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1. 发明申请

WO2004004668A3 IMMUNE MODULATORY ACTIVITY OF HUMAN RIBONUCLEASES 审中-公开
标题翻译：人类免疫调节剂的免疫调节活性
公开(公告)号：WO2004004668A3
公开(公告)日：2005-03-03
申请号：PCT/US0308824
申请日：2003-04-02
申请人： MOLECULAR STAGING INC , FU QIN , TCHERNEV VELIZAR , SATYARAJ EBENEZER , PATEL DHAVALKUMAR D , KINGSMORE STEPHEN F , SCHWEITZER BARRY
发明人： FU QIN , TCHERNEV VELIZAR , SATYARAJ EBENEZER , PATEL DHAVALKUMAR D , KINGSMORE STEPHEN F , SCHWEITZER BARRY
IPC分类号： A61K39/39 , G01N33/573 , C12Q1/68 , C07H21/04
CPC分类号： G01N33/573 , A61K39/39 , A61K2039/55516 , G01N2333/922
摘要： Human extracellular ribonucleases (RNases) are widely distributed in various organs and body fluids and together with other members of the mammalian RNase A superfamily. In addition to their RNase activity, several RNases have been shown to have special biological actions, i.e., antitumor, antiviral and antigiogenic properties. However, the molecular mechanisms of such activities are unclear. Using protein microarrays amplified rolling circle amplification (RCA), we investigated the effects of EDN (Rnase 2), ECP (Rnase 3) and RNase 1om leukocytes cytokine production. We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with different combinations of RNases and RNase inhibitors. Members of human ribonuclease family (such as Rnase 1, hEDN (Rnase 2) and Rnase 3 ) induced expression of certain sets of cytokines in human leukocytes, including ENA-78, EOT2, BLC, GDNF, I309, IFN-alpha, IFN-gamma, IL-10, IL-12p70, IL-13, IL-16, IL-18, IL1beta, IL-1ra, IL-2Sra, IL-3, IL-6, IL-6Sr, IL-7, IL-8, IP-10, MCP-1, MCP-2, MCP-3, MCSF, MIG, MDC, MIP-1alpha, MIP-1beta, MPIF-1, NAP-2, RANTES, sCD23, OSM, TARC, TNF-alpha, TNF-R1 and uPAR. Thus members of the Rnase superfamily are therapeutic targets for treatment of inflammatory diseases and clinical conditions. Inhibition or augmentation of Rnase expression is used to modulate the immune system and is beneficial for host defense against various diseases and is exploited as an adjuvant. The expression of Rnases is a diagnostic marker for inflammation related conditions and is used to determine various disease stages. In addition, expression of cytokines, chemokines, growth factors is used to monitor efficacy of Rnase-base therapies.
摘要翻译：人类细胞外核糖核酸酶（RNases）广泛分布在各种器官和体液中，并与哺乳动物核糖核酸酶A超家族的其他成员一起分布。除了它们的RNA酶活性外，已经显示出几种RNA酶具有特殊的生物学作用，即抗肿瘤，抗病毒和抗病毒性质。然而，这些活动的分子机制尚不清楚。使用蛋白质微阵列扩增滚环扩增（RCA），我们研究了EDN（Rnase 2），ECP（Rnase 3）和RNase 1om白细胞细胞因子产生的影响。我们测量培养上清液中78种不同细胞因子和生长因子的水平，以确定用不同RNA酶和RNA酶抑制剂组合处理的细胞的细胞因子谱。人类核糖核酸酶家族（如Rnase 1，hEDN（Rnase 2）和Rnase 3）的成员诱导人白细胞中某些细胞因子的表达，包括ENA-78，EOT2，BLC，GDNF，I309，IFN-α，IFN- γ，IL-10，IL-12p70，IL-13，IL-16，IL-18，IL1β，IL-1ra，IL-2Sra，IL-3，IL-6，IL-6Sr， 8，IP-10，MCP-1，MCP-2，MCP-3，MCSF，MIG，MDC，MIP-1alpha，MIP-1beta，MPIF-1，NAP-2，RANTES，sCD23，OSM，TARC， α，TNF-R1和uPAR。因此，Rnase超家族成员是治疗炎症性疾病和临床病症的治疗靶点。 Rnase表达的抑制或增加用于调节免疫系统，有利于宿主防御各种疾病，并被开发为佐剂。 Rnases的表达是炎症相关病症的诊断标记，用于确定各种疾病阶段。此外，细胞因子，趋化因子，生长因子的表达用于监测Rnase基疗法的疗效。

2. 发明申请

WO2004048324A3 CHEMOKINE PARC SUPPRESSES SPECIFIC CYTOKINE PRODUCTION 审中-公开
标题翻译：趋化因子PARC抑制特异性细胞因子生产
公开(公告)号：WO2004048324A3
公开(公告)日：2004-11-11
申请号：PCT/US0337607
申请日：2003-11-26
申请人： MOLECULAR STAGING INC , FU QIN , SATYARAJ EBENEZER , KINGSMORE STEPHEN F , TCHERNEV VELIZAR T , PATEL DHAVALKUMAR D
发明人： FU QIN , SATYARAJ EBENEZER , KINGSMORE STEPHEN F , TCHERNEV VELIZAR T , PATEL DHAVALKUMAR D
IPC分类号： A61K38/19 , G01N33/68 , C12M1/34 , G01N33/563
CPC分类号： A61K38/195 , G01N33/6863
摘要： We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with PARC. We found that specific cytokines were suppressed by PARC. PARC can be used to treat diseases such as cancer, autoimmune diseases, rheumatoid arthritis, myeloproliferative disorders, and coronary artery disease, which are characterized by too much mitosis.
摘要翻译：我们测量培养上清液中78种不同细胞因子和生长因子的水平，以确定用PARC处理的细胞的细胞因子谱。我们发现特定的细胞因子被PARC抑制。 PARC可用于治疗以有丝分裂为特征的疾病，如癌症，自身免疫性疾病，类风湿性关节炎，骨髓增殖性疾病和冠状动脉疾病。

3. 发明申请

WO2005009339A3 INFLAMMATORY BOWEL DISEASES 审中-公开
标题翻译：炎症性腹膜疾病
公开(公告)号：WO2005009339A3
公开(公告)日：2006-05-18
申请号：PCT/US2004017024
申请日：2004-06-01
申请人： MOLECULAR STAGING INC , SATYARAJ EBENEZER , TCHERNEV VELIZAR T , LEJNINE SERGUEI , KOTLER GREGORY , PATEL DHAVALKUMAR D , KINGSMORE STEPHEN F
发明人： SATYARAJ EBENEZER , TCHERNEV VELIZAR T , LEJNINE SERGUEI , KOTLER GREGORY , PATEL DHAVALKUMAR D , KINGSMORE STEPHEN F
IPC分类号： A61B5/00 , A61K20060101 , C07K14/52 , G01N33/68
CPC分类号： G01N33/6893 , G01N2800/065
摘要： Biomarkers and combinations of biomarkers are defined useful for diagnosis and monitoring of inflammatory bowel diseases.
摘要翻译：生物标志物和生物标志物的组合被定义用于诊断和监测炎症性肠病。

4. 发明专利

AU2003293023A1 CHEMOKINE PARC SUPPRESSES SPECIFIC CYTOKINE PRODUCTION 未知
公开(公告)号：AU2003293023A1
公开(公告)日：2004-06-18
申请号：AU2003293023
申请日：2003-11-26
申请人： MOLECULAR STAGING INC
发明人： TCHERNEV VELIZAR T , PATEL DHAVALKUMAR D , FU QIN , SATYARAJ EBENEZER , KINGSMORE STEPHEN F
IPC分类号： A61K38/19 , G01N33/68
摘要： We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with PARC. We found that specific cytokines were suppressed by PARC. PARC can be used to treat diseases such as cancer, autoimmune diseases, rheumatoid arthritis, myeloproliferative disorders, and coronary artery disease, which are characterized by too much mitosis.

5. 发明申请

WO0188190A2 POLY-PRIMED AMPLIFICATION OF NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：核酸序列的多重扩增
公开(公告)号：WO0188190A2
公开(公告)日：2001-11-22
申请号：PCT/US0016130
申请日：2000-06-12
申请人： MOLECULAR STAGING INC
发明人： KINGSMORE STEPHEN F , WILTSHIRE RICHARD STEVEN , LAMBERT JEREMY P
IPC分类号： G01N33/53 , C12N15/09 , C12P21/04 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6804 , C12Q2531/125
摘要： Methods for the amplification of selected nucleic acids at high rate but with high specificity and control are disclosed using a secondary, tertiary, quaternary or higher order platform especially designed to amplify selected sequences within the primary product of linear or exponential rolling circle amplification and amplifying said sequences along with specialized detector or reporter molecules that serve to enhance the ability to detect the amplification products.
摘要翻译：使用二级，三级，四级或更高级平台来扩增选择的核酸的高速但具有高特异性和对照性的方法，其特别设计用于扩增线性或指数滚环扩增的初级产物内的选定序列，并扩增所述序列以及用于增强检测扩增产物的能力的专门的检测器或报告分子。

6. 发明专利

AU2003293023A8 Chemokine parc suppresses specific cytokine production 未知
公开(公告)号：AU2003293023A8
公开(公告)日：2004-06-18
申请号：AU2003293023
申请日：2003-11-26
申请人： MOLECULAR STAGING INC
发明人： TCHERNEV VELIZAR T , SATYARAJ EBENEZER , KINGSMORE STEPHEN F , PATEL DHAVALKUMAR D , FU QIN
IPC分类号： A61K38/19 , G01N33/68 , C12M1/34 , G01N33/563
摘要： We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with PARC. We found that specific cytokines were suppressed by PARC. PARC can be used to treat diseases such as cancer, autoimmune diseases, rheumatoid arthritis, myeloproliferative disorders, and coronary artery disease, which are characterized by too much mitosis.

7. 发明专利

AU2003218339A8 Immune modulatory activity of human ribonucleases 未知
公开(公告)号：AU2003218339A8
公开(公告)日：2004-01-23
申请号：AU2003218339
申请日：2003-04-02
申请人： MOLECULAR STAGING INC
发明人： PATEL DHAVALKUMAR D , SATYARAJ EBENEZER , FU QIN , SCHWEITZER BARRY , TCHERNEV VELIZAR , KINGSMORE STEPHEN F
IPC分类号： A61K39/39 , G01N33/573 , C12Q1/68 , C07H21/04
摘要： Human extracellular ribonucleases (RNases) are widely distributed in various organs and body fluids and together with other members of the mammalian RNase A superfamily. In addition to their RNase activity, several RNases have been shown to have special biological actions, i.e., antitumor, antiviral and angiogenic properties. However, the molecular mechanisms of such activities are unclear. Using protein microarrays amplified rolling circle amplification (RCA), we investigated the effects of EDN (Rnase 2), ECP (Rnase 3) and RNase 1 on leukocytes cytokine production. We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with different combinations of RNases and RNase inhibitors. Members of human ribonuclease family (such as Rnase 1, hEDN (Rnase 2) and Rnase 3) induced expression of certain sets of cytokines in human leukocytes, including ENA-78, EOT2, BLC, GDNF, 1309, IFN-alpha, IFN-gamma, IL-10, IL-12P40, IL-12p70, IL-13, IL-16, IL-18, IL-1beta, IL-1ra, IL-2Sra, IL-3, IL-6, IL-6sR, IL-7, IL-8, IP-10, MCP-1, MCP-2, MCP-3, MCSF, MIG, MDC, MIP-1alpha, MIP-1beta, MPIF-1, NAP-2, RANTES, sCD23, OSM, TARC, TNF-alpha, TNF-R1 and uPAR. Thus members of the Rnase superfamily are therapeutic targets for treatment of inflammatory diseases and clinical conditions. Inhibition or augmentation of Rnase expression is used to modulate the immune system and is beneficial for host defense against various diseases and is exploited as an adjuvant. The expression of Rnases is a diagnostic marker for inflammation related conditions and is used to determine various disease stages. In addition, expression of cytokines, chemokines, growth factors is used to monitor efficacy of Rnase-base therapies.

8. 发明专利

AU2003218339A1 IMMUNE MODULATORY ACTIVITY OF HUMAN RIBONUCLEASES 未知
公开(公告)号：AU2003218339A1
公开(公告)日：2004-01-23
申请号：AU2003218339
申请日：2003-04-02
申请人： MOLECULAR STAGING INC
发明人： SCHWEITZER BARRY , FU QIN , TCHERNEV VELIZAR , SATYARAJ EBENEZER , PATEL DHAVALKUMAR D , KINGSMORE STEPHEN F
IPC分类号： A61K39/39 , G01N33/573
摘要： Human extracellular ribonucleases (RNases) are widely distributed in various organs and body fluids and together with other members of the mammalian RNase A superfamily. In addition to their RNase activity, several RNases have been shown to have special biological actions, i.e., antitumor, antiviral and angiogenic properties. However, the molecular mechanisms of such activities are unclear. Using protein microarrays amplified rolling circle amplification (RCA), we investigated the effects of EDN (Rnase 2), ECP (Rnase 3) and RNase 1 on leukocytes cytokine production. We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with different combinations of RNases and RNase inhibitors. Members of human ribonuclease family (such as Rnase 1, hEDN (Rnase 2) and Rnase 3) induced expression of certain sets of cytokines in human leukocytes, including ENA-78, EOT2, BLC, GDNF, 1309, IFN-alpha, IFN-gamma, IL-10, IL-12P40, IL-12p70, IL-13, IL-16, IL-18, IL-1beta, IL-1ra, IL-2Sra, IL-3, IL-6, IL-6sR, IL-7, IL-8, IP-10, MCP-1, MCP-2, MCP-3, MCSF, MIG, MDC, MIP-1alpha, MIP-1beta, MPIF-1, NAP-2, RANTES, sCD23, OSM, TARC, TNF-alpha, TNF-R1 and uPAR. Thus members of the Rnase superfamily are therapeutic targets for treatment of inflammatory diseases and clinical conditions. Inhibition or augmentation of Rnase expression is used to modulate the immune system and is beneficial for host defense against various diseases and is exploited as an adjuvant. The expression of Rnases is a diagnostic marker for inflammation related conditions and is used to determine various disease stages. In addition, expression of cytokines, chemokines, growth factors is used to monitor efficacy of Rnase-base therapies.

9. 发明专利

AU5332800A Poly-primed amplification of nucleic acid sequences 未知
公开(公告)号：AU5332800A
公开(公告)日：2001-11-26
申请号：AU5332800
申请日：2000-06-12
申请人： MOLECULAR STAGING INC
发明人： KINGSMORE STEPHEN F , WILTSHIRE RICHARD STEVEN , LAMBERT JEREMY P
IPC分类号： G01N33/53 , C12N15/09 , C12P21/04 , C12Q1/68 , C12Q1/6804 , G01N33/566
摘要： Methods for the amplification of selected nucleic acids at high rate but with high specificity and control are disclosed using a secondary, tertiary, quaternary or higher order platform especially designed to amplify selected sequences within the primary product of linear or exponential rolling circle amplification and amplifying said sequences along with specialized detector or reporter molecules that serve to enhance the ability to detect the amplification products.

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