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1. 发明申请

WO2004104547A2 SYSTEMS AND METHODS FOR FLUORESCENCE DETECTION WITH A MOVABLE DETECTION MODULE 审中-公开
标题翻译：用可变检测模块进行荧光检测的系统和方法
公开(公告)号：WO2004104547A2
公开(公告)日：2004-12-02
申请号：PCT/US2004/014566
申请日：2004-05-10
申请人： MJ RESEARCH, INC. , KORDUNSKY, Igor , GOLDMAN, Jeffrey, A. , FINNEY, Michael, J.
发明人： KORDUNSKY, Igor , GOLDMAN, Jeffrey, A. , FINNEY, Michael, J.
IPC分类号： G01N
CPC分类号： C12Q1/686 , B01L7/52 , B01L2300/0654 , B01L2300/0829 , B01L2300/1822 , G01N21/276 , G01N21/6452 , G01N2201/0446
摘要： A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.
摘要翻译：提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。检测模块可从支撑结构移除，以方便更换。

2. 发明申请

WO2007121324A1 APPARATUS FOR GUIDING SAMPLE AND REAGENT MANIPULATIONS AND RECEPTACLES FOR HOLDING SAME 审中-公开
标题翻译：用于指导样品和试剂操作的装置和用于控制样品的插入物
公开(公告)号：WO2007121324A1
公开(公告)日：2007-10-25
申请号：PCT/US2007/066569
申请日：2007-04-12
申请人： SAGE SCIENCE, INC. , MAGNANT, Gary , FINNEY, Michael, J. , BARBERA, Todd, J. , COREY, George , BOLES, Chris
发明人： MAGNANT, Gary , FINNEY, Michael, J. , BARBERA, Todd, J. , COREY, George , BOLES, Chris
IPC分类号： G01N35/00 , B01L11/00
CPC分类号： G01N35/00584 , B01L3/0227 , B01L3/50855 , B01L9/50 , B01L2200/143 , B01L2200/16 , B01L2300/021 , B01L2300/023 , B01L2300/0829
摘要： A system has utility is guiding and tracking the execution of manual procedures. The system includes a support that holds multiple sample receptacles, computational circuitry to execute a protocol script that delivers instructions for executing various steps of the procedure, and a protocol progress sensor that advances the execution of the protocol script. The computer may be comparable in size to a support for holding the receptacles The receptacles be arranged in a frame, may be sealed with peelable or puncturable films and may include identifiers that are read by the system. The receptacles may be filled with a high heat capacity material to maintain a given temperature range. A variety of companion devices may interact with the system using the protocol script. An instrumented pipettor can communicate with the system for semi-automated execution of protocols.
摘要翻译：系统的实用程序是指导和跟踪手动过程的执行。该系统包括一个支持多个样本插座的支持，执行一个协议脚本的计算电路，该协议脚本提供用于执行该过程的各个步骤的指令，以及协议进程传感器，其执行协议脚本的执行。计算机的尺寸可以与用于保持插座的支撑件相当。插座布置在框架中，可以用可剥离的或可穿刺的膜密封，并且可以包括由系统读取的标识符。容器可以填充高热容材料以保持给定的温度范围。各种伴侣设备可以使用协议脚本与系统进行交互。仪器化移液器可与系统进行通信，以实现协议的半自动执行。

3. 发明申请

WO1997021834A1 SAMPLE CARTRIDGE SLIDE BLOCK 审中-公开
标题翻译：样品盒滑块
公开(公告)号：WO1997021834A1
公开(公告)日：1997-06-19
申请号：PCT/US1996019323
申请日：1996-12-05
申请人： MJ RESEARCH, INC.
发明人： MJ RESEARCH, INC. , TITCOMB, Paul , FINNEY, Michael, J. , COHEN, David
IPC分类号： C12Q01/68
CPC分类号： G01N1/312 , B01L7/52 , G01N2035/00089 , G01N2035/00138 , G01N2035/00376 , G01N2035/0463 , Y10T436/11
摘要： A sample cartridge block that includes a first plate (12), a second plate (14) and a third plate (16). The third plate (16) is thermally connected to the first plate (12) and the second plate (14). In some embodiments, the block is capable of holding a relatively high density of sample cartridges. In certain embodiments, the block provides good sample temperature stability while the sample temperature is held constant or while the sample temperature is being changed. According to the invention, a sample block may include one material or more than one material. Preferably, a sample cartridge block has a relatively low thermal mass. In some embodiments, the first plate of a sample cartridge block may have a larger surface area than the surface area of the third plate. According to the present invention, the first plate of the sample cartridge block may be thermally connected to a temperature controller. In certain embodiments, a sample cartridge block may have a relatively large surface area in contact with a temperature controller.
摘要翻译：一种样品盒块，包括第一板（12），第二板（14）和第三板（16）。第三板（16）热连接到第一板（12）和第二板（14）。在一些实施例中，该块能够保持较高密度的样品盒。在某些实施方案中，该块提供良好的样品温度稳定性，同时样品温度保持恒定或在样品温度改变时。根据本发明，样品块可以包括一种材料或多种材料。优选地，样品盒块具有相对低的热质量。在一些实施例中，样品盒块的第一板可以具有比第三板的表面积更大的表面积。根据本发明，样品盒块的第一板可以热连接到温度控制器。在某些实施例中，样品盒块可以具有与温度控制器接触的相对大的表面积。

4. 发明授权

EP0868531B1 SAMPLE CARTRIDGE SLIDE BLOCK 失效
标题翻译：支架SLIDE
公开(公告)号：EP0868531B1
公开(公告)日：2003-04-23
申请号：EP96942140.3
申请日：1996-12-05
申请人： MJ Research, Inc.
发明人： TITCOMB, Paul , FINNEY, Michael, J. , COHEN, David
IPC分类号： C12Q1/68 , B01L7/00 , G02B21/34 , B01L9/00
CPC分类号： G01N1/312 , B01L7/52 , G01N2035/00089 , G01N2035/00138 , G01N2035/00376 , G01N2035/0463 , Y10T436/11
摘要： A sample cartridge block that includes a first plate (12), a second plate (14) and a third plate (16). The third plate (16) is thermally connected to the first plate (12) and the second plate (14). In some embodiments, the block is capable of holding a relatively high density of sample cartridges. In certain embodiments, the block provides good sample temperature stability while the sample temperature is held constant or while the sample temperature is being changed. According to the invention, a sample block may include one material or more than one material. Preferably, a sample cartridge block has a relatively low thermal mass. In some embodiments, the first plate of a sample cartridge block may have a larger surface area than the surface area of the third plate. According to the present invention, the first plate of the sample cartridge block may be thermally connected to a temperature controller. In certain embodiments, a sample cartridge block may have a relatively large surface area in contact with a temperature controller.

5. 发明公开

EP0868531A1 SAMPLE CARTRIDGE SLIDE BLOCK 失效
标题翻译： BLOCK在载玻片上安装的样品
公开(公告)号：EP0868531A1
公开(公告)日：1998-10-07
申请号：EP96942140.0
申请日：1996-12-05
申请人： MJ Research, Inc.
发明人： TITCOMB, Paul , FINNEY, Michael, J. , COHEN, David
IPC分类号： B01L7 , C12M1 , G01N1 , G01N35
CPC分类号： G01N1/312 , B01L7/52 , G01N2035/00089 , G01N2035/00138 , G01N2035/00376 , G01N2035/0463 , Y10T436/11
摘要： A sample cartridge block that includes a first plate (12), a second plate (14) and a third plate (16). The third plate (16) is thermally connected to the first plate (12) and the second plate (14). In some embodiments, the block is capable of holding a relatively high density of sample cartridges. In certain embodiments, the block provides good sample temperature stability while the sample temperature is held constant or while the sample temperature is being changed. According to the invention, a sample block may include one material or more than one material. Preferably, a sample cartridge block has a relatively low thermal mass. In some embodiments, the first plate of a sample cartridge block may have a larger surface area than the surface area of the third plate. According to the present invention, the first plate of the sample cartridge block may be thermally connected to a temperature controller. In certain embodiments, a sample cartridge block may have a relatively large surface area in contact with a temperature controller.

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