light-scanning unit disposed therebetween, to collect fluorescence emitted from the specimen, and a light detector configured to detect the fluorescence collected by the collector lens. The collector lens has a higher numerical aperture and a larger field number than the objective lens.
摘要翻译：提供能够有效地收集从样本发出的荧光以获得更明亮的多光子激发荧光图像的多光子激发激光扫描显微镜。该多光子激发激光扫描显微镜包括用于发射超短脉冲激光的多光子激发激光光源，被配置为使用从多光子激发激光光源发射的超短脉冲激光二维扫描样本的光扫描单元配置为将由所述光扫描单元扫描的超短脉冲激光对准在所述检体上的物镜，与所述物镜相对设置的集光透镜，其间设置有所述光扫描单元，以收集从所述检体发出的荧光，以及光检测器，被配置为检测由所述收集透镜收集的荧光。收集透镜具有比物镜更高的数值孔径和更大的场数。

5. 发明授权

US07485876B2 Laser scanning microscope 有权
标题翻译：激光扫描显微镜
公开(公告)号：US07485876B2
公开(公告)日：2009-02-03
申请号：US11711407
申请日：2007-02-27
申请人： Masaharu Tomioka , Tatsuo Nakata , Hiroshi Sasaki
发明人： Masaharu Tomioka , Tatsuo Nakata , Hiroshi Sasaki
IPC分类号： G01J1/58
CPC分类号： G02B21/0076 , G02B21/0064 , G02B21/0068
摘要： A laser scanning microscope includes an exciting observation light source, a stimulation light source, a first scanning portion that two-dimensionally scans the exciting observation light across a specimen, a second scanning portion that sets an incident position of the stimulation light on the specimen, an optical path combining portion that brings the exciting observation light and the stimulation light to an identical optical path, an objective lens that irradiates the specimen with the exciting observation light and/or the stimulation light while collecting fluorescence light emitted from the specimen, and a detecting portion that detects the collected fluorescence light, the optical path combining portion being disposed so as to be in an optically conjugate relationship with the first scanning portion and the second scanning portion.
摘要翻译：激光扫描显微镜包括激发观察光源，刺激光源，二维地扫描穿过样本的激发观察光的第一扫描部分，将刺激光的入射位置设定在样本上的第二扫描部，将激发观察光和刺激光带入相同的光路的光路组合部，在收集从样本发出的荧光的同时照射具有激发观察光和/或刺激光的样本的物镜，检测部分，其检测所收集的荧光，所述光路组合部分设置成与所述第一扫描部分和所述第二扫描部分处于光学共轭关系。

6. 发明授权

US07456378B2 Confocal microscope and multiphoton excitation microscope 有权
标题翻译：共焦显微镜和多光子激发显微镜
公开(公告)号：US07456378B2
公开(公告)日：2008-11-25
申请号：US11805378
申请日：2007-05-22
申请人： Hiroshi Sasaki , Eiji Yokoi , Tatsuo Nakata
发明人： Hiroshi Sasaki , Eiji Yokoi , Tatsuo Nakata
IPC分类号： H01J40/14 , G02B7/04 , G02B21/00
CPC分类号： G02B21/16 , G02B21/0032 , G02B21/004
摘要： The invention provides a confocal microscope comprising a light source; a light scanning unit; an array device; a line-beam generating unit for imaging illumination light in the form of a straight line extending, on the array device, in a direction intersecting the scanning direction of the light scanning unit; an objective lens for imaging the illumination light reflected or transmitted at the array device on a specimen; a beamsplitter, between the array device and the light scanning unit, for splitting off from the illumination light detection light from the specimen; a two-dimensional image-acquisition unit for acquiring the split off detection light; and a control unit for controlling the light scanning unit and the array device, wherein the array device is disposed in an optically conjugate positional relationship with a focal plane of the objective lens, and the control unit performs control so as to synchronize the light scanning unit and the array device.
摘要翻译：本发明提供一种包括光源的共焦显微镜; 光扫描单元; 阵列器件; 一个线束产生单元，用于在阵列装置上沿与光扫描单元的扫描方向相交的方向成直线的形式的照明光; 用于对在样品上的阵列装置反射或透射的照明光进行成像的物镜; 阵列器件和光扫描单元之间的分束器，用于从来自样本的照明光检测光分离; 用于获取分离检测光的二维图像获取单元; 以及控制单元，用于控制光扫描单元和阵列器件，其中阵列器件与物镜的焦平面以光学共轭位置关系设置，并且控制单元执行控制以使光扫描单元和阵列设备。

7. 发明申请

US20070272843A1 Confocal microscope and multiphoton excitation microscope 有权
标题翻译：共焦显微镜和多光子激发显微镜
公开(公告)号：US20070272843A1
公开(公告)日：2007-11-29
申请号：US11805378
申请日：2007-05-22
申请人： Hiroshi Sasaki , Eiji Yokoi , Tatsuo Nakata
发明人： Hiroshi Sasaki , Eiji Yokoi , Tatsuo Nakata
IPC分类号： H01J40/14 , H01J3/14
CPC分类号： G02B21/16 , G02B21/0032 , G02B21/004
摘要： The invention provides a confocal microscope comprising a light source; a light scanning unit; an array device; a line-beam generating unit for imaging illumination light in the form of a straight line extending, on the array device, in a direction intersecting the scanning direction of the light scanning unit; an objective lens for imaging the illumination light reflected or transmitted at the array device on a specimen; a beamsplitter, between the array device and the light scanning unit, for splitting off from the illumination light detection light from the specimen; a two-dimensional image-acquisition unit for acquiring the split off detection light; and a control unit for controlling the light scanning unit and the array device, wherein the array device is disposed in an optically conjugate positional relationship with a focal plane of the objective lens, and the control unit performs control so as to synchronize the light scanning unit and the array device.
摘要翻译：本发明提供一种包括光源的共焦显微镜; 光扫描单元; 阵列器件; 一个线束产生单元，用于在阵列装置上沿与光扫描单元的扫描方向相交的方向成直线的形式的照明光; 用于对在样品上的阵列装置反射或透射的照明光进行成像的物镜; 阵列器件和光扫描单元之间的分束器，用于从来自样本的照明光检测光分离; 用于获取分离检测光的二维图像获取单元; 以及控制单元，用于控制光扫描单元和阵列器件，其中阵列器件与物镜的焦平面以光学共轭位置关系设置，并且控制单元执行控制以使光扫描单元和阵列设备。

8. 发明申请

US20070205378A1 Laser scanning microscope 有权
标题翻译：激光扫描显微镜
公开(公告)号：US20070205378A1
公开(公告)日：2007-09-06
申请号：US11711407
申请日：2007-02-27
申请人： Masaharu Tomioka , Tatsuo Nakata , Hiroshi Sasaki
发明人： Masaharu Tomioka , Tatsuo Nakata , Hiroshi Sasaki
IPC分类号： G01J1/58 , F21V9/16
CPC分类号： G02B21/0076 , G02B21/0064 , G02B21/0068
摘要： A laser scanning microscope provides advantages that replacement of any optical element becomes unnecessary, and ease of operation and positioning repeatability of light stimulation are improved. The laser scanning microscope includes an exciting observation light source, a stimulation light source, a first scanning portion that two-dimensionally scans the exciting observation light across a specimen, a second scanning portion that sets an incident position of the stimulation light on the specimen, an optical path combining portion that brings the exciting observation light and the stimulation light to an identical optical path, an objective lens that irradiates the specimen with the exciting observation light and/or the stimulation light while converging fluorescence light emitted from the specimen, and a detecting portion that detects the converged fluorescence light, the optical path combining portion being disposed so as to be in an optically conjugate relationship with the first scanning portion and the second scanning portion.
摘要翻译：激光扫描显微镜提供了不需要更换任何光学元件的优点，并且提高了光刺激的操作和定位重复性的容易性。激光扫描显微镜包括激发观察光源，刺激光源，二维地扫描穿过样本的激发观察光的第一扫描部分，将刺激光的入射位置设定在样本上的第二扫描部，将激发观察光和刺激光带到相同的光路的光路组合部，使从激光观察光和/或刺激光照射到样本的物镜同时会聚从样本发出的荧光，以及检测所述会聚的荧光的检测部，所述光路组合部被配置为与所述第一扫描部和所述第二扫描部成为光学共轭关系。

9. 发明授权

US07176428B2 Laser-based, multiphoton-excitation-type optical examination apparatus 有权
标题翻译：基于激光的多光子激发型光学检查装置
公开(公告)号：US07176428B2
公开(公告)日：2007-02-13
申请号：US11070191
申请日：2005-03-03
申请人： Yoshihiro Kawano , Tadashi Hirata , Tatsuo Nakata , Hiroshi Sasaki
发明人： Yoshihiro Kawano , Tadashi Hirata , Tatsuo Nakata , Hiroshi Sasaki
IPC分类号： G02B7/04 , H01J3/14 , H04B10/12
CPC分类号： G01N21/6486 , G01N21/6456
摘要： The invention provides a multiphoton-excitation-type examination apparatus that efficiently generates a multiphoton-excitation effect, that makes the measurement head compact, and that can be easily adjusted when the measurement head is replaced. The multiphoton-excitation-type examination apparatus comprises a laser light source that oscillates ultrashort pulsed laser light; an optical fiber that transmits the ultrashort pulsed laser light from the laser light source; a support member; a measurement head supported on the support member so as to be movable upwards and downwards and at an angle, and having an optical system that irradiates a specimen with the ultrashort pulsed laser light transmitted by the optical fiber that measures fluorescence or reflected light coming from the specimen; and a dispersion-compensating member, in the measurement head, that compensates for group velocity dispersion of the ultrashort pulsed laser light irradiated onto the specimen.
摘要翻译：本发明提供了一种多光子激发型检查装置，其有效地产生使得测量头紧凑，并且在更换测量头时可以容易地调节的多光子激发效果。多光子激发型检查装置包括：振荡超短脉冲激光的激光光源; 从激光光源发射超短脉冲激光的光纤; 支撑构件; 测量头支撑在支撑构件上，以便可上下移动一定角度，并且具有光学系统，该光学系统用由光纤透射的超短脉冲激光照射样本，该光纤测量荧光或来自标本; 以及在测量头中补偿照射到样本上的超短脉冲激光的组速度色散的色散补偿部件。

10. 发明授权

US07268344B2 Scanning laser microscope apparatus 有权
标题翻译：扫描激光显微镜装置
公开(公告)号：US07268344B2
公开(公告)日：2007-09-11
申请号：US11447761
申请日：2006-06-06
申请人： Kunihiko Sasaki , Yasunari Matsukawa , Hiroshi Sasaki , Tatsuo Nakata
发明人： Kunihiko Sasaki , Yasunari Matsukawa , Hiroshi Sasaki , Tatsuo Nakata
IPC分类号： G01J1/32
CPC分类号： G02B21/008 , G01N21/6458
摘要： A scanning laser microscope that can quantitatively display a laser irradiation power on a display unit and that can suppress fluctuations in the laser irradiation power is provided. The scanning laser microscope includes a light source configured to emit laser light, a scanning unit configured to scan the laser light emitted from the light source on a sample, a photodetector configured to detect light from the sample, a processing unit configured to convert a signal from the photodetector into an image signal of the sample and to output the image signal, a reference light detector configured to detect part of the laser light emitted from the light source as a reference light signal, a laser light control unit configured to control the power of the laser light emitted from the light source, an irradiation-power calculation unit configured to calculate an irradiation power value at the sample on the basis of the reference light signal detected by the reference light detector, and a display unit configured to display the calculated irradiation power value at the sample.
摘要翻译：提供了一种可以在显示单元上定量显示激光照射功率并且可以抑制激光照射功率的波动的扫描激光显微镜。该扫描激光显微镜包括配置为发射激光的光源，被配置为扫描从样品上的光源发射的激光的扫描单元，被配置为检测来自样品的光的光电检测器，被配置为将信号从光电检测器到样品的图像信号并输出图像信号;参考光检测器，被配置为检测从光源发射的激光的一部分作为参考光信号;激光控制单元，被配置为控制功率照射功率计算单元，被配置为基于由参考光检测器检测的参考光信号计算样本处的照射功率值;以及显示单元，被配置为显示所计算的样品照射功率值。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式