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1. 发明专利

CA2117290A1 Downhole Pressure Gauge and Convertor 未知
公开(公告)号：CA2117290A1
公开(公告)日：1995-11-27
申请号：CA2117290
申请日：1994-05-26
申请人： MILLER MARK , MILLER THOMAS
发明人： MILLER MARK , MILLER THOMAS
IPC分类号： E21B47/01 , E21B47/06 , G01L9/00 , G01L9/02

2. 发明专利

CA2117290C DOWNHOLE PRESSURE GAUGE AND CONVERTOR 未知
公开(公告)号：CA2117290C
公开(公告)日：2000-10-31
申请号：CA2117290
申请日：1994-05-26
申请人： MILLER MARK , MILLER THOMAS
发明人： MILLER MARK , MILLER THOMAS
IPC分类号： E21B47/01 , E21B47/06 , G01L9/00 , G01L9/02
摘要： The apparatus disclosed is a type of downhole pressure gauge to be used to measure and record pressure information about oil and gas wells. The apparatus measures flunctuations in pressure by means of a mechanical pressure sensitive device, such as a Bourdon tube, and records and stores this information by converting mechanical movement, associated with pressure changes as detected by the mechanical pressure sensitive device, into corresponding voltage changes across a potentiometer which are stored in an electronic memory board. The change in voltage over time corresponds to the change in well pressure over time, thereby providing important information to the well operator. Also disclosed is a method for measuring well pressure by means of combining a mechanical pressure sensitive device with an electrical system and an electronic memory board for storing the measurements. Also disclosed is a kit, whereby an existing downhole mechanical pressure gauge can be converted to a mechanical/electrical combination by the replacement of certain parts.

3. 发明申请

WO2008013910A3 METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS 审中-公开
标题翻译：鉴别，诊断和预测淋巴瘤存活的方法
公开(公告)号：WO2008013910A3
公开(公告)日：2008-12-24
申请号：PCT/US2007016843
申请日：2007-07-25
申请人： US GOV HEALTH & HUMAN SERV , BRITISH COLUMBIA CANCER AGENCY , CATALAN INST OF ONCOLOGY , RIKSHOSPITALET RADIUMHOSPITALE , ST BARTHOLOMEW S HOSPITAL , UNIV ARIZONA CANCER CT , UNIV BARCELONA , UNIV NEBRASKA MEDICAL CT , UNIV ROCHESTER MEDICAL CT , UNIV WUERZBURG , POWELL JOHN I , STAUDT LOUIS M , WRIGHT GEORGE , DAVE SANDEEP , TAN BRUCE , WILSON WYNDHAM , JAFFE ELAINE , CHAN WING C , GREINER TIMOTHY C , WEISENBURGER DENNIS , ARMITAGE JAMES , FU KAI , FISHER RICHARD I , RIMSZA LISA , MILLER THOMAS , GROGAN THOMAS , CAMPO ELIAS , BEA SILVIA M , SALAVERRIA ITZIAR , LOPEZ-GUILLERMO ARMANDO , MONTSERRAT EMILI , MORENO VICTOR , ZETTL ANDREAS , OTT GERMAN , MULLER-HERMELINK HANS-KONRAD , ROSENWALD ANDREAS , VOSE JULIE , GASCOYNE RANDY , CONNORS JOSEPH , SMELAND ERLEND , KVALOY STEIN , HOLTE HARALD , DELABIE JAN , LISTER T ANDREW
发明人： STAUDT LOUIS M , WRIGHT GEORGE , DAVE SANDEEP , TAN BRUCE , WILSON WYNDHAM , JAFFE ELAINE , CHAN WING C , GREINER TIMOTHY C , WEISENBURGER DENNIS , ARMITAGE JAMES , FU KAI , FISHER RICHARD I , RIMSZA LISA , MILLER THOMAS , GROGAN THOMAS , CAMPO ELIAS , BEA SILVIA M , SALAVERRIA ITZIAR , LOPEZ-GUILLERMO ARMANDO , MONTSERRAT EMILI , MORENO VICTOR , ZETTL ANDREAS , OTT GERMAN , MULLER-HERMELINK HANS-KONRAD , ROSENWALD ANDREAS , VOSE JULIE , GASCOYNE RANDY , CONNORS JOSEPH , SMELAND ERLEND , KVALOY STEIN , HOLTE HARALD , DELABIE JAN , LISTER T ANDREW
IPC分类号： C07H21/04 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

4. 发明申请

WO2007100657A3 INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译： HISTONE DEACETYLASE的抑制剂
公开(公告)号：WO2007100657A3
公开(公告)日：2008-12-11
申请号：PCT/US2007004724
申请日：2007-02-23
申请人： MERCK & CO INC , GRIMM JONATHAN B , HUBBS JED L , MILLER THOMAS , OTTE KARIN M , SILIPHAIVANH PHIENG , STANTON MATTHEW G , WILSON KEVIN , WITTER DAVID , ZHOU HUA
发明人： GRIMM JONATHAN B , HUBBS JED L , MILLER THOMAS , OTTE KARIN M , SILIPHAIVANH PHIENG , STANTON MATTHEW G , WILSON KEVIN , WITTER DAVID , ZHOU HUA
IPC分类号： A61K31/381 , A61K31/397 , A61K31/415 , A61K31/4535 , C07D333/04 , C07D409/08
CPC分类号： C07C237/42 , C07D333/20
摘要： The present invention relates to a novel class of compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
摘要翻译：本发明涉及一类新颖的化合物。这些化合物可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经退行性疾病本发明进一步提供包含本发明化合物和易于遵循的这些药物组合物的安全给药方案的药物组合物，并且其在体内导致治疗有效量的这些化合物。

5. 发明授权

US1066495A Spring-clamp. 失效
公开(公告)号：US1066495A
公开(公告)日：1913-07-08
申请号：US1912705328
申请日：1912-06-22
申请人： HELVIG GILBERT O , MILLER THOMAS
发明人： HELVIG GILBERT O , MILLER THOMAS
CPC分类号： E05F11/00 , E05C3/042 , Y10S411/923 , Y10S411/96 , Y10T24/3668 , Y10T24/44017 , Y10T292/1083

6. 发明授权

US817791A Mechanism for molding and vulcanizing rubber soles on shoes. 失效
标题翻译：用于模具和鞋底上的橡胶密封件的机构。
公开(公告)号：US817791A
公开(公告)日：1906-04-17
申请号：US1905265941
申请日：1905-06-19
申请人： MILLER THOMAS
发明人： MILLER THOMAS
CPC分类号： B29C45/006

7. 发明专利

DE10128410A1 Roadway barrier for speed control comprises protruding mushroom head retracting when traveled at permitted speed but remaining rigidly in place and resistant at excessive speed. 未知
公开(公告)号：DE10128410A1
公开(公告)日：2002-12-19
申请号：DE10128410
申请日：2001-06-12
申请人： MILLER THOMAS
发明人： MILLER THOMAS
IPC分类号： E01F9/529 , E01F13/00
摘要： The road barrier takes the form of a mushroom head (5) which sinks within its casing (3) when traveled at permitted speeds but remains rigidly in place when traveled at excessive speed. The mushroom is carried on an absorber (11) fitted with setscrew and ratchet screw (13,14) and the absorber holding plate and connected cylinder rod (12) can disengage their anchorage (20) under excessive loads. Additional components include the roadway (1) and ground (2) plus seal (6) fitted with fins for water runoff.

8. 发明专利

GB190419838A Means by which the Points of and Electrical Railway or Car Line may be Operated from an Approaching Car 未知
公开(公告)号：GB190419838A
公开(公告)日：1905-09-14
申请号：GB190419838D
申请日：1904-09-15
申请人： MILLER THOMAS
发明人： MILLER THOMAS
摘要： 19,838. Miller, T. Sept. 15. Switches for the rails of electric railways and tramways on the overhead-conductor system are operated by electromagnets which are excited from the overhead conductor by means under the control of the driver. Figs. 1 and 2 show an electric switch S on the vehicle connected to the usual distributing-block which is energized from the overhead conductor J. Insulated wires 3, 4 supported by the wires T, T are placed near the points, and are engaged by auxiliary trolleys 1, 2 carried on branch arms of the trolley pole 0. By operating the switch S, a current will pass through the wire K, pole 0, trolley 1, auxiliary wire 3, supporting-wire T', and the wire K, down to the electromagnets in the box C, thereby operating the rail-points, and returning by the wires K , 4 to the trolley 2 and switch S. To reverse the points, a current is reversed in the above circuit by reversing the switch. The electromagnets are shown in Figs. 2 and 4 situated in pairs facing one another in a waterproof box C having its surface level with the roadway. The two magnets A are connected to, and move with, the point-operating rod R, and have their windings in a branch circuit which is connected to earth through the resistance 5. By this device, the current always flows in the same direction through these coils, although its direction in the main circuit and the coils of the fixed magnets B may be varied at will. Thus, the points can be operated in either direction.

10. 发明专利

CA100632A MOULD FOR RUBBER SOLES 未知
公开(公告)号：CA100632A
公开(公告)日：1906-08-28
申请号：CA100632D
申请日：1906-03-23
申请人： MILLER THOMAS
发明人： MILLER THOMAS

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