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    • 4. 发明申请
    • REFRIGERATED CORE COMPRISING CARBONATING SYSTEM FOR DRINKS DISPENSER
    • 用于饮料分配器的碳酸饮料系统的制冷核心
    • WO2006092704A1
    • 2006-09-08
    • PCT/IB2006/000420
    • 2006-03-01
    • DIEAUDIETSCHI, EricFOURNIER, EricPEREIRA, Alexandre
    • DIETSCHI, EricFOURNIER, EricPEREIRA, Alexandre
    • B01F3/04B01F15/00
    • B01F3/04787B01F15/066B01F2003/049B01F2015/061B67D1/0057B67D1/0067B67D1/0861
    • The present invention relates to Integrated core (18) adapted for use in a beverage dispenser system, comprising a multi-chamber cooling system comprising an outer upper chamber (21) and a inner lower chamber (22), the inner lower chamber (22) being located partially within the upper outer chamber (21) and interconnected in such a way to permit a fluid to flow from the upper chamber (21) to the lower chamber (22) and vice-versa ; beverage transport means (26, 27, 28, 29, 30) distributed throughout the upper chamber (21) capable of transporting beverage to be cooled through said upper chamber (21) ; cooling means (34) distributed throughout substantially a lower zone (32) of the lower chamber (22) ; cooling transfer fluid distributed throughout both chambers (21, 22) and capable of flowing from one chamber to the other ; and a beverage carbonator (35), located substantially in an upper zone (31) of the inner lower chamber (22).
    • 本发明涉及一种适用于饮料分配器系统的集成式芯体(18),包括一个包括一个外部上部腔室(21)和一个内部下部腔室(22)的多室冷却系统,内部下部腔室(22) 部分地位于上部外部腔室21内并且以这样一种方式相互连接以允许流体从上腔室(21)流向下腔室(22),反之亦然; 饮料输送装置(26,27,28,29,30)分布在整个上部室(21)中,能够通过所述上部室(21)输送待冷却的饮料; 分布在下腔室(22)的大致下部区域(32)的冷却装置(34); 冷却传递流体分布在两个室(21,22)中并且能够从一个室流到另一个室; 以及基本上位于所述内部下部腔室(22)的上部区域(31)中的饮料碳酸化器(35)。
    • 5. 发明申请
    • SALTS, SOLVATES, AND PHARMACEUTICAL COMPOSITIONS OF MACROCYCLIC GHRELIN RECEPTOR AGONISTS AND METHODS OF USING THE SAME
    • 大肠杆菌GHRELIN受体激动剂的盐,溶剂和药物组合物及其使用方法
    • WO2011041369A1
    • 2011-04-07
    • PCT/US2010/050661
    • 2010-09-29
    • TRANZYME PHARMA, INC.HOVEYDA, Hamid R.VEZINA, MartinFOURNIER, EricGAGNON, RenéBHERER, Patrick
    • HOVEYDA, Hamid R.VEZINA, MartinFOURNIER, EricGAGNON, RenéBHERER, Patrick
    • A61K31/352A61P1/00A61K31/395C07D269/00
    • C07D273/00A61K9/0019
    • The present invention provides novel salts and solvates of macrocyclic compounds that bind to and/or are functional agonists of the ghrelin (growth hormone secretagogue) receptor. The invention also relates to polymorphs of these salts and solvates, pharmaceutical compositions containing these salts or solvates, and methods of using the pharmaceutical compositions. These pharmaceutical compositions are useful as therapeutics for a range of disease indications, in particular, for treatment and prevention of gastrointestinal disorders including, but not limited to, postoperative ileus, gastroparesis, including diabetic and postsurgical gastroparesis, opioid bowel dysfunction, chronic intestinal pseudo-obstruction, short bowel syndrome, functional gastrointestinal disorders and gastrointestinal dysmotility, such as that occurring in conjunction with other disease states, in critical care situations or as a result of treatment with pharmaceutical agents. Additionally, the pharmaceutical compositions have application to the treatment and prevention of metabolic and/or endocrine disorders, cardiovascular disorders, central nervous system disorders, bone disorders, inflammatory disorders, hyperproliferative disorders, disorders characterized by apoptosis and genetic disorders.
    • 本发明提供与生长素释放肽(生长激素促分泌素)受体结合和/或是功能性激动剂的大环化合物的新型盐和溶剂化物。 本发明还涉及这些盐和溶剂合物的多晶型物,含有这些盐或溶剂化物的药物组合物,以及使用该药物组合物的方法。 这些药物组合物可用作一系列疾病适应症,特别是用于治疗和预防胃肠道疾病的治疗剂,包括但不限于术后肠梗阻,胃轻瘫,包括糖尿病和手术后胃轻瘫,阿片样物质肠功能障碍, 梗阻,短肠综合征,功能性胃肠道疾病和胃肠动力障碍,例如与其他疾病状态一起发生,在重症监护情况下或作为药物治疗的结果。 此外,药物组合物可用于治疗和预防代谢和/或内分泌疾病,心血管疾病,中枢神经系统疾病,骨骼疾病,炎症性疾病,过度增殖性疾病,以凋亡和遗传疾病为特征的疾病。