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1. 发明专利

FR2557873A1 未知
公开(公告)号：FR2557873A1
公开(公告)日：1985-07-12
申请号：FR8400301
申请日：1984-01-10
申请人： MITSUI TOATSU CHEMICALS
发明人： MASAHARU OHOKA , YUKIHIRO YOSHIKAWA , NOBUYUKI KAWASHIMA , NOBUHIRO KAWASHIMA , SYOSUKE NAGAI , TAKAO TAKANO
IPC分类号： C07D209/20 , C12N1/02 , C12P13/22 , C12P17/10

2. 发明专利

FR2557872B1 未知
公开(公告)号：FR2557872B1
公开(公告)日：1987-07-10
申请号：FR8400302
申请日：1984-01-10
申请人： MITSUI TOATSU CHEMICALS
发明人： MASAHARU OHOKA , YUKIHIRO YOSHIKAWA , NOBUYUKI KAWASHIMA , NOBUHIRO KAWASHIMA , SYOSUKE NAGAI , TAKAO TAKANO
IPC分类号： C07D209/20 , C12N1/02 , C12P13/04 , C12P13/06 , C12P13/22 , C12R1/19 , C12R1/40 , C07C99/12

3. 发明专利

FR2557873B1 未知
公开(公告)号：FR2557873B1
公开(公告)日：1986-05-16
申请号：FR8400301
申请日：1984-01-10
申请人： MITSUI TOATSU CHEMICALS
发明人： MASAHARU OHOKA , YUKIHIRO YOSHIKAWA , NOBUYUKI KAWASHIMA , NOBUHIRO KAWASHIMA , SYOSUKE NAGAI , TAKAO TAKANO
IPC分类号： C07D209/20 , C12N1/02 , C12P13/22 , C12P17/10

4. 发明专利

IT1174459B L-tryptophan sepn. from microorganism suspensions 未知
公开(公告)号：IT1174459B
公开(公告)日：1987-07-01
申请号：IT1905484
申请日：1984-01-06
申请人： MITSUI TOATSU CHEMICALS
发明人： MASAHARU OHOKA , YUKIHIRO YOSHIKAWA , NOBUYUKI KAWASHIMA , NOBUHIRO KAWASHIMA , SYOSUKE NAGAI
摘要： Process L-tryptophan from a reaction mixt. contg. L-tryptophan and a microorganism, obtd. in the microbial prod. of L-tryptophan, in which (A) the reaction mixt. is adjusted top H 2-5 with a mineral acid, (B) the mixt. is heated, and either (C) the heated reaction mixt. is filtered to remove the microorganism of (D) an alkali is added to the heated reaction mixt. in order to convert the L-tryptophan into its alkali salt and thereaction mixt. is subsequently filtered.

5. 发明专利

IT1170100B Enzymic reactions where substrate(s) deteriorate activity 未知
公开(公告)号：IT1170100B
公开(公告)日：1987-06-03
申请号：IT2447183
申请日：1983-12-30
申请人： MITSUI TOATSU CHEMICALS
发明人： MASAHARU OHOKA , YUKIHIRO YOSHIKAWA , NOBUYUKI KAWASHIMA , NOBUHIRO KAWASHIMA , SYOSUKE NAGAI , TAKAO TAKANO
IPC分类号： C12P20060101 , C12P
摘要： Reaction is effected in a water-immiscible but substrate-miscible organic solvent in order to keep the substrate conc. in the aq. medium lower than that inhibiting the enzyme activity. Process is applicable to reaction of indole with L- or DL-serine into L-tryptophan by tryptophan synthetase produced by E. coli, where the following organic solvent may be employed; aromatic hydrocarbons (e.g. benzene, toluene, chlorobenzene, nitrobenzene, acetophenone), aliphatic esters of 6C or higher (e.g. n-BuOAc, i-AmOAc, EtOCOPr, i-BuOAc), citric acid esters (e.g. acetyltriethyl citrate, acetyltributyl citrate, triethyl citrate, tributyl citrate), tartaric acid esters, malic acid esters, ethers (e.g. anisole). In producing tryptophan, a variant of E. coli is cultured in an aerobic condition at 28-40 deg. C or pH 6-8, and the culture broth or the cells sepd. from the broth are dispersed into a soln. contg. pyridoxal HCl, L-serine and inorganic materials. A soln. of indole dissolved in the above solvent (pH 7.5-9.5 (8-9)) is added in one portion or successively in small portions to the above prepd. suspension and kept at 20-40 deg. C to yield L-tryptophan. The indole content in the solvent may be fixed to be 800 (750 ppm or lower) in industrial scale prodn. In certain reactions utilising enzymes, excess content of substrates sometimes deteriorates enzyme activity to decrease the yield of desired prod. Deterioration is now avoided by controlling substrate concn. in the reaction medium.

6. 发明专利

IT1151407B 未知
公开(公告)号：IT1151407B
公开(公告)日：1986-12-17
申请号：IT2131882
申请日：1982-05-17
申请人： MITSUI TOATSU CHEMICALS
发明人： MASAHARU OHOKA , TOSHIO KATOH , RYUICHI MITA , NOBUYUKI KAWASHIMA , CHOJIRO HIGUCHI , NOBUHIRO KAWASHIMA , AKIHIRO YAMAGUCHI , SHOUSUKE NAGAI , TAKAO TAKANO
IPC分类号： C07C227/14 , C07C
摘要： PCT No. PCT/JP82/00174 Sec. 371 Date Dec. 29, 1982 Sec. 102(e) Date Dec. 29, 1982 PCT Filed May 17, 1982 PCT Pub. No. WO82/04043 PCT Pub. Date Nov. 25, 1982. beta -Chloroalanine is prepared by reacting in an aqueous medium an aziridine-2-carboxylate with hydrogen chloride in an amount of 2.0-5.0 moles per mole of the aziridine-2-carboxyalte and causing the thus-formed beta -chloroalanine to selectively crystallize out from the liquid reaction mixture. Since the solution recovered after the isolation of the crystallized beta -chloroalanine still contains beta -chloroalanine and by-produced alpha -chloro- beta -alanine dissolved therein, they may be converted into an aziridine-2-carboxylate by treating them with a base to recirculate it for reuse.

7. 发明专利

FR2557872A1 未知
公开(公告)号：FR2557872A1
公开(公告)日：1985-07-12
申请号：FR8400302
申请日：1984-01-10
申请人： MITSUI TOATSU CHEMICALS
发明人： MASAHARU OHOKA , YUKIHIRO YOSHIKAWA , NOBUYUKI KAWASHIMA , NOBUHIRO KAWASHIMA , SYOSUKE NAGAI , TAKAO TAKANO
IPC分类号： C07D209/20 , C12N1/02 , C12P13/04 , C12P13/06 , C12P13/22 , C12R1/19 , C12R1/40 , C07C99/12

8. 发明专利

FR2557590B1 未知
公开(公告)号：FR2557590B1
公开(公告)日：1988-03-04
申请号：FR8321118
申请日：1983-12-30
申请人： MITSUI TOATSU CHEMICALS
发明人： MASAHARU OHOKA , YUKIHIRO YOSHIKAWA , NOBUYUKI KAWASHIMA , NOBUHIRO KAWASHIMA , SYOSUKE NAGAI , TAKAO TAKANO
IPC分类号： C12P1/00 , C12P13/22 , C12R1/19 , C12R1/38 , C12N9/96

9. 发明专利

IT1184301B Isolating L-aminoacid from enzymic reaction mixt. contg. microorganism 未知
公开(公告)号：IT1184301B
公开(公告)日：1987-10-28
申请号：IT1905684
申请日：1984-01-06
申请人： MITSUI TOATSU CHEMICALS
发明人： MASAHARU OHOKA , YUKIHIRO YOSHIKAWA , NOBUYUKI KAWASHIMA , NOBUHIRO KAWASHIMA , SYOSUKE NAGAI , TAKAO TAKANO
IPC分类号： B01D20060101 , C07D209/20 , B01D
摘要： L-Amino acid (I), is isolated from an enzymic reaction mixt. (II) contg. microorganisms, by treating (II) with an H-type strongly acidic cation exchange resin (III). (III), is e.g. Lewatit sp-120, Lewatit sc-102, Diaion pk-208, Daion sk-102, Amberlite XE-100, (RTM's), etc. To isolate (I) from (II), the microorganism is firstly removed from (II) by centrifugation, etc., and the supernatant is treated with ion exchange resin. The mycelium of microorganism can be easily removed from (II), when (II) is passed through a (III)-bed. The mycelium accumulated among (III)-particles can also be easily removed by passing water in up-stream. Thus, the step for sepn. of the mycelium is unnecessary.

10. 发明专利

IT1151414B 未知
公开(公告)号：IT1151414B
公开(公告)日：1986-12-17
申请号：IT2133782
申请日：1982-05-18
申请人： MITSUI TOATSU CHEMICALS
发明人： NOBUYUKI KAWASHIMA , TOSHIO KATOH , RYUICHI MITA , MASAHARU OHOKA , CHOJIRO HIGUCHI , NOBUHIRO KAWASHIMA , AKIHIRO YAMAGUCHI , SHOUSUKE NAGAI , TAKAO TAKANO
IPC分类号： C07C227/14 , C07C
摘要： Process for mfg. beta hydroxy amino acid, e.g. DL serine, threonine, beta hydroxyvaline or beta hydroxyphenylalanine, on an industrial scale with hardly any side prods. is effected by adsorbing aziridine-2-carboxylic acids of formula (I) (R1= hydrogen or methyl, (un)substd. phenyl or pyridyl gp.; R2= methyl gp. or hydrogen; X=-CO2H, CO2M (M=alkali metal or alkali earth metal), -CO2R3 (R3=1-5C lower alkyl or aralkyl gp.) -CONH2 or -CN, but is not -CO2H or CO2M when both R1 and R2 are hydrogen) or its deriv. on strongly acidic cation exchange resin, pref. H type resin, and heating in the presence of water for 1-100 hr. at 40-120 deg.C, pref. 2-50 hr. at 50-100 deg.C.

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