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1. 发明申请

WO2015040390A1 CHAMBER SEAL FOR MASS SPECTROMETER 审中-公开
标题翻译：大孔分光光度计密封
公开(公告)号：WO2015040390A1
公开(公告)日：2015-03-26
申请号：PCT/GB2014/052824
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： O'BRIEN, Stephen , TRIVETT, Ian
IPC分类号： H01J49/24
CPC分类号： F16J15/025 , H01J49/24 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a first component, an annular vacuum chamber seal and a second component. The first component has a groove. The annular vacuum chamber seal comprises a main body portion and one or more blade or rib portions which protrude from the main body portion. The main body portion is located in the groove and the one or more blade or rib portions protrude above or beyond a surface of the first component. The second component is slid, in use, along the surface of the first component thereby deforming the one or more blade or rib portions so that the one or more blade or rib portions form a radial, diametric or piston seal between the first and second components.
摘要翻译：公开了一种质谱仪，其包括第一部件，环形真空室密封件和第二部件。第一个组件有一个凹槽。环形真空室密封件包括主体部分和从主体部分突出的一个或多个刀片或肋部分。主体部分位于槽中，并且一个或多个刀片或肋部突出在第一部件的表面之上或之上。第二部件在使用中沿着第一部件的表面滑动，从而使一个或多个刀片或肋部分变形，使得一个或多个刀片或肋部分在第一和第二部件之间形成径向，直径或活塞密封。

2. 发明申请

WO2019229458A1 BENCH-TOP TIME OF FLIGHT MASS SPECTROMETER 审中-公开
公开(公告)号：WO2019229458A1
公开(公告)日：2019-12-05
申请号：PCT/GB2019/051499
申请日：2019-05-31
申请人： MICROMASS UK LIMITED
发明人： WAMSLEY, Ruth , WILSON, Michael , TRIVETT, Ian , CARNEY, Peter , MURRAY, Haydn , MCIVER, Paul
IPC分类号： H01J49/06
摘要： A mass spectrometer comprising: a vacuum chamber; and an ion inlet assembly for transmitting analyte ions into the vacuum chamber; wherein the spectrometer is configured to operate in a cooling mode in which it selectively controls one or more gas flow to the ion inlet assembly for actively cooling the ion inlet assembly.

3. 发明申请

WO2015040387A1 TOOL FREE GAS CONE RETAINING DEVICE FOR MASS SPECTROMETER ION BLOCK ASSEMBLY 审中-公开
标题翻译：用于大量光谱仪离子块组件的工具自由气体保持装置
公开(公告)号：WO2015040387A1
公开(公告)日：2015-03-26
申请号：PCT/GB2014/052820
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： O'BRIEN, Steve , TRIVETT, Ian
IPC分类号： H01J49/04
CPC分类号： H01J49/24 , H01J49/04 , H01J49/165 , H01J49/26
摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising an ion block or sub-assembly (3) having an internal passage. The atmospheric pressure interface further comprises either an inner sampling cone (13), a capillary interface or other gas limiting interface. The mass spectrometer comprises a clamp (2) formed from a thermally insulating material and a removable outer gas cone (1) which is slidably inserted into or onto the clamp (2) so that the outer gas cone (1) is retained by the clamp (2) in use. The clamp (2) is arranged and adapted to be pushed by a user into engagement with the ion block or sub-assembly (3) so as to position the outer gas cone (1) adjacent the inner sampling cone (13), capillary interface or other gas limiting interface so as to secure the outer gas cone (1) to the ion block or sub-assembly (3) and to form a gas tight seal with the ion block or sub-assembly (3) without use of mechanical fasteners.
摘要翻译：公开了一种质谱仪，其包括大气压力界面，其包括具有内部通道的离子块或子组件（3）。大气压力界面还包括内取样锥体（13），毛细管界面或其它气体限制界面。质谱仪包括由绝热材料形成的夹具（2）和可滑动地插入到夹具（2）中或其上的可移除的外部气体锥体（1），使得外部气体锥体（1）由夹具（2）使用中。夹具（2）被布置并适于被使用者推动以与离子块或子组件（3）接合，以便将外部气体锥体（1）定位成邻近内部采样锥体（13），毛细管接口或其它气体限制界面，以便将外部气体锥体（1）固定到离子块或子组件（3）并且与离子块或子组件（3）形成气密密封而不使用机械紧固件。

4. 发明申请

WO2022223977A1 NEBULISER OUTLET 审中-公开
公开(公告)号：WO2022223977A1
公开(公告)日：2022-10-27
申请号：PCT/GB2022/051008
申请日：2022-04-21
申请人： MICROMASS UK LIMITED
发明人： TRIVETT, Ian , WALFORD, Mark , KENNY, Daniel James , BAJIC, Stevan , MATHAI, Suloke
IPC分类号： H01J49/16 , H01J49/04
摘要： A nebuliser outlet (20) comprises one or more first channels (24), wherein the nebuliser outlet (20) is configured such that liquid received by the nebuliser outlet (20) can pass to one or more nebulisation regions via the one or more first channels (24), and one or more second channels (25), wherein the nebuliser outlet (20) is configured such that gas received by the nebuliser outlet (20) can pass to the one or more nebulisation regions via the one or more second channels (25). The one or more first channels (24) comprise a first portion (24a) and a second portion (24b), wherein the first portion (24a) comprises a tubular channel, and wherein the second portion (24b) comprises multiple channels, an annular channel, or a segmented annular channel. The one or more second channels (25) converge with the second portion (24b) at the one or more nebulisation regions.

5. 发明申请

WO2015040383A1 INTERFACE FOR ION SOURCE AND VACUUM HOUSING 审中-公开
标题翻译：离子源和真空容器接口
公开(公告)号：WO2015040383A1
公开(公告)日：2015-03-26
申请号：PCT/GB2014/052815
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： HESS, Anthony , O'BRIEN, Steve , TRIVETT, Ian
IPC分类号： H01J49/04 , H01J49/02 , H01J49/10
CPC分类号： H01J49/02 , G01N27/622 , H01J49/0013 , H01J49/0031 , H01J49/044 , H01J49/049 , H01J49/10
摘要： Amass spectrometer or ion mobility spectrometer is disclosed comprising: an ion block(2)for receiving ions;a heater (8) for heating the ion block(2); a vacuum housing(6); and an interface block (4) arranged between the ion block (2) and the vacuum housing(6); wherein the interface block (4) is formed from a polymer. The polymer interface block (4) inhibits the heat transfer from the ion block (2) to the vacuum housing(6) and also electrically isolates the ion block (2) and vacuum housing(6). The interface block (4) further comprises at least one conduit (12) through the body of the interface block (4). This enables gas to be transmitted through the interface block (4) to the ion block (2), and also enables the interface block (4) to be cooled.
摘要翻译：公开了一种Amass光谱仪或离子迁移谱仪，包括：用于接收离子的离子块（2）;用于加热离子块（2）的加热器（8）; 真空壳体（6）; 和布置在离子块（2）和真空壳体（6）之间的界面块（4）; 其中所述界面块（4）由聚合物形成。聚合物界面块（4）抑制从离子块（2）到真空壳体（6）的热传递，并且电离离子块（2）和真空壳体（6）。接口块（4）还包括穿过接口块（4）的主体的至少一个导管（12）。这使得气体能够通过界面块（4）传递到离子块（2），并且还使接口块（4）能够被冷却。

6. 发明申请

WO2010136825A1 DETACHABLE AND REPLACEABLE ION SOURCE FOR A MASS SPECTROMETER 审中-公开
标题翻译：用于质谱仪的可拆卸和可更换的离子源
公开(公告)号：WO2010136825A1
公开(公告)日：2010-12-02
申请号：PCT/GB2010/050925
申请日：2010-06-01
申请人： MICROMASS UK LIMITED , HOWES, Kevin R. , TRIVETT, Ian , READ, Paul Anthony , MOULDS, Richard B.
发明人： HOWES, Kevin R. , TRIVETT, Ian , READ, Paul Anthony , MOULDS, Richard B.
IPC分类号： H01J49/10
CPC分类号： H01J49/004 , H01J49/0027 , H01J49/42 , H02M7/48 , H02M2001/008
摘要： A detachable and replaceable ion source for a mass spectrometer. The ion source comprises a housing which defines an ion source chamber, an ion source mounting means complementary to mounting means on the mass spectrometer to detachably couple with the mass spectrometer. This allows movement of the housing to bring the ion source chamber into a position of use at the inlet of said mass spectrometer and to take the ion source chamber from said position of use into a retracted position. Sealing means is provided to create an air tight seal between the housing and the mass spectrometer when the ion source chamber is in its position of use.A release mechanism is provided which cooperates with the mass spectrometer to allow the said movement of said housing.
摘要翻译：用于质谱仪的可拆卸和可更换的离子源。离子源包括限定离子源室的壳体，与质谱仪上的安装装置互补的离子源安装装置，以可拆卸地与质谱仪耦合。这允许壳体移动以使离子源室进入使用的位置，并且将离子源室从所述使用位置带入缩回位置。提供密封装置以在离子源室处于其使用位置时在壳体和质谱仪之间形成气密密封。提供了一种与质谱仪配合以允许所述壳体运动的释放机构。

7. 发明申请

WO2022172036A1 ION SOURCE NEBULISER 审中-公开
公开(公告)号：WO2022172036A1
公开(公告)日：2022-08-18
申请号：PCT/GB2022/050399
申请日：2022-02-15
申请人： MICROMASS UK LIMITED
发明人： BOOTH, Alastair , TRIVETT, Ian , HESSE, Anthony , WALFORD, Mark , GORDON, David , MURRAY, Haydn , ARYTON, Stephen
IPC分类号： H01J49/04 , B05B7/00
摘要： A nebuliser comprises an outlet aperture and a liquid capillary. A method of operating the nebuliser comprises supplying a gas to the outlet aperture, measuring a flow rate of the gas supplied to the outlet aperture, and determining a position of the liquid capillary relative to the outlet aperture based on the measured flow rate.

8. 发明申请

WO2016142685A1 COLLISION SURFACE FOR IMPROVED IONISATION 审中-公开
标题翻译：冲击表面改进
公开(公告)号：WO2016142685A1
公开(公告)日：2016-09-15
申请号：PCT/GB2016/050614
申请日：2016-03-07
申请人： MICROMASS UK LIMITED
发明人： KARANCSI, Tamás , SIMON, Dániel , GÖDÖRHÁZY, Lajos , SZALAY, Dániel , PRINGLE, Steven Derek , JONES, Emrys , TRIVETT, Ian , O'BRIEN, Stephen , HESS, Anthony , HENDERSON, Matt , CHUA, Alvin , TAKÁTS, Zoltán
IPC分类号： H01J49/00 , H01J49/04 , H01J49/06 , H01J49/16 , G01N33/68 , G01N33/92 , G01N27/62 , A61B10/02 , A61B18/14
CPC分类号： H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/18 , G06F19/324 , G06F19/3481 , G16H50/20 , H01J49/0004 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0422 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
摘要： An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped,coil- shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.
摘要翻译：公开了一种用于执行环境电离质量和/或离子迁移谱的装置。该装置包括大致圆柱形，管状，棒状，螺旋形，螺旋形或螺旋状的碰撞组件; 以及布置并适于将分析物，烟雾，烟雾，液体，气体，手术烟雾，气溶胶或蒸气引导到所述碰撞组件上的第一装置。

9. 发明申请

WO2015040393A1 GASKET SEAL FOR A MASS SPECTROMETER 审中-公开
标题翻译：气垫密封用于质谱仪
公开(公告)号：WO2015040393A1
公开(公告)日：2015-03-26
申请号：PCT/GB2014/052827
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： O'BRIEN, Stephen , TRIVETT, Ian
IPC分类号： H01J49/24
CPC分类号： H01J49/24 , F16J15/061 , H01J49/0027
摘要： A gasket seal (1) for a mass spectrometer is disclosed. The gasket seal (1) comprises a membrane having an outer profile and an inner profile and one or more protrusions (11). One or more ports are provided in the body of the membrane. In use a gas or fluid is supplied through at least one of the one or more ports via at least one of the one or more protrusions (11).
摘要翻译：公开了一种用于质谱仪的垫圈密封件（1）。垫圈密封件（1）包括具有外部轮廓和内部轮廓的膜，以及一个或多个突起（11）。一个或多个端口设置在膜的主体中。在使用中，一个或多个突起（11）中的至少一个突起（11）中的至少一个通过至少一个或多个端口供应气体或流体。

10. 发明申请

WO2015040392A1 ION INLET ASSEMBLY 审中-公开
标题翻译：离子入口大会
公开(公告)号：WO2015040392A1
公开(公告)日：2015-03-26
申请号：PCT/GB2014/052826
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： GORDON, David , JARRELL, Joseph , KENNY, Daniel James , O'BRIEN, Stephen , TRIVETT, Ian
IPC分类号： H01J49/04 , H01J49/06
CPC分类号： H01J49/0422 , H01J49/0013 , H01J49/04 , H01J49/0495 , H01J49/066
摘要： An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body (325) having a sampling orifice (329). The sampling limiting body (325) comprises a nickel disk wherein the disk and sampling orifice (329) are made or formed by an electroforming process.
摘要翻译：公开了一种用于连接到质谱仪壳体的离子入口组件，其包括具有采样孔（329）的采样限制体（325）。采样限制体（325）包括镍盘，其中盘和采样孔（329）由电铸工艺制成或形成。

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