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1. 发明申请

WO0130830A2 GENE SEQUENCES IDENTIFIED BY PROTEIN MOTIF DATABASE SEARCHING 审中-公开
标题翻译：蛋白质MOTIF数据库搜索鉴定的基因序列
公开(公告)号：WO0130830A2
公开(公告)日：2001-05-03
申请号：PCT/US0029787
申请日：2000-10-26
申请人： MITOKOR , MURPHY ANNE N , FAHY EOIN D , WILEY SANDRA E , CLEVENGER WILLIAM
发明人： MURPHY ANNE N , FAHY EOIN D , WILEY SANDRA E , CLEVENGER WILLIAM
IPC分类号： C07K14/435 , G06F19/22 , G06F19/00
CPC分类号： G06F19/22 , C07K14/43545 , C12N2799/021
摘要： The invention relates to sequences of specific mitochondrial proteins that bind, transport and/or regulate intracellular calcium ions. The invention identifies these amino acid sequences and nucleotide sequences encoding them in databases of biological sequences for which subcellular localization and function are not described, by providing a computer system and a method of querying the database according to multiple preferred parameters. The invention further discloses production and use of these sequences in recombinant expression constructs, polypeptides, host cells, drug screening assays and related compositions and methods. For identification of such sequences, an automated motif extraction engine is disclosed that receives or creates a motif, such as a hidden Markov model. Using the hidden Markov model, a sequence database such as GenBank is searched, and identifying numbers such as accession numbers are retrieved. Proteins or polypeptide sequences associated with the accession numbers are retrieved and desired sequences filtered therefrom according to desired parameters such as species of origin, or conformity with one or several algorithms (e.g., PSORT, mitochondrial targeting domain, etc.). The resulting filtered data are provided in a tabular format, or as input into a database for later query.
摘要翻译：本发明涉及结合，转运和/或调节细胞内钙离子的特异性线粒体蛋白的序列。本发明通过提供计算机系统和根据多个优选参数查询数据库的方法，将这些氨基酸序列和编码它们的核苷酸序列识别在生物序列的数据库中，其中亚细胞定位和功能未被描述。本发明还公开了这些序列在重组表达构建体，多肽，宿主细胞，药物筛选测定和相关组合物和方法中的生产和使用。为了识别这样的序列，公开了一种自动图案提取引擎，其接收或创建诸如隐马尔可夫模型的图案。使用隐马尔科夫模型，搜索诸如GenBank的序列数据库，并且检索诸如登录号的识别号码。检索与登录号相关的蛋白质或多肽序列，并根据期望的参数例如原产地或与一种或多种算法（例如，PSORT，线粒体靶向域等）的一致性从其过滤所需的序列。所得到的过滤数据以表格格式提供，或作为输入到数据库中供以后查询。

2. 发明申请

WO9966075A2 DIAGNOSTIC METHOD BASED ON QUANTIFICATION OF EXTRAMITOCHONDRIAL DNA 审中-公开
标题翻译：基于超临界DNA定量诊断方法
公开(公告)号：WO9966075A2
公开(公告)日：1999-12-23
申请号：PCT/US9913426
申请日：1999-06-14
申请人： MITOKOR , HERRNSTADT CORINNA , GHOSH SOUMITRA S , CLEVENGER WILLIAM , FAHY EOIN D , DAVIS ROBERT E
发明人： HERRNSTADT CORINNA , GHOSH SOUMITRA S , CLEVENGER WILLIAM , FAHY EOIN D , DAVIS ROBERT E
IPC分类号： C12N15/09 , A61K45/00 , A61P3/00 , A61P3/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.
摘要翻译：提供了基于定量线粒体DNA（exmtDNA）序列的组合物和方法，其可用于检测与改变的线粒体功能相关的疾病的存在或风险，以及用于鉴定适合于治疗这些疾病的药剂。 exmtDNA序列与真实的线粒体DNA（mtDNA）序列具有很强的同源性。

3. 发明公开

EP0888378A4 AN OPTIMAL PROCEDURE FOR ISOLATION OF MUTANT MITOCHONDRIAL ALLELES 失效
标题翻译：增强式分离方法线粒体突变等位基因
公开(公告)号：EP0888378A4
公开(公告)日：2000-06-07
申请号：EP97951451
申请日：1997-11-26
申请人： MITOKOR
发明人： HERRNSTADT CORINNA , GHOSH SOUMITRA , FAHY EOIN D , DAVIS ROBERT E
IPC分类号： C12N15/09 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q1/6858 , C12Q2600/156 , C12Q2600/16 , C12Q2527/101
摘要： A sample preparation procedure for mitochondrial (mt) DNA analysis is described. The present method for isolating mtDNA uses sedimentation techniques for separating erythrocytes from lymphocytes and platelets (crude buffy coat fraction), followed by DNA extraction from the crude buffy coat fraction by boiling in water. This approach improves the yield of mutant DNA, enhancing the sensitivity of subsequent mutation interrogation techniques and allowing for meaningful statistical treatment of the degree of heteroplasmy within the mitochondrial DNA.

4. 发明专利

AU6662898A Methods for detecting mitochondrial mutations diagnostic for alzheimer's diseaseand determining heteroplasmy of mitochondrial nucleic acid 未知
公开(公告)号：AU6662898A
公开(公告)日：1998-09-18
申请号：AU6662898
申请日：1998-02-27
申请人： MITOKOR
发明人： PARKER WILLIAM DAVIS , HERRNSTADT CORINNA , GHOSH SOUMITRA , FAHY EOIN D
IPC分类号： C12N15/09 , C12Q1/68 , C07H21/04
摘要： The present invention relates to methods of detecting genetic mutations in mitochondrial cytochrome oxidase c genes that segregate with Alzheimer's Disease and methods for determining the amount of heteroplasmy of mitochondrial nucleic acid. The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms.

5. 发明专利

AU5296496A Mutation detection by differential primer extension of mutant and wildtype target sequences 未知
公开(公告)号：AU5296496A
公开(公告)日：1996-10-16
申请号：AU5296496
申请日：1996-02-14
申请人： MITOKOR
发明人： GHOSH SOUMITRA , FAHY EOIN D
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12Q1/70

6. 发明专利

AU2003223520A8 Targets for therapeutic intervention identified in the mitochondrial proteome 未知
公开(公告)号：AU2003223520A8
公开(公告)日：2003-10-27
申请号：AU2003223520
申请日：2003-04-04
申请人： BUCK INST FOR AGE RES , MITOKOR
发明人： GLENN GARY M , WARNOCK DALE E , GHOSH SOUMITRA S , FAHY EOIN D , ZHANG BING , GIBSON BRADFORD W , TAYLOR STEVEN W
IPC分类号： G01N33/50
摘要： Mitochondrial targets for drug screening assays and for therapeutic intervention in the treatment of diseases associated with altered mitochondrial function are provided. Complete amino acid sequences [SEQ ID NOS:1-3025] of polypeptides that comprise the human heart mitochondrial proteome are provided, using fractionated proteins derived from highly purified mitochondrial preparations, to identify previously unrecognized mitochondrial molecular components.

7. 发明专利

AU4823099A Diagnostic method based on quantification of extramitochondrial dna 未知
公开(公告)号：AU4823099A
公开(公告)日：2000-01-05
申请号：AU4823099
申请日：1999-06-14
申请人： MITOKOR
发明人： HERRNSTADT CORINNA , GHOSH SOUMITRA S , CLEVENGER WILLIAM , FAHY EOIN D , DAVIS ROBERT E
IPC分类号： C12N15/09 , A61K45/00 , A61P3/00 , A61P3/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C12Q1/68
摘要： Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.

8. 发明专利

AU2003223520A1 TARGETS FOR THERAPEUTIC INTERVENTION IDENTIFIED IN THE MITOCHONDRIAL PROTEOME 未知
公开(公告)号：AU2003223520A1
公开(公告)日：2003-10-27
申请号：AU2003223520
申请日：2003-04-04
申请人： MITOKOR
发明人： GLENN GARY M , WARNOCK DALE E , GHOSH SOUMITRA S , FAHY EOIN D , ZHANG BING , GIBSON BRADFORD W , TAYLOR STEVEN W
IPC分类号： G01N33/50
摘要： Mitochondrial targets for drug screening assays and for therapeutic intervention in the treatment of diseases associated with altered mitochondrial function are provided. Complete amino acid sequences [SEQ ID NOS:1-3025] of polypeptides that comprise the human heart mitochondrial proteome are provided, using fractionated proteins derived from highly purified mitochondrial preparations, to identify previously unrecognized mitochondrial molecular components.

9. 发明专利

AT235560T 未知
公开(公告)号：AT235560T
公开(公告)日：2003-04-15
申请号：AT99931800
申请日：1999-06-14
申请人： MITOKOR
发明人： HERRNSTADT CORINNA , GHOSH SOUMITRA S , CLEVENGER WILLIAM , FAHY EOIN D , DAVIS ROBERT E
IPC分类号： C12N15/09 , A61K45/00 , A61P3/00 , A61P3/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C12Q1/68
摘要： Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.

10. 发明专利

AU739913B2 Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and determining heteroplasmy of mitochondrial nucleic acid 未知
公开(公告)号：AU739913B2
公开(公告)日：2001-10-25
申请号：AU6662898
申请日：1998-02-27
申请人： MITOKOR
发明人： PARKER WILLIAM DAVIS , HERRNSTADT CORINNA , GHOSH SOUMITRA , FAHY EOIN D
IPC分类号： C12N15/09 , C12Q1/68 , C07H21/04
摘要： The present invention relates to methods of detecting genetic mutations in mitochondrial cytochrome oxidase c genes that segregate with Alzheimer's Disease and methods for determining the amount of heteroplasmy of mitochondrial nucleic acid. The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms.

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