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1. 发明申请

WO2013142336A1 COMBINATION THERAPY TO IMPROVE JOINT, TENDON, AND LIGAMENT HEALING 审中-公开
标题翻译：组合治疗以改善联合，腱和大便健康
公开(公告)号：WO2013142336A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/032138
申请日：2013-03-15
申请人： MILLER, Leonard B. , WARREN, Stephen
发明人： MILLER, Leonard B. , WARREN, Stephen
IPC分类号： A61P19/02
CPC分类号： A61K38/29 , A61K9/16 , A61K31/395 , A61K45/06
摘要： The present invention is directed to kit, drug combinations and methods for promoting endogenous bone marrow (BM)-derived vasculogenic progenitor cell (PC) mobilization, sensitization of such cells and chemotaxis to sites of joint injury or disease. One embodiment of the present invention, directed to a method of promoting joint complex healing, comprises the step of administering an effective amount of a bone marrow (BM) derived vasculogenic progenitor cell mobilization factor to an animal or human exhibiting joint injury or joint disease. The method further comprises the step of administering, concurrently to the mobilization factor, an effective amount of a progenitor cell sensitizing factor to mobilize progenitor cells and sensitize the progenitor cells to one or more chemotactic agents present at the site of joint injury or joint disease.
摘要翻译：本发明涉及用于促进内源性骨髓（BM）衍生的血管生成祖细胞（PC）动员，这种细胞的致敏和趋化性到关节损伤或疾病部位的试剂盒，药物组合和方法。涉及促进关节复合物愈合的方法的本发明的一个实施方案包括将有效量的衍生血管生成的祖细胞移动因子的骨髓（BM）给予显示关节损伤或关节疾病的动物或人的步骤。该方法还包括同时给动员因子施用有效量的祖细胞致敏因子以动员祖细胞并使祖细胞对存在于关节损伤或关节疾病部位的一种或多种趋化剂致敏的步骤。

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