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1. 发明申请

WO9924612A3 MULTIPLE SEQUENTIAL POLYNUCLEOTIDE DISPLACEMENT REACTIONS FOR SIGNAL AMPLIFICATION AND PROCESSING 审中-公开
标题翻译：用于信号放大和处理的多次序列多核苷酸移位反应
公开(公告)号：WO9924612A3
公开(公告)日：1999-07-15
申请号：PCT/US9823634
申请日：1998-11-06
申请人： MOSAIC TECHNOLOGIES , HAMMOND PHILIP W , ABRAMS EZRA S , BOLES T CHRISTIAN , MUIR ANDREW R
发明人： HAMMOND PHILIP W , ABRAMS EZRA S , BOLES T CHRISTIAN , MUIR ANDREW R
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/50
CPC分类号： C12Q1/6823 , C12Q1/6813 , C12Q1/682 , C12Q1/6827
摘要： Methods for determining the presence of a target polynucleotide sequence using chemical hybridization in sequential probe and displacement complex formation with potential for signal gain prior to detection are disclosed.
摘要翻译：公开了用于在序列探针和置换复合物形成中使用化学杂交来确定靶多核苷酸序列的存在的方法，其在检测之前具有潜在的信号增益。

2. 发明申请

WO9945374A3 PURIFICATION AND DETECTION PROCESSES USING REVERSIBLE AFFINITY ELECTROPHORESIS 审中-公开
标题翻译：使用可逆性电泳的纯化和检测过程
公开(公告)号：WO9945374A3
公开(公告)日：2000-02-17
申请号：PCT/US9904849
申请日：1999-03-03
申请人： MOSAIC TECHNOLOGIES , ABRAMS EZRA S , HAMMOND PHILIP W , MUIR ANDREW R , BOLES T CHRISTIAN
发明人： ABRAMS EZRA S , HAMMOND PHILIP W , MUIR ANDREW R , BOLES T CHRISTIAN
IPC分类号： G01N27/447 , G01N27/26 , B01D57/02 , G01N27/453
CPC分类号： G01N27/44726 , G01N27/44773
摘要： An affinity electrophoresis process is described, in which the direction of electrophoresis is varied in a cyclical manner while synchronously changing one or more property of the electrophoretic medium between two states, said states being characterized as favoring or disfavoring specific reversible binding of sample analytes to affinity ligands which are immobilized within the medium. The resulting process enables extremely efficient and convenient separation of the specific analytes for detection or purification, using simple materials and apparatus.
摘要翻译：描述亲和电泳方法，其中电泳方向以循环方式变化，同时改变两种状态之间的电泳介质的一种或多种性质，所述状态的特征在于有利或不利于样品分析物与亲和力的特异性可逆结合固定在培养基中的配体。所得的方法可以使用简单的材料和设备，极高效方便地分离特定的分析物进行检测或纯化。

3. 发明申请

WO0029619A3 MULTIELEMENT ANALYTICAL DEVICE FOR ASSAY OF NUCLEIC ACID SEQUENCES AND USES THEREFORE 审中-公开
标题翻译：用于测定核酸序列的多元分析装置及其用途
公开(公告)号：WO0029619A3
公开(公告)日：2000-08-10
申请号：PCT/US9926673
申请日：1999-11-12
申请人： MOSAIC TECHNOLOGIES , BOLES T CHRISTIAN , MUIR ANDREW R
发明人： BOLES T CHRISTIAN , MUIR ANDREW R
IPC分类号： C12Q1/68 , B01L3/00
CPC分类号： C12Q1/686 , C12Q1/6837 , C12Q2537/143 , C12Q2565/543
摘要： A multielement analytical device is described which can be used in highly efficient multiplexed assay for detecting the presence of a target nucleic acid sequence in a plurality of test samples. The device contains a plurality of elements, each containing at least one essentially flat surface in which an array of amplification sites containing a plurality of pairs of surface bound nucleic acid probes, configured so that the essentially flat surface of each element can be simultaneously immersed in a single test sample container.
摘要翻译：描述了一种多元素分析装置，其可用于高效多路复用测定中以检测多个测试样品中靶核酸序列的存在。该装置包含多个元件，每个元件包含至少一个基本上平坦的表面，其中包含多对表面结合的核酸探针的扩增位点阵列被配置为使得每个元件的基本上平坦的表面可以同时浸入一个测试样品容器。

4. 发明申请

WO9926724A3 DEVICES AND METHODS FOR DETECTING TARGET MOLECULES IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于检测生物样品中目标分子的装置和方法
公开(公告)号：WO9926724A3
公开(公告)日：1999-09-02
申请号：PCT/US9824918
申请日：1998-11-25
申请人： MOSAIC TECHNOLOGIES , MUIR ANDREW R , BOLES TRUETT C , ADAMS CHRISTOPHER P
发明人： MUIR ANDREW R , BOLES TRUETT C , ADAMS CHRISTOPHER P
IPC分类号： B01L3/00 , C12Q1/68 , G01N33/49
CPC分类号： C12Q1/689 , B01L3/502 , B01L3/505 , C12Q1/6834 , C12Q1/703 , C12Q2565/125 , C12Q2531/119
摘要： Devices and methods for detecting the presence, or absence of the presence, of at least one target molecule employing a receptacle housing a reaction chamber comprised of at least one compartment containing suitable reagents for the detection of the target molecule are disclosed. The device can be used in particular for screening donated blood or other biological fluids for the presence of contaminants. Preferably, the device comprises two or more breakable compartments separated by breakable barriers, and is associated with a collection system such as a blood bag.
摘要翻译：公开了用于检测至少一个靶分子的存在或不存在的装置和方法，所述至少一个靶分子使用容纳包含至少一个包含用于检测靶分子的合适试剂的隔室的反应室的容器。该装置特别可用于筛选捐赠的血液或其它生物流体以存在污染物。优选地，该装置包括两个或更多个由可破坏的屏障隔开的可破坏的隔室，并且与诸如血袋的收集系统相关联。

5. 发明申请

WO0234197A9 MICRO STORAGE, REACTION AND DETECTION CELLS AND METHODS AND APPARATUS FOR USE THEREOF 审中-公开
标题翻译：微存储，反应和检测细胞及其使用的方法和装置
公开(公告)号：WO0234197A9
公开(公告)日：2002-09-12
申请号：PCT/US0147265
申请日：2001-10-22
申请人： MICROBIOSCIENCES INC , JOBIN MICHAEL J , MUIR ANDREW R , SYKES DAVID M , WOODWARD JAMES L
发明人： JOBIN MICHAEL J , MUIR ANDREW R , SYKES DAVID M , WOODWARD JAMES L
IPC分类号： B01L3/00 , B01L99/00 , B81B1/00 , C40B60/14 , G01N30/02 , B01L9/00 , B01L11/00
CPC分类号： B01L3/5025 , B01J2219/00315 , B01J2219/00317 , B01L3/0293 , B01L3/50255 , B81B1/00 , C40B60/14
摘要： Disclosed are devices and methods for the storage, shipment, moving and/or transferring, mixing, reacting, isolation, conditioning, lyophilization, stabilization, metering, dispensing, detecting, manipulation and management of materials, particularly solids, powders and liquids. Each such device or method provides a means of storing one or more quantities of one or more materials in one or more reservoirs, optionally protecting said quantities from air, moisture or light. Optionally, multiple such reservoirs may be placed or arranged in ensembles such as in arrays or other physical patterns, optionally providing for the simultaneous, parallel or rapid access to more than one such reservoir at once. Devices and methods of the invention may also be configured to deliver material from a reservoir in such manner that a defined or desired quantity of material is dispensed from the reservoir or that such dispensing is performed at a defined or desired rate or that the material is dispensed until one or more criteria are met for such dispensing to cease.
摘要翻译：公开了用于储存，运输，移动和/或转移，混合，反应，隔离，调节，冻干，稳定，计量，分配，检测，操作和管理材料，特别是固体，粉末和液体的装置和方法。每个这样的装置或方法提供了将一种或多种量的一种或多种材料存储在一个或多个储存器中的方法，可任选地保护所述量免受空气，水分或光的影响。可选地，多个这样的储存器可以放置或排列成诸如阵列或其它物理图案的组合，任选地同时提供同时，平行或快速地进入多于一个这样的储存器。本发明的装置和方法还可以被配置成以这样的方式从储存器输送材料，即从容器中分配限定的或期望量的材料，或者以限定的或期望的速度进行这种分配，或者材料被分配直到满足这种分配的一个或多个标准才能停止。

6. 发明申请

WO0234197A2 MICRO STORAGE, REACTION AND DETECTION CELLS AND METHODS AND APPARATUS FOR USE THEREOF 审中-公开
标题翻译：微存储，反应和检测细胞及其使用方法和装置
公开(公告)号：WO0234197A2
公开(公告)日：2002-05-02
申请号：PCT/US0147265
申请日：2001-10-22
申请人： MICROBIOSCIENCES INC , JOBIN MICHAEL J , MUIR ANDREW R , SYKES DAVID M , WOODWARD JAMES L
发明人： JOBIN MICHAEL J , MUIR ANDREW R , SYKES DAVID M , WOODWARD JAMES L
IPC分类号： B01L3/00 , B01L99/00 , B81B1/00 , C40B60/14 , A61J
CPC分类号： B01L3/5025 , B01J2219/00315 , B01J2219/00317 , B01L3/0293 , B01L3/50255 , B81B1/00 , C40B60/14
摘要： Disclosed are devices and methods for the storage, shipment, moving and/or transferring, mixing, reacting, isolation, conditioning, lyophilization, stabilization, metering, dispensing, detecting, manipulation and management of materials, particularly solids, powders and liquids. Each such device or method provides a means of storing one or more quantities of one or more materials in one or more reservoirs, optionally protecting said quantities from air, moisture or light. Optionally, multiple such reservoirs may be placed or arranged in ensembles such as in arrays or other physical patterns, optionally providing for the simultaneous, parallel or rapid access to more than one such reservoir at once. Devices and methods of the invention may also be configured to deliver material from a reservoir in such manner that a defined or desired quantity of material is dispensed from the reservoir or that such dispensing is performed at a defined or desired rate or that the material is dispensed until one or more criteria are met for such dispensing to cease.
摘要翻译：公开了用于材料特别是固体，粉末和液体的储存，运输，移动和/或转移，混合，反应，隔离，调节，冻干，稳定化，计量，分配，检测，操纵和管理的装置和方法。每个这样的装置或方法提供了一种或多种量的一种或多种材料存储在一个或多个储存器中的手段，可选地保护所述量不受空气，潮湿或光线的影响。可选地，可以将多个这样的储存器放置或布置在诸如阵列或其它物理模式的组合中，可选地提供一次同时，平行或快速访问多于一个这样的储存器。本发明的装置和方法也可以被构造成以这样的方式从储存器输送材料，即从储存器分配限定的或期望的量的材料或者以限定的或期望的速率执行这种分配或者分配材料直到满足一个或多个标准才能停止这种分配。

7. 发明专利

CA2311501A1 DEVICES AND METHODS FOR DETECTING TARGET MOLECULES IN BIOLOGICAL SAMPLES 未知
公开(公告)号：CA2311501A1
公开(公告)日：1999-06-03
申请号：CA2311501
申请日：1998-11-25
申请人： MOSAIC TECHNOLOGIES
发明人： MUIR ANDREW R , BOLES TRUETT C , ADAMS CHRISTOPHER P
IPC分类号： B01L3/00 , C12Q1/68 , C12Q1/6834 , C12Q1/689 , G01N33/49
摘要： Devices and methods for detecting the presence, or absence of the presence, of at least one target molecule employing a receptacle housing a reaction chamber comprised of at least one compartment containing suitable reagents for the detection of the target molecule are disclosed. The device can be used in particular for screening donated blood or other biological fluids for the presence of contaminants. Preferably, the device comprises two or more breakable compartments separated by breakable barriers, and is associated with a collection system such as a blood bag.

8. 发明专利

CA2289925A1 ELECTROPHORETIC ANALYSIS OF MOLECULES USING IMMOBILIZED PROBES 未知
公开(公告)号：CA2289925A1
公开(公告)日：1998-11-19
申请号：CA2289925
申请日：1998-05-15
申请人： MOSAIC TECHNOLOGIES
发明人： KRON STEPHEN J , MUIR ANDREW R , ABRAMS EZRA S , BOLES TRUETT C
IPC分类号： C12N15/09 , C12Q1/68 , G01N27/447 , G01N35/10
摘要： Methods of detecting target molecules using electrophoresis and media containing immobilized capture are described.

9. 发明专利

AU2896399A Purification and detection processes using reversible affinity electrophoresis 未知
公开(公告)号：AU2896399A
公开(公告)日：1999-09-20
申请号：AU2896399
申请日：1999-03-03
申请人： MOSAIC TECHNOLOGIES
发明人： ABRAMS EZRA S , HAMMOND PHILIP W , MUIR ANDREW R , BOLES T CHRISTIAN
IPC分类号： G01N27/447 , G01N27/26

10. 发明专利

CA2322975A1 PURIFICATION AND DETECTION PROCESSES USING REVERSIBLE AFFINITY ELECTROPHORESIS 未知
公开(公告)号：CA2322975A1
公开(公告)日：1999-09-10
申请号：CA2322975
申请日：1999-03-03
申请人： MOSAIC TECHNOLOGIES
发明人： BOLES T CHRISTIAN , MUIR ANDREW R , ABRAMS EZRA S , HAMMOND PHILIP W
IPC分类号： G01N27/447 , B01D57/02
摘要： An affinity electrophoresis process is described, in which the direction of electrophoresis is varied in a cyclical manner while synchronously changing one or more property of the electrophoretic medium between two states, said states being characterized as favoring or disfavoring specific reversible binding of sample analytes to affinity ligands which are immobilized within the medium. The resulting process enables extremely efficient and convenient separation of the specific analytes for detection or purification, using simple materials and apparatus.

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