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1. 发明申请

WO2011038291A1 INJECTABLE HYDROGEL FILAMENTS FOR BIOMEDICAL USES 审中-公开
标题翻译：用于生物医学用途的可注射的水凝胶膜
公开(公告)号：WO2011038291A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/050296
申请日：2010-09-24
申请人： MICROVENTION, INC. , CONSTANT, Michael, J. , CRUISE, Gregory, M. , KEELEY, E., Michael , BERENSTEIN, Alejandro
发明人： CONSTANT, Michael, J. , CRUISE, Gregory, M. , KEELEY, E., Michael , BERENSTEIN, Alejandro
IPC分类号： A61F2/02
CPC分类号： A61L31/18 , A61L31/06 , A61L31/145 , A61L31/16 , A61L2400/06 , C08L71/02
摘要： Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
摘要翻译：这里描述的是用不透射线的水凝胶细丝堵塞结构和畸形的装置，组合物，系统和相关方法，其具有延迟的受控扩张速率，允许将装置重新定位在结构或畸形内。进一步描述了用于植入动物中的装置，其包括双功能低分子量烯属不饱和可成形大分子单体; 烯属不饱和单体; 和不透射线的元件，其中所述装置不包含支撑构件。还公开了形成这种装置的方法。

2. 发明申请

WO2009086208A2 HYDROGEL FILAMENTS FOR BIOMEDICAL USES 审中-公开
标题翻译：用于生物医学用途的HYDROGEL FILAMENTS
公开(公告)号：WO2009086208A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/087846
申请日：2008-12-19
申请人： MICROVENTION, INC. , CRUISE, Gregory, M. , CONSTANT, Michael, J. , KEELEY, E., Michael , TERRANCE, Tran, T.
发明人： CRUISE, Gregory, M. , CONSTANT, Michael, J. , KEELEY, E., Michael , TERRANCE, Tran, T.
IPC分类号： A61L31/04 , A61L31/14 , A61L31/18
CPC分类号： A61B17/12113 , A61B17/12181 , A61B90/39 , A61B2017/00004 , A61B2017/1205 , A61B2090/3966 , A61K49/0404 , A61L24/001 , A61L24/0031 , A61L24/046 , A61L27/16 , A61L27/18 , A61L27/56 , A61L31/048 , A61L31/06 , A61L31/146 , A61L31/18 , A61L2430/36 , C08L39/06 , C08L71/02
摘要： Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
摘要翻译：这里描述的是用不透射线的水凝胶细丝堵塞结构和畸形的装置，组合物，系统和相关方法，其具有延迟的受控扩张速率，允许将装置重新定位在结构或畸形内。进一步描述了用于植入动物中的装置，其包括双功能低分子量烯属不饱和可成形大分子单体; 烯属不饱和单体; 和不透射线的元件，其中所述装置不包含支撑构件。还公开了形成这种装置的方法。

3. 发明申请

WO2002071994A1 HYDROGELS THAT UNDERGO VOLUMETRIC EXPANSION IN RESPONSE TO CHANGES IN THEIR ENVIRONMENT AND THEIR METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译：水下体积膨胀对其环境变化的响应及其制造和使用方法
公开(公告)号：WO2002071994A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/005988
申请日：2002-02-28
申请人： MICROVENTION, INC.
发明人： CRUISE, Gregory, M. , CONSTANT, Michael, J.
IPC分类号： A61F13/00
CPC分类号： C08F22/385 , A61K9/0024 , A61K49/0457 , A61L31/145
摘要： Hydrogels that expand volumetrically in response to a change in their environment (e.g., a change in pH or temperature) and their methods of manufacture and use. Generally, the hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After the hydrogel is formed, the porosigen is removed to create pores in the hydrogel. The hydrogel may also be treated to cause it to assume a non-expanded volume in which it remains until a change in its environment causes it to expand. These hydrogels may be prepared in many forms including pellets, filaments, and particles. Biomedical uses of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand it situ.
摘要翻译：响应于其环境变化（例如pH或温度的变化）及其制造和使用方法，体积膨胀的水凝胶。通常，水凝胶通过形成液体反应混合物来制备，所述液体反应混合物含有至少一部分其至少部分对环境变化（例如pH或温度的变化）的单体和/或聚合物， b）交联剂，和c）聚合引发剂。如果需要，可以将多孔性原子结合到液体反应混合物中以产生孔。在形成水凝胶之后，除去孔结构以在水凝胶中产生孔。水凝胶也可以被处理以使其呈现未膨胀的体积，其中它保持直到其环境变化导致它膨胀。这些水凝胶可以以许多形式制备，包括颗粒，细丝和颗粒。这些水凝胶的生物医学用途包括其中将水凝胶植入患者体内的应用，并且在植入部位的环境条件导致水凝胶原位扩张。

4. 发明申请

WO2014062696A1 POLYMERIC TREATMENT COMPOSITIONS 审中-公开
标题翻译：聚合物处理组合物
公开(公告)号：WO2014062696A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/065078
申请日：2013-10-15
申请人： MICROVENTION, INC.
发明人： CRUISE, Gregory, M. , CONSTANT, Michael, J. , KEELEY, Edward, Michael , GREENE, Rob , HARRIS, Clayton
IPC分类号： A61K47/48 , A61K47/30 , A61K38/17 , A61K38/16
CPC分类号： A61L24/06 , A61K49/0442 , A61K49/12 , A61L24/001 , A61L24/0015 , A61L2300/44 , A61L2400/06 , A61L2430/36 , C08L33/08 , C08L33/26
摘要： Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
摘要翻译：描述了包含生物相容性聚合物的聚合物组合物，其包括与可视化试剂和非生理pH溶液的生物可降解连接; 其中所述生物相容性聚合物可溶于非生理pH溶液中，并且在生理pH下不溶。公开了形成溶液和聚合物的方法以及治疗用途的方法。

5. 发明申请

WO2013188681A1 POLYMERIC TREATMENT COMPOSITIONS 审中-公开
标题翻译：聚合物处理组合物
公开(公告)号：WO2013188681A1
公开(公告)日：2013-12-19
申请号：PCT/US2013/045692
申请日：2013-06-13
申请人： MICROVENTION, INC.
发明人： CRUISE, Gregory, M. , CONSTANT, Michael, J. , GARRETSON, Joshua
IPC分类号： A61K47/30 , A61K9/08 , A61K9/00
CPC分类号： A61K31/785 , A61K9/0024 , A61K31/78 , A61K47/32 , A61L24/0089 , A61L24/046 , A61L2430/36
摘要： Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
摘要翻译：描述包含聚合物的组合物; 非生理pH溶液; 和可视化代理; 其中所述聚合物可溶于所述非生理pH溶液并且在生理pH下不溶。公开了形成溶液和聚合物的方法以及治疗用途的方法。

6. 发明授权

EP2906254B1 POLYMERIC TREATMENT COMPOSITIONS 有权
公开(公告)号：EP2906254B1
公开(公告)日：2020-01-08
申请号：EP13846860.8
申请日：2013-10-15
申请人： Microvention, Inc.
发明人： CRUISE, Gregory, M. , CONSTANT, Michael, J. , KEELEY, Edward, Michael , GREENE, Rob , HARRIS, Clayton
IPC分类号： A61L31/06 , A61L31/18

7. 发明公开

EP2480166A1 INJECTABLE HYDROGEL FILAMENTS FOR BIOMEDICAL USES 失效
标题翻译：注射用HYDROGELFILAMENTE生物医学应用
公开(公告)号：EP2480166A1
公开(公告)日：2012-08-01
申请号：EP10819570.2
申请日：2010-09-24
申请人： Microvention, Inc.
发明人： CONSTANT, Michael, J. , CRUISE, Gregory, M. , KEELEY, E., Michael , BERENSTEIN, Alejandro
IPC分类号： A61F2/02
CPC分类号： A61L31/18 , A61L31/06 , A61L31/145 , A61L31/16 , A61L2400/06 , C08L71/02
摘要： Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.

8. 发明授权

EP1372553B1 HYDROGELS THAT UNDERGO VOLUMETRIC EXPANSION IN RESPONSE TO CHANGES IN THEIR ENVIRONMENT AND THEIR METHODS OF MANUFACTURE AND USE 有权
标题翻译：水凝胶，在响应体积膨胀的面积的变化经历及其制造方法和用途
公开(公告)号：EP1372553B1
公开(公告)日：2014-06-25
申请号：EP02750563.5
申请日：2002-02-28
申请人： Microvention, Inc.
发明人： CRUISE, Gregory, M. , CONSTANT, Michael, J.
IPC分类号： A61F13/00 , A61F2/00 , A61K9/70 , A61K9/14 , A61K31/74 , A61K47/48
CPC分类号： C08F22/385 , A61K9/0024 , A61K49/0457 , A61L31/145

9. 发明公开

EP2027729A2 EMBOLIZATION DEVICE CONSTRUCTED FROM EXPANSIBLE POLYMER 审中-公开
标题翻译：可拉伸聚合物栓塞
公开(公告)号：EP2027729A2
公开(公告)日：2009-02-25
申请号：EP07798666.9
申请日：2007-06-15
申请人： MicroVention, Inc.
发明人： CRUISE, Gregory M. , CONSTANT, Michael, J. , TRAN, Terrance
IPC分类号： H04Q7/20
CPC分类号： A61B17/1219 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12168 , A61L31/00 , A61L31/022 , A61L31/041 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/145 , A61L31/146 , A61L2400/04 , C08L71/02
摘要： A method for preparing an environmentally-responsive hydrogel for implantation in an animal comprising: a) combining at least one ethylenically unsaturated macromer, at least one macromer or monomer comprising at least one ionizable functional group, at least one polymerization initiator, and at least one solvent to prepare a hydrogel; b) treating said hydrogel to prepare an environmentally-responsive hydrogel that is responsive at physiological conditions.

10. 发明授权

EP2231215B1 HYDROGEL FILAMENTS FOR BIOMEDICAL USES 有权
公开(公告)号：EP2231215B1
公开(公告)日：2019-01-30
申请号：EP08867736.4
申请日：2008-12-19
申请人： MicroVention, Inc.
发明人： CRUISE, Gregory, M. , CONSTANT, Michael, J. , KEELEY, E., Michael , TERRANCE, Tran, T.
IPC分类号： A61L27/16 , A61L27/18 , A61B17/00 , A61B17/12 , A61B90/00

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