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2. 发明申请

WO2015038988A1 EDIBLE AND ANIMAL-PRODUCT-FREE MICROCARRIERS FOR ENGINEERED MEAT 审中-公开
标题翻译：食用和动物无产品的工程机械微生物
公开(公告)号：WO2015038988A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/055532
申请日：2014-09-12
申请人： MODERN MEADOW, INC.
发明人： MARGA, Francoise , FORGACS, Gabor , PURCELL, Brendan, Patrick , FORGACS, Andras
IPC分类号： A23L1/31 , C12N5/07 , C12N5/077
CPC分类号： C12N5/0658 , A23L13/00 , A23P10/20 , A23V2002/00 , C12N2500/92 , C12N2531/00 , A23V2200/264
摘要： Edible microcarriers, including microcarrier beads, microspheres and microsponges, appropriate for use in a bioreactor to culture cells that may be used to form a comestible engineered meat product. For example, the edible microcarriers described herein may include porous microcarriers that may be used to grow cells (e.g., smooth muscle cells) and may be included with the cells in the final engineered meat product, without requiring modification or removal of the cells from the microcarriers. In a particular example, the edible microcarriers may be formed of cross-linked pectin, such as pectin-thiopropionylamide (PTP), and RGD- containing polypeptide, such as thiolated cardosin A. Methods of forming edible microcarriers, methods of using the edible microcarriers to make engineered meat, and engineered meat including the edible microcarriers are also described herein.
摘要翻译：适用于生物反应器的可食用微载体，包括微载体珠，微球和微球，可用于培养可用于形成可食用工程肉制品的细胞。例如，本文所述的可食用微载体可以包括可用于生长细胞（例如平滑肌细胞）的多孔微载体，并且可以与最终工程化的肉制品中的细胞一起被包含，而不需要将细胞从微载体。在具体实例中，可食用的微载体可以由交联的果胶形成，例如果胶 - 硫代丙酰胺（PTP）和含RGD的多肽，例如硫苷化的心苷A.形成食用微载体的方法，使用可食用微载体的方法制造工程肉和包括可食用微载体的工程肉也在本文中描述。

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