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1. 发明授权

US09931600B2 Compact interaction chamber with multiple cross micro impinging jets 有权
公开(公告)号：US09931600B2
公开(公告)日：2018-04-03
申请号：US14796160
申请日：2015-07-10
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Renqiang Xiong , John Michael Bernard
IPC分类号： B01F5/02 , B01F3/08 , B01F13/00
CPC分类号： B01F5/0256 , B01F3/0861 , B01F13/0059 , B01F2215/0032
摘要： A mixing assembly includes an inlet, an outlet and a mixing chamber, the inlet is fluidly connected to the outlet through a plurality of micro fluid flow paths in a direction perpendicular from the inlet. The micro fluid flow paths fluidly connect to the perpendicular inlet via a transition portion. The micro fluid flow paths are constructed radially inwardly to a concentration area in the mixing chamber. By directing multiple fluid flows to a concentrated area within the mixing chamber at high speeds, the energy dissipated at the point of collision is maximized, which helps to increase consistency and quality of mixing, and to reduce particle size of the fluid in the mixing chamber.

2. 发明授权

US11519512B2 High-pressure priming valve 有权
公开(公告)号：US11519512B2
公开(公告)日：2022-12-06
申请号：US17326667
申请日：2021-05-21
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Rachel Otte , Ahmad Shehata , Jocemar Ramina , Marco Catalani , David Harney , John Michael Bernard , Michael Ratigan , Harshit Kumar Patel
IPC分类号： F16K11/04 , F16K1/12 , F16K25/00 , F16K27/02 , F16K41/02 , F16K31/60 , F16K1/36 , F16K1/46
摘要： A new and innovative high-pressure priming valve is provided for use in high-pressure fluid systems that require a high level of fluid purity. The priming valve includes at least three ports, some of which are angled. The priming valve also includes a needle that variably blocks and unblocks a pathway to one of the ports between normal operation and a priming operation, respectively. The priming valve includes a sealing insert positioned below a stack of washers that maintain the needle's alignment in response to high fluid pressures exerted on the needle. The sealing insert helps prevent fluid from contacting the stack of washers, which helps prevent biological growth within the valve. The angled ports help facilitate priming valve drainage to further help prevent biological growth. By helping prevent biological growth, the sealing insert helps prevent fluid contamination and enables the priming valve to be utilized for high-purity fluid applications.

3. 发明授权

US10898869B2 Low holdup volume mixing chamber 有权
公开(公告)号：US10898869B2
公开(公告)日：2021-01-26
申请号：US16420718
申请日：2019-05-23
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Renqiang Xiong , John Michael Bernard
IPC分类号： B01F5/02 , B01F13/00
摘要： A compact interaction chamber is used to cause high shear, impact forces, and cavitation to reduce particle size and mix fluids while reducing waste and holdup volume. A first housing made of stainless steel holds an inlet mixing chamber element and an outlet mixing chamber element in a female bore using thermal expansion. The inlet and outlet mixing chamber elements are manufactured so that the diameter of the cooled female bore is slightly smaller than the diameter of the mixing chamber elements. The first housing is heated, expanding the diameter of the female bore enough to allow the inlet and outlet mixing chamber elements to be inserted. After the mixing chamber elements are inserted and aligned within the female bore, the first housing is allowed to cool. Once cooled, the female bore contracts and applies sufficient hoop stress to securely hold the mixing chamber elements during high shear force mixing.

4. 发明申请

US20210190052A1 HIGH-PRESSURE PUMP CONFIGURATION 有权
公开(公告)号：US20210190052A1
公开(公告)日：2021-06-24
申请号：US17127497
申请日：2020-12-18
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Yang SU , John Michael Bernard , Marco Catalani , David Harney , Jocemar Ramina , Michael Ratigan
IPC分类号： F04B19/04 , F04B53/14 , F16J15/3204
摘要： The present application provides new and innovative high-pressure fluid systems for preventing seal burning due to gas auto-ignition. The provided systems include an o-ring disposed within a seal cavity of a cup seal to decrease the dead volume in the seal cavity. By reducing the dead volume, the o-ring decreases the volume of gas that is able to accumulate and thus helps prevent the gas from auto-igniting as the gas is compressed. By preventing the gas from auto-igniting, the provided system helps prevent seal burning, which helps prevent premature cup seal failure and prevent fluid contamination.

5. 发明申请

US20150336060A1 COMPACT INTERACTION CHAMBER WITH MULTIPLE CROSS MICRO IMPINGING JETS 有权
标题翻译：具有多个交叉微型冲击喷嘴的紧凑型相互作用室
公开(公告)号：US20150336060A1
公开(公告)日：2015-11-26
申请号：US14796160
申请日：2015-07-10
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Renqiang Xiong , John Michael Bernard
IPC分类号： B01F5/02 , B01F3/08
CPC分类号： B01F5/0256 , B01F3/0861 , B01F13/0059 , B01F2215/0032
摘要： A mixing assembly includes an inlet, an outlet and a mixing chamber, the inlet is fluidly connected to the outlet through a plurality of micro fluid flow paths in a direction perpendicular from the inlet. The micro fluid flow paths fluidly connect to the perpendicular inlet via a transition portion. The micro fluid flow paths are constructed radially inwardly to a concentration area in the mixing chamber. By directing multiple fluid flows to a concentrated area within the mixing chamber at high speeds, the energy dissipated at the point of collision is maximized, which helps to increase consistency and quality of mixing, and to reduce particle size of the fluid in the mixing chamber.
摘要翻译：混合组件包括入口，出口和混合室，入口通过多个微流体流动路径在与入口垂直的方向上流体地连接到出口。微流体流动路径经由过渡部分流体地连接到垂直入口。微流体流路径向向内构成混合室中的浓度区域。通过将多个流体流以高速将多个流体流引导到混合室内的集中区域，在碰撞点消散的能量最大化，这有助于提高混合的一致性和质量，并且减小混合室中的流体的粒径。

6. 发明公开

US20230321616A1 HIGH-PRESSURE FLUID PROCESSING DEVICE CONFIGURED FOR BATCH PROCESSING 审中-公开
公开(公告)号：US20230321616A1
公开(公告)日：2023-10-12
申请号：US18210952
申请日：2023-06-16
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Michael P. Ratigan , David G. Harney , John Michael Bernard
IPC分类号： B01F25/50 , B02C23/18 , B02C23/36 , B02C23/22 , F04B49/08 , F04B49/22 , F04B15/02 , B01F33/83 , B01F35/21 , B01F35/22 , B02C25/00
CPC分类号： B01F25/50 , B02C23/18 , B02C23/36 , B02C23/22 , F04B49/08 , F04B49/22 , F04B15/02 , B01F33/83 , B01F35/2113 , B01F35/2115 , B01F35/2209 , B02C25/00 , F04B43/04
摘要： The present disclosure provides apparatuses and methods related to a high pressure processing device that is configured to simplify batch processing. In an embodiment, a high pressure processing device includes a processing module configured to reduce a particle size of a material or achieve a desired liquid processing result for the material, a pump configured to pump the material to an inlet of the processing module, a recirculation pathway configured to recirculate the material from an outlet of the processing module back to the pump, an input device configured to receive at least one user input variable, and a controller configured to (i) determine a number of pump strokes for the pump based on the user input variable, and (ii) control the pump according to the determined number of pump strokes so that the material makes a plurality of passes through the processing module.

7. 发明授权

US10933428B2 High-pressure fluid processing device configured for batch processing 有权
公开(公告)号：US10933428B2
公开(公告)日：2021-03-02
申请号：US15457117
申请日：2017-03-13
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Michael P. Ratigan , David G. Harney , John Michael Bernard
IPC分类号： B02C25/00 , B01F5/10 , B01F13/10 , B01F15/00 , B02C23/18 , B02C23/36 , B02C23/22 , F04B49/08 , F04B49/22 , F04B15/02 , F04B43/04 , F04B9/10 , F04B43/12 , F04B17/03 , F04B43/06
摘要： The present disclosure provides apparatuses and methods related to a high pressure processing device that is configured to simplify batch processing. In an embodiment, a high pressure processing device includes a processing module configured to reduce a particle size of a material or achieve a desired liquid processing result for the material, a pump configured to pump the material to an inlet of the processing module, a recirculation pathway configured to recirculate the material from an outlet of the processing module back to the pump, an input device configured to receive at least one user input variable, and a controller configured to (i) determine a number of pump strokes for the pump based on the user input variable, and (ii) control the pump according to the determined number of pump strokes so that the material makes a plurality of passes through the processing module.

8. 发明申请

US20190299171A1 LOW HOLDUP VOLUME MIXING CHAMBER 审中-公开
公开(公告)号：US20190299171A1
公开(公告)日：2019-10-03
申请号：US16420718
申请日：2019-05-23
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Renqiang Xiong , John Michael Bernard
IPC分类号： B01F5/02 , B01F13/00
摘要： A compact interaction chamber is used to cause high shear, impact forces, and cavitation to reduce particle size and mix fluids while reducing waste and holdup volume. A first housing made of stainless steel holds an inlet mixing chamber element and an outlet mixing chamber element in a female bore using thermal expansion. The inlet and outlet mixing chamber elements are manufactured so that the diameter of the cooled female bore is slightly smaller than the diameter of the mixing chamber elements. The first housing is heated, expanding the diameter of the female bore enough to allow the inlet and outlet mixing chamber elements to be inserted. After the mixing chamber elements are inserted and aligned within the female bore, the first housing is allowed to cool. Once cooled, the female bore contracts and applies sufficient hoop stress to securely hold the mixing chamber elements during high shear force mixing.

9. 发明申请

US20150336061A1 INTERACTION CHAMBER WITH FLOW INLET OPTIMIZATION 有权
标题翻译：相互作用的室与流入口优化
公开(公告)号：US20150336061A1
公开(公告)日：2015-11-26
申请号：US14800166
申请日：2015-07-15
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Renqiang Xiong , John Michael Bernard
IPC分类号： B01F5/02 , B01F3/08
CPC分类号： B01F5/0256 , B01F3/0865 , B01F13/0059 , B01F2215/0032
摘要： A mixing assembly includes an inlet, an outlet and a mixing chamber, the inlet is fluidly connected to the outlet through a plurality of micro fluid flow paths in a direction perpendicular from the inlet. The micro fluid flow paths fluidly connect to the perpendicular inlet via a curved transition portion. The curved transition portion provides a more efficient flow path for the fluid to travel from the inlet to the micro fluid flow paths to the mixing chamber. By transitioning the direction change, flow resistance is decreased, and the fluid flow rate and shear rate is increased. Increased fluid flow rate and shear rate helps to increase consistency and quality of mixing, and to reduce particle size of the fluid in the mixing chamber.
摘要翻译：混合组件包括入口，出口和混合室，入口通过多个微流体流动路径在与入口垂直的方向上流体地连接到出口。微流体流动路径经由弯曲的过渡部分流体地连接到垂直入口。弯曲的过渡部分提供了一种更有效的流动路径，用于流体从入口到微流体流动路径行进到混合室。通过转变方向变化，流阻减小，流体流速和剪切速率增加。增加的流体流速和剪切速率有助于提高混合的一致性和质量，并减少混合室中的流体的粒径。

10. 发明授权

US11679363B2 High-pressure fluid processing device configured for batch processing 有权
公开(公告)号：US11679363B2
公开(公告)日：2023-06-20
申请号：US17188345
申请日：2021-03-01
申请人： MICROFLUIDICS INTERNATIONAL CORPORATION
发明人： Michael P. Ratigan , David G. Harney , John Michael Bernard
IPC分类号： B02C23/22 , B01F33/83 , B02C25/00 , B01F25/50 , B02C23/18 , B02C23/36 , F04B49/08 , F04B49/22 , F04B15/02 , B01F35/21 , B01F35/22 , F04B43/04 , F04B9/10 , F04B43/12 , F04B17/03 , F04B43/06 , F04B43/14 , B01F33/80
CPC分类号： B01F25/50 , B01F33/83 , B01F35/2113 , B01F35/2115 , B01F35/2209 , B02C23/18 , B02C23/22 , B02C23/36 , B02C25/00 , F04B15/02 , F04B49/08 , F04B49/22 , B01F33/8361 , F04B9/10 , F04B17/03 , F04B43/04 , F04B43/06 , F04B43/1238 , F04B43/14 , F04B2205/09 , F04B2205/10 , F04B2205/11
摘要： The present disclosure provides apparatuses and methods related to a high pressure processing device that is configured to simplify batch processing. In an embodiment, a high pressure processing device includes a processing module configured to reduce a particle size of a material or achieve a desired liquid processing result for the material, a pump configured to pump the material to an inlet of the processing module, a recirculation pathway configured to recirculate the material from an outlet of the processing module back to the pump, an input device configured to receive at least one user input variable, and a controller configured to (i) determine a number of pump strokes for the pump based on the user input variable, and (ii) control the pump according to the determined number of pump strokes so that the material makes a plurality of passes through the processing module.

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