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1. 发明申请

WO2005003100A3 4-ARYLAMINO-QUINAZOLINES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS 审中-公开
标题翻译： 4-ARYLAMINO-QUINAZOLINES作为活化剂和杀虫剂的诱导剂
公开(公告)号：WO2005003100A3
公开(公告)日：2005-05-12
申请号：PCT/US2004021631
申请日：2004-07-06
申请人： MYRIAD GENETICS INC , CYTOVIA INC , CAI SUI XIONG , SIRISOMA NILANTHA SUDATH , PERVIN AZRA , DREWE JOHN A , KASIBHATLA SHAILAJA , JAING SONGCHUN , ZHANG HONG , PLEIMAN CHRIS , BAICHWAL VIJAY , MANFREDI JOHN , BHOITE LEENA
发明人： CAI SUI XIONG , SIRISOMA NILANTHA SUDATH , PERVIN AZRA , DREWE JOHN A , KASIBHATLA SHAILAJA , JAING SONGCHUN , ZHANG HONG , PLEIMAN CHRIS , BAICHWAL VIJAY , MANFREDI JOHN , BHOITE LEENA
IPC分类号： A61K31/517 , A61K31/519 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D473/34 , C07D487/04 , A61K31/47 , A61P35/00 , C07D215/44 , C07D217/22 , C07D409/12 , C07D473/16 , C07D475/06
CPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D473/34 , C07D487/04
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。

2. 发明申请

WO2008011045A2 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-b][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开
标题翻译： 3-ARYL-6-ARYL-7H- [1,2,4]三唑并[3,4-b] [1,3,4]缬氨酸和类似物作为杀虫剂和杀虫剂的激活剂及其用途
公开(公告)号：WO2008011045A2
公开(公告)日：2008-01-24
申请号：PCT/US2007016238
申请日：2007-07-18
申请人： CYTOVIA INC , CAI SUI XIONG , DREWE JOHN A , ZHANG HAN-ZHONG , KASIBHATLA SHAILAJA , CLAASSEN GISELA , SIRISOMA NILANTHA SUDATH , KEMNITZER WILLIAM EDWARD
发明人： CAI SUI XIONG , DREWE JOHN A , ZHANG HAN-ZHONG , KASIBHATLA SHAILAJA , CLAASSEN GISELA , SIRISOMA NILANTHA SUDATH , KEMNITZER WILLIAM EDWARD
IPC分类号： A61K31/53 , A61K31/542 , A61P35/00 , C07D487/04 , C07D513/04
CPC分类号： A61K31/53 , A61K31/542 , C07D487/04 , C07D513/04
摘要： Disclosed are 3-aryl-6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and analogs thereof, represented by the Formula (I), wherein Ar 1 , Q 2 , R 1 , R 2 , dashed line and X are defined herein. The present invention relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：公开了由式（I）表示的3-芳基-6-芳基-7H- [1,2,4]三唑并[3,4-b] [1,3,4]噻二嗪及其类似物，其中Ar < 在本文中定义了SUB 1，Q 2，R 1，R 2，X和X。本发明涉及具有式（I）的化合物是胱天蛋白酶的活化剂和凋亡诱导剂的发现。因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。

3. 发明申请

WO2004094647A2 METHODS OF TREATING DISEASES RESPONSIVE TO INDUCTION OF APOPTOSIS AND SCREENING ASSAYS 审中-公开
标题翻译：治疗反应性感染和筛查测定的方法
公开(公告)号：WO2004094647A2
公开(公告)日：2004-11-04
申请号：PCT/US2004011915
申请日：2004-04-19
申请人： CYTOVIA INC , KASIBHATLA SHAILAJA , CAI SUI XIONG , TSENG BEN , JESSEN KATAYOUN ALAVI , MALIARTCHOUK SERGUEI , ENGLISH NICOLE MARION , JIANG SONGCHUN , SIRISOMA NILANTHA SUDATH , ZHANG HAN-ZHONG , KUEMMERLE JARED
发明人： KASIBHATLA SHAILAJA , CAI SUI XIONG , TSENG BEN , JESSEN KATAYOUN ALAVI , MALIARTCHOUK SERGUEI , ENGLISH NICOLE MARION , JIANG SONGCHUN , SIRISOMA NILANTHA SUDATH , ZHANG HAN-ZHONG , KUEMMERLE JARED
IPC分类号： A61K31/352 , A61K38/17 , A61K49/00 , C07D493/20 , C07D519/00 , C12Q20060101 , C12Q
CPC分类号： A61K49/0052 , A61K31/352 , A61K49/0043 , A61K51/0412 , A61K51/0419 , A61K51/0421 , A61K51/0453 , A61K51/0495
摘要： The present invention pertains to a method of treating, preventing or ameliorating a disease responsive to induction of the caspase cascade in an animal, comprising administering to the animal a compound which binds specifically to one or more Apoptosis Inducing Proteins (AIPs). AIPs include Transferrin Receptor Related Apoptosis Inducing Proteins (TRRAIPs), Clathrin Heavy Chain Related Apoptosis Inducing Proteins (CHCRAIPs), IQ motif containing GTPase Activating Protein Related Apoptosis Inducing Proteins (IQGAPRAIPs), and Heat Shock Protein Related Apoptosis Inducing Proteins (HSPRAIPs). The present invention also relates to screening methods useful for drug discovery of apoptosis inducing compounds. In particular, the screening methodology relates to using AIPs as a target for the discovery of apoptosis activators useful as anticancer agents. The screening methods of the present invention can employ homogenous or heterogenous binding assays using purified or partially purified AIPs; or whole cell assays using cells with altered levels of one or more AIPs. The invention also contemplates use of gambogic acid or GA-related compounds which bind AIPs and can accordingly be used to raise antibodies useful for drug discovery. Alternatively, labeled GA is used for competitive binding assays for drug discovery. Such assays afford high throughput screening of chemical libraries for apoptosis activators.
摘要翻译：本发明涉及一种治疗，预防或改善对动物中胱天蛋白酶级联诱导起反应的疾病的方法，包括向动物施用与一种或多种凋亡诱导蛋白（AIP）特异性结合的化合物。 AIPs包括转铁蛋白受体相关凋亡诱导蛋白（TRRAIP），网格蛋白重链相关凋亡诱导蛋白（CHCRAIPs），包含GTPase激活蛋白相关凋亡诱导蛋白（IQGAPRAIPs）和热休克蛋白相关凋亡诱导蛋白（HSPRAIPs）的IQ基序。本发明还涉及可用于药物发现凋亡诱导化合物的筛选方法。特别地，筛选方法涉及使用AIP作为发现用作抗癌剂的凋亡激活剂的靶标。本发明的筛选方法可以使用纯化或部分纯化的AIPs进行均一或异源结合测定; 或使用具有改变水平的一种或多种AIP的细胞的全细胞测定。本发明还考虑使用结合AIP的葡萄糖酸或GA相关化合物，因此可以用于产生可用于药物发现的抗体。或者，标记的GA用于药物发现的竞争性结合测定。这样的测定提供用于凋亡激活剂的化学文库的高通量筛选。

4. 发明申请

WO2005037196A2 SUBSTITUTED 2-ARYLMETHYLENE-N-ARYL-N'-ARYL-MALONAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS 审中-公开
标题翻译：取代的2-芳基甲基-N-芳基-N'-芳基 - 马来酰胺和模拟物作为宿主和杀虫剂的激活剂
公开(公告)号：WO2005037196A2
公开(公告)日：2005-04-28
申请号：PCT/US2004032570
申请日：2004-10-05
申请人： CYTOVIA INC , CAI SUI XIONG , PERVIN AZRA , KASIBHATLA SHAILAJA , NGUYEN BAO NGOC
发明人： CAI SUI XIONG , PERVIN AZRA , KASIBHATLA SHAILAJA , NGUYEN BAO NGOC
IPC分类号： A61K20060101 , A61K31/16 , A61K
CPC分类号： A61K31/16 , A61K31/165 , A61K31/381 , A61K31/4025 , A61K31/405 , A61K31/416 , A61K31/4178 , A61K31/444 , A61K31/4709 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to substituted 2-arylmethylene-N-aryl-N'-aryl-malonamides and analogs thereof. The present invention also relates to the discovery that the compounds are activators of caspases and inducers of apoptosis. Therefore, the activators os caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of anormal cells occurs.
摘要翻译：本发明涉及取代的2-芳基亚甲基-N-芳基-N'-芳基 - 丙二酰胺及其类似物。本发明还涉及这些化合物是胱天蛋白酶的激活剂和凋亡诱导剂的发现。因此，本发明的活化剂os胱天蛋白酶和细胞凋亡诱导剂可用于在其中发生非正常细胞的不受控生长和扩散的各种临床条件下诱导细胞死亡。

5. 发明申请

WO2008005572A2 SUBSTITUTED 4-ARYL-CHROMENE AS ACTIVATOR OF CASPASES AND INDUCER OF APOPTOSIS AND AS ANTIVASCULAR AGENT AND THE USE THEREOF 审中-公开
标题翻译：取代的4-ARYL-CHROMENE作为CASPASES的激活剂和疫苗诱导剂和抗微生物剂及其用途
公开(公告)号：WO2008005572A2
公开(公告)日：2008-01-10
申请号：PCT/US2007015676
申请日：2007-07-06
申请人： CYTOVIA INC , CAI SUI XIONG , DREWE JOHN A , KASIBHATLA SHAILAJA , KEMNITZER WILLIAM E , TSENG BEN Y , BLAIS CHARLES , GOURDEAU HENRIETTE , LABRECQUE DENIS
发明人： CAI SUI XIONG , DREWE JOHN A , KASIBHATLA SHAILAJA , KEMNITZER WILLIAM E , TSENG BEN Y , BLAIS CHARLES , GOURDEAU HENRIETTE , LABRECQUE DENIS
IPC分类号： A61K31/353
CPC分类号： C07D405/12 , C07D311/58
摘要： The present invention is directed to a substituted 4H-chromene represented by the Formula 1R, substantially free from the corresponding (S)-stereoisomer: The present invention also relates to the discovery that compound 1R, substantially free from the corresponding (S)-stereoisomer, is an activator of caspases and inducer of apoptosis, as well as an antivascular agent. Therefore, compound 1R, substantially free from the corresponding (S)-stereoisomer, can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth, and spread of abnormal cells occurs. Compound 1R, substantially free from the corresponding (S)-stereoisomer, also can be used for the treatment of diseases due to overgrowth of vasculature, such as solid tumors and ocular neovascularization.
摘要翻译：本发明涉及基本上不含相应（S） - 立体异构体的由式1R表示的取代的4H-色烯。本发明还涉及发现基本上不含相应的（S） - 立体异构体的化合物1R 是胱天蛋白酶和凋亡诱导剂的激活剂，以及抗血管性药剂。因此，可以使用基本上不含相应（S） - 立体异构体的化合物1R在多种临床条件下诱导细胞死亡，其中发生不受控制的生长和异常细胞的扩散。基本上不含相应（S） - 立体异构体的化合物1R也可用于治疗由于脉管系统过度生长（如实体瘤和眼新生血管形成）引起的疾病。

6. 发明申请

WO02100826A2 SUBSTITUTED 3-ARYL-5-ARYL-[1,2,4]-OXADIAZOLES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开
标题翻译：取代的3-ARYL-5-ARYL- [1,2,4] - 氧化氮和类似物作为杀虫剂和杀虫剂的激活剂及其用途
公开(公告)号：WO02100826A2
公开(公告)日：2002-12-19
申请号：PCT/US0217892
申请日：2002-06-10
申请人： CYTOVIA INC , CAI SUI XIONG , ZHANG HAN-ZHONG , DREWE JOHN A , REDDY P SANJEEVA , KASIBHATLA SHAILAJA , KUEMMERLE JARED DANIEL , OLLIS KRISTIN P
发明人： CAI SUI XIONG , ZHANG HAN-ZHONG , DREWE JOHN A , REDDY P SANJEEVA , KASIBHATLA SHAILAJA , KUEMMERLE JARED DANIEL , OLLIS KRISTIN P
IPC分类号： C07D487/04 , A61K31/335 , A61K31/38 , A61K31/395 , A61K31/4155 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/54 , A61P1/04 , A61P17/00 , A61P17/06 , A61P29/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D
CPC分类号： C07D413/14 , A61K31/335 , A61K31/38 , A61K31/395 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14 , C07D471/04
摘要： The present invention is directed to substituted 3-aryl-5-aryl-[1,2,3]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由式I表示的取代的3-芳基-5-芳基 - [1,2,3] - 恶二唑及其类似物：其中Ar1，Ar3，A，B和D如本文所定义。本发明还涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。

7. 发明申请

WO02072544A3 MULTIFLUORO-SUBSTITUTED CHALCONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开
标题翻译：多取代的小分子和类似物作为凋亡和诱导细胞凋亡的激活剂及其用途
公开(公告)号：WO02072544A3
公开(公告)日：2002-12-19
申请号：PCT/US0207569
申请日：2002-03-14
申请人： CYTOVIA INC , CAI SUI XIONG , REDDY P SANJEEVA , DREWE JOHN A , NGUYEN BAO NGOC , KASIBHATLA SHAILAJA
发明人： CAI SUI XIONG , REDDY P SANJEEVA , DREWE JOHN A , NGUYEN BAO NGOC , KASIBHATLA SHAILAJA
IPC分类号： A61K31/12 , A61K31/34 , A61K31/40 , A61K31/47 , A61K45/06 , A61P31/04 , A61P43/00 , C07C45/74 , C07C49/84 , C07C205/45 , C07D213/50 , C07C45/27
CPC分类号： C07D213/50 , A61K31/12 , A61K31/34 , A61K31/40 , A61K31/47 , A61K45/06 , C07C45/74 , C07C49/84 , C07C205/45 , A61K2300/00
摘要： The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula (I), wherein Ar, and R6-R10 are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由通式（I）表示的多氟取代查耳酮及其类似物，其中Ar和R6-R10如本文所定义。本发明还涉及具有式（I）的化合物是半胱天冬酶活化剂和细胞凋亡诱导剂的发现。因此，本发明的半胱天冬酶活化剂和细胞凋亡诱导剂可用于在异常细胞发生不受控制的生长和扩散的各种临床条件下诱导细胞死亡。

8. 发明专利

AU2002303694A1 Substituted n'-(arylcarbonyl)-benzhydrazides, n'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof 未知
公开(公告)号：AU2002303694A1
公开(公告)日：2002-11-18
申请号：AU2002303694
申请日：2002-05-10
申请人： REDDY P SANJEEVA , KASIBHATLA SHAILAJA , CAI SUI XIONG , DREWE JOHN , CYTOVIA INC , ZHANG HAN ZHONG
发明人： ZHANG HAN-ZHONG , REDDY P SANJEEVA , CAI SUI XIONG , KASIBHATLA SHAILAJA , DREWE JOHN
IPC分类号： A61K31/165 , A61K31/44 , C07D213/87 , C07D213/89 , C07D401/14 , A61K31/16 , A61K31/505 , C07D213/69 , C07D213/63 , C07D213/643 , A61K31/445
摘要： The present invention is directed to substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar 1 , Ar 2 , and R 1 -R 2 are defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

9. 发明申请

WO2004094648A3 METHODS OF TREATING DISEASES RESPONSIVE TO INDUCTION OF APOPTOSIS AND SCREENING ASSAYS 审中-公开
标题翻译：治疗反应性感染和筛查测定的方法
公开(公告)号：WO2004094648A3
公开(公告)日：2006-03-23
申请号：PCT/US2004011916
申请日：2004-04-19
申请人： CYTOVIA INC , KASIBHATLA SHAILAJA , CAI SUI XIONG , TSENG BEN , JESSEN KATAYOUN ALAVI , MALIARTCHOUK SERGUEI , ENGLISH NICOLE MARION , KUEMMERLE JARED , KEMNITZER WILLIAM E , ZHANG HAN-ZHONG
发明人： KASIBHATLA SHAILAJA , CAI SUI XIONG , TSENG BEN , JESSEN KATAYOUN ALAVI , MALIARTCHOUK SERGUEI , ENGLISH NICOLE MARION , KUEMMERLE JARED , KEMNITZER WILLIAM E , ZHANG HAN-ZHONG
IPC分类号： A61K31/47 , A61K38/00 , C12Q20060101 , A61K48/00 , A61K39/395 , C12Q1/68
CPC分类号： G01N33/5011 , A61K31/729
摘要： The present invention pertains to a method of treating, preventing or ameliorating a disease responsive to induction of the caspase cascade in an animal, comprising administering to the animal a compound which binds specifically to a Tail Interacting Protein Related Apoptosis Inducing Protein (TIPRAIP). The present invention also relates to screening methods useful for drug discovery of apoptosis inducing compounds. In particular, the screening methodology relates to using TIPRAIP as a target for the discovery of apoptosis activators useful as anticancer agents. The screening methods of the present invention can employ homogenous or heterogenous binding assays using purified or partially purified TIPRAIP; or whole cell assays using cells with altered levels of TIPRAIP. The invention also contemplates use of 3-(4azidophenyl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazole or a substituted 3aryl-5-aryl-[1,2,4]-oxadiazole which bind TIPRAIP and can accordingly be used to raise antibodies useful for drug discovery. Alternatively, labeled 3-(4azidophenyl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazole (or a labeled substituted 3-aryl-5-aryl-[1,2,4]-oxadiazole) is used for competitive binding assays for drug discovery. Such assays afford high throughput screening of chemical libraries for apoptosis activators.
摘要翻译：本发明涉及治疗，预防或改善对动物中胱天蛋白酶级联诱导有反应的疾病的方法，包括向动物施用与尾部相互作用蛋白相关的细胞凋亡诱导蛋白（TIPRAIP）特异性结合的化合物。本发明还涉及可用于药物发现凋亡诱导化合物的筛选方法。特别地，筛选方法涉及使用TIPRAIP作为发现可用作抗癌剂的凋亡激活剂的靶标。本发明的筛选方法可以使用纯化或部分纯化的TIPRAIP的均一或异源结合测定; 或使用具有改变的TIPRAIP水平的细胞的全细胞测定。本发明还考虑使用3-（4-氮杂苯基）-5-（3-氯 - 噻吩-2-基） - [1,2,4] - 恶二唑或取代的3-芳基-5-芳基 - [1,2 ，4] - 恶二唑，其结合TIPRAIP，因此可用于引发可用于药物发现的抗体。或者，标记3-（4-氮杂苯基）-5-（3-氯 - 噻吩-2-基） - [1,2,4] - 恶二唑（或标记的取代的3-芳基-5-芳基 - [1,2 ，4] - 恶二唑）用于药物发现的竞争性结合测定。这样的测定提供用于凋亡激活剂的化学文库的高通量筛选。

10. 发明申请

WO02089745A3 SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开
标题翻译：取代的N' - （亚苄基） - 苯甲酰肼，N' - （芳基苄基） - 苯并噻唑和类似物作为杀虫剂和杀虫剂的激活剂及其用途
公开(公告)号：WO02089745A3
公开(公告)日：2003-02-27
申请号：PCT/US0214722
申请日：2002-05-10
申请人： CYTOVIA INC , CAI SUI XIONG , KASIBHATLA SHAILAJA , DREWE JOHN , REDDY P SANJEEVA , ZHANG HAN-ZHONG
发明人： CAI SUI XIONG , KASIBHATLA SHAILAJA , DREWE JOHN , REDDY P SANJEEVA , ZHANG HAN-ZHONG
IPC分类号： A61K31/165 , A61K31/44 , C07D213/87 , C07D213/89 , C07D401/14 , A61K31/16 , A61K31/445 , A61K31/505 , C07D213/63 , C07D213/643 , C07D213/69
CPC分类号： A61K31/165 , A61K31/44 , C07D213/87 , C07D213/89 , C07D401/14
摘要： The present invention is directed to substituted N'-(arylcarbonyl)- benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae (I) and (II) wherein Ar1, Ar2, and R1-R2 are defined herein. The present invention also relates to the discovery that compounds having Formulae (I) and (II) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由式（I）和（II）表示的取代的N' - （芳基羰基） - 苯甲酰肼，N' - （芳基羰基） - 亚苄基 - 酰肼及其类似物，其中Ar1，Ar2和R1-R2 在本文中定义。本发明还涉及具有式（I）和（II）的化合物是胱天蛋白酶的激活剂和凋亡诱导剂的发现。因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。

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