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    • 1. 发明申请
    • NUTRITIONAL COMPOSITIONS FOR PROMOTING GUT BARRIER FUNCTION AND AMELIORATING VISCERAL PAIN
    • 促进肠屏障功能和消除内脏痛的营养组合物
    • WO2017078907A1
    • 2017-05-11
    • PCT/US2016/056207
    • 2016-10-10
    • MJN U.S. HOLDINGS LLC
    • ZHONG, YanLAMBERS, Teartse TimGROSS, GabrieleMANURUNG, SarmauliVAN TOL, Eric A.F.WAWORUNTU, Rosaline
    • A23L33/00A61K35/747A23L33/135
    • A61K35/747A23L29/065A23L33/135A23L33/40A23V2002/00A23Y2220/73A61K38/40A61K2035/115A61K2300/00
    • The present disclosure is directed to methods for i) promoting gut regeneration, ii) promoting gut maturation and/or adaptation, iii) supporting gut barrier resistance and/or iv) protecting gut barrier function in a pediatric subject comprising administering to the pediatric subject a composition comprising an effective amount of a soluble mediator preparation derived from a late-exponential growth phase of a probiotic batch-cultivation process, such as Lactobacillus rhamnosus GG (LGG). The present methods advantageously provide the gut-protection benefits of LGG soluble mediators without introducing live bacterial culture to individuals with impaired gut barrier function. In some embodiments, the pediatric subject has impaired gut barrier function and/or short bowel syndrome. The present disclosure in other embodiments, directed methods for reducing visceral pain in a pediatric subject comprising administering to the pediatric subject a composition comprising an effective amount of a soluble mediator preparation from a late-exponential growth phase of a probiotic batch-cultivation process, such as LGG.
    • 本公开涉及用于i)促进肠再生,ii)促进肠成熟和/或适应,iii)支持肠屏障耐受性和/或iv)保护儿科中的肠屏障功能的方法 包括向儿科对象施用包含有效量的衍生自益生菌分批培养过程的指数生长后期阶段的可溶性介质制剂(例如鼠李糖乳杆菌GG(LGG))的组合物。 本发明方法有利地提供LGG可溶性介质的肠道保护益处,而不会将活细菌培养物引入具有受损肠功能障碍的个体。 在一些实施方案中,儿科对象的肠道屏障功能和/或短肠综合征受损。 在其它实施方案中,本公开内容的用于减少儿科患者内脏疼痛的定向方法包括向儿科患者给药包含有效量的来自益生菌批培养过程的指数生长期后期的可溶性介质制剂的组合物,例如 作为LGG。