专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0071669A8 DEVICE FOR PERFORMING ANALYSES ON CELL-CULTURES 审中-公开
标题翻译：设备技术开展研究对细胞培养物
公开(公告)号：WO0071669A8
公开(公告)日：2001-02-22
申请号：PCT/EP0003860
申请日：2000-04-28
申请人： MICRONAS GMBH , LEHMANN MIRKO , BRISCHWEIN MARTIN , BAUMANN WERNER , EHRET RALF , FREUND INGO , WOLF BERNHARD
发明人： LEHMANN MIRKO , BRISCHWEIN MARTIN , BAUMANN WERNER , EHRET RALF , FREUND INGO , WOLF BERNHARD
IPC分类号： C12M1/34 , B01L3/00 , C12M3/00 , C12M3/04
CPC分类号： C12M23/12 , B01L3/505 , C12M23/38
摘要： The invention relates to a device (1) for performing analyses on cell-cultures (2) which are present in a liquid culture medium (4). The device has at least one receptacle (3) for receiving the culture medium containing the cell-culture. One or more sensors (6) are provided for the cell-culture readings and the receptacle (3) has at least one access opening for supplying and evacuating the liquid culture medium (4). A separating element (7) can be introduced into the receptacle which is open at the top and moved into position in close proximity to the base. In this position, said separating element delimits a sub-chamber which has a reduced volume (8) in relation to the total receiving volume of the receptacle. In addition, at least one flow channel (9) is provided, which on one side adjoins the reduced-volume sub-chamber (8) and on the other adjoins a reservoir chamber (14). The sensor(s) (6) are arranged in the area of the reduced-volume sub-chamber.
摘要翻译：的装置（1）位于进行在液体培养基上延伸的细胞培养物（2）的调查（4）。该装置包括：至少一个接收器（3），用于与细胞培养物，其特征在于，一个或多个传感器提供（6），用于测量在细胞培养物中，并且其中所述接收器（3）至少一个用于供给和液体培养基的排出通路接收所述培养基（4）等具有。的分离体（7）内，所述容器在它的相对限定在插座的插座小容积室（8）的总吸收体积为地电平位置可插入到敞开的顶部容器和接合。另外，至少设置一个流动通道（9），其连接在一方面的小体积隔室（8），并且在另一方面，储液空间（149）。一个或多个传感器（6）被布置在小容积子腔室的区域中。

2. 发明申请

WO2006040142A3 METHOD FOR DETECTING AND/OR DETERMINING THE CONCENTRATION OF AT LEAST ONE LIGAND 审中-公开
标题翻译：检测和/或确定浓度至少一个配体的程序
公开(公告)号：WO2006040142A3
公开(公告)日：2006-08-10
申请号：PCT/EP2005010976
申请日：2005-10-12
申请人： MICRONAS GMBH , MICRONAS HOLDING GMBH , LEHMANN MIRKO , FREUND INGO , KLAPPROTH HOLGER , MOHRY SONJA
发明人： LEHMANN MIRKO , FREUND INGO , KLAPPROTH HOLGER , MOHRY SONJA
IPC分类号： G01N33/543 , G01N33/58
CPC分类号： G01N33/54373
摘要： The invention relates to a method for detecting and/or determining the concentration of a ligand (2) contained in a solution (1) to be analyzed, during which a receptor (5), which can enter into a specific bond with the ligand (2), is immobilized on a semiconductor chip (4) at a test location (3). In order to bind the ligand (2) to the receptor (5), the solution is applied to the test location (3). A luminescence radiation (14) or a color change is generated according to the binding of the ligand (2) to the receptor (5). A radiation measurement signal is picked up with the aid of a radiation receiver (6) integrated in the semiconductor chip (4), whereas the solution (1) and/or an auxiliary liquid that does not contain the luminophore (17) is in contact with the radiation receiver (6). While the generation of luminescence radiation is prevented and the radiation receiver (6) is in contact with the auxiliary liquid and/or with a substitute liquid, a darkness measurement signal is measured for the radiation receiver (6). The radiation measurement signal is compensated for with the darkness measurement signal.
摘要翻译：在用于检测和/或确定的溶液的浓度的方法将待分析（1）包含（2）在一个测试位点（3）与配位体固定在半导体芯片（4）上的受体（5）的配位体（2）可以形成特定的结合。为了将配体（2）与受体（5）结合，将溶液（1）施加到测试部位（3）。取决于配体（2）与受体（5）的结合，产生发光辐射（14）或颜色变化。通过在半导体芯片（4）被检测到的辐射接收器（6），一个辐射测量信号的装置集成在一起，同时将溶液（1）和/或不包含辅助液体于辐射接收器（6）所接触的发光体（17）。在防止发光辐射的产生并且辐射接收器（6）与辅助液体和/或替换液体接触的同时，测量辐射接收器（6）的暗测量信号。辐射测量信号由暗测量信号补偿。

3. 发明申请

WO03068671A2 METHOD FOR PRODUCING A SENSOR OR ACTUATOR ARRANGEMENT, AND CORRESPONDING SENSOR OR ACTUATOR ARRANGEMENT 审中-公开
标题翻译：一种用于生产传感器或执行器和传感器或执行器
公开(公告)号：WO03068671A2
公开(公告)日：2003-08-21
申请号：PCT/EP0301222
申请日：2003-02-07
申请人： MICRONAS GMBH , ROGALLA MARKUS , FREUND INGO , LEHMANN MIRKO
发明人： ROGALLA MARKUS , FREUND INGO , LEHMANN MIRKO
IPC分类号： G12B9/04 , B81B7/00 , G01N35/00 , H05K5/00 , H05K7/14
CPC分类号： B81B7/0061
摘要： The invention relates to a sensor or actuator arrangement in which at least one sensor (S1) or one actuator is provided on or in a chip (C). The aim of the invention is to safely protect both the chip (C) and the electrical contacts thereof from the environment, and also to be able to use the sensor (Sl) or actuator to measure parameters of a liquid or a gas. To this end, the chip (C) comprising the sensor (S1) is covered with a protective coating (A1) and at least one channel (K1) is provided, which is guided at least partially laterally in relation to the surface of the chip (C), towards a sensor (S1) or actuator. Preferably, the channel (K1) extends from one side of the arrangement to the sensor (S1).
摘要翻译：为了使传感器或致动器，其中，设置在或在一个芯片C中的至少一个传感器S1或致动器，一方面这两个芯片C以及它的电触点可靠地被保护免受环境，另一方面，传感器S1中或致动器能够使用用于测量液体或气体的参数，与传感器S1配有保护盖A1中的芯片C被覆盖。本发明提供至少一个信道K1至传感器S1或致动器，其被引导至少部分地横向于芯片C的表面优选地，所述信道K1从组装到传感器S1的一侧打开。

4. 发明专利

JP2002055102A METHOD FOR TESTING MEMBRANE ENCLOSED BIOCOMPARTMENT 失效
公开(公告)号：JP2002055102A
公开(公告)日：2002-02-20
申请号：JP2001171289
申请日：2001-06-06
申请人： MICRONAS GMBH
发明人： LEHMANN MIRKO , BAUMANN WERNER DR , MARTIN BURISSHUVAIN , RALF EHRET , HEINZ-PETER FRERIKS , FREUND INGO , GAHLE HANS-JUERGEN DR , HOFMANN KARL , MARTIN KLEINTGES , JOACHIM RUF , SIEBEN ULRICH , WOLF BERNHARD
IPC分类号： G01N33/48 , C12M1/34 , C12Q1/00 , G01N27/30 , G01N27/416 , G01N33/483
摘要： PROBLEM TO BE SOLVED: To provide a method for testing membrane enclosed biocompartments. SOLUTION: OH-ions and/or H+ions are formed from a substance existing in a culture medium and releasable and/or ingestible by the biocompartments in a culture medium region adjacently existing to the biocompartments; a first measured value of pH value of the culture medium is measured while impressing voltage; the voltage is cut off or changed so as to finish the formation of the OH-ions and the H+ions from the substance; and before or after measuring the first measured value, a second measured value of the pH value of the culture medium is measured when cutting the voltage or at a voltage of not forming hydroxy ions and hydrogen ions from the substance. After repeating this whole measurement by at least one time, the concentration of the substance in the culture medium, acidification or basification of the culture medium are decided from the first measured value and the second measured value. Thus, plural substance exchange parameters of the biocompartments can be measured in one place by this method.

5. 发明专利

DE102004010635A1 未知
公开(公告)号：DE102004010635A1
公开(公告)日：2005-09-29
申请号：DE102004010635
申请日：2004-03-02
申请人： MICRONAS GMBH
发明人： BAUMANN WERNER , FREUND INGO , LEHMANN MIRKO , GAHLE HANS-JUERGEN
IPC分类号： G01N27/414 , G01N33/487 , G01N33/483

6. 发明专利

DE102004006428A1 Device for analyzing biological components, e.g. nucleic acids or proteins, comprises a moveable two-compartment container that contains reaction and storage spaces 未知
公开(公告)号：DE102004006428A1
公开(公告)日：2005-09-01
申请号：DE102004006428
申请日：2004-02-09
申请人： MICRONAS GMBH
发明人： SIEBEN ULRICH , FREUND INGO , LEHMANN MIRKO
IPC分类号： B01L3/00 , C12M1/20 , C12M1/34
摘要： Device (1) for performing examinations on biocomponents (A), present in a liquid medium, comprising a container divided into two compartments (2,3) by a separator, where (2) has at least one reaction space (4) bounded by the separator, is new. Device (1) for performing examinations on biocomponents (A), present in a liquid medium, comprises a container divided into two compartments (2,3) that are joined at a separator level (7). (2) includes at least one reaction space (4), adjacent (7), for receiving the medium containing (A), while (3) includes at least one storage space (6) for at least the medium. (2) and (3) can be moved relative to each other (parallel to (7)) between first and second positions, where the first position (4) is connected with (6), on (7), and in the second position (4) and (6) are separated (or their cross-sectional area of contact is reduced). (1) includes at least one sensor for performing measurements on (A).

7. 发明专利

DE10236925A1 未知
公开(公告)号：DE10236925A1
公开(公告)日：2003-10-30
申请号：DE10236925
申请日：2002-08-12
申请人： MICRONAS GMBH , MICRONAS HOLDING GMBH , KLAPPROTH HOLGER
发明人： KLAPPROTH HOLGER , SIEBEN ULRICH , FREUND INGO
IPC分类号： B01J20/32 , G01N33/543 , B01D15/08 , B01J20/30 , C12N15/11 , G01N33/48 , G01N33/53

8. 发明专利

AU2003208812A1 METHOD FOR PRODUCING A SENSOR OR ACTUATOR ARRANGEMENT, AND CORRESPONDING SENSOR OR ACTUATOR ARRANGEMENT 未知
公开(公告)号：AU2003208812A1
公开(公告)日：2003-09-04
申请号：AU2003208812
申请日：2003-02-07
申请人： MICRONAS GMBH
发明人： ROGALLA MARKUS , FREUND INGO , LEHMANN MIRKO
IPC分类号： G12B9/04 , B81B7/00 , G01N35/00 , H05K5/00 , H05K7/14
摘要： In a method for producing a sensor arrangement and the resulting sensor arrangement, a sensor is provided on or in a chip and the chip is covered with a protective cover, the cover being an interface between the sensor and the environment. An adhesive layer is provided between the chip and the protective cover, the adhesive layer alone or together with the protective cover being an interface between the sensor and the environment. The protective cover and/or the adhesive layer may have a channel formed therein, the channel functioning as the reception channel for a sensor. In an alternative embodiment, the protective cover placed on a wafer with several chips, and the wafer is cut up to produce the individual chips with the protective cover. Thus, a sensor arrangement may have the protective cover applied to the individual chip after the chip is cut from the wafer, or the protective cover may be applied to the wafer, and the wafer and cover are then cut up into the individual chips and corresponding covers. The channel leading from one side of the arrangement to the sensor may be taken through the adhesive layer, through the protective cover, or through both. A hole may be formed in the protective cover above the sensor, with the sensor lying loosely in the hole. The reaction volume may be determined by the dimensions of the hole.

9. 发明专利

DE102004050032A1 未知
公开(公告)号：DE102004050032A1
公开(公告)日：2006-04-27
申请号：DE102004050032
申请日：2004-10-13
申请人： MICRONAS GMBH , MICRONAS HOLDING GMBH
发明人： LEHMANN MIRKO , FREUND INGO , KLAPPROTH HOLGER , MOHRY SONJA
IPC分类号： G01N33/58 , G01N33/50 , G01N33/543 , G01N33/68
摘要： The invention relates to a method for detecting and/or determining the concentration of a ligand contained in a solution to be analyzed, during which a receptor, which can enter into a specific bond with the ligand, is immobilized on a semiconductor chip at a test location. In order to bind the ligand to the receptor, the solution is applied to the test location. A luminescence radiation or a color change is generated according to the binding of the ligand to the receptor. A radiation measurement signal is picked up with the aid of a radiation receiver integrated in the semiconductor chip, whereas the solution and/or an auxiliary liquid that does not contain the luminophore is in contact with the radiation receiver. While the generation of luminescence radiation is prevented and the radiation receiver is in contact with the auxiliary liquid and/or with a substitute liquid, a darkness measurement signal is measured for the radiation receiver. The radiation measurement signal is compensated for with the darkness measurement signal

10. 发明专利

DE10245435B4 未知
公开(公告)号：DE10245435B4
公开(公告)日：2006-03-16
申请号：DE10245435
申请日：2002-09-27
申请人： MICRONAS GMBH
发明人： LEHMANN MIRKO , MUELLER CLAAS , KLAPPROTH HOLGER , FREUND INGO
IPC分类号： G01N33/50 , B01L3/00 , G01N21/55 , G01N21/64 , G01N21/77 , G01N33/483 , G01N33/543
摘要： Disclosed is a device for detecting at least one ligand contained in a sample that is to be analyzed. Said device comprises an optical waveguide, on the surface of which at least one ligand-specific receptor is directly or indirectly immobilized. The ligand bonds to said receptor during contact therewith. The inventive device comprises at least one optical source of radiation for injecting excitation radiation into the waveguide, the radiation being used for exciting emission of luminescence radiation in accordance with the bonding of the ligand to the receptor. At least one radiation receiver is integrated into the semiconductor substrate of a semiconductor chip so as to detect the luminescence radiation. The waveguide is integrated in a monolithic manner into the semiconductor substrate or is applied thereupon as a wave-guiding layer.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式