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1. 发明申请

WO2015148976A1 PESTICIDAL TOXIN PROTEINS ACTIVE AGAINST COLEOPTERAN INSECTS 审中-公开
标题翻译：杀虫剂蛋白质主动对抗复合体
公开(公告)号：WO2015148976A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/023091
申请日：2015-03-27
申请人： MONSANTO TECHNOLOGY LLC
发明人： BOWEN, David J. , CHAY, Catherine A. , FLASINSKI, Stanislaw , FU, Xiaoran , KESANAPALLI, Uma R , MILLIGAN, Jason S. , SLIGHTOM, Rachael N. , TU, Daqi , WOLLACOTT, Andrew M. , YIN, Yong
IPC分类号： C12N15/82
CPC分类号： C12N15/8286 , A01N63/02 , C07K14/325 , Y02A40/162
摘要： The invention generally relates to the field of insect inhibitory toxin proteins. A novel class of proteins exhibiting insect inhibitory activity against agriculturally relevant pests of crop plants and seeds are disclosed. Insecticidal activity is particularly effective against the Coleopteran order of insect pests. Plants, plant parts, and seed are provided containing a polynucleotide construct encoding one or more of the toxin proteins disclosed herein. The proteins are referred to herein variously as the TIC2463-related toxin protein class or family, the TIC2463-related toxin proteins, the TIC2463-related protein genus, toxin proteins related to the TIC2463 toxin protein, proteins related to TIC2463, TIC2463-related toxin polypeptides, TIC2463-related pesticidal proteins, and the like.
摘要翻译：本发明一般涉及昆虫抑制毒素蛋白质的领域。公开了一类新的对农作物和种子的农业相关害虫的抑制活性的蛋白质。杀虫活性对昆虫有害生物的鞘翅目顺序特别有效。提供植物，植物部分和种子，其含有编码本文公开的一种或多种毒素蛋白质的多核苷酸构建体。蛋白质不同地被称为TIC2463相关毒素蛋白质类别或家族，TIC2463相关毒素蛋白，TIC2463相关蛋白属，与TIC2463毒素蛋白相关的毒素蛋白，与TIC2463相关的蛋白质，TIC2463相关毒素多肽，TIC2463相关的杀虫蛋白等。

2. 发明申请

WO2018118776A1 NOVEL INSECT INHIBITORY PROTEINS 审中-公开
公开(公告)号：WO2018118776A1
公开(公告)日：2018-06-28
申请号：PCT/US2017/067019
申请日：2017-12-18
申请人： MONSANTO TECHNOLOGY LLC
发明人： BOWEN, David J. , CHAY, Catherine A. , CICHE, Todd A. , FLASINSKI, Stanislaw , HOWE, Arlene R. , MILLIGAN, Jason S. , ROBERTS, James K. , YIN, Yong
IPC分类号： A01N37/18 , A01N37/46 , A01N37/00
摘要： Pesticidal proteins exhibiting toxic activity against Coleopteran, Lepidopteran, Hemipteran, and Thysanopteran pest species are disclosed, and include, but are not limited to, TIC6280, TIC6281, TIC6282, TIC6283, TIC8808, TIC9480, TIC9257, TIC7106, TIC7017, TIC7107, TIC7108, TIC7109, TIC7110, TIC7111, TIC7589, TIC9258, and TIC9259. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the pesticidal proteins provided. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran, Coleopteran, Hemipteran and Thysanopteran infestation are provided which contain recombinant nucleic acid sequences encoding the disclosed pesticidal proteins. Methods for detecting the presence of the recombinant nucleic acid sequences or the protein of the present invention in a biological sample, and methods of controlling Coleopteran, Lepidopteran, Hemipteran, and Thysanopteran species pests using the disclosed pesticidal proteins are also provided.

3. 发明申请

WO2015021354A2 PESTICIDAL TOXIN ACTIVE AGAINST COLEOPTERAN AND/OR HEMIPTERAN INSECTS 审中-公开
标题翻译：杀虫剂对活性物质和/或HEMIPTERAN INSECTS有效
公开(公告)号：WO2015021354A2
公开(公告)日：2015-02-12
申请号：PCT/US2014/050284
申请日：2014-08-08
申请人： MONSANTO TECHNOLOGY LLC
发明人： ANDERSON, Heather M. , BOWEN, David J. , CHAY, Catherine A. , FLASINSKI, Stanislaw , KESANAPALLI, Uma R. , MILLIGAN, Jason S. , SLIGHTOM, Rachael N. , YIN, Yong
IPC分类号： A01N37/18 , C12N15/82
CPC分类号： A01N37/18 , A01N37/46 , A01N63/02 , C07K14/325 , C12N15/8286 , Y02A40/162
摘要： The present invention provides novel insecticidal proteins active against a Coleopteran and/or Hemipteran species pest, which include, but are not limited to, TIC3131, TIC3400 and TIC3407 proteins. The present invention also provides a DNA construct comprising operably linked to a heterologous promoter a polynucleotide that encodes the novel insecticidal protein or an insecticidal fragment thereof. The present invention further provides transgenic plants/plant cells/plant parts expressing the insecticidal proteins, methods for detecting the presence of the polynucleotide or the protein in a biological sample, and methods of controlling a Coleopteran and/or Hemipteran species pest using the insecticidal proteins.
摘要翻译：本发明提供了对鞘翅目和/或半翅目种类害虫有活性的新型杀虫蛋白，其包括但不限于TIC3131，TIC3400和TIC3407蛋白。本发明还提供了包含与异源启动子有效连接的DNA构建体，所述多核苷酸编码新的杀虫蛋白或其杀虫片段。本发明还提供表达杀虫蛋白的转基因植物/植物细胞/植物部分，用于检测生物样品中多核苷酸或蛋白质的存在的方法，以及使用杀虫蛋白质控制鞘翅目和/或半翅目种类害虫的方法。

4. 发明公开

EP3122882A1 PESTICIDAL TOXIN PROTEINS ACTIVE AGAINST COLEOPTERAN INSECTS 审中-公开
标题翻译：糖皮质激素蛋白GEGEN COOPOPTERA
公开(公告)号：EP3122882A1
公开(公告)日：2017-02-01
申请号：EP15769020.7
申请日：2015-03-27
申请人： Monsanto Technology LLC
发明人： BOWEN, David J. , CHAY, Catherine A. , FLASINSKI, Stanislaw , FU, Xiaoran , KESANAPALLI, Uma R , MILLIGAN, Jason S. , SLIGHTOM, Rachael N. , TU, Daqi , WOLLACOTT, Andrew M. , YIN, Yong
IPC分类号： C12N15/82
CPC分类号： C12N15/8286 , A01N63/02 , C07K14/325 , Y02A40/162
摘要： The invention generally relates to the field of insect inhibitory toxin proteins. A novel class of proteins exhibiting insect inhibitory activity against agriculturally relevant pests of crop plants and seeds are disclosed. Insecticidal activity is particularly effective against the Coleopteran order of insect pests. Plants, plant parts, and seed are provided containing a polynucleotide construct encoding one or more of the toxin proteins disclosed herein. The proteins are referred to herein variously as the TIC2463-related toxin protein class or family, the TIC2463-related toxin proteins, the TIC2463-related protein genus, toxin proteins related to the TIC2463 toxin protein, proteins related to TIC2463, TIC2463-related toxin polypeptides, TIC2463-related pesticidal proteins, and the like.
摘要翻译：本发明一般涉及昆虫抑制毒素蛋白质的领域。公开了一类新的对农作物和种子的农业相关害虫的抑制活性的蛋白质。杀虫活性对昆虫害虫的鞘翅目顺序特别有效。提供植物，植物部分和种子，其含有编码本文公开的一种或多种毒素蛋白质的多核苷酸构建体。蛋白质不同地被称为TIC2463相关的毒素蛋白质类别或家族，TIC2463相关毒素蛋白质，TIC2463相关蛋白质属，与TIC2463毒素蛋白相关的毒素蛋白质，与TIC2463相关的蛋白质，TIC2463相关毒素多肽，TIC2463相关的杀虫蛋白等。

5. 发明公开

EP3483274A1 PESTICIDAL TOXIN PROTEINS ACTIVE AGAINST COLEOPTERAN INSECTS 审中-公开
公开(公告)号：EP3483274A1
公开(公告)日：2019-05-15
申请号：EP18184618.9
申请日：2015-03-27
申请人： Monsanto Technology LLC
发明人： BOWEN, David J. , CHAY, Catherine A. , FLASINSKI, Stanislaw , FU, Xiaoran , KESANAPALLI, Uma R. , MILLIGAN, Jason S. , SLIGHTOM, Rachael N. , TU, Daqi , WOLLACOTT, Andrew M. , YIN, Yong
IPC分类号： C12N15/82
摘要： The invention generally relates to the field of insect inhibitory toxin proteins. A novel class of proteins exhibiting insect inhibitory activity against agriculturally relevant pests of crop plants and seeds are disclosed. Insecticidal activity is particularly effective against the Coleopteran order of insect pests. Plants, plant parts, and seed are provided containing a polynucleotide construct encoding one or more of the toxin proteins disclosed herein. The proteins are referred to herein variously as the TIC2463-related toxin protein class or family, the TIC2463-related toxin proteins, the TIC2463-related protein genus, toxin proteins related to the TIC2463 toxin protein, proteins related to TIC2463, TIC2463-related toxin polypeptides, TIC2463-related pesticidal proteins, and the like.

6. 发明公开

EP4262400A1 NOVEL INSECT INHIBITORY PROTEINS 审中-实审
公开(公告)号：EP4262400A1
公开(公告)日：2023-10-25
申请号：EP21911957.5
申请日：2021-12-20
申请人： Monsanto Technology LLC
发明人： BOWEN, David J. , CHAY, Catherine A. , HOWE, Arlene R. , MARENGO, Matthew S. , MEYER, Jason , MILLIGAN, Jason S. , WEINER, Brian E.
IPC分类号： A01P7/04 , C07K14/195 , C07K14/32 , C07K14/325 , C07K14/415 , C12N15/11

7. 发明公开

EP3557996A1 NOVEL INSECT INHIBITORY PROTEINS 有权
公开(公告)号：EP3557996A1
公开(公告)日：2019-10-30
申请号：EP17884172.2
申请日：2017-12-18
申请人： Monsanto Technology LLC
发明人： BOWEN, David J. , CHAY, Catherine A. , CICHE, Todd A. , FLASINSKI, Stanislaw , HOWE, Arlene R. , MILLIGAN, Jason S. , ROBERTS, James K. , YIN, Yong
IPC分类号： A01N37/18 , A01N37/46 , A01N37/00

8. 发明公开

EP3221454A1 NOVEL INSECT INHIBITORY PROTEINS 有权
标题翻译：新型昆虫抑制蛋白
公开(公告)号：EP3221454A1
公开(公告)日：2017-09-27
申请号：EP15802314.3
申请日：2015-11-18
申请人： Monsanto Technology LLC
发明人： BEAN, Gregory J. , BOWEN, David J. , CHAY, Catherine A. , HOWE, Arlene R. , MILLIGAN, Jason S. , YIN, Yong
IPC分类号： C12N15/82 , C07K14/32
CPC分类号： C12N15/8286 , A01N63/02 , C07K14/195 , Y02A40/162
摘要： Insecticidal proteins exhibiting toxic activity against Coleopteran and Lepidopteran pest species are disclosed, and include, but are not limited to, TIC3668, TIC3669, TIC3670, TIC4076, TIC4078, TIC4260, TIC4346, TIC4826, TIC4861, TIC4862, TIC4863, and TIC-3668-type proteins. DNA molecules and constructs are provided which contain a polynucleotide sequence encoding one or more of the disclosed TIC3668-type proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran and Coleopteran infestation are provided which contain polynucleotide sequences encoding the insecticidal proteins of the present invention. Methods for detecting the presence of the polynucleotides or the proteins of the present invention in a biological sample, and methods of controlling Coleopteran and Lepidopteran species pests using any of the TIC3668-type insecticidal proteins are also provided.
摘要翻译：包括但不限于TIC3668，TIC3669，TIC3670，TIC4076，TIC4078，TIC4260，TIC4346，TIC4826，TIC4861，TIC4862，TIC4863和TIC-3668- 型蛋白质。提供了含有编码一种或多种公开的TIC3668型蛋白质的多核苷酸序列的DNA分子和构建体。提供了抗鳞翅目和鞘翅目侵染的转基因植物，植物细胞，种子和植物部分，其含有编码本发明的杀虫蛋白的多核苷酸序列。还提供了用于检测生物样品中多核苷酸或蛋白质的存在的方法，以及使用任何TIC3668型杀虫蛋白质来控制鞘翅目和鳞翅目物种害虫的方法。

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