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1. 发明申请

WO2013184782A2 CATHETER SYSTEMS AND METHODS USEFUL FOR CELL THERAPY 审中-公开
标题翻译：导管系统和用于细胞治疗的方法
公开(公告)号：WO2013184782A2
公开(公告)日：2013-12-12
申请号：PCT/US2013/044287
申请日：2013-06-05
申请人： MUFFIN INCORPORATED , COOK MEDICAL TECHNOLOGIES LLC
发明人： FISCHER, Frank, J. , RANDOLPH, James, R. , FEARNOT, Neal, E. , TAYLOR, Jimmy, L. , SHIRLEY, Gary, Bradford
IPC分类号： A61M25/00
CPC分类号： A61M25/1011 , A61B34/20 , A61M25/0026 , A61M25/0041 , A61M25/0068 , A61M25/007 , A61M25/10 , A61M37/0092 , A61M2025/0003 , A61M2025/0004 , A61M2025/0042 , A61M2025/1015 , A61M2025/1052 , A61M2025/1061 , A61M2025/1093
摘要： Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.
摘要翻译：一方面描述了一种用于细胞或其它疗法的多压力监测系统，包括具有用于接受治疗装置的第一腔的第一导管，用于充气气囊的第二腔，用于监测第一腔内的流体压力的压力传感器，以及限流器，例如止血阀，用于在第一腔内存在或更换治疗装置的同时限制流体进入和离开第一腔的流体。还公开了一种使用具有耦合到第一压力传感器的第一压力监测器的第一导管以及连接到耦合到第二压力监测器的第二压力传感器的第二导管的方法。在治疗操作期间，第二导管定位在第一导管的第一腔内，并且在整个过程中使用第一和第二压力监测器来验证适当的压力。还描述了用于向患者递送可流动治疗物质（例如活细胞制剂）的新颖方法，系统和导管。

2. 发明授权

EP2125058B1 MEDICAL DEVICE COATINGS FOR RELEASING A THERAPEUTIC AGENT AT MULTIPLE RATES 有权转让
标题翻译：医疗器械涂层用于治疗性活化与几批释放
公开(公告)号：EP2125058B1
公开(公告)日：2014-12-03
申请号：EP08725134.4
申请日：2008-02-04
申请人： Cook Medical Technologies LLC
发明人： SHIRLEY, Gary, Bradford , MOORE, William, F.
IPC分类号： A61L27/34 , A61L31/10 , A61L27/54 , A61L31/16
CPC分类号： A61L31/08 , A61F2/90 , A61F2240/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416
摘要： Medical device coatings are provided that simultaneously release a therapeutic agent at different rates from different portions of the medical device coating. In a first embodiment, medical device coatings are provided that include particles comprising a therapeutic agent with two or more different particles sizes within a single layer on a surface of the implantable device. In a second embodiment, medical device coatings are provided having a higher concentration of the therapeutic agent in a first region of the coating than in a second region of the coating. In a third embodiment, medical device coatings are provided that are formed by certain coating processes wherein the droplet size of a spray coating solution is changed during the coating process. These coating processes preferably include applying a solution comprising a therapeutic agent and a suitable solvent to a surface of an implantable medical device. In a fourth embodiment, methods of treatment are provided that include implanting a coated medical device.
摘要翻译：提供医疗装置的涂层在从医疗装置涂层的不同部分不同的速率并同时释放的治疗剂。在第一实施例中，提供了医疗装置的涂层也包括包含治疗剂与可植入装置的表面上的单个层内的两个或更多个不同的颗粒尺寸的颗粒。在第二实施例，医疗装置的涂层提供了具有治疗剂在涂层的第一区域中比在所述涂层的第二区域更高的浓度。在第三个实施方式，提供了医疗装置的涂层也由worin在涂覆过程中喷涂溶液的液滴尺寸被改变某些涂料工艺形成。这些涂布方法优选包括将溶液包含治疗剂和合适的溶剂到可植入医疗装置的表面。在第四，提供了治疗的实施方式的方法也包括注入的涂覆的医疗装置。

3. 发明公开

EP2854923A2 CATHETER SYSTEMS AND METHODS USEFUL FOR CELL THERAPY 审中-公开
标题翻译：导管系统和方法细胞治疗
公开(公告)号：EP2854923A2
公开(公告)日：2015-04-08
申请号：EP13734222.6
申请日：2013-06-05
申请人： Muffin Incorporated
发明人： FISCHER, Frank, J. , RANDOLPH, James, R. , FEARNOT, Neal, E. , TAYLOR, Jimmy, L. , SHIRLEY, Gary, Bradford
IPC分类号： A61M25/00 , A61M25/10 , A61N7/00 , A61M37/00
CPC分类号： A61M25/1011 , A61B34/20 , A61M25/0026 , A61M25/0041 , A61M25/0068 , A61M25/007 , A61M25/10 , A61M37/0092 , A61M2025/0003 , A61M2025/0004 , A61M2025/0042 , A61M2025/1015 , A61M2025/1052 , A61M2025/1061 , A61M2025/1093
摘要： Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.

4. 发明公开

EP3597254A1 CATHETER SYSTEMS AND METHODS USEFUL FOR CELL THERAPY 审中-公开
公开(公告)号：EP3597254A1
公开(公告)日：2020-01-22
申请号：EP19189191.0
申请日：2013-06-05
申请人： Muffin Incorporated
发明人： FISCHER, Frank J. , RANDOLPH, James, R. , FEARNOT, Neal E. , TAYLOR, Jimmy, L. , SHIRLEY, Gary, Bradford
IPC分类号： A61M25/00 , A61M25/10 , A61N7/00 , A61M37/00 , A61M25/01
摘要： Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter (570) having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor (545) for monitoring fluid pressure within the first lumen, and a flow restrictor (115) such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor (4545) along with a second catheter (525) attached to a second pressure sensor (520) coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.

5. 发明授权

EP2854923B1 CATHETER SYSTEMS AND METHODS USEFUL FOR CELL THERAPY 有权
公开(公告)号：EP2854923B1
公开(公告)日：2019-08-21
申请号：EP13734222.6
申请日：2013-06-05
申请人： Muffin Incorporated
发明人： FISCHER, Frank, J. , RANDOLPH, James, R. , FEARNOT, Neal, E. , TAYLOR, Jimmy, L. , SHIRLEY, Gary, Bradford
IPC分类号： A61M25/00 , A61M25/10 , A61N7/00 , A61M37/00

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