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1. 发明申请

WO0138302A3 COUPLING CONDENSATION SYNTHESIS OF HETEROCYCLES 审中-公开
标题翻译：杂环离合器凝汽合成
公开(公告)号：WO0138302A3
公开(公告)日：2002-03-14
申请号：PCT/EP0011600
申请日：2000-11-21
申请人： MORPHOCHEM AG , MUELLER THOMAS , ANSORGE MARKUS
发明人： MUELLER THOMAS , ANSORGE MARKUS
IPC分类号： A61P31/04 , A61P31/10 , C07D231/06 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/415 , A61K31/435 , A61K31/44 , A61K31/55 , A61K33/00
CPC分类号： C07D231/06 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The invention relates to a method for producing heterocycles, characterised in that the following components are reacted, preferably in a one-pot reaction by cyclocondensation, to obtain a 4- to 10-, preferably 5- to 7-membered, heterocyclic aromatic or non-aromatic ring system: i) a propargyl derivative of general structural formula (I), Het being an optionally substituted hetero atom and A being a substituted or unsubstituted aromatic, a substituted or unsubstituted aromatic heterocycle, a substituted or unsubstituted vinyl arene and/or a derivative thereof, an olefin, an alkin, an acceptor group or a nitrile; (ii) a compound of general structural formula (II), wherein B is an electron-deficient substituted or unsubstituted aromatic with or without an acceptor group, an electron-deficient substituted or unsubstituted heteroaromatic with or without an acceptor group, an electron-deficient olefin and/or alkin, a metal complex; and X is a leaving group; (iii) a nucleophile of general structural formula (III), wherein Y and/or Z, independently of each other are an amino group, a thio group (mercapto group), a seleno group, a telluro group, a hydroxy group (alcohol group), an imido group, a carbonyl group, a thiocarbonyl group, a selenocarbonyl group, a tellurocarbonyl group; C is a substituted or unsubstituted C atom, a substituted or unsubstituted or anellated CC double bond or simple bond and n = 0-10, preferably 1-5.
摘要翻译：本发明涉及一种用于杂环的制备方法，其特征在于以下组分：i）的通用结构式（Ⅰ），其中Het是任选取代的杂原子，A是取代或未取代的芳族的，取代或未取代的芳族杂环炔丙基衍生物是取代的或未取代的乙烯基芳烃和/或其衍生物，烯烃，炔烃，受体基团或腈; （ii）具有结构通式的化合物（II）其中B是缺电子取代或未取代的芳族的，具有或不具有受体基团，缺电子取代或未取代的杂芳族，具有或不具有受体基团，缺电子烯烃和/或炔烃，金属络合物，且X是是离去基团; （iii）具有结构通式（III），其中Y和/或Z分别独立地表示氨基，硫基（巯基），硒基，Tellurogruppe，羟基（醇基团），酰亚氨基，羰基，硫代羰基，Selenocarbonylgruppe，Tellurocarbonylgruppe亲核试剂; C是一个取代的或未取代的C原子，取代或未取代的或稠合的C = C双键或单键，且n = 0-10，优选1-5，最好是在由环化缩合一锅反应，以4〜10，优选5 - 至7元杂环，是反应的芳族或非芳族环系统。

2. 发明申请

WO2009016029A2 STARTING OF A STEAM TURBINE 审中-公开
标题翻译： STARTING蒸汽涡轮机
公开(公告)号：WO2009016029A2
公开(公告)日：2009-02-05
申请号：PCT/EP2008059241
申请日：2008-07-15
申请人： SIEMENS AG , KEIPER RUDOLF , MUELLER THOMAS
发明人： KEIPER RUDOLF , MUELLER THOMAS
CPC分类号： F01K13/02 , F01D19/00
摘要： The invention relates to a method and a control unit (CM) for starting a steam turbine (ST) to a synchronous rotation speed (nsync), which steam turbine (ST) is operated in a thermal power coupling system (1) with a boiler (B) and at least one valve (CV), which is arranged in a steam line (FSL) between the boiler (B) and the steam turbine (ST) and has a controllable open position. Conventional starting procedures provide that the open position (X) of the valve (CF) is controlled exclusively as a function of the rotation speed (n) of the steam turbine (ST). This can lead to inadvertent quick-shut-off events. The invention overcomes this in that the open position of the control valve (CV) is temporarily controlled during the starting process as a function of the fresh steam pressure (PF).
摘要翻译：本发明涉及一种方法和一种用于在热电联产系统（1）与锅炉（B）和（锅炉B之间的至少一个开始蒸汽涡轮（ST）到同步速度（Nsync时），该蒸汽涡轮（ST）的控制单元（CM）排列），并在蒸汽管线（FSL）阀的蒸汽涡轮（ST）（CV）与可调节的开口位置操作。常规启动程序提供蒸汽涡轮（ST）的所述阀（CF）仅在对速度（N）的依赖性的开口位置（X）被控制。这可能会导致不必要的快速关闭事件。在启动过程中（CV）暂时响应于所述蒸汽压力（PF）被调节本发明解决了这个问题，在所述控制阀的打开位置。

3. 发明申请

WO2005056507A3 METHOD FOR PRODUCING ASTAXANTHIN AND CANTHAXANTHIN INTERMEDIATE PRODUCTS 审中-公开
标题翻译：工艺用于生产和虾青素，角黄素前体
公开(公告)号：WO2005056507A3
公开(公告)日：2006-12-21
申请号：PCT/EP2004014119
申请日：2004-12-10
申请人： BASF AG , RUMPF BERND , DECKERT PETRA , MUELLER THOMAS , GRIMMER JOHANNES
发明人： RUMPF BERND , DECKERT PETRA , MUELLER THOMAS , GRIMMER JOHANNES
IPC分类号： C07C403/08 , C07C45/00 , C07C45/59 , C07C49/743
CPC分类号： C07C403/08 , C07C2601/16 , Y02P20/55
摘要： The invention relates to a method for producing cyclohexenone derivatives of general formula (I), wherein R 1 represents hydrogen or OH; R 2 represents (Ia), comprising the following steps: (a) hydrolyzing a cyclohexenol compound of formula (II), wherein R 3 represents hydrogen and R 4 represents C 1 -C 6 -alkoxy or R 3 and R 4 represent vicinal hydroxy groups, which carry a common acetal protective group or a ketone protective group, R 5 represents (IIa), and R 6 represents a protected hydroxy group, in the absence of an organic solvent and in the presence of an acid catalyst; and; (b) extracting the reaction mixture by using a polar extracting agent.
摘要翻译：本发明涉及一种用于（I），其中R ^{1 是氢或OH通式环己烯酮衍生物的制备; [R ^{2 表示（Ia）中，其包括以下步骤：（a）式的Cyclohexenolverbindung水解（II）其中R ^{3 是氢并且R ^{4 < 6 为C _{1 -C _{>烷氧基，或R ^{3 和R ^{4 连位羟基的都携带一个共同的缩醛或缩酮保护基团，R ^{5 是（IIa）中，R ^{6 是被保护的羟基，在酸中不存在有机溶剂的存在催化剂; 和（b）用与极性萃取反应混合物。}}}}}}}}}}

4. 发明申请

WO2006050781A2 METHOD FOR PRODUCING HYDROGEN CYANIDE AND A REACTION TUBE USED FOR CARRYING OUT SAID METHOD 审中-公开
标题翻译：工艺生产氢氰化物和反应管的程序
公开(公告)号：WO2006050781A2
公开(公告)日：2006-05-18
申请号：PCT/EP2005010997
申请日：2005-10-13
申请人： DEGUSSA , ADRIAENSSENS JOZEF , BATHEN DIETER , BAEUML MANFRED , BEWERSDORF MARTIN , GAIL ERNST , LIESER THOMAS , MUELLER THOMAS , PELGRIMS IVAN , RINNER MICHAEL , WEBER ROBERT
发明人： ADRIAENSSENS JOZEF , BATHEN DIETER , BAEUML MANFRED , BEWERSDORF MARTIN , GAIL ERNST , LIESER THOMAS , MUELLER THOMAS , PELGRIMS IVAN , RINNER MICHAEL , WEBER ROBERT
IPC分类号： C01C3/02 , B01J12/00
CPC分类号： B01J19/0053 , B01J12/007 , B01J19/2415 , C01C3/0229
摘要： The invention relates to reaction tubes provided with catalyst coated inserts whose main faces are inclined at an angle equal to or less than 10° with respect to the longitudinal axis of a reaction tube, wherein said reaction tubes enable to attain an improved yield for a hydrogen cyanide production according to a BMA process without increased sooting in the reaction tubes.
摘要翻译：反应管与其主面是倾斜的不超过10度至反应管的纵向轴线，导致产生由BMA工艺提高产量氰化氢而不增加反应管的碳污损催化剂涂覆的刀片。

5. 发明申请

WO2005000213A8 METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH ENZYME INHIBITORS 审中-公开
标题翻译：使用HSP90-抑制剂与酶抑制剂组合治疗疾病的方法
公开(公告)号：WO2005000213A8
公开(公告)日：2005-06-23
申请号：PCT/US2004016889
申请日：2004-05-28
申请人： KOSAN BIOSCIENCES INC , JOHNSON ROBERT JR , ZHOU YIQING , MUELLER THOMAS
发明人： JOHNSON ROBERT JR , ZHOU YIQING , MUELLER THOMAS
IPC分类号： A61K20060101 , A61K31/19 , A61K31/33 , A61K31/16 , A61K31/165 , A61K31/535
CPC分类号： A61K31/165 , A61K31/395 , A61K31/517
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an enzyme inhibitor, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an enzyme inhibitor in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an enzyme inhibitor. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an enzyme inhibitor and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供了一种治疗癌症的方法。该方法包括施用HSP90抑制剂和酶抑制剂，其中联合施用提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一剂HSP90抑制剂治疗受试者并且在另一步骤中用一剂酶抑制剂治疗受试者。在本发明的另一方面，提供了治疗癌症的方法，其中首先用一剂HSP90抑制剂治疗受试者，随后用一定剂量的酶抑制剂治疗受试者。在本发明的另一方面，提供了治疗癌症的方法，其中首先用一定剂量的酶抑制剂治疗受试者，随后用一剂HSP90抑制剂治疗受试者。

6. 发明申请

WO2011023167A3 METHOD FOR PRODUCING HOT-ROLLED HOLLOW PROFILED ELEMENTS HAVING A RECTANGULAR CROSS-SECTION AND SMALL EDGE RADII 审中-公开
标题翻译：用于生产热轧空心型材矩形截面及与小角落RADIUS
公开(公告)号：WO2011023167A3
公开(公告)日：2011-04-28
申请号：PCT/DE2010000974
申请日：2010-08-12
申请人： V&M DEUTSCHLAND GMBH , HELTEN BURKHARD , MUELLER THOMAS , TRAPP NICOLAS , ARZT NORBERT , SCHMITZ THORSTEN
发明人： HELTEN BURKHARD , MUELLER THOMAS , TRAPP NICOLAS , ARZT NORBERT , SCHMITZ THORSTEN
IPC分类号： B21D47/01 , B21D3/14 , E04C3/32
CPC分类号： B21C37/15 , B21D3/14 , B21D47/01 , B66C23/286 , B66C23/62 , Y10T428/12292
摘要： The invention relates to a method for producing hot-rolled hollow profiled elements (1) made from steel and having a rectangular or square cross-section, a substantially circular pipe blank produced seamlessly by hot rolling or cold-rolled and welded and having a defined nominal outside diameter (D) first being produced and then formed into a hollow profiled element (1) having the required cross-section at a forming temperature and the visible edges (C1 and C2) of the hollow profiled elements (1) having a value
摘要翻译：本发明涉及一种用于生产钢的热轧空心型材（1）具有矩形或正方形的横截面，其中，首先基本上圆形无缝通过热轧或冷成形焊接管空白具有限定的公称外径（D）制造，然后在形成温度以形成一空心型材（ 1）再成形具有所需横截面和空心型材（1）的可见边缘（C1和C2）具有<1.5 XT（T =壁厚的值）。在这种情况下，这是从一个确定为减少初步管的实现程度，并达到空心型材尺寸具有预定的轮廓横截面被引入到型材轧机头管具有公称外径（D），其中还原的范围内的程度从-2％至-13％是并且根据下面的公式确定：还原率R [％] = [（×2（H + B）） - PX D]。×100％[2×（H + B）]; 其中D对应于所述初步管的公称外径和H5B中空部分（高度，宽度）的边缘长度。

7. 发明申请

WO2009152884A3 SOUND DAMPER FOR COMPRESSED AIR SYSTEMS OF VEHICLES 审中-公开
标题翻译：消声器对车辆的空气系统
公开(公告)号：WO2009152884A3
公开(公告)日：2010-02-18
申请号：PCT/EP2009001400
申请日：2009-02-27
申请人： WABCO GMBH , HARTING HENDRIK , KOENIG HEINZ-WERNER , MUELLER THOMAS , RIEDIGER-JANISCH KARL-HEINZ
发明人： HARTING HENDRIK , KOENIG HEINZ-WERNER , MUELLER THOMAS , RIEDIGER-JANISCH KARL-HEINZ
IPC分类号： B60T17/00 , F16L55/02
CPC分类号： B60T17/008
摘要： The invention relates to a sound damper for compressed air systems of vehicles. Said sound damper comprises a housing (1a, 1b), damping means (2) and at least one strut (3a, 3b, 3c). According to the invention, the housing (1a, 1b) has an air inlet (4) and an air outlet (5), the damping means (2) are located in the housing (1a, 1b) and the strut or struts (3a, 3b, 3c) is or are located in the housing (1a, 1b) in such a way, that it or they protrude at least partially into the damping means (2). Air that flows through the housing (1a, 1b) from the air inlet (4) to the air outlet (5) is conducted by the strut or struts (3a, 3b, 3c) into the damping means (2).
摘要翻译：本发明涉及一种用于车辆压缩空气系统的消音器。所述减噪器包括壳体（1A，1B），绝缘装置（2）和至少一个腹板（3A，3B，3C），其中所述壳体（1A，B 1）具有空气入口（4）和空气出口（5），在外壳内的绝缘装置（2）（1，图1b）被设置，并且所述至少一个腹板（3A，3B，3C）被设置在壳体内（1A，1B），使得它（在绝缘装置2 ）至少部分地突出，并且（从空气入口4）（至空气吹出口5）穿过所述壳体（1A，1B）中流动的空气被从所述至少一个腹板（3A，3B，针对3C）在绝缘装置（2）。

8. 发明申请

WO2009103489A2 TITANIUM DIOXIDE NANOPARTICLES DOPED WITH ALKALI METAL AND/OR EARTH ALKALI METAL, AND METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：碱金属和/或碱土金属掺杂的氧化钛纳米粒子及其制造方法
公开(公告)号：WO2009103489A2
公开(公告)日：2009-08-27
申请号：PCT/EP2009001113
申请日：2009-02-17
申请人： LEIBNIZ INST NEUE MATERIALIEN , OLIVEIRA PETER WILLIAM DE , MUELLER THOMAS , VEITH MICHAEL
发明人： OLIVEIRA PETER WILLIAM DE , MUELLER THOMAS , VEITH MICHAEL
IPC分类号： C01G23/053 , C09C1/36
CPC分类号： C01G23/053 , B82Y30/00 , C01G23/003 , C01P2002/52 , C01P2002/54 , C01P2004/64 , C08K3/22 , C09C1/3607 , C09D7/62 , C09D7/67
摘要： The invention relates nanoscale titanium dioxide particles having greatly reduced or suppressed photo-catalytic activity, and to a method for the production thereof. The invention further relates to compositions comprising said nanoscale particles, and to the use thereof in optical materials.
摘要翻译：本发明涉及纳米级二氧化钛颗粒与大大减少或抑制光催化活性，以及它们的制备方法。此外，本发明提供了含有这些纳米级颗粒和它们在光学材料用组合物。关注

9. 发明申请

WO2007010375B1 COMPRESSED AIR MICROMOTOR 审中-公开
标题翻译： MICRO气动马达
公开(公告)号：WO2007010375B1
公开(公告)日：2007-04-19
申请号：PCT/IB2006002000
申请日：2006-07-21
申请人： ROTOMED AG , MUELLER THOMAS , MUELLER DANIEL , MUELLER KURT
发明人： MUELLER THOMAS , MUELLER DANIEL , MUELLER KURT
IPC分类号： F01C1/348 , F01C13/02 , F01C20/04 , F01C20/14 , F01C21/08
CPC分类号： A61C1/05 , A61B17/320758 , F01C1/348 , F01C13/02 , F01C20/04 , F01C20/14 , F01C21/0809 , F05C2253/04
摘要： The invention relates to a compressed air micromotor comprising a collector(6) that is rotatably mounted in a housing (1) for the supply and evacuation of compressed air to or from the rotor (2). The rotation of the collector (6) into its end positions, permits a reversal of the rotational direction and an infinitely variable regulation of the speed. When the collector (6) is in a neutral position, the rotor (2) can be shut down and locked.
摘要翻译：一种微空气马达包含在一个壳体（1）可旋转地安装收集器（6），用于将空气供给和排放到，和（2）从所述转子到。通过将收集器（6）旋转到最终位置，方向反转和无级速度控制成为可能。在收集器（6）的中立位置，转子（2）也可以停止并锁定。

10. 发明申请

WO2005078143A8 METHOD FOR PRODUCING A THREE-DIMENSIONALLY FORMED ARMOURING COMPONENT FOR VEHICLE BODIES 审中-公开
标题翻译：用于生产的三维成形护甲部件FOR车身
公开(公告)号：WO2005078143A8
公开(公告)日：2006-11-30
申请号：PCT/DE2005000169
申请日：2005-02-03
申请人： FES GMBH FAHRZEUG ENTWICKLUNG , SOBE MARION , SCHROEDER MEINHARD , MUELLER THOMAS
发明人： SOBE MARION , SCHROEDER MEINHARD , MUELLER THOMAS
IPC分类号： C21D8/00 , C21D1/25 , C21D1/58 , C21D1/673 , C21D9/42
CPC分类号： C21D9/42 , C21D1/25 , C21D1/58 , C21D1/673 , Y10T29/49622
摘要： The invention relates to a method for producing a three-dimensionally formed armouring component for vehicle bodies. The aim of the invention is to be able to produce armouring components in a repeatedly accurate manner with minimal post-machining requirements and with lower dimensional tolerances than comparable weldments. To this end, sheet metal moulded parts are produced from hardenable steel by means of a thermal pre-treatment, the heating speed and temperature being selected at least until the austenitic or partially austenitic state depending on the alloy content is achieved, and the formed armouring components are then press-formed and optionally subsequently subjected to quench or thermal treatment. According to the invention, the hot-forming and quench-hardening of the steel plates is carried out in one working cycle, the austenitic steel plates are formed within a maximum period of 90 seconds by means of a compression mould, the entire formed component is held in contact with the compression mould, and the formed component is cooled in the closed compression mould, with a cooling speed which corresponds at least to the material-specific critical cooling speed.
摘要翻译：它是用于生产用于汽车车身的三维形成的铠装部件的方法。装甲部件要被制造为焊接结构可比重复性和与最小化的后处理要求更少的尺寸公差。这可通过制备下热处理由硬化钢的金属板形部件，其中，所述加热速率和温度中的至少直到达到合金含量取决于奥氏体或teilaustenischen状态，并进行完成后续的压制成形和形成的铠装部件的任选随后硬度或热处理，与钢板坯的热成形和淬火硬化是在一个操作中进行时，奥氏体化钢板坯件通过挤压工具的手段的周期的最大的90秒内形，所形成的部件是与加压工具全区域保持接触取所形成的部件的地方冷却在封闭加压工具并且在关闭压模所形成的部件的冷却发生在的冷却速度，其至少材料特定临界Abkühlgeschwindigke 它对应。

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