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1. 发明专利

ES2362877T3 COMPUESTOS DE IMIDAZOLIN-2-ONA. 未知
公开(公告)号：ES2362877T3
公开(公告)日：2011-07-14
申请号：ES04728708
申请日：2004-04-21
申请人： MITSUBISHI TANABE PHARMA CORP , MITSUBISHI TANABE PHARMA CORP
发明人： KUBO AKIRA , IMASHIRO RITSUO , OGASAWARA AKIHITO , NAKAJIMA TATSUO , NAKANE TETSU , MIYOSHI HIDETAKA
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/506 , A61P3/10 , A61P7/02 , A61P9/10 , A61P19/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Un compuesto seleccionado entre los compuestos base libre de estructuras 399 a 478, o una de sus sales farmacéuticamente aceptables. 399 Etilo 1,1-Dioxotetrahidrotiofen-3-ilamino 400 Etilo trans-4-(Metilcarbamoil)ciclohexilamino 401 Etilo 1,5-Dimetil-5-hidroxihexilamino 402 Isopropilo 1,5-Dimetil-5-hidroxihexilamino 403 Etilo cis-4-Hidroxi-4-metilciclohexilamino 404 Isopropilo trans-4-Hidroxi-4-metilciclohexilamino 405 Isopropilo trans-4-(1-Hidroxi-1-metiletil)ciclohexilamino 406 Etilo trans-4-Hidroxi-4-metilciclohexilamino 407 Isopropilo cis-4-Hidroxi-4-metilciclohexilamino 408 Etilo trans-4-(1-Hidroxi-1-metiletil)ciclohexilamino 409 Etilo (S)-1,2-Dimetil-2-hidroxipropilamino 410 Isopropilo (S)-1,2-Dimetil-2-hidroxipropilamino 411 Etilo 1,3-Dimetil-3-hidroxibutilamino 412 Isopropilo 1,3-Dimetil-3-hidroxibutilamino 413 Isopropilo 2-Mercapto-2-metilpropilamino 414 Isopropilo 1,1-Bishidroximetilpropilamino 415 Isopropilo 2-Hidroxi-2-metilpropilamino 416 Etilo 4-Piperidilamino 417 1,2-Dimetil-2-hidroxipropilo Isopropilamino 418 1,2-Dimetil-2-hidroxipropilo cis-4-Hidroxi-4-metilciclohexilamino 419 1,2-Dimetil-2-hidroxipropilo (S)-1,2-Dimetil-2-hidroxipropilamino 420 1,2-Dimetil-2-hidroxipropilo Trans-4-Hidroxi-4-metilciclohexilamino 421 2-Hidroxi-1,1,2-trimetilpropilo Isopropilamino 422 2-Hidroxi-1,1,2-trimetilpropilo Trans-4-Hidroxi-4-metilciclohexilamino 423 3-Hidroxi-3-metilbutilo Isopropilamino 424 3-Hidroxi-3-metilbutilo 1,1-Dimetil-2-hidroxietilamino 425 3-Hidroxi-3-metilbutilo 2,2-Dimetil-3-hidroxipropilamino 426 3-Hidroxi-3-metilbutilo 1-Hidroximetilciclopentilamino 427 3-Hidroxi-3-metilbutilo trans-4-Hidroxi-4-metilciclohexilamino 428 3-Hidroxi-3-metilbutilo 4-Tetrahidropiranilamino 429 3-Hidroxi-3-metilbutilo (R)-1,2-Dimetil-2-hidroxipropilamino 430 3-Hidroxi-3-metilbutilo (S)-1,2-Dimetil-2-hidroxipropilamino 431 3-Hidroxi-3-metilbutilo trans-4-Hidroxiciclohexilamino 432 3-Hidroxi-3-metilbutilo 1-Metanosulfonilpiperidin-4-ilamino 433 3-Hidroxi-3-metilbutilo 1-Etanosulfonilpiperidin-4-ilamino 434 4-Tetrahidropiranilo Isobutilamino 435 4-Tetrahidropiranilo Isopropilamino 436 4-Tetrahidropiranilo trans-4-Hidroxi-4-metilciclohexilamino 437 4-Tetrahidropiranilo Ciclopropilamino 438 4-Tetrahidropiranilo 2,2-Dimetilpropilamino 439 1-Acetilpiperidin-4-ilo trans-4-Hidroxi-4-metilciclohexilamino 440 1-Acetilpiperidin-4-ilo 2,2-Dimetilpropilamino 441 1-Acetilpiperidin-4-ilo Isopropilamino 442 1-Acetilpiperidin-4-ilo Isobutilamino 443 1-Acetilpiperidin-4-ilo Ciclopropilamino 444 4-Tetrahidropiranil (R)-1,2-Dimetil-2-hidroxipropilamino 445 4-Tetrahidropiranil (S)-1,2-Dimetil-2-hidroxipropilamino 446 4-Tetrahidropiranilo (S)-2-Hidroxi-1-metiletilamino 447 4-Tetrahidropiranilo (S)-1-Hidroximetilpropilamino 448 4-Tetrahidropiranilo 1,1-Dimetil-2-hidroxietilamino 449 4-Tetrahidropiranilo 4-Tetrahidropiranilamino 450 1-Acetilpiperidin-4-ilo 1,1-Dimetil-2-hidroxietilamino 451 1-Acetilpiperidin-4-ilo 4-Tetrahidropiranilamino 452 1-Acetilpiperidin-4-ilo (S)-1-Hidroximetilpropilamino 453 1-Acetilpiperidin-4-ilo (S)-1,2-Dimetil-2-hidroxipropilamino 454 4-Tetrahidropiranilo trans-4-Hidroxiciclohexilamino 455 1-Acetilpiperidin-4-ilo trans-4-Hidroxiciclohexilamino 456 1-Metanosulfonilpiperidin-4-ilo trans-4-Hidroxiciclohexilamino 457 1-Metanosulfonilpiperidin-4-ilo trans-4-Hidroxi-4-metilciclohexilamino 458 1-Metanosulfonilpiperidin-4-ilo Isopropilamino 459 4-Tetrahidropiranilo 1-Metanosulfonilpiperidin-4-ilamino 460 1-Acetilpiperidin-4-ilo 1-Metanosulfonilpiperidin -4-ilamino 461 Isopropilo 1-Acetilpiperidin-4-ilamino 462 Isopropilo 1-Metanosulfonilpiperidin-4-ilamino 463 Isopropilo 1-(Isopropilosulfonil)piperidin-4-ilamino 464 Isopropilo 1-(Propilsulfonil)piperidin-4-ilamino 465 Isopropilo 1-(Butilsulfonil)piperidin-4-ilamino 466 Isopropilo 1-(Isobutiloxicarbonil)piperidin-4-ilamino 467 Isopropilo 1-butirilpiperidin-4-ilamino 468 Etilo 1-Acetilpiperidin-4-ilamino 469 Etilo 1-Metanosulfonilpiperidin-4-ilamino 470 Etilo 1-Etanosulfonilpiperidin-4-ilamino 471 Isopropilo 1-Etilcarbamoilpiperidin-4-ilamino 472 Isopropilo 1-Propilcarbamoilpiperidin-4-ilamino 473 Isopropilo 1-Isopropilcarbamoilpiperidin-4-ilamino 474 Isopropilo 1-Etanosulfonilpiperidin-4-ilamino 475 Isopropilo 1-Metoxicarbonilpiperidin-4-ilamino 476 Isopropilo 1-Etoxicarbonilpiperidin-4-ilamino 477 1-Metanosulfonilpiperidin-4-ilo Isopropilamino 478 1-Etanosulfonilpiperidin-4-ilo Isopropilamino

2. 发明公开

EP1628968A4 4-IMIDAZOLIN-2-ONE COMPOUNDS 有权
标题翻译： 4-咪唑啉-2-酮化合物
公开(公告)号：EP1628968A4
公开(公告)日：2008-03-05
申请号：EP04728708
申请日：2004-04-21
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： KUBO AKIRA , IMASHIRO RITSUO , OGASAWARA AKIHITO , NAKAJIMA TATSUO , NAKANE TETSU , MIYOSHI HIDETAKA
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/506 , A61P3/10 , A61P7/02 , A61P9/10 , A61P19/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14

3. 发明专利

AT504583T 未知
公开(公告)号：AT504583T
公开(公告)日：2011-04-15
申请号：AT04728708
申请日：2004-04-21
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： KUBO AKIRA , IMASHIRO RITSUO , OGASAWARA AKIHITO , NAKAJIMA TATSUO , NAKANE TETSU , MIYOSHI HIDETAKA
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/506 , A61P3/10 , A61P7/02 , A61P9/10 , A61P19/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14

4. 发明专利

AU2005238390C1 Heterocyclic compound 未知
公开(公告)号：AU2005238390C1
公开(公告)日：2009-06-25
申请号：AU2005238390
申请日：2005-04-28
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： OGASAWARA AKIHITO , NAKANE TETSU , KUBO AKIRA , MIYOSHI HIDETAKA , MURAKAMI TAKANORI , NAKAJIMA TATSUO
IPC分类号： C07D401/14 , A61K31/506 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is to provide a novel heterocyclic compound of the formula [I]: wherein R1 is a halogen, nitro, an alkyl, etc.; R2 is hydrogen, an alkyl, etc.; Ring A is 2-oxo-4-imidazolin-3,4-diyl, etc.; Ring B is a cycloalkyl, monocyclic saturated heterocyclic group; X is CH, N; Y is a single bond, CO, SO2; Z is O, NH, etc.; and Ring C is an aryl, a heterocyclic group, or a pharmaceutically acceptable salt thereof, which is useful as a p38 MAP kinase inhibitor.

5. 发明专利

AT550332T 未知
公开(公告)号：AT550332T
公开(公告)日：2012-04-15
申请号：AT02802049
申请日：2002-10-22
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： KUBO AKIRA , IMASHIRO RITSUO , SAKURAI HIROAKI , MIYOSHI HIDETAKA , OGASAWARA AKIHITO , HIRAMATSU HAJIME
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/18 , A61P35/00 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to a compound of the formula ÄIÜ : wherein G is an alkyl which,may be substituted by a halogen atom or an alkoxy, or a group of the formula: wherein ring B is benzene ring which may be substituted, etc., Q and Q may be the same or different, and each is hydrogen atom, a halogen atom or an alkyl, n is 0, 1, 2, 3 or 4, R is hydrogen atom, an alkyl which may be substituted, a cycloalkyl which may be substituted, a phenyl which may be substituted, etc., Z , Z , Z and Z may be the same or different, and each is CH or N, provided that 3 or more of Z , Z , Z and Z should not be N at the same time, G is hydrogen atom, -NR R , -OR , etc., where R to R each is independently hydrogen atom, an alkyl which may be substituted, an alkenyl, an alkynyl, etc., or a pharmaceutically acceptable salt thereof.

6. 发明专利

PL1628968T3 Związki 4-imidazolino-2-onu 未知
公开(公告)号：PL1628968T3
公开(公告)日：2011-09-30
申请号：PL04728708
申请日：2004-04-21
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： KUBO AKIRA , IMASHIRO RITSUO , OGASAWARA AKIHITO , NAKAJIMA TATSUO , NAKANE TETSU , MIYOSHI HIDETAKA
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/506 , A61P3/10 , A61P7/02 , A61P9/10 , A61P19/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14

7. 发明专利

DK1628968T3 4-imidazolin-2-on-forbindelser 未知
公开(公告)号：DK1628968T3
公开(公告)日：2011-07-25
申请号：DK04728708
申请日：2004-04-21
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： IMASHIRO RITSUO , OGASAWARA AKIHITO , NAKAJIMA TATSUO , NAKANE TETSU , MIYOSHI HIDETAKA , KUBO AKIRA
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/506 , A61P3/10 , A61P7/02 , A61P9/10 , A61P19/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14

8. 发明专利

MY143245A 4- 2-(CYCLOALKYLAMINO)PYRIMIDIN-4-YL-(PHENYL)-IMIDAZOLIN-2-ONE DERIVATIVES AS P38 MAP-KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES 未知
公开(公告)号：MY143245A
公开(公告)日：2011-04-15
申请号：MYPI20051847
申请日：2005-04-27
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： KUBO AKIRA , NAKANE TETSU , NAKAJIMA TATSUO , MURAKAMI TAKANORI , MIYOSHI HIDETAKA , OGASAWARA AKIHITO
IPC分类号： A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： THE PRESENT INVENTION IS TO PROVIDE A NOVEL HETEROCYCLIC COMPOUND OF THE FORMULA [&Igr;]: WHEREIN R¹ IS A HALOGEN, NITRO, AN ALKYL, ETC. ;R² IS HYDROGEN, AN ALKYL, ETC.; RING A IS 2—OXO--4- IMIDAZOLIN —3, 4—DIYL, ETC RING B IS A CYCLOALKYL,MONOCYCCLIC SATURATED HETEROCYCLIC GROUP;X ETC.;AND RING C IS AN ARYL,A HETEROCYCLIC GROUP,OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF,WHICH IS USEFUL AS A P38 MAP KINASE INHIBITOR.

10. 发明专利

DE602004032130D1 4-IMIDAZOLIN-2-ONVERBINDUNGEN 未知
公开(公告)号：DE602004032130D1
公开(公告)日：2011-05-19
申请号：DE602004032130
申请日：2004-04-21
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： KUBO AKIRA , IMASHIRO RITSUO , OGASAWARA AKIHITO , NAKAJIMA TATSUO , NAKANE TETSU , MIYOSHI HIDETAKA
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/506 , A61P3/10 , A61P7/02 , A61P9/10 , A61P19/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14

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