专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2018170245A1 BROAD SPECTRUM INFLUENZA VIRUS VACCINE 审中-公开
公开(公告)号：WO2018170245A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022605
申请日：2018-03-15
申请人： MODERNATX, INC. , BABAOGLU, Kerim , FLYNN, Jessica, Anne , ZHANG, Lan , NICKLE, David
发明人： BABAOGLU, Kerim , FLYNN, Jessica, Anne , ZHANG, Lan , NICKLE, David , CIARAMELLA, Giuseppe , HUANG, Eric, Yi-chun
IPC分类号： A61K39/145 , A61K31/7105 , A61K31/7115 , A61K9/51 , A61P31/16
CPC分类号： A61K45/06 , A61K9/5123 , A61K31/7105 , A61K31/7115 , A61K39/12 , A61K2039/53 , A61K2039/543 , A61K2039/55555 , A61K2039/575 , A61P31/16 , C12N2760/16134 , C12N2760/16234
摘要： The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccine. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.

2. 发明申请

WO2018075592A1 INFLUENZA HEMAGGLUTININ PROTEIN VACCINES 审中-公开
标题翻译：流感血凝素蛋白疫苗
公开(公告)号：WO2018075592A1
公开(公告)日：2018-04-26
申请号：PCT/US2017/057107
申请日：2017-10-18
申请人： MERCK SHARP & DOHME CORP. , FLYNN, Jessica Anne , ZHANG, Lan , BABAOGLU, Kerim , FRIDMAN, Arthur , NICKLE, David
发明人： FLYNN, Jessica Anne , ZHANG, Lan , BABAOGLU, Kerim , FRIDMAN, Arthur , NICKLE, David
IPC分类号： A61K38/00 , A61K39/00 , A61K39/12 , A61K39/145
摘要： The disclosure relates to influenza virus hemagglutinin protein and DNA vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
摘要翻译：本公开涉及流感病毒血凝素蛋白和DNA疫苗，以及使用疫苗和包含疫苗的组合物的方法。

3. 发明申请

WO2008109059A2 CONSERVED-ELEMENT VACCINES AND METHODS FOR DESIGNING CONSERVED-ELEMENT VACCINES 审中-公开
标题翻译：保护元素疫苗和设计保护元素疫苗的方法
公开(公告)号：WO2008109059A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/002833
申请日：2008-03-03
申请人： UNIVERSITY OF WASHINGTON , MULLINS, James , NICKLE, David , ROLLAND, Morgane
发明人： MULLINS, James , NICKLE, David , ROLLAND, Morgane
IPC分类号： G06F19/00
CPC分类号： G06F19/22 , G06F19/18
摘要： Embodiments of the present invention include conserved-element vaccines and methods for designing and producing conserved-element vaccines. A conserved-element vaccine ("CEVac") is a recombinant and/or synthetic vaccine that incorporates only highly conserved epitopes from an observed set of pathogen variants. The conserved epitopes are identified computationally by aligning biopolymer sequences, such as concatenated polypeptide sequences that together represent a pathogen proteome, corresponding to an observed set of pathogen variants, and computationally selecting conserved subsequences according to a number of subsequence-selection criteria. These subsequence-selection criteria may include a minimum conserved-subsequence length, a threshold frequency of occurrence of a particular monomer at each conserved, single-monomer position within a conserved subsequence, a threshold combined occurrence for a set of allowable variant monomers at a particular conserved, variable position within a conserved subsequence, and a maximum number of variable positions within a subsequence. A set of conserved subsequences identified according to the subsequence-selection criteria are then filtered to remove subsequences identical to, or too similar to, naturally-occurring host subsequences, and are then assembled into expression vectors for incorporation into microbial hosts for biosynthesis of a recombinant CEVac or assembled into one or more synthetic constructs for a synthetic CEVac.
摘要翻译：本发明的实施方案包括保守元件疫苗和用于设计和生产保守元件疫苗的方法。保守元件疫苗（“CEVac”）是重组和/或合成疫苗，其仅包含观察到的一组病原体变体的高度保守的表位。通过对齐生物聚合物序列，例如一起代表病原体蛋白质组的连接多肽序列，对应于观察到的病原体变体组，并且根据子序列选择标准的数量计算选择保守的子序列，可以计算地鉴定保守表位。这些子序列选择标准可以包括最小保守亚序列长度，在保守子序列内的每个保守的单单体位置处特定单体出现的阈值频率，特定的一组允许的变体单体的阈值组合出现保守的子序列内的保守的，可变的位置，以及子序列内可变位置的最大数目。然后将根据子序列选择标准鉴定的一组保守的亚序列过滤以去除与天然存在的宿主亚序列相同或类似于的天然存在的宿主亚序列的亚序列，然后将其组装到表达载体中，以结合到微生物宿主中用于生物合成重组 CEVac或组装成合成CEVac的一种或多种合成构建体。

4. 发明公开

EP3609534A1 BROAD SPECTRUM INFLUENZA VIRUS VACCINE 审中-公开
公开(公告)号：EP3609534A1
公开(公告)日：2020-02-19
申请号：EP18768674.6
申请日：2018-03-15
申请人： ModernaTX, Inc.
发明人： BABAOGLU, Kerim , FLYNN, Jessica, Anne , ZHANG, Lan , NICKLE, David , CIARAMELLA, Giuseppe , HUANG, Eric, Yi-chun
IPC分类号： A61K39/145 , A61K31/7105 , A61K31/7115 , A61K9/51 , A61P31/16

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式