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    • 6. 发明申请
    • METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS
    • 用于治疗胃肠疾病的方法和组合物
    • WO2008002971A3
    • 2008-08-28
    • PCT/US2007072223
    • 2007-06-27
    • MICROBIA INCCURRIE MARK GZIMMER DANIEL P
    • CURRIE MARK GZIMMER DANIEL P
    • A01N37/18A61K38/00
    • C07K14/4705A61K38/00
    • Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders and disorders and conditions associated with excess fluid and/or salt retention as well as other conditions and disorders are described. The compositions feature polypeptides that activate the guanylate cyclase C (GC-C) receptor.
    • (例如胃肠动力障碍,功能性胃肠病症,胃食管反流病(GERD),十二指肠胃反流,克罗恩氏病,溃疡性结肠炎,炎性肠病,功能性胃灼热,消化不良(包括胃肠动力障碍, 功能性消化不良或非溃疡性消化不良),胃轻瘫,慢性肠假性梗阻(或结肠假梗阻),与便秘相关的病症和病症,例如与使用阿片剂止痛药有关的便秘,手术后便秘和与神经病性病症相关的便秘; 描述了与过量的液体和/或盐潴留以及其他病症和病症相关的病症和病症。所述组合物的特征在于活化鸟苷酸环化酶C(GC-C)受体的多肽。