专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08344003B2 2-pyridinecarboxamide derivatives 有权
标题翻译： 2-吡啶甲酰胺衍生物
公开(公告)号：US08344003B2
公开(公告)日：2013-01-01
申请号：US12604835
申请日：2009-10-23
申请人： Morihiro Mitsuya , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Morihiro Mitsuya , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/4436 , C07D417/14 , C07D401/14
CPC分类号： C07D471/04 , C07D417/14
摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：[其中X1表示氮原子，硫原子，氧原子等 ; R1表示6-至10-元芳基，5-至7-元杂芳基等; D表示氧原子或硫原子; R2和R3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

2. 发明申请

US20100041660A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES 有权
标题翻译：新型2-吡啶甲酰胺衍生物
公开(公告)号：US20100041660A1
公开(公告)日：2010-02-18
申请号：US12604835
申请日：2009-10-23
申请人： MORIHIRO MITSUYA , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
发明人： MORIHIRO MITSUYA , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/53 , C07D417/14 , A61K31/4436 , C07D401/14 , A61K31/444 , C07D513/02 , A61K31/4365 , C07D403/02 , A61K31/501 , A61K31/497 , A61P3/10 , A61K31/506 , C07D253/065
CPC分类号： C07D471/04 , C07D417/14
摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：[其中X1表示氮原子，硫原子，氧原子等 ; R1表示6-至10-元芳基，5-至7-元杂芳基等; D表示氧原子或硫原子; R2和R3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

3. 发明授权

US07629362B2 2-pyridine carboxamide derivatives 有权
标题翻译： 2-吡啶甲酰胺衍生物
公开(公告)号：US07629362B2
公开(公告)日：2009-12-08
申请号：US10545424
申请日：2004-02-13
申请人： Morihiro Mitsuya , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Morihiro Mitsuya , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/4436 , C07D417/14 , C07D401/14
CPC分类号： C07D471/04 , C07D417/14
摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：[其中X1表示氮原子，硫原子，氧原子等 ; R1表示6-至10-元芳基，5-至7-元杂芳基等; D表示氧原子或硫原子; R2和R3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

4. 发明申请

US20080125429A1 Aryloxy-Substituted Benzimidazole Derivatives 有权
标题翻译：芳氧基取代的苯并咪唑衍生物
公开(公告)号：US20080125429A1
公开(公告)日：2008-05-29
申请号：US11666555
申请日：2005-11-01
申请人： Noriaki Hashimoto , Keiji Takahashi , Chisato Nakama , Yoshio Ogino , Fumiko Sakai , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Noriaki Hashimoto , Keiji Takahashi , Chisato Nakama , Yoshio Ogino , Fumiko Sakai , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/5377 , C07D213/02 , C07D221/00 , C07D239/06 , C07D241/10 , C07D295/00 , A61P3/10 , A61K31/4439 , A61K31/4545 , A61K31/444 , A61K31/506 , A61K31/497
CPC分类号： A61K38/31 , A61K31/155 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K38/28 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/06 , C07D413/14 , A61K2300/00
摘要： A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided.The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.
摘要翻译：提供葡糖激酶活化剂; 提供糖尿病的治疗和/或预防，或治疗和/或预防糖尿病如视网膜病，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的治疗和/或预防肥胖症。本发明涉及式（I）的化合物：其中R 1和R 2代表氢等; R 3表示氢原子，卤素原子等; R 4各自独立地表示氢原子，低级烷基等; Q表示碳原子，氮原子或硫原子（硫原子可以被氧代基单取代或二取代）。 R 5和R 6各自表示氢原子，低级烷基等; X 1，X 2，X 3和X 4各自独立地表示碳原子或氮原子; Z表示氧原子，硫原子或氮原子; Ar表示任选被选自取代基组β的基团单取代至三取代的芳基或杂芳基; 环A表示5-或6-元含氮杂芳基; m表示1〜6的整数， n表示0〜3的整数， p表示0〜2的整数（条件是X 1〜X 4中的至少2个为碳原子）; q表示0或1]或其药学上可接受的盐，其具有葡糖激酶活化的作用，并且可用作糖尿病的治疗。

5. 发明申请

US20080070928A1 Novel 2-Heteroaryl-Substituted Benzimidazole Derivative 有权
标题翻译：新型2-杂芳基取代的苯并咪唑衍生物
公开(公告)号：US20080070928A1
公开(公告)日：2008-03-20
申请号：US10582564
申请日：2004-12-28
申请人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura , Jun-Ichi Eiki
发明人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura , Jun-Ichi Eiki
IPC分类号： A61K31/497 , A61K31/4184 , A61K31/422 , A61K31/4245 , A61K31/427 , A61P3/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/02 , C07D413/02 , C07D403/02 , A61P3/10 , A61K31/506 , A61K31/433 , A61K31/4439 , A61K31/444
CPC分类号： C07D401/14 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided.A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; the ring A represents a 5- or 6-membered nitrogen-containing aromatic hetero ring of a formula (II): (in the formula, X represents a carbon atom or a nitrogen atom); R1 represents an aryl, etc.; R2 represents a hydroxy, etc.; R3 represents a —C1-6 alkyl, etc.; R4 represents a —C1-6 alkyl, etc.; X5 represents —O—, etc.; a indicates an integer of 1, 2 or 3; q indicates an integer of from 0 to 2; m indicates an integer of from 0 to 2].
摘要翻译：提供葡糖激酶活化剂; 提供了糖尿病的补救措施和/或预防，糖尿病的补救和/或预防，如视网膜病变，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的补救措施和/或预防肥胖症。一种葡糖激酶活化剂，其特征在于含有通式（I-0）的2-杂芳基取代的苯并咪唑衍生物或其药学上可接受的盐：[式中X表示碳原子或氮原子; X 1，X 2，X 3和X 4各自独立地表示碳原子或氮原子; 环A表示式（II）的5-或6-元含氮芳族杂环：（式中，X表示碳原子或氮原子）; R 1表示芳基等; R 2表示羟基等; R 3表示-C 1-6烷基等; R 4表示-C 1-6烷基等; X 5表示-O-等; a表示1,2或3的整数; q表示0〜2的整数， m表示0〜2的整数]。

6. 发明授权

US07932394B2 Aryloxy-substituted benzimidazole derivatives 有权
标题翻译：芳氧基取代的苯并咪唑衍生物
公开(公告)号：US07932394B2
公开(公告)日：2011-04-26
申请号：US11666555
申请日：2005-11-01
申请人： Noriaki Hashimoto , Keiji Takahashi , Chisato Nakama , Yoshio Ogino , Fumiko Sakai , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Noriaki Hashimoto , Keiji Takahashi , Chisato Nakama , Yoshio Ogino , Fumiko Sakai , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： C07D401/00 , A61K31/445
CPC分类号： A61K38/31 , A61K31/155 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K38/28 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/06 , C07D413/14 , A61K2300/00
摘要： A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided.The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.
摘要翻译：提供葡糖激酶活化剂; 提供糖尿病的治疗和/或预防，或治疗和/或预防糖尿病如视网膜病，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的治疗和/或预防肥胖症。本发明涉及式（I）化合物：其中R 1和R 2表示氢等; R3表示氢原子，卤原子等; R4各自独立地表示氢原子，低级烷基等; Q表示碳原子，氮原子或硫原子（硫原子可以被氧代基单取代或二取代）。 R5和R6各自表示氢原子，低级烷基等; X1，X2，X3和X4各自独立地表示碳原子或氮原子; Z表示氧原子，硫原子或氮原子; Ar表示任选被选自取代基组中的基团单取代至三取代的芳基或杂芳基; 环A表示5-或6-元含氮杂芳基; m表示1〜6的整数， n表示0〜3的整数， p表示0〜2的整数（X1〜X4中的至少2个为碳原子）。 q表示0或1]或其药学上可接受的盐，其具有葡糖激酶活化的作用，并且可用作糖尿病的治疗。

7. 发明授权

US07728025B2 2-heteroaryl-substituted benzimidazole derivative 有权
标题翻译： 2-杂芳基取代的苯并咪唑衍生物
公开(公告)号：US07728025B2
公开(公告)日：2010-06-01
申请号：US10582564
申请日：2004-12-28
申请人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura
发明人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura
IPC分类号： A01N43/50
CPC分类号： C07D401/14 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided.A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; the ring A represents a 5- or 6-membered nitrogen-containing aromatic hetero ring of a formula (II): (in the formula, X represents a carbon atom or a nitrogen atom); R1 represents an aryl, etc.; R2 represents a hydroxy, etc.; R3 represents a —C1-6 alkyl, etc.; R4 represents a —C1-6 alkyl, etc.; X5 represents —O—, etc.; a indicates an integer of 1, 2 or 3; q indicates an integer of from 0 to 2; m indicates an integer of from 0 to 2].
摘要翻译：提供葡糖激酶活化剂; 提供了糖尿病的补救措施和/或预防，糖尿病的补救和/或预防，如视网膜病变，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的补救措施和/或预防肥胖症。一种葡糖激酶活化剂，其特征在于含有通式（I-0）的2-杂芳基取代的苯并咪唑衍生物或其药学上可接受的盐：[式中X表示碳原子或氮原子; X1，X2，X3和X4各自独立地表示碳原子或氮原子; 环A表示式（II）的5-或6-元含氮芳族杂环：（式中，X表示碳原子或氮原子）; R1表示芳基等。 R2代表羟基等; R3代表-C 1-6烷基等; R4代表-C 1-6烷基等; X5表示-O-等。 a表示1,2或3的整数; q表示0〜2的整数， m表示0〜2的整数]。

8. 发明授权

US5350634A Thermochromic composition 失效
标题翻译：热变色组合物
公开(公告)号：US5350634A
公开(公告)日：1994-09-27
申请号：US103674
申请日：1993-08-10
申请人： Masaaki Sumii , Fumiko Sakai , Yasuyuki Yoshimura
发明人： Masaaki Sumii , Fumiko Sakai , Yasuyuki Yoshimura
IPC分类号： B41M5/337 , B41M5/28 , B41M5/30 , C09K9/02 , B41M5/128
CPC分类号： B41M5/284 , Y10T428/2985
摘要： A thermochromic composition which comprises (1) an electron-donating chromogenic organic compound, (2) an electron-accepting compound, and (3) at least one desensitizer selected from among diphenylamine derivatives of-the following formulas: ##STR1## wherein R.sup.1 and R.sup.2 each independently is H, an alkyl group containing 1 to 22 carbon atoms, ##STR2## (in which R.sup.3 and R.sup.4 each independently is H, an alkyl group containing 1 to 4 carbon atoms). A thermochromic composition which comprises (1) an electron-donating chromogenic organic compound, (2) an electron-accepting compound, (3) at least one desensitizer selected from among diphenylamine derivatives mentioned above, and (4) a thermochromic transition temperature modifier. A thermochromic composition which comprises one of the thermochromic compositions mentioned above as enclosed in microcapsule.
摘要翻译：一种热致变色组合物，其包含（1）给电子显色有机化合物，（2）电子接受性化合物和（3）至少一种选自下式的二苯胺衍生物的脱敏剂：＆lt; IMAGE＆gt; [1] 其中R 1和R 2各自独立地为H，含有1至22个碳原子的烷基是H，含有1至4个碳原子的烷基。一种热致变色组合物，其包含（1）给电子显色有机化合物，（2）电子接受性化合物，（3）至少一种选自上述二苯胺衍生物的脱敏剂，和（4）热变色转变温度调节剂。一种热致变色组合物，其包含上述包含在微胶囊中的一种热变色组合物。

9. 发明授权

US5350633A Thermochromic composition 失效
标题翻译：热变色组合物
公开(公告)号：US5350633A
公开(公告)日：1994-09-27
申请号：US103673
申请日：1993-08-10
申请人： Masaaki Sumii , Fumiko Sakai , Yasuyuki Yoshimura
发明人： Masaaki Sumii , Fumiko Sakai , Yasuyuki Yoshimura
IPC分类号： B41M5/337 , B41M5/28 , B41M5/30 , C09K9/02 , B41M5/128
CPC分类号： B41M5/284 , Y10T428/2985
摘要： A thermochromic composition which comprises (1) an electron-donating chromogenic organic compound, (2) an electron-accepting compound, and (3) at least one desensitizer selected from among carbazole derivatives of the following formulas: ##STR1## wherein R is an alkyl group containing 1 to 22 carbon atoms, a phenyl group or a benzyl group and X is a hydrogen atom, a halogen atom, --NH.sub.2, --NO.sub.2 or --CHO; ##STR2## wherein R is an alkyl group containing 1 to 22 carbon atoms and X is a hydrogen atom, a halogen atom, --NH.sub.2, --NO.sub.2 or --CHO. A thermochromic composition which comprises (1) an electron-donating chromogenic organic compound, (2) an electron-accepting compound, (3) at least one desensitizer selected from among carbazole derivatives mentioned above, and (4) a thermochromic transition temperature modifier. A thermochromic composition which comprises one of the thermochromic compositions mentioned above as enclosed in microcapsule.
摘要翻译：一种热致变色组合物，其包含（1）给电子显色有机化合物，（2）电子接受性化合物，和（3）选自下式的咔唑衍生物中的至少一种脱敏剂：其中 R是含有1至22个碳原子的烷基，苯基或苄基，X是氢原子，卤素原子，-NH 2，-NO 2或-CHO; [2]其中R是含有1至22个碳原子的烷基，X是氢原子，卤素原子，-NH 2，-NO 2或-CHO。一种热变色组合物，其包含（1）给电子显色有机化合物，（2）电子接受性化合物，（3）至少一种选自上述咔唑衍生物的脱敏剂，和（4）热变色转变温度调节剂。一种热致变色组合物，其包含上述包含在微胶囊中的一种热变色组合物。

10. 发明授权

US5527385A Thermochromic composition 失效
标题翻译：热变色组合物
公开(公告)号：US5527385A
公开(公告)日：1996-06-18
申请号：US100997
申请日：1993-08-03
申请人： Masaaki Sumii , Fumiko Sakai , Yasuyuki Yoshimura
发明人： Masaaki Sumii , Fumiko Sakai , Yasuyuki Yoshimura
IPC分类号： B41M5/337 , B41M5/28 , B41M5/30 , C09D11/00 , C09D13/00 , C09K9/02
CPC分类号： C09D11/50 , B41M5/305 , C09D13/00
摘要： A thermochromic composition which comprises(1) an electron-donating chromogenic organic compound,(2) an electron-accepting compound,(3) at least one desensitizer selected from among hydrazide compounds, and(4) a thermochromic transition temperature modifier.
摘要翻译：一种热致变色组合物，其包含（1）给电子显色有机化合物，（2）电子接受性化合物，（3）至少一种选自酰肼化合物的脱敏剂，和（4）热变色转变温度改性剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式