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1. 发明申请

WO0050870A9 BIOCHEMICAL PURIFICATION DEVICES WITH IMMOBILIZED CAPTURE PROBES AND THEIR USES 审中-公开
标题翻译：具有固定捕获探针的生物化学纯化装置及其用途
公开(公告)号：WO0050870A9
公开(公告)日：2001-11-22
申请号：PCT/US0004771
申请日：2000-02-25
申请人： MOSAIC TECHNOLOGIES , ADAMS CHRISTOPHER P , BOLES T CHRISTIAN , WEIR LAWRENCE , DHANDA RAHUL K , KRON STEPHEN J
发明人： ADAMS CHRISTOPHER P , BOLES T CHRISTIAN , WEIR LAWRENCE , DHANDA RAHUL K , KRON STEPHEN J
IPC分类号： B01L3/00 , B01L3/02 , G01N1/34 , G01N27/447
CPC分类号： G01N1/405 , B01L3/0275 , B01L3/5025 , B01L3/50255 , B01L2200/0631 , B01L2300/0829 , B01L2300/087 , B01L2400/0421 , C12N15/1006 , C12Q1/6806 , C12Q1/6834 , G01N1/34 , G01N27/44747 , G01N2001/4038 , C12Q2565/125 , C12Q2565/519
摘要： The present invention pertains to devices comprising at least one purification unit, used to purify and/or concentrate a target molecule contained within a test sample. Typically, the target molecule is a test sample will be a nucleic acid. These purified nucleic acids can be used in a variety of ways, including being subjected to nucleotide sequence analysis. Methods of using the devices and kits containing the devices are also provided.
摘要翻译：本发明涉及包含至少一个纯化单元的装置，其用于纯化和/或浓缩测试样品中包含的靶分子。通常，靶分子是测试样品将是核酸。这些纯化的核酸可以以多种方式使用，包括进行核苷酸序列分析。还提供了使用包含装置的装置和试剂盒的方法。

2. 发明申请

WO0162982A3 METHODS FOR MULTI-STAGE SOLID PHASE AMPLIFICATION OF NUCLEIC ACIDS 审中-公开
标题翻译：用于核酸的多阶段固相扩增的方法
公开(公告)号：WO0162982A3
公开(公告)日：2002-09-19
申请号：PCT/US0105940
申请日：2001-02-23
申请人： MOSAIC TECHNOLOGIES INC , AFFYMETRIX INC , GINGERAS THOMAS R , BOLES T CHRISTIAN , FODOR STEPHEN P A , ADAMS CHRISTOPHER P
发明人： GINGERAS THOMAS R , BOLES T CHRISTIAN , FODOR STEPHEN P A , ADAMS CHRISTOPHER P
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6834 , C12Q1/686 , C12Q2523/107 , C12Q2525/131 , C12Q2563/155 , C12Q2565/543 , C12Q2537/149 , C12Q2523/319
摘要： The present invention discloses multi-stage bridge amplification methods which employs a double-stranded amplification product to initiate a subsequent stage of amplification. This double-stranded amplification product is formed during an amplification reaction and can be used to establish an iterative process. Using this double-stranded amplification product, the efficiency of bridge amplification increases significantly as a result of multiple stages of bridge amplification and permits, for example, the detection of a target molecule using a non-radioactive label (such as fluorescence).
摘要翻译：本发明公开了使用双链扩增产物开始后续扩增阶段的多级桥扩增方法。这种双链扩增产物在扩增反应期间形成，可用于建立迭代过程。使用这种双链扩增产物，由于桥接扩增的多个阶段，桥接扩增的效率显着增加，例如使用非放射性标记（如荧光）检测靶分子。

3. 发明申请

WO9926724A3 DEVICES AND METHODS FOR DETECTING TARGET MOLECULES IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于检测生物样品中目标分子的装置和方法
公开(公告)号：WO9926724A3
公开(公告)日：1999-09-02
申请号：PCT/US9824918
申请日：1998-11-25
申请人： MOSAIC TECHNOLOGIES , MUIR ANDREW R , BOLES TRUETT C , ADAMS CHRISTOPHER P
发明人： MUIR ANDREW R , BOLES TRUETT C , ADAMS CHRISTOPHER P
IPC分类号： B01L3/00 , C12Q1/68 , G01N33/49
CPC分类号： C12Q1/689 , B01L3/502 , B01L3/505 , C12Q1/6834 , C12Q1/703 , C12Q2565/125 , C12Q2531/119
摘要： Devices and methods for detecting the presence, or absence of the presence, of at least one target molecule employing a receptacle housing a reaction chamber comprised of at least one compartment containing suitable reagents for the detection of the target molecule are disclosed. The device can be used in particular for screening donated blood or other biological fluids for the presence of contaminants. Preferably, the device comprises two or more breakable compartments separated by breakable barriers, and is associated with a collection system such as a blood bag.
摘要翻译：公开了用于检测至少一个靶分子的存在或不存在的装置和方法，所述至少一个靶分子使用容纳包含至少一个包含用于检测靶分子的合适试剂的隔室的反应室的容器。该装置特别可用于筛选捐赠的血液或其它生物流体以存在污染物。优选地，该装置包括两个或更多个由可破坏的屏障隔开的可破坏的隔室，并且与诸如血袋的收集系统相关联。

4. 发明申请

WO2011068887A3 ELECTROMAGNETIC SCANNING IMAGER 审中-公开
标题翻译：电磁扫描图像
公开(公告)号：WO2011068887A3
公开(公告)日：2011-09-29
申请号：PCT/US2010058579
申请日：2010-12-01
申请人： TECHTRONIC POWER TOOLS TECH , HOLBROOK DAVID S , ADAMS CHRISTOPHER P , GREGORICH BRENT , RAJANI UMESH , WHITMIRE JASON PORTER , BUBLITZ SCOTT D , HESSENBERGER JEFFREY C , SCOTT JOHN S , HUGGINS MARK , MERGENER MATTHEW J
发明人： HOLBROOK DAVID S , ADAMS CHRISTOPHER P , GREGORICH BRENT , RAJANI UMESH , WHITMIRE JASON PORTER , BUBLITZ SCOTT D , HESSENBERGER JEFFREY C , SCOTT JOHN S , HUGGINS MARK , MERGENER MATTHEW J
IPC分类号： G01B11/24 , G01B15/04
CPC分类号： H04N1/107 , G01S7/024 , G01S7/03 , G01S7/046 , G01S13/0209 , G01S13/86 , G01S13/887 , G01S13/89 , H04N7/18
摘要： In one aspect, the present invention provides an imager, preferably portable, that includes a source of electromagnetic radiation capable of generating radiation with one or more frequencies in a range of about 1 GHz to about 2000 GHz. An optical system that is optically coupled to the source focuses radiation received therefrom onto an object plane, and directs at least a portion of the focused radiation propagating back from the object plane onto an image plane. The imager further includes a scan mechanism coupled to the optical system for controlling thereof so as to move the focused radiation over the object plane. A detector optically coupled to the lens at the image plane detects at least a portion of the radiation propagating back from a plurality of scanned locations in the object plane, thereby generating a detection signal. A processor that is in communication with the detector generates an image of at least a portion of the object plane based on the detection signal.
摘要翻译：在一个方面，本发明提供一种成像器，优选便携式的，其包括能够在约1GHz至约2000GHz的范围内产生具有一个或多个频率的辐射的电磁辐射源。光学耦合到源的光学系统将从其接收的辐射聚焦到物平面上，并将从物体平面传播的聚焦辐射的至少一部分引导到图像平面上。成像器还包括耦合到光学系统的扫描机构，用于对其进行控制，以便将被聚焦的辐射移动到物体平面上。在图像平面处光学耦合到透镜的检测器检测从物体平面中的多个扫描位置传播回来的辐射的至少一部分，从而产生检测信号。与检测器通信的处理器基于检测信号产生对象平面的至少一部分的图像。

5. 发明申请

WO2006088845A3 ELECTROMAGNETIC SCANNING IMAGER 审中-公开
标题翻译：电磁扫描图像
公开(公告)号：WO2006088845A3
公开(公告)日：2007-02-01
申请号：PCT/US2006005133
申请日：2006-02-14
申请人： WALLEYE TECHNOLOGIES INC , HOLBROOK DAVID S , ADAMS CHRISTOPHER P
发明人： HOLBROOK DAVID S , ADAMS CHRISTOPHER P
IPC分类号： G01S13/89
CPC分类号： H01Q19/065 , G01S13/42 , G01S13/426 , G01S13/88 , G01S13/89
摘要： In one aspect, the present invention provides an imager, preferably portable, that includes a source of electromagnetic radiation capable of generating radiation with one or more frequencies in a range of about 1 GHz to about 2000 GHz. An optical system that is optically coupled to the source focuses radiation received therefrom onto an object plane, and directs at least a portion of the focused radiation propagating back from the object plane onto an image plane. The imager further includes a scan mechanism coupled to the optical system for controlling thereof so as to move the focused radiation over the object plane. A detector optically coupled to the lens at the image plane detects at least a portion of the radiation propagating back from a plurality of scanned locations in the object plane, thereby generating a detection signal. A processor that is in communication with the detector generates an image of at least a portion of the object plane based on the detection signal.
摘要翻译：一方面，本发明提供了一种成像器，优选便携式的，其包括能够产生在约1GHz至约2000GHz范围内的一个或多个频率的辐射的电磁辐射源。光学耦合到源的光学系统将从其接收的辐射聚焦到物平面上，并将从物体平面传播的聚焦辐射的至少一部分引导到图像平面上。成像器还包括耦合到光学系统的扫描机构，用于对其进行控制，以便将被聚焦的辐射移动到物体平面上。在图像平面处光学耦合到透镜的检测器检测从物体平面中的多个扫描位置传播回来的辐射的至少一部分，从而产生检测信号。与检测器通信的处理器基于检测信号产生对象平面的至少一部分的图像。

6. 发明申请

WO2007075639A3 MICROWAVE DATUM TOOL 审中-公开
标题翻译： MICROWAVE DATUM工具
公开(公告)号：WO2007075639A3
公开(公告)日：2008-07-03
申请号：PCT/US2006048365
申请日：2006-12-19
申请人： WALLEYE TECHNOLOGIES INC , HOLBROOK DAVID S , ADAMS CHRISTOPHER P
发明人： HOLBROOK DAVID S , ADAMS CHRISTOPHER P
IPC分类号： G01S13/00
CPC分类号： G01N22/00
摘要： In one aspect, a measurement system is disclosed that includes a source of microwave radiation having one or more wavelengths capable of penetrating through a visibly opaque obstruction, e.g., a wall. The source can be movably positioned on one side of the obstruction for illuminating thereof. The system can further include a microwave reflecting element disposed on another side of the obstruction, where the reflecting element is capable of reflecting at least a portion of the radiation transmitted through the obstruction. A plurality of radiation sensors are positioned relative to the obstruction so as to differentially detect at least a portion of the reflected radiation transmitted through the obstruction so as to determine a position of the source relative to the reflective element.
摘要翻译：在一个方面，公开了一种测量系统，其包括具有一个或多个波长的微波辐射源，该波长能够穿透可见的不透明阻挡物，例如壁。源可以可移动地定位在障碍物的一侧以用于照明。该系统还可以包括设置在障碍物另一侧的微波反射元件，其中反射元件能够反射透过障碍物的辐射的至少一部分。多个辐射传感器相对于障碍物定位，以差异地检测透过障碍物的反射辐射的至少一部分，以便确定源相对于反射元件的位置。

7. 发明申请

WO2004073645A3 INHIBITION OF OLFATORY NEUROSENSORY FUNCTION OF TREAT EATING DISORDERS AND OBESITY 审中-公开
标题翻译：抑郁症神经功能障碍治疗障碍和肥胖的抑制作用
公开(公告)号：WO2004073645A3
公开(公告)日：2005-02-17
申请号：PCT/US2004004908
申请日：2004-02-18
申请人： COMPELLIS PHARMACEUTICALS , ADAMS CHRISTOPHER P , FLYNN JAMES
发明人： ADAMS CHRISTOPHER P , FLYNN JAMES
IPC分类号： A61K9/00 , A61K31/00 , A61K31/455 , A61K31/554 , G01N33/68 , A61K31/47 , A61K31/55
CPC分类号： A61K9/0043 , A61K31/00 , A61K31/277 , A61K31/455 , A61K31/554 , G01N33/6872 , G01N2500/00 , Y10S514/866 , Y10S514/909
摘要： The use of calcium channel blockers administered intra-nasally to inhibit olfactory sensory perception to treat eating disorders, including obesity, is described. Also described is a method of reducing food intake in a subject by administering a pharmaceutical composition comprising an effective amount of a calcium channel blocker to the nasal mucosa, as well as screening methods for drugs to be used in treating obesity or associated disorders.
摘要翻译：描述了使用经鼻内给予的钙通道阻滞剂来抑制嗅觉感觉来治疗饮食失调，包括肥胖症。还描述了通过向鼻粘膜施用包含有效量的钙通道阻滞剂的药物组合物以及用于治疗肥胖症或相关疾病的药物的筛选方法来减少受试者的食物摄取的方法。

8. 发明专利

AU6436498A Nucleic acid-containing polymerizable complex 未知
公开(公告)号：AU6436498A
公开(公告)日：1998-09-22
申请号：AU6436498
申请日：1998-02-20
申请人： MOSAIC TECHNOLOGIES INC
发明人： BOLES T CHRISTIAN , KRON STEPHEN J , ADAMS CHRISTOPHER P
IPC分类号： C07H21/04 , C07H21/00 , C07H21/02 , C08F20/34 , C08F20/60 , C07H19/00
摘要： Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.

9. 发明专利

DE69526511D1 未知
公开(公告)号：DE69526511D1
公开(公告)日：2002-05-29
申请号：DE69526511
申请日：1995-08-03
申请人： MOSAIC TECHNOLOGIES INC , WHITEHEAD BIOMEDICAL INST
发明人： ADAMS CHRISTOPHER P , KRON STEPHEN JOSEPH
IPC分类号： C12N15/09 , C12Q1/68 , C12Q1/686

10. 发明专利

CA2283798A1 NUCLEIC ACID-CONTAINING POLYMERIZABLE COMPLEX 未知
公开(公告)号：CA2283798A1
公开(公告)日：1998-09-11
申请号：CA2283798
申请日：1998-02-20
申请人： MOSAIC TECHNOLOGIES INC
发明人： ADAMS CHRISTOPHER P , BOLES T CHRISTIAN , KRON STEPHEN J
IPC分类号： C07H21/04 , C07H21/00 , C07H21/02 , C08F20/34 , C08F20/60 , C07H19/00
摘要： Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.

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