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1. 发明申请

WO2016196978A1 MIR-155 INHIBITORS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) 审中-公开
标题翻译： MIR-155用于治疗多发性前列腺硬化症（ALS）的抑制剂
公开(公告)号：WO2016196978A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035794
申请日：2016-06-03
申请人： MIRAGEN THERAPEUTICS, INC. , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： JACKSON, Aimee , DALBY, Christina , WEINER, Howard L. , BUTOVSKY, Oleg
IPC分类号： C12N15/113 , A61K31/7125 , A61K31/712 , A61P25/28
CPC分类号： A61K31/712 , A61K31/7125 , A61P25/28 , C12N15/113 , C12N2310/315 , C12N2310/3231 , C12N2310/3341
摘要： The present invention provides methods for treating a neurological disease such as ALS in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for treating neuroinflammation by administering an oligonucleotide inhibitor of miR-155.
摘要翻译：本发明提供了通过向受试者施用miR-155的寡核苷酸抑制剂来治疗受试者神经疾病如ALS的方法。本发明还提供了通过施用miR-155的寡核苷酸抑制剂治疗神经炎症的方法。

2. 发明公开

EP3303589A1 MIR-155 INHIBITORS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) 审中-公开
标题翻译： MIR-155抑制剂治疗肌萎缩侧索硬化（ALS）
公开(公告)号：EP3303589A1
公开(公告)日：2018-04-11
申请号：EP16804549.0
申请日：2016-06-03
申请人： Miragen Therapeutics, Inc. , The Brigham and Women's Hospital, Inc.
发明人： JACKSON, Aimee , DALBY, Christina , WEINER, Howard L. , BUTOVSKY, Oleg
IPC分类号： C12N15/113 , A61K31/7125 , A61K31/712 , A61P25/28
CPC分类号： A61K31/712 , A61K31/7125 , A61P25/28 , C12N15/113 , C12N2310/315 , C12N2310/3231 , C12N2310/3341
摘要： The present invention provides methods for treating a neurological disease such as ALS in a subject by administering to the subject an oligonucleotide inhibitor of miR-155. The invention also provides methods for treating neuroinflammation by administering an oligonucleotide inhibitor of miR-155.

3. 发明申请

WO2016197024A2 MIR-155 INHIBITORS FOR TREATING CUTANEOUS T CELL LYMPHOMA (CTCL) 审中-公开
标题翻译： MIR-155用于治疗胰岛细胞淋巴瘤（CTCL）的抑制剂
公开(公告)号：WO2016197024A2
公开(公告)日：2016-12-08
申请号：PCT/US2016/035865
申请日：2016-06-03
申请人： MIRAGEN THERAPEUTICS, INC.
发明人： RODMAN, David , SETO, Anita , DALBY, Christina , JACKSON, Aimee , BEATTY, Xuan
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/315 , C12N2310/3231 , C12N2310/344 , C12N2320/31 , C12N2310/322 , C12N2310/3531
摘要： The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR- 155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.
摘要翻译：本发明提供miR-155的寡核苷酸抑制剂及其组合物。本发明还提供了通过向受试者施用miR-155的寡核苷酸抑制剂来治疗受试者中的癌症如T细胞淋巴瘤的方法。本发明还提供了通过施用寡核苷酸抑制剂来减少或抑制恶性T细胞增殖的方法的miR-155。

4. 发明申请

WO2016069717A1 INHIBITORS OF MIRNAS IN REGULATION OF ARTERIAL STIFFNESS AND USES THEREOF 审中-公开
标题翻译： MIRNAS的抑制剂调节其硬度和其用途
公开(公告)号：WO2016069717A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/057760
申请日：2015-10-28
申请人： MIRAGEN THERAPEUTICS, INC.
发明人： MONTGOMERY, Rusty , DALBY, Christina
IPC分类号： A61K31/7088 , A61K31/712 , C12N15/113
CPC分类号： A61K31/7088 , C12N15/111 , C12N15/113 , C12N2310/113 , C12N2320/30
摘要： The present invention provides methods of treating or preventing arterial stiffness in a subject by administering to the subject an inhibitor of miR-137 function or activity and/or an inhibitor of miR-138 function or activity. The present invention also provides methods of treating or preventing one or more conditions associated with arterial stiffness by inhibiting the function or activity of miR-137 and/or miR-138. The present invention further provides methods of modulating the activity or expression of miR-137 and/or miR-138 in cells of a subject.
摘要翻译：本发明提供了通过向受试者施用miR-137功能或活性的抑制剂和/或miR-138功能或活性的抑制剂来治疗或预防受试者的动脉硬化的方法。本发明还提供通过抑制miR-137和/或miR-138的功能或活性来治疗或预防与动脉僵硬相关的一种或多种病症的方法。本发明还提供调节受试者细胞中miR-137和/或miR-138的活性或表达的方法。

5. 发明申请

WO2016040373A1 MIR-29 MIMICS AND USES THEREOF 审中-公开
标题翻译： MIR-29 MIMICS及其用途
公开(公告)号：WO2016040373A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/049018
申请日：2015-09-08
申请人： MIRAGEN THERAPEUTICS, INC.
发明人： MONTGOMERY, Rusty L. , DALBY, Christina , VAN ROOIJ, Eva , GALLANT-BEHM, Corrie
IPC分类号： C07H21/02
CPC分类号： C12N15/113 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K31/7105 , A61K31/713 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/3231 , C12N2310/343 , C12N2310/346 , C12N2320/51 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要： The present invention relates to synthetic oligonucleotide mimetics of miRNAs. In particular, the present invention provides double-stranded, chemically-modified oligonucleotide mimetics of miR-29. Pharmaceutical compositions comprising the mimetics and their use in treating or preventing conditions associated with dysregulation of extracellular matrix genes, such as tissue fibrotic conditions, are also described.
摘要翻译：本发明涉及miRNA的合成寡核苷酸模拟物。特别地，本发明提供miR-29的双链，化学修饰的寡核苷酸模拟物。还描述了包含模拟物的药物组合物及其在治疗或预防与细胞外基质基因失调相关的病症如组织纤维化病症中的用途。

6. 发明申请

WO2016149370A1 MIRNA MIMETICS AND THEIR USE IN TREATING SENSORY CONDITIONS 审中-公开
标题翻译： MIRNA MIME及其在处理传感条件中的应用
公开(公告)号：WO2016149370A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/022645
申请日：2016-03-16
申请人： MIRAGEN THERAPEUTICS, INC.
发明人： JACKSON, Aimee , DALBY, Christina
IPC分类号： C12N15/86 , C12N15/113
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/7105 , A61K48/00 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/3515 , C12N2320/31 , C12N2310/322 , C12N2310/3533 , C12N2310/3521
摘要： The present invention provides microRNA mimetic compounds that mimic the function or activity of miR-96, miR-182, and/or miR-183. The microRNA mimetic compounds of the invention comprise a first strand of about (22) to about (26) ribonucleotides comprising a mature miR-96, miR-182, or miR-183 sequence; and a second strand of about (20) to about (24) ribonucleotides comprising a sequence that is substantially complementary to the first strand and having at least one modified nucleotide, wherein the first strand has a 3' nucleotide overhang relative to the second strand. The invention additionally provides expression vectors comprising a polynucleotide(s) encoding one or more of miR-96, miR-182, and miR-183. The invention also provides methods of treating ophthalmological or otic conditions by administering the microRNA mimetic compounds of miR-96, miR-182, and/or miR-183 and/or an expression vector encoding at least one of miR-96, miR-182, and miR-183 to a subject in need thereof.
摘要翻译：本发明提供了模拟miR-96，miR-182和/或miR-183的功能或活性的微小RNA模拟化合物。本发明的微RNA模拟化合物包含包含成熟miR-96，miR-182或miR-183序列的约（22）至约（26）个核糖核苷酸的第一链; 和约（20）至约（24）个核糖核苷酸的第二链，其包含与第一链基本上互补并且具有至少一个修饰的核苷酸的序列，其中第一链相对于第二链具有3'核苷酸突出端。本发明另外提供了包含编码miR-96，miR-182和miR-183中的一种或多种的多核苷酸的表达载体。本发明还提供了通过施用miR-96，miR-182和/或miR-183的微小RNA模拟化合物和/或编码miR-96，miR-182中的至少一种的表达载体来治疗眼科或耳部病症的方法，和miR-183与需要的对象相关联。

7. 发明申请

WO2016022536A2 INHIBITORS OF MYH7B AND USES THEREOF 审中-公开
标题翻译： MYH7B的抑制剂及其用途
公开(公告)号：WO2016022536A2
公开(公告)日：2016-02-11
申请号：PCT/US2015/043571
申请日：2015-08-04
申请人： MIRAGEN THERAPEUTICS, INC.
发明人： MONTGOMERY, Rusty , DALBY, Christina
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/713 , A61K45/06 , A61K2300/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3521
摘要： The present invention provides nucleic acid inhibitors of MYH7B and compositions thereof. The present invention also provides methods of treating or preventing a cardiac disorder such as cardiac hypertrophy, myocardial infarction, or heart failure in a subject by administering to the subject an inhibitor of MYH7B. The present invention further provides methods of modulating the activity or expression of ?-MHC in cardiac cells of a subject by administering to the subject an inhibitor of MYH7B.
摘要翻译：本发明提供MYH7B的核酸抑制剂及其组合物。本发明还提供了通过向受试者施用MYH7B抑制剂来治疗或预防受试者心脏疾病如心脏肥大，心肌梗塞或心力衰竭的方法。本发明还提供了通过向受试者施用MYH7B抑制剂来调节受试者的心脏细胞中α-MHC的活性或表达的方法。

8. 发明公开

EP3271464A1 MIRNA MIMETICS AND THEIR USE IN TREATING SENSORY CONDITIONS 审中-公开
标题翻译： MIRNA模型及其在治疗感觉状况中的应用
公开(公告)号：EP3271464A1
公开(公告)日：2018-01-24
申请号：EP16765657.8
申请日：2016-03-16
申请人： Miragen Therapeutics, Inc.
发明人： JACKSON, Aimee , DALBY, Christina
IPC分类号： C12N15/86 , C12N15/113
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/7105 , A61K48/00 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/3515 , C12N2320/31 , C12N2310/322 , C12N2310/3533 , C12N2310/3521
摘要： The present invention provides microRNA mimetic compounds that mimic the function or activity of miR-96, miR-182, and/or miR-183. The microRNA mimetic compounds of the invention comprise a first strand of about (22) to about (26) ribonucleotides comprising a mature miR-96, miR-182, or miR-183 sequence; and a second strand of about (20) to about (24) ribonucleotides comprising a sequence that is substantially complementary to the first strand and having at least one modified nucleotide, wherein the first strand has a 3′ nucleotide overhang relative to the second strand. The invention additionally provides expression vectors comprising a polynucleotide(s) encoding one or more of miR-96, miR-182, and miR-183. The invention also provides methods of treating ophthalmological or otic conditions by administering the microRNA mimetic compounds of miR-96, miR-182, and/or miR-183 and/or an expression vector encoding at least one of miR-96, miR-182, and miR-183 to a subject in need thereof.

9. 发明公开

EP3177327A2 INHIBITORS OF MYH7B AND USES THEREOF 审中-公开
标题翻译： MYH7B的抑制剂及其用途
公开(公告)号：EP3177327A2
公开(公告)日：2017-06-14
申请号：EP15829559.2
申请日：2015-08-04
申请人： Miragen Therapeutics, Inc.
发明人： MONTGOMERY, Rusty , DALBY, Christina
IPC分类号： A61K48/00 , C07H21/04
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/713 , A61K45/06 , A61K2300/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3521
摘要： The present invention provides nucleic acid inhibitors of MYH7B and compositions thereof. The present invention also provides methods of treating or preventing a cardiac disorder such as cardiac hypertrophy, myocardial infarction, or heart failure in a subject by administering to the subject an inhibitor of MYH7B. The present invention further provides methods of modulating the activity or expression of β-MHC in cardiac cells of a subject by administering to the subject an inhibitor of MYH7B.
摘要翻译：本发明提供了MYH7B的核酸抑制剂及其组合物。本发明还提供了通过向受试者施用MYH7B抑制剂来治疗或预防受试者的心脏病，例如心脏肥大，心肌梗塞或心力衰竭的方法。本发明进一步提供了通过给受试者施用MYH7B抑制剂来调节受试者心脏细胞中β-MHC活性或表达的方法。

10. 发明公开

EP3201213A1 MIR-29 MIMICS AND USES THEREOF 无效转让
标题翻译： MIR-29 MIMICS及其用途
公开(公告)号：EP3201213A1
公开(公告)日：2017-08-09
申请号：EP15840320.4
申请日：2015-09-08
申请人： Miragen Therapeutics, Inc.
发明人： MONTGOMERY, Rusty L. , DALBY, Christina , VAN ROOIJ, Eva , GALLANT-BEHM, Corrie
IPC分类号： C07H21/02
CPC分类号： C12N15/113 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K31/7105 , A61K31/713 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/3231 , C12N2310/343 , C12N2310/346 , C12N2320/51 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要： The present invention relates to synthetic oligonucleotide mimetics of miRNAs. In particular, the present invention provides double-stranded, chemically-modified oligonucleotide mimetics of miR-29. Pharmaceutical compositions comprising the mimetics and their use in treating or preventing conditions associated with dysregulation of extracellular matrix genes, such as tissue fibrotic conditions, are also described.
摘要翻译：本发明涉及miRNA的合成寡核苷酸模拟物。特别地，本发明提供了miR-29的双链化学修饰的寡核苷酸模拟物。还描述了包含模拟物的药物组合物及其在治疗或预防与细胞外基质基因失调有关的病症例如组织纤维化病症中的用途。

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