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1. 发明申请

WO2009067629A3 IMPROVED ANEURYSM NECK BRIDGING PROCESSES WITH REVASCULARIZATION SYSTEMS METHODS AND PRODUCTS THEREBY 审中-公开
标题翻译：改进的神经网络桥接过程与重新整合系统的方法和产品
公开(公告)号：WO2009067629A3
公开(公告)日：2009-07-16
申请号：PCT/US2008084245
申请日：2008-11-20
申请人： MINDFRAME INC , FERRERA DAVID A , FULKERSON JOHN
发明人： FERRERA DAVID A , FULKERSON JOHN
IPC分类号： A61M25/09 , A61M25/088
CPC分类号： A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/90 , A61F2002/823 , A61F2250/0059
摘要： Devices, methods and systems facilitate and enable vessel wall treatment, particularly at the neck of an aneurysm. A tethered cage-like structure functions in conjunction with supplemental therapies such as a vaso-occlusive coil delivering microcatheter system and/or pharmaceutical delivery, among other things, by stabilizing vessel walls and providing tethered cage-like therapeutic support for treating aneurysms, temporarily or on an implantable basis.
摘要翻译：装置，方法和系统便于和启用血管壁治疗，特别是在动脉瘤的颈部。拴系的笼状结构与补充疗法结合起来，例如通过稳定血管壁并提供用于治疗动脉瘤的拴系的笼状治疗支持物临时或临时地治疗动脉瘤，其中包括递送微导管系统和/或药物递送的血管闭塞线圈在可植入的基础上。

2. 发明申请

WO2009114046A3 ACUTE STROKE REVASCULARIZATION/RECANALIZATION SYSTEMS PROCESSES AND PRODUCTS THEREBY 审中-公开
标题翻译：急性呼吸/再生系统过程和产品
公开(公告)号：WO2009114046A3
公开(公告)日：2009-12-17
申请号：PCT/US2008083185
申请日：2008-11-12
申请人： MINDFRAME INC , FULKERSON JOHN , FERRERA DAVID A , CRAGG ANDREW
发明人： FULKERSON JOHN , FERRERA DAVID A , CRAGG ANDREW
IPC分类号： A61M25/09 , A61F2/82 , A61M25/00
CPC分类号： A61B17/3207 , A61B17/221 , A61B17/320725 , A61B2017/00845 , A61B2017/00867 , A61B2017/22038 , A61B2017/22082 , A61F2/013 , A61F2/82 , A61F2250/0059 , A61M29/02 , A61M2025/1095 , A61M2025/1097
摘要： An acute stroke recanalization system and processes include catheter-based improved reconstrainable or tethered neurological devices which are deliverable through highly constricted and tortuous vessels, crossing the zone associated with subject thrombi/emboli, where deployment impacts, addresses or bridges the embolus, compacting the same into luminal walls which enables perfusion and lysis of the embolus, while the improved neurological medical device itself remains contiguous with the delivery system acting as a filter, basket or stand alone stenting mechanism, depending on the status of the embolus and other therapeutic aspects of the treatment being offered for consideration.
摘要翻译：急性中风再通系统和过程包括基于导管的改善的可重建或系留的神经系统装置，其可通过高度收缩和曲折的血管交付，穿过与受试者血栓/栓塞相关的区域，其中部署影响，解决或桥接栓塞，压制相同进入能够灌注和溶解栓塞的腔壁，而改进的神经医学装置本身与作为过滤器，篮子或独立支架机构的输送系统保持连续，这取决于栓塞的状态和其他治疗方面治疗被提供考虑。

3. 发明申请

WO2009086154A2 IMPROVED DEVICES AND METHODS FOR EMBOLUS REMOVAL DURING ACUTE ISCHEMIC STROKE 审中-公开
标题翻译：改进的设备和方法用于在急性间歇性移植期间去除栓塞
公开(公告)号：WO2009086154A2
公开(公告)日：2009-07-09
申请号：PCT/US2008087759
申请日：2008-12-19
申请人： MINDFRAME INC , FERRERA DAVID A , FULKERSON JOHN
发明人： FERRERA DAVID A , FULKERSON JOHN
IPC分类号： A61B17/22 , A61M25/01 , A61M25/08
CPC分类号： A61B17/221 , A61B2017/22039 , A61B2017/22094 , A61B2017/2212 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61M25/09 , A61M25/09025
摘要： Devices, methods, and systems facilitate and enable treatment of ischemic stroke. More specifically, a tethered basket-like system operates in conjunction with a microcatheter system, to provide arterial support and capture emboli.
摘要翻译：设备，方法和系统有助于和治疗缺血性卒中。更具体地，系绳式篮状系统与微导管系统一起操作，以提供动脉支撑和捕获栓塞。

4. 发明申请

WO2009089297A2 NOVEL ENHANCED PTNA RAPID EXCHANGE TYPE OF CATHETER SYSTEM 审中-公开
标题翻译：新型增强型PTNA快速交流型导流管系统
公开(公告)号：WO2009089297A2
公开(公告)日：2009-07-16
申请号：PCT/US2009030356
申请日：2009-01-07
申请人： INTERSECT PARTNERS LLC , FERRERA DAVID A , RIZK ISA , FULKERSON JOHN , SOSNOWSKI STEPHEN A
发明人： FERRERA DAVID A , RIZK ISA , FULKERSON JOHN , SOSNOWSKI STEPHEN A
IPC分类号： A61F2/958
CPC分类号： A61M29/02 , A61M25/10 , A61M25/1027 , A61M25/104 , A61M2025/0042 , A61M2025/0046 , A61M2025/0183 , A61M2025/1088
摘要： Novel systems enable PTNA rapid exchange (RX) types of systems for ICAD, support balloon test occlusion, treatment of vasospasm after sub-arachnoid hemorrhage (SAH) and facilitate aneurysm neck remodeling during coiling embolization. The systems disclosed include an embodiment having a catheter comprising a RX port for providing catheter support within and above the carotid siphon and distal vertebral arteries, a conformable, semi-compliant balloon manipulable to gain forward progress through intracranial vessels substantially narrowed by plaque in combination with at least a guidewire, and a tip disposed at a distal end of the catheter.
摘要翻译：新型系统使PTNA快速交换（RX）类型的ICAD系统，支持球囊测试闭塞，蛛网膜下腔出血（SAH）治疗血管痉挛，并有助于动脉瘤颈部重塑在卷取栓塞期间。所公开的系统包括具有导管的实施例，该导管包括用于在颈动脉虹吸管和远端椎动脉之内和之上提供导管支撑的RX端口，适合的半顺应性球囊，其可操纵以通过与斑块相结合基本变窄的颅内血管获得前进进展至少一个导丝，以及设置在导管远端的尖端。

5. 发明专利

JP2012183366A Blood flow restoration and thrombus management 有权
标题翻译：血流恢复和血栓管理
公开(公告)号：JP2012183366A
公开(公告)日：2012-09-27
申请号：JP2012124910
申请日：2012-05-31
申请人： Mindframe Inc , マインドフレーム, インコーポレイテッド
发明人： FERRERA DAVID A , CRAGG ANDREW H , FULKERSON JOHN , BENJAMIN JOSHUA
IPC分类号： A61F2/84 , A61M25/08
CPC分类号： A61F2/82 , A61B17/12118 , A61B17/1214 , A61B17/221 , A61B17/320725 , A61B2017/00309 , A61B2017/00867 , A61B2017/22001 , A61B2017/22034 , A61B2017/22039 , A61B2017/22079 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/32096 , A61B2090/3966 , A61F2/91 , A61F2/915 , A61M25/0074 , A61M2025/0042
摘要： PROBLEM TO BE SOLVED: To provide an improved device and system for use in vascular treatment.SOLUTION: A catheter-based revascularization system 100 provides a platform for lysing emboli in occluded blood vessels. Accordingly, the catheter-based revascularization system 100 generally comprises a control end 102 and a deployment end 104. The control end 102 is a portion of the device that allows a user, such as a surgeon, to control deployment of the device through the blood vessels of a patient. Included as part of the control end 102 is a delivery handle 106 and a winged apparatus 108. The control end 102 can include a Tuohy Borst adapter and one or more rotating hemostasis valves. A module is detachable.
摘要翻译：要解决的问题：提供用于血管治疗的改进的装置和系统。解决方案：基于导管的血运重建系统100提供用于在闭塞的血管中裂解栓塞的平台。因此，基于导管的血运重建系统100通常包括控制端102和部署端104.控制端102是允许诸如外科医生的用户通过血液控制装置的部署的装置的一部分患者血管包括作为控制端102的一部分的是输送手柄106和有翼的装置108.控制端102可以包括Tuohy Borst适配器和一个或多个旋转止血阀。模块是可拆卸的。版权所有（C）2012，JPO＆INPIT

6. 发明申请

WO2011028665A3 SYSTEMS, METHODS AND DEVICES FOR ABLATION, CROSSING, AND CUTTING OF OCCLUSIONS 审中-公开
标题翻译：用于消融，交叉和切割闭塞的系统，方法和设备
公开(公告)号：WO2011028665A3
公开(公告)日：2011-09-29
申请号：PCT/US2010047170
申请日：2010-08-30
申请人： REFLOW MEDICAL INC , RIZK ISA , FULKERSON JOHN
发明人： RIZK ISA , FULKERSON JOHN
IPC分类号： A61B17/3205 , A61F2/84 , A61M25/09 , A61M25/10 , A61M29/00
CPC分类号： A61B17/3207 , A61B2017/22094 , A61F2/95 , A61M25/0021 , A61M29/02 , A61M2025/0042
摘要： Ablation, crossing, and cutting systems, devices and associated methods, including a crossing device, comprising, in combination: a spring-enhanced handle and body configured to controllably extend and retract a blade within a microcatheter for addressing an occlusion within a vessel of a patient to provide improved access for supplemental treatment and reperfusion.
摘要翻译：烧蚀，道口，和切割系统，装置和相关方法，其中包括一个交叉装置，包括以下组合：一个弹簧增强手柄和主体构造成在微导管内可控地伸展和缩回的叶片为一血管内寻址的闭塞患者为补充治疗和再灌注提供改善的通路。

7. 发明专利

AU2010339405A1 Blood flow restoration and thrombus management 未知
公开(公告)号：AU2010339405A1
公开(公告)日：2012-08-16
申请号：AU2010339405
申请日：2010-12-30
申请人： MINDFRAME INC
发明人： FERRERA DAVID A , CRAGG ANDREW H , FULKERSON JOHN , BENJAMIN JOSHUA
IPC分类号： A61B17/22
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.

8. 发明申请

WO2009091692A2 MALARIA VACCINE COMPOSITIONS AND CONSTITUENTS WHICH ELICIT CELL MEDIATED IMMUNITY 审中-公开
标题翻译： MALARIA VACCINE组合物和ELICIT细胞介导免疫的组成
公开(公告)号：WO2009091692A2
公开(公告)日：2009-07-23
申请号：PCT/US2009030734
申请日：2009-01-12
申请人： AERAS GLOBAL TB VACCINE FOUND , SHAFFERMAN AVIGDOR , ZVI ANAT , FULKERSON JOHN , SADOFF JERALD C
发明人： SHAFFERMAN AVIGDOR , ZVI ANAT , FULKERSON JOHN , SADOFF JERALD C
IPC分类号： A61K38/08
CPC分类号： C07K14/445 , C07K7/08
摘要： Malaria vaccines based on polyepitope constructs that elicit cell-mediated immunity against a broad spectrum of malaria parasites and which cover the majority of HLA alleles are provided. Epitopes in the polyepitope constructs are from regions of the Plasmodium falciparum circumsporozoite protein (CSP) known to contain CD4 and CD8 T cell epitopes, and include both epitopes from highly variable and highly conserved regions of CSP.
摘要翻译：提供了基于多表位构建体的疟疾疫苗，其引发针对广谱疟原虫的细胞介导的免疫并且覆盖大多数HLA等位基因。多表位构建体中的表位来自已知含有CD4和CD8 T细胞表位的恶性疟原虫环子孢子蛋白（CSP）的区域，并且包括来自高度可变和高度保守的CSP区的两个表位。

9. 发明申请

WO2009023360A2 BACTERIAL PACKAGING STRAINS USEFUL FOR GENERATION AND PRODUCTION OF RECOMBINANT DOUBLE-STRANDED RNA NUCLEOCAPSIDS AND USES THEREOF 审中-公开
标题翻译：用于产生和生产重组双链RNA核糖体的细菌包装菌株及其用途
公开(公告)号：WO2009023360A2
公开(公告)日：2009-02-19
申请号：PCT/US2008065234
申请日：2008-05-30
申请人： AERAS GLOBAL TB VACCINE FOUND , HONE DAVID , FULKERSON JOHN , SADOFF JERALD C , ONYABE DAVID , STONE MICHELE
发明人： HONE DAVID , FULKERSON JOHN , SADOFF JERALD C , ONYABE DAVID , STONE MICHELE
IPC分类号： A61K39/295 , A61P43/00 , C12N7/00 , C12N15/74
CPC分类号： C12N15/88 , A61K39/04 , A61K2039/523 , A61K2039/53 , A61K2039/543 , A61K2039/57 , C12N15/86 , C12N2770/24211 , C12N2770/36143 , C12N2840/203
摘要： Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo. The packaging strains and rdsRNs may also comprise nucleic acid sequences that stabilize a closed loop eukaryotic translation complex; nucleic acid sequences encoding one or more proteins that interfere with a host cell type I interferon (IFN) response; as well as recombinant alphavirus replicons encoding a protein complex specific for plus strand RNA- dependent synthesis of minus strand RNA.
摘要翻译：提供了用于产生重组双链RNA核衣壳（rdsRNs）的细菌包装菌株。包装菌株可用于在真核细胞或组织中产生编码疫苗抗原，生物活性蛋白，免疫调节蛋白，反义RNA和催化性RNA的RNA。将重组ssRNA引入菌株并包装以从头形成rdsRNs。包装菌株和rdsRN还可以包含稳定闭环真核翻译复合物的核酸序列; 编码干扰宿主细胞I型干扰素（IFN）应答的一种或多种蛋白质的核酸序列; 以及编码对正链RNA依赖性合成负链RNA特异的蛋白质复合物的重组α病毒复制子。

10. 发明申请

WO2007041303A3 KNEE BRACE HAVING A RIGID FRAME AND PATELLOFEMORAL SUPPORT 审中-公开
标题翻译： KNEE BRACE具有坚硬的框架和PATELLOFEMORAL支持
公开(公告)号：WO2007041303A3
公开(公告)日：2007-08-23
申请号：PCT/US2006038085
申请日：2006-09-29
申请人： DJO LLC , KAZMIERCZAK ANDY , MARTIN JOHN , GILDERSLEEVE RICHARD E , FULKERSON JOHN , JACOBSON KURT , SELIGMAN SCOTT
发明人： KAZMIERCZAK ANDY , MARTIN JOHN , GILDERSLEEVE RICHARD E , FULKERSON JOHN , JACOBSON KURT , SELIGMAN SCOTT
IPC分类号： A61F5/01
CPC分类号： A61F5/0123 , A61F2005/0176
摘要： Embodiments of the knee brace disclosed herein provide a combination of external ligament support and/or relief from pain caused by osteoarthritis with patellofemoral support. The brace includes a rigid frame and a flexible strap configured to extend across the wearer's patella to provide anterior loading thereto. The strap is operatively secured at either end to components of the rigid frame, thereby providing maximum leverage for applying force to the wearer's patella. In some embodiments, the strap includes a removable and adjustable buttress for directly contacting the wearer's patella. The patellar strap provides dynamic loading to the patella through the wearer's range of motion for relief of patellofemoral dysfunction, such as patellar shift, subluxation and dislocation, and malalignments such as patella alta, patella baja, tilt and glide. In some embodiments, a conversion kit is provided for converting a rigid brace frame into a knee brace capable of providing patellofemoral support to a wearer's knee. The kit includes at least a patellar strap and at least one tab for securing the strap to the rigid frame.
摘要翻译：本文公开的护膝的实施例提供了外部韧带支撑和/或缓解由髌骨股骨支撑引起的骨关节炎引起的疼痛的组合。支架包括刚性框架和柔性带，所述柔性带被配置成延伸穿过穿着者的髌骨以提供向前的负载。该带在任一端可操作地固定到刚性框架的部件，从而提供最大的杠杆作用力以向佩戴者的髌骨施加力。在一些实施例中，带子包括用于直接接触佩戴者的髌骨的可移除和可调整的支撑物。髌骨带通过佩戴者的运动范围为髌骨提供动态载荷，以减轻髌骨股骨功能障碍，如髌骨移位，半脱位和脱位，以及踝关节如髌骨，髌骨下倾，歪斜和滑动等。在一些实施例中，提供了一种转换套件，用于将刚性支架框架转换成膝盖支架，该膝盖支架能够向佩戴者的膝盖提供髌骨股骨支撑。该套件至少包括髌骨带和至少一个用于将带固定到刚性框架的翼片。

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