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1. 发明公开

EP2380884A4 CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF 有权
标题翻译：以噻唑炭酸衍生物及其药物用途
公开(公告)号：EP2380884A4
公开(公告)日：2012-06-06
申请号：EP09830399
申请日：2009-12-01
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： ANDO NAOKO
IPC分类号： C07D277/20 , A61K31/426 , A61K31/4439 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/36 , C07D417/12
CPC分类号： C07D277/20 , C07D277/36 , C07D417/12

2. 发明公开

EP2154135A4 THERAPEUTIC AGENT FOR CEREBRAL INFARCTION 失效转让
标题翻译：治疗剂，脑梗塞
公开(公告)号：EP2154135A4
公开(公告)日：2010-09-01
申请号：EP08764628
申请日：2008-05-23
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： NAKAGAWA HARUTO , ANDO NAOKO
IPC分类号： C07D401/12 , A61K31/506 , A61P9/10 , C07D403/04 , C07D487/18
CPC分类号： C07D487/08 , A61K31/427 , A61K31/444 , A61K31/496 , A61K31/506 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D409/06 , C07D409/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D487/18

3. 发明公开

EP1816128A4 CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译：以噻唑炭酸衍生物及其药物用途
公开(公告)号：EP1816128A4
公开(公告)日：2009-11-18
申请号：EP05800453
申请日：2005-11-04
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： TOZAWA TAKASHI , TSURUTA OSAMU , KITAJIMA HIROSHI , AOKI YOSHIYUKI , ANDO NAOKO , TAMAKAWA HIROKI
IPC分类号： C07D277/36 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61P3/06
CPC分类号： C07D277/36

4. 发明专利

CA2744985C CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING USEFUL FOR THE PREVENTION OR TREATMENT OF HYPERLIPIDEMIA 未知
公开(公告)号：CA2744985C
公开(公告)日：2014-05-06
申请号：CA2744985
申请日：2009-12-01
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： ANDO NAOKO
IPC分类号： C07D277/20 , A61K31/426 , A61K31/4439 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/36 , C07D417/12
摘要： A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof has excellent PPAR.alpha. agonist action and lipid-lowering action, and is useful as a preventive or therapeutic agent for hyperlipidemia, etc. In general formula (I), R1 and R2 independently represent a hydrogen atom, an alkyl group, or the like; R3 represents a hydrogen atom, an alkyl group, or the like; R4 represents a hydrogen atom, an alkyl group, or the like; m represents an integer of 0 to 3; X represents a bond, an oxygen atom, or a sulfur atom; Y represents a carbonyl group, a hydroxymethylene group, or the like; and Z represents a halogen atom, an alkyl group, an aryl group, a heteroaryl group, or the like.

5. 发明专利

CA2744985A1 CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF 未知
公开(公告)号：CA2744985A1
公开(公告)日：2010-06-10
申请号：CA2744985
申请日：2009-12-01
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： ANDO NAOKO
IPC分类号： C07D277/20 , A61K31/426 , A61K31/4439 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/36 , C07D417/12
摘要： A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof has excellent PPARa agonist action and lipid-lowering action, and is useful as a preventive or therapeutic agent for hyperlipidemia, etc. In general formula (I), R1 and R2 independently represent a hydrogen atom, an alkyl group, or the like; R3 represents a hydrogen atom, an alkyl group, or the like; R4 represents a hydrogen atom, an alkyl group, or the like; m represents an integer of 0 to 3; X represents a bond, an oxygen atom, or a sulfur atom; Y represents a carbonyl group, a hydroxymethylene group, or the like; and Z represents a halogen atom, an alkyl group, an aryl group, a heteroaryl group, or the like.

6. 发明专利

AU2009323367B2 Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof 未知
公开(公告)号：AU2009323367B2
公开(公告)日：2013-05-23
申请号：AU2009323367
申请日：2009-12-01
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： ANDO NAOKO
IPC分类号： C07D277/20 , A61K31/426 , A61K31/4439 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/36 , C07D417/12
摘要： A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof has excellent PPARα agonist action and lipid-lowering action, and is useful as a preventive or therapeutic agent for hyperlipidemia, etc. In general formula (I), R

7. 发明专利

AU2008255885A1 Therapeutic agent for cerebral infarction 未知
公开(公告)号：AU2008255885A1
公开(公告)日：2008-12-04
申请号：AU2008255885
申请日：2008-05-23
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： ANDO NAOKO , NAKAGAWA HARUTO
IPC分类号： C07D401/12 , A61K31/506 , A61P9/10 , C07D403/04 , C07D487/18
摘要： The present invention provides a novel therapeutic drug for cerebral infarction, which contains a piperazine compound as an active ingredient. The compound of the present invention can be provided as a novel therapeutic drug for cerebral infarction having an effect of suppressing brain injury volume or improving neurological deficit, since it suppresses production of plural inflammatory cytokines and chemokines present in the brain such as TNF-±, IL-1², IL-6 and MCP-1 and the like.

8. 发明专利

BRPI0811222A2 未知
公开(公告)号：BRPI0811222A2
公开(公告)日：2014-10-29
申请号：BRPI0811222
申请日：2008-05-23
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： NAKAGAWA HARUTO , ANDO NAOKO
IPC分类号： C07D401/12 , A61K31/506 , A61P9/10 , C07D403/04 , C07D487/18
摘要： The present invention provides a novel therapeutic drug for cerebral infarction, which contains a piperazine compound as an active ingredient. The compound of the present invention can be provided as a novel therapeutic drug for cerebral infarction having an effect of suppressing brain injury volume or improving neurological deficit, since it suppresses production of plural inflammatory cytokines and chemokines present in the brain such as TNF-±, IL-1², IL-6 and MCP-1 and the like.

9. 发明专利

ES2405542T3 Agente terapéutico para el infarto cerebral 未知
公开(公告)号：ES2405542T3
公开(公告)日：2013-05-31
申请号：ES08764628
申请日：2008-05-23
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： NAKAGAWA HARUTO , ANDO NAOKO
IPC分类号： C07D401/12 , A61K31/506 , A61P9/10 , C07D403/04 , C07D487/18
摘要： Un agente que comprende un compuesto de piperazina representado por la fórmula **Fórmula** en donde R1 y R2 son iguales o diferentes y cada uno es hidrógeno, halógeno, alquilo que tiene un número de carbonos de1-4, alcoxi que tiene un número de carbonos de 1-4, amino, amino que está mono- o di-sustituido con uno o variosgrupos seleccionados de alquilo que tiene un número de carbonos de 1-4 y alcanoílo que tiene un número decarbonos de 1-4, nitro, hidroxi o ciano, R3, R4 y R5 son iguales o diferentes y cada uno es hidrógeno, halógeno, alquilo que tiene un número de carbonos de1-4, alcoxi que tiene un número de carbonos de 1-4, nitro, amino, amino que está mono- o di-sustituido con uno ovarios grupos seleccionados de alquilo que tiene un número de carbonos de 1-4 y alcanoílo que tiene un número decarbonos de 1-4, hidroxi o ciano, R6 y R7 son iguales o diferentes y cada uno es hidrógeno, alquilo que tiene un número de carbonos de 1-4, alquiloque tiene un número de carbonos de 1-4 sustituido con 1 a 3 halógenos, aralquilo, acilo o acilo que tiene un númerode carbonos de 1-4 sustituido con 1 a 3 halógenos, R8, R9 son iguales o diferentes y cada uno es hidrógeno o alquilo que tiene un número de carbonos de 1-4,Ra-Rd son iguales o diferentes y cada uno es hidrógeno, alquilo que tiene un número de carbonos de 1-4, aralquilo ohidroxi-alquilo que tiene un número de carbonos de 1-4, o bien dos cualesquiera de Ra-Rd están unidos entre sí paraformar alquileno que tiene un número de carbonos de 1 ó 2, Y es un grupo representado por la fórmula **Fórmula**

10. 发明专利

CA2687942A1 THERAPEUTIC AGENT FOR CEREBRAL INFARCTION 未知
公开(公告)号：CA2687942A1
公开(公告)日：2008-12-04
申请号：CA2687942
申请日：2008-05-23
申请人： MITSUBISHI TANABE PHARMA CORP
发明人： ANDO NAOKO , NAKAGAWA HARUTO
IPC分类号： C07D401/12 , A61K31/506 , A61P9/10 , C07D403/04 , C07D487/18
摘要： It is intended to provide a novel therapeutic agent for cerebral infarcti on containing a piperazine compound as an active ingredient. The compound ac cording to the invention can be formulated into a novel therapeutic agent fo r cerebral infarction having an effect of reducing the volume of brain injur y or improving neurologic symptoms by suppressing the production of a plural ity of inflammatory cytokines and chemokines present in the brain such as TN F-.alpha., IL-1.beta., IL-6 and MCP-1.

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