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1. 发明申请

WO2015189540A1 MONITORING ION MOBILITY SPECTROMETRY ENVIRONMENT FOR IMPROVED COLLISION CROSS SECTION ACCURACY AND PRECISION 审中-公开
标题翻译：监测离子移动光谱环境改善碰撞交叉部分精度和精度
公开(公告)号：WO2015189540A1
公开(公告)日：2015-12-17
申请号：PCT/GB2015/000168
申请日：2015-06-10
申请人： MICROMASS UK LIMITED
发明人： PRINGLE, Steven Derek , SALARZAEI, Farnoush , TOMCZYK, Nick , WILDGOOSE, Jason Lee
IPC分类号： G01N27/62 , H01J49/26 , H01J49/00
CPC分类号： H01J49/24 , G01N27/622 , G01N30/7233 , H01J49/0009 , H01J49/0027 , H01J49/004 , H01J49/0045
摘要： A mass spectrometer is disclosed comprising an ion mobility separator 4 for separating ions according to their ion mobility, one or more first devices or stages arranged upstream of the ion mobility separator and a control system. The control system is arranged and adapted to monitor directly or indirectly the operating environment within the ion mobility separator 4, and to control the operating environment within the ion mobility separator 4 based on the monitoring by controlling one or more gas flows to or within one or more of the one or more first devices or stages.
摘要翻译：公开了一种质谱仪，其包括用于根据其离子迁移率分离离子的离子迁移率分离器4，以及设置在离子迁移率分离器上游的一个或多个第一装置或级和控制系统。控制系统被布置和适于直接或间接地监测离子迁移分离器4内的操作环境，并且基于监测来控制离子迁移分离器4内的操作环境，通过控制一个或多个气体流到或者在一个或多个更多的一个或多个第一设备或阶段。

2. 发明申请

WO2015071650A1 METHOD OF CORRELATING PRECURSOR AND FRAGMENT IONS 审中-公开
标题翻译：相关前提条件和碎片离子的方法
公开(公告)号：WO2015071650A1
公开(公告)日：2015-05-21
申请号：PCT/GB2014/053336
申请日：2014-11-11
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , PRINGLE, Steven Derek , SALARZAEI, Farnoush , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/0045 , H01J49/421
摘要： A method of mass spectrometry is disclosed comprising separating precursor ions using an ion mobility separator such that different precursor ions have different drift times through the ion mobility separator;mass filtering said separated precursor ions with a mass filter, wherein the mass to charge ratios of the precursor ions transmitted by the mass filter vary as a function of the drift times of the precursor ions through the ion mobility separator; performing a first mode of operation comprising fragmenting the separated and mass filtered precursor ions in a fragmentation device to form fragment ions; urging the fragment ions through the fragmentation device such that fragment ions derived from different precursor ions that have been separated by the ion mobility separator are maintained spatially separated from each other as they are urged through the fragmentation device; and detecting the fragment ions. The method enables precursor ions to be associated with their related fragment ions more accurately.
摘要翻译：公开了一种质谱法，其包括使用离子迁移率分离器分离前体离子，使得不同的前体离子通过离子迁移率分离器具有不同的漂移时间;用质量过滤器大量过滤所分离的前体离子，其中质量比由质量过滤器传播的前体离子作为前体离子通过离子迁移分离器的漂移时间的函数而变化; 执行第一操作模式，包括在分离装置中分离和质量过滤的前体离子碎裂以形成碎片离子; 促使碎片离子通过碎裂装置，使得衍生自已被离子迁移率分离器分离的不同前体离子的碎片离子保持空间上彼此分离，因为它们通过破碎装置被推动; 并检测碎片离子。该方法使前体离子更准确地与其相关的片段离子相关联。

3. 发明申请

WO2015071647A2 METHOD OF ISOLATING IONS 审中-公开
标题翻译：分离离子的方法
公开(公告)号：WO2015071647A2
公开(公告)日：2015-05-21
申请号：PCT/GB2014/053333
申请日：2014-11-11
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , PRINGLE, Steven Derek , SALARZAEI, Farnoush , WILDGOOSE, Jason Lee
CPC分类号： G01N27/622 , H01J49/0031 , H01J49/40 , H01J49/4215
摘要： A method of mass spectrometry is disclosed comprising isolating a group of different ions derived from chemical compounds in the same class (12,13), wherein the different ions have different mass to charge ratios and ion mobilities. The step of isolating comprises temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter. The mass to charge ratios transmitted by the mass filter are varied as a function of time such that said different ions derived from chemical compounds in the same class (12,13) are transmitted by the mass filter and other ions are not transmitted by the mass filter.
摘要翻译：公开了一种质谱方法，其包括分离衍生自同一类别（12,13）中的化合物的一组不同离子，其中不同的离子具有不同的质荷比和离子迁移率。分离步骤包括在离子迁移分离器中根据其离子迁移率暂时分离离子; 并根据质量与质量过滤器的质荷比质量过滤离子。通过质量过滤器传输的质荷比随着时间的变化而变化，使得衍生自相同等级（12,13）中的化合物的所述不同离子通过质量过滤器传输，而其他离子不被质量传递过滤。

4. 发明申请

WO2014140542A1 A DDA EXPERIMENT WITH REDUCED DATA PROCESSING 审中-公开
标题翻译：具有减少数据处理的DDA实验
公开(公告)号：WO2014140542A1
公开(公告)日：2014-09-18
申请号：PCT/GB2014/050697
申请日：2014-03-10
申请人： MICROMASS UK LIMITED
发明人： BROWN, Jeffery Mark , GILES, Kevin , GREEN, Martin Raymond , HOYES, John Brian , JONES, Christopher , MORRIS, Michael Raymond , PRINGLE, Steven Derek , RICHARDSON, Keith , SALARZAEI, Farnoush , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： H01J49/005 , G01N27/622 , H01J49/0031 , H01J49/0045 , H01J49/0072
摘要： A method of mass spectrometry is disclosed comprising: performing a survey scan of a plurality of different types of parent or precursor ions, wherein said survey scan comprises analysing the ion mobilities of the ions and mass analysing the ions; determining the charge states of parent or precursor ions analysed in the survey scan based on their determined combinations of ion mobility and mass to charge ratio; selecting a parent or precursor ion for fragmentation or reaction; and fragmenting or reacting said selected ion, wherein the fragmentation or reaction conditions are selected from a plurality of different fragmentation or reaction conditions based upon the determined charge state of the selected ion.
摘要翻译：公开了一种质谱方法，包括：对多种不同类型的母体或前体离子进行测量扫描，其中所述测量扫描包括分析离子的离子迁移率和大量分析离子; 基于它们确定的离子迁移率和质荷比的组合来确定在测量扫描中分析的亲本或前体离子的电荷状态; 选择母体或前体离子进行碎裂或反应; 并且使所述选择的离子断裂或反应，其中基于所选离子的确定的电荷状态，所述断裂或反应条件选自多个不同的断裂或反应条件。

5. 发明公开

EP3155414A1 MONITORING ION MOBILITY SPECTROMETRY ENVIRONMENT FOR IMPROVED COLLISION CROSS SECTION ACCURACY AND PRECISION 有权
标题翻译： ÜBERWACHUNGDERIONENMOBILITÄTSSPEKTROMETRIEUMGEBUNGFÜRVERBESSERTE KOLLISIONSQUERSCHNITTSGENAUIGKEIT UND-PRÄZISION
公开(公告)号：EP3155414A1
公开(公告)日：2017-04-19
申请号：EP15730214.2
申请日：2015-06-10
申请人： Micromass UK Limited
发明人： PRINGLE, Steven Derek , SALARZAEI, Farnoush , TOMCZYK, Nicholas , WILDGOOSE, Jason Lee
IPC分类号： G01N27/62 , H01J49/26 , H01J49/00
CPC分类号： H01J49/24 , G01N27/622 , G01N30/7233 , H01J49/0009 , H01J49/0027 , H01J49/004 , H01J49/0045
摘要： A mass spectrometer is disclosed comprising an ion mobility separator for separating ions according to their ion mobility, one or more first devices or stages arranged upstream of the ion mobility separator and a control system. The control system is arranged and adapted to monitor directly or indirectly the operating environment within the ion mobility separator, and to control the operating environment within the ion mobility separator based on the monitoring by controlling one or more gas flows to or within one or more of the one or more first devices or stages.
摘要翻译：公开了一种质谱仪，其包括用于根据其离子迁移率分离离子的离子迁移率分离器，设置在离子迁移率分离器上游的一个或多个第一装置或级和控制系统。控制系统被布置和适于直接或间接地监测离子迁移分离器内的操作环境，并且基于监测来控制离子迁移分离器内的操作环境，该控制系统通过控制一个或多个气体流到或者在一个或多个一个或多个第一设备或阶段。

6. 发明公开

EP3069373A1 METHOD OF CORRELATING PRECURSOR AND FRAGMENT IONS 有权
标题翻译：方法相关性前兆与片中的的
公开(公告)号：EP3069373A1
公开(公告)日：2016-09-21
申请号：EP14799849.6
申请日：2014-11-11
申请人： Micromass UK Limited
发明人： HOYES, John Brian , PRINGLE, Steven Derek , SALARZAEI, Farnoush , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/0045 , H01J49/421
摘要： A method of mass spectrometry is disclosed comprising separating precursor ions using an ion mobility separator such that different precursor ions have different drift times through the ion mobility separator;mass filtering said separated precursor ions with a mass filter, wherein the mass to charge ratios of the precursor ions transmitted by the mass filter vary as a function of the drift times of the precursor ions through the ion mobility separator; performing a first mode of operation comprising fragmenting the separated and mass filtered precursor ions in a fragmentation device to form fragment ions; urging the fragment ions through the fragmentation device such that fragment ions derived from different precursor ions that have been separated by the ion mobility separator are maintained spatially separated from each other as they are urged through the fragmentation device; and detecting the fragment ions. The method enables precursor ions to be associated with their related fragment ions more accurately.

7. 发明公开

EP3961202A1 MONITORING ION MOBILITY SPECTROMETRY ENVIRONMENT FOR IMPROVED COLLISION CROSS SECTION ACCURACY AND PRECISION 审中-实审
公开(公告)号：EP3961202A1
公开(公告)日：2022-03-02
申请号：EP21200802.3
申请日：2015-06-10
申请人： Micromass UK Limited
发明人： PRINGLE, Steven Derek , SALARZAEI, Farnoush , TOMCZYK, Nicholas , WILDGOOSE, Jason Lee
IPC分类号： G01N27/622 , H01J49/26 , H01J49/00 , G01N27/624 , G01N27/623
摘要： A mass spectrometer is disclosed comprising an ion mobility separator 4 for separating ions according to their ion mobility, one or more first devices or stages arranged upstream of the ion mobility separator and a control system. The control system is arranged and adapted to monitor directly or indirectly the operating environment within the ion mobility separator 4, and to control the operating environment within the ion mobility separator 4 based on the monitoring by controlling one or more gas flows to or within one or more of the one or more first devices or stages.

8. 发明公开

EP3069376A2 METHOD OF ISOLATING IONS 审中-公开
标题翻译：式分离方法离子
公开(公告)号：EP3069376A2
公开(公告)日：2016-09-21
申请号：EP14796879.6
申请日：2014-11-11
申请人： Micromass UK Limited
发明人： HOYES, John Brian , PRINGLE, Steven Derek , SALARZAEI, Farnoush , WILDGOOSE, Jason Lee
IPC分类号： H01J49/42 , G01N27/62
CPC分类号： G01N27/622 , H01J49/0031 , H01J49/40 , H01J49/4215
摘要： A method of mass spectrometry is disclosed comprising isolating a group of different ions derived from chemical compounds in the same class (12,13), wherein the different ions have different mass to charge ratios and ion mobilities. The step of isolating comprises temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter. The mass to charge ratios transmitted by the mass filter are varied as a function of time such that said different ions derived from chemical compounds in the same class (12,13) are transmitted by the mass filter and other ions are not transmitted by the mass filter.

9. 发明公开

EP2973643A1 A DDA EXPERIMENT WITH REDUCED DATA PROCESSING 无效
标题翻译： DDA实验麻省理工学院DATENVERARBEITUNG
公开(公告)号：EP2973643A1
公开(公告)日：2016-01-20
申请号：EP14710625.6
申请日：2014-03-10
申请人： Micromass UK Limited
发明人： BROWN, Jeffery Mark , GILES, Kevin , GREEN, Martin Raymond , HOYES, John Brian , JONES, Christopher , MORRIS, Michael Raymond , PRINGLE, Steven Derek , RICHARDSON, Keith , SALARZAEI, Farnoush , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： H01J49/005 , G01N27/622 , H01J49/0031 , H01J49/0045 , H01J49/0072
摘要： A method of mass spectrometry is disclosed comprising: performing a survey scan of a plurality of different types of parent or precursor ions, wherein the survey scan comprises analyzing the ion mobilities of the ions and mass analyzing the ions; determining the charge states of parent or precursor ions analyzed in the survey scan based on their determined combinations of ion mobility and mass to charge ratio; selecting a parent or precursor ion for fragmentation or reaction; and fragmenting or reacting the selected ion, wherein the fragmentation or reaction conditions are selected from a plurality of different fragmentation or reaction conditions based upon the determined charge state of the selected ion.
摘要翻译：公开了一种质谱方法，包括：对多种不同类型的母体或前体离子进行测量扫描，其中所述测量扫描包括分析离子的离子迁移率和大量分析离子; 基于它们确定的离子迁移率和质荷比的组合来确定在测量扫描中分析的亲本或前体离子的电荷状态; 选择母体或前体离子进行碎裂或反应; 并且使所述选择的离子断裂或反应，其中基于所选离子的确定的电荷状态，所述断裂或反应条件选自多个不同的断裂或反应条件。

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