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1. 发明申请

WO2008122115A1 INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译： HISTONE DEACETYLASE的抑制剂
公开(公告)号：WO2008122115A1
公开(公告)日：2008-10-16
申请号：PCT/CA2008/000631
申请日：2008-04-09
申请人： METHYLGENE INC. , TESSIER, Pierre , LEIT, Silvana , SMIL, David , DÉZIEL, Robert , AJAMIAN, Alain , CHANTIGNY, Yves, Andre , DOMINGUEZ, Celia
发明人： TESSIER, Pierre , LEIT, Silvana , SMIL, David , DÉZIEL, Robert , AJAMIAN, Alain , CHANTIGNY, Yves, Andre , DOMINGUEZ, Celia
IPC分类号： C07C259/06 , A61K31/16 , A61K31/18 , A61K31/33 , C07C311/19 , C07C323/50 , C07D521/00
CPC分类号： C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/088 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
摘要翻译：本发明涉及抑制组蛋白脱乙酰酶的化合物。更具体地，本发明提供式（I）的式化合物及其N-氧化物，水合物，溶剂合物，药学上可接受的盐，前体药物和复合物的化合物及其外消旋和可饱和的混合物，非对映异构体和对映异构体，其中基团L， M，X和Y如本文所定义。

2. 发明申请

WO2006102760A1 INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译： HISTONE DEACETYLASE的抑制剂
公开(公告)号：WO2006102760A1
公开(公告)日：2006-10-05
申请号：PCT/CA2006/000483
申请日：2006-03-31
申请人： METHYLGENE INC. , LEIT DE MORADEI, Silvana, Marcela , TESSIER, Pierre , SMIL, David , WAHHAB, Amal , DÉZIEL, Robert , MANKU, Sukhdev , MANCUSO, John , THERRIEN, Eric , ALLAN, Martin , CHANTIGNY, Yves, Andre , AJAMIAN, Alain , BEAULIEU, Patrick
发明人： LEIT DE MORADEI, Silvana, Marcela , TESSIER, Pierre , SMIL, David , WAHHAB, Amal , DÉZIEL, Robert , MANKU, Sukhdev , MANCUSO, John , THERRIEN, Eric , ALLAN, Martin , CHANTIGNY, Yves, Andre , AJAMIAN, Alain , BEAULIEU, Patrick
IPC分类号： C07D417/04 , A61K31/18 , A61K31/166 , A61K31/195 , A61K31/34 , A61K31/404 , A61K31/4184 , A61K31/4192 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/495 , A61K31/505 , C07C237/38 , C07C311/21 , C07C323/33 , C07C323/60 , C07D207/16 , C07D209/30 , C07D209/42 , C07D211/22 , C07D215/38 , C07D217/12 , C07D235/04 , C07D239/08 , C07D241/40 , C07D277/82 , C07D285/12 , C07D317/46 , C07D319/14 , C07D333/32 , C07D403/06 , C07D409/06 , C07D413/04
CPC分类号： C07D209/14 , C07C237/22 , C07C309/51 , C07C311/13 , C07C311/29 , C07C311/46 , C07C311/51 , C07C311/59 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/60 , C07C2601/14 , C07C2603/32 , C07D209/42 , C07D209/46 , C07D213/30 , C07D213/32 , C07D213/40 , C07D213/70 , C07D213/89 , C07D215/40 , C07D235/14 , C07D239/38 , C07D241/52 , C07D277/82 , C07D285/12 , C07D285/135 , C07D295/185 , C07D307/42 , C07D307/81 , C07D317/58 , C07D333/16 , C07D333/24 , C07D333/34 , C07D401/06 , C07D405/12 , C07D409/06 , C07D409/12
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I); wherein Y, L, Z, W, X, Q, R 1 , R 2 and R 3 are as defined in the specification.
摘要翻译：本发明涉及抑制组蛋白脱乙酰酶的化合物。更具体地，本发明提供式（I）的化合物; 其中Y，L，Z，W，X，Q，R 1，R 2和R 3均如说明书中所定义。

3. 发明申请

WO2009055917A1 INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译： HISTONE DEACETYLASE的抑制剂
公开(公告)号：WO2009055917A1
公开(公告)日：2009-05-07
申请号：PCT/CA2008/001911
申请日：2008-11-03
申请人： METHYLGENE INC. , MALLAIS, Tammy , MORADEI, Oscar , AJAMIAN, Alain , TESSIER, Pierre , SMIL, David , FRECHETTE, Sylvie , MACHAALANI, Roger , LEIT, Silvana , BEAULIEU, Patrick , DÉZIEL, Robert , MANCUSO, John
发明人： MALLAIS, Tammy , MORADEI, Oscar , AJAMIAN, Alain , TESSIER, Pierre , SMIL, David , FRECHETTE, Sylvie , MACHAALANI, Roger , LEIT, Silvana , BEAULIEU, Patrick , DÉZIEL, Robert , MANCUSO, John
IPC分类号： C07D333/38 , A61K31/16 , A61K31/381 , A61K31/415 , C07C259/10 , C07C311/16 , C07D231/14 , C07D267/18 , C07D277/56 , C07D333/20 , C07D333/70 , C07D413/04 , C07D513/04
CPC分类号： C07D277/593 , C07C259/10 , C07C311/29 , C07D207/327 , C07D207/34 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/14 , C07D235/18 , C07D239/28 , C07D239/38 , C07D261/18 , C07D263/34 , C07D267/20 , C07D277/30 , C07D277/64 , C07D307/85 , C07D307/91 , C07D317/60 , C07D333/24 , C07D333/38 , C07D401/04 , C07D403/10 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： ABSTRACT OF THE DISCLOSURE This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
摘要翻译：本发明的摘要本发明涉及抑制HDAC酶活性的化合物和方法。更具体地，本发明提供式（I），（I）和N-氧化物，水合物，溶剂合物，药学上可接受的盐，前药和络合物的化合物，以及外消旋和可比混合物，非对映异构体和对映异构体，其中L，M ，n，R，W，X和Y如说明书中所定义。

4. 发明申请

WO2009026717A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY 审中-公开
标题翻译：蛋白酪氨酸激酶活性的抑制剂
公开(公告)号：WO2009026717A1
公开(公告)日：2009-03-05
申请号：PCT/CA2008/001538
申请日：2008-08-28
申请人： METHYLGENE INC. , CLARIDGE, Stephen William , ISAKOVIC, Ljubomir , MANNION, Michael , RAEPPEL, Stéphane , SAAVEDRA, Oscar Mario , GAUDETTE, Frédéric , ZHAN, Lijie , ZHOU, Nancy Z. , RAEPPEL, Franck , DÉZIEL, Robert , VAISBURG, Arkadii , UNO, Tetsuyuki
发明人： CLARIDGE, Stephen William , ISAKOVIC, Ljubomir , MANNION, Michael , RAEPPEL, Stéphane , SAAVEDRA, Oscar Mario , GAUDETTE, Frédéric , ZHAN, Lijie , ZHOU, Nancy Z. , RAEPPEL, Franck , DÉZIEL, Robert , VAISBURG, Arkadii , UNO, Tetsuyuki
IPC分类号： C07D495/04 , A61K31/00 , A61K31/4365 , A61P27/02 , A61P35/00 , A61P9/00
CPC分类号： C07D495/04
摘要： The invention relates to compounds of Formula (I) and their use for inhibiting protein tyrosine kinase activity In Formula (I), the group M is thieno[3,2,b]pyridinyl as shown, and the group D is a ring or ring system, and the groups Z, Ar, and G are as defined herein The invention relates particularly to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signalling, for example, the inhibition of VEGF receptor signalling and HGF receptor signalling The invention also provides compositions and methods for treating cell proliferative diseases and conditions, such as cancer, and for treating ophthalmic diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR).
摘要翻译：本发明涉及式（I）化合物及其抑制蛋白质酪氨酸激酶活性的用途。在式（I）中，M基团如噻吩并[3,2，b]吡啶基，组D为环或环系统，并且基团Z，Ar和G如本文所定义。本发明特别涉及抑制生长因子受体的蛋白酪氨酸激酶活性的化合物，导致受体信号传导的抑制，例如VEGF受体信号传导的抑制和HGF受体信号传导本发明还提供用于治疗细胞增殖性疾病和病症如癌症的组合物和方法，以及用于治疗眼科疾病，包括年龄相关性黄斑变性（AMD）和糖尿病性视网膜病变（DR）的组合物和方法。

5. 发明申请

WO2003080612A1 DIPYRIDODIAZEPINONES AS REVERSE TRANSCRIPTASE INHIBITORS 审中-公开
标题翻译： DIPYRIDODIAZEPINONES作为反向转录酶抑制剂
公开(公告)号：WO2003080612A1
公开(公告)日：2003-10-02
申请号：PCT/CA2003/000418
申请日：2003-03-24
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , O'MEARA, Jeffrey , SIMONEAU, Bruno , YOAKIM, Christiane , DÉZIEL, Robert , OGILVIE, William, W.
发明人： O'MEARA, Jeffrey , SIMONEAU, Bruno , YOAKIM, Christiane , DÉZIEL, Robert , OGILVIE, William, W.
IPC分类号： C07D471/14
CPC分类号： A61K31/55 , C07D471/14
摘要： Disclosed are compounds of formula I:whereinR2 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, NH(C1-4alkyl) or N(C1-4alkyl)2;R4 is H or CH3;R5 is H or CH3;R12 is H, halogen, (C1-4)alkyl, CF3, or NO2; R13 is H, (C1-4)alkyl, halogen, OH, or NH2, with the proviso that R12 and R13 are not both H; andR14 is COOR14a wherein R14a is H or (C1-6)alkyl; or R14 is (C2-4)alkenyl-COOR14a wherein R14a is as defined herein; or R14 is (C1-4)alkyl-COOR14a wherein R14a is as defined above;or a salt or a prodrug thereof, useful as inhibitors of HIV reverse transcriptase.
摘要翻译：公开了式I的化合物：其中R2是H，卤素，（C1-4）烷基，O（C1-4）烷基，NH（C1-4烷基）或N（C1-4烷基）2; R4是H或CH3; R5 是H或CH 3; R 12是H，卤素，（C 1-4）烷基，CF 3或NO 2; R 13是H，（C 1-4）烷基，卤素，OH或NH 2，条件是R 12和R 13不同时为H; R14是COOR14a，其中R14a是H或（C1-6）烷基; 或R 14为（C 2-4）烯基-COOR 14a，其中R 14a如本文所定义; 或R14是（C 1-4）烷基-COOR14a，其中R14a如上定义;或其盐或其前药，可用作HIV逆转录酶的抑制剂。

6. 发明申请

WO2003011862A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 审中-公开
标题翻译：非核苷酸逆转录酶抑制剂
公开(公告)号：WO2003011862A1
公开(公告)日：2003-02-13
申请号：PCT/CA2002/001161
申请日：2002-07-26
申请人： BOEHRINGER INGELHEIM (CANADA) LTD. , OGILVIE, William, W. , DÉZIEL, Robert , O'MEARA, Jeffrey , SIMONEAU, Bruno
发明人： OGILVIE, William, W. , DÉZIEL, Robert , O'MEARA, Jeffrey , SIMONEAU, Bruno
IPC分类号： C07D471/14
CPC分类号： C07D471/14
摘要： Provided are compounds represented by formula (I):wherein R 2 is H, halogen, NHNH 2 , (C 1-4 )alkyl, O(C 1-6 )alkyl, and haloalkyl; R 4 is H or Me; R 5 is H or (C 1-4 )alkyl; R 11 is (C 1-4 )alkyl, (C 1-4 )alkyl(C 3-7 )cycloalkyl, or (C 3-7 )cycloalkyl; and Q is naphthyl, fused phenyl(C 4-7 )cycloalkyl and fused phenyl-5, 6, or 7-membered saturated heterocycle having one to two heteroatom selected from O, N, or S, said Q being substituted with from 1 to 4 R 12 substituents selected from: R 13 , (C 1-6 )alkyl, (C 3-7 )cycloalkyl, or (C 2-6 )alkenyl, said alkyl, cycloalkyl, or alkenyl being optionally substituted with R 13 ; or a salt thereof. Compounds represented by formula I have inhibitory activity against Wild Type, single and double mutant strains of HIV.
摘要翻译：提供由式（I）表示的化合物：其中R 2是H，卤素，NHNH 2，（C 1-4）烷基，O（C 1-6）烷基和卤代烷基; R 4是H或Me; R 5是H或（C 1-4）烷基; R 11是（C 1-4）烷基，（C 1-4）烷基（C 3-7）环烷基或（C 3-7）环烷基; 且Q为萘基，稠合苯基（C4-7）环烷基和稠合苯基-5,6或7元饱和杂环，其具有一至二个选自O，N或S的杂原子，所述Q被1至4个取代 R 12取代基选自：R 13，（C 1-6）烷基，（C 3-7）环烷基或（C 2-6）烯基，所述烷基，环烷基或烯基任选被R 13取代， ; 或其盐。由式I表示的化合物具有针对野生型，HIV和HIV双突变株的抑制活性。

7. 发明申请

WO2004026875A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 审中-公开
标题翻译：非核苷酸逆转录酶抑制剂
公开(公告)号：WO2004026875A1
公开(公告)日：2004-04-01
申请号：PCT/CA2003/001410
申请日：2003-09-15
申请人： BOEHRINGER INGELHEIM (CANADA) LTD. , YOAKIM, Christiane , O'MEARA, Jeffrey , SIMONEAU, Bruno , OGILVIE, William, W. , DÉZIEL, Robert
发明人： YOAKIM, Christiane , O'MEARA, Jeffrey , SIMONEAU, Bruno , OGILVIE, William, W. , DÉZIEL, Robert
IPC分类号： C07D471/22
CPC分类号： C07D471/22
摘要： Compounds represented by formula (1), wherein R 1 is H, halogen, (C 1-4 )alkyl, O(C 1-4 )alkyl, and haloalkyl; R 2 is H or methyl; R 3 is H or (C 1-4 )alkyl; R 4 is H or (C 1-4 )alkyl; R 5 is (C 1-4 )alkyl, (C 1-4 )alkyl(C 3-7 )cyclo-alkyl or (C 3-7 )cycloalkyl; and W is a fused phenyl-5 or 6-membered heterocycle having one or two heteroatoms selected from N or S; or W is phenyl, 1,1'-biphenyl, 2, 3-dihydro-1 H -indene, 1, 2, 3, 4-tetrahydronaphthyl, or naphthyl; said W being optionally substituted with (C 1-4 )alkyl, which in turn can be optionally substituted with a carboxy or (C 1-4 )alkoxycarbonyl, or a salt or ester thereof. The compounds have inhibitory activity against Wild Type, single and double mutant strains of HIV.
摘要翻译：由式（1）表示的化合物，其中R 1是H，卤素，（C 1-4）烷基，O（C 1-4）烷基和卤代烷基; R 2是H或甲基; R 3是H或（C 1-4）烷基; R 4是H或（C 1-4）烷基; R 5为（C 1-4）烷基，（C 1-4）烷基（C 3-7）环烷基或（C 3-7）环烷基; W是具有一个或两个选自N或S的杂原子的稠合苯基-5或6元杂环; 或W是苯基，1,1'-联苯基，2,3-二氢-1H-茚，1,2,3,4-四氢萘基或萘基; 所述W任选被（C 1-4）烷基取代，其又可任选地被羧基或（C 1-4）烷氧羰基或其盐或酯取代。该化合物对野生型，单突变和双突变株具有抑制活性。

8. 发明申请

WO2002076982A2 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 审中-公开
标题翻译：非核苷反义转录酶抑制剂
公开(公告)号：WO2002076982A2
公开(公告)日：2002-10-03
申请号：PCT/CA2002/000385
申请日：2002-03-21
申请人： BOEHRINGER INGELHEIM (CANADA) LTD. , OGILVIE, William, W. , DÉZIEL, Robert , NAUD, Julie , O'MEARA, Jeffrey
发明人： OGILVIE, William, W. , DÉZIEL, Robert , NAUD, Julie , O'MEARA, Jeffrey
IPC分类号： C07D471/00
CPC分类号： C07D471/14
摘要： A compound of formula I:wherein A is a connecting chain of (C 1-3 ) alkyl; B is O or S; R 1 is H, (C 1-6 ) alkyl, halo, CF 3 , or OR 1a wherein R 1a is H or (C 1-6 )alkyl; R 2 is H or Me; R 3 is H or Me; R 4 is H, (C 1-4 ) alkyl, (C 3-4 ) cycloalkyl and (C 1-4 )alkyl(C 3-7 )cycloalkyl; W is selected form formula (i), (ii) or (iii) wherein, a) one of Y is SO 2 and the other Y is NR 5 , provided that both are not the same, wherein R 5 is H, (C 1-6 )alkyl,(C 3-6 ) cycloalkyl, the alkyl being substituted, COR 5o , COOR 5p or CONR 5p R 5q ; and each R 8 is H, (C 1-4 ) alkyl, (C 3-6 ) cycloalkyl, or (C 1-4 ) alkyl-(C 3-6 ) cycloalkyl; or b) E is CR 8a R 8b wherein R 8a and R 8b is H, or alkyl and J is CH 2 ; or J is CR 8a R 8b and E is CH 2 , and the dotted line represents a single bond; or c) E is C(O) and J is CR 8a R 8b or J is C(O) and E is CR 8a R 8b and the dotted line represents a single bond; or d) E and J are CR 8a R 8b and the dotted line represents a double bond. Compounds of formula I have activity against HIV WT and double mutant strains.
摘要翻译：式I化合物：其中A是（C 1-3烷基）的连接链; B是O或S; R 1是H，（C 1-6烷基），卤素，CF 3或OR 1a，其中 R1a是H或（C1-6）烷基; R 2是H或Me; R 3是H或Me; R 4是H，（C 1-4）烷基，（C 3-4）环烷基和（C 1-4））烷基（C <子> 3-7 ）环烷基; W选自式（i），（ii）或（iii），其中a）Y是SO 2中的一个且另一个Y是NR 5，条件是两者不相同，其中R 5是H，（C 1-6烷基），（C 3-6 - ）环烷基，烷基被取代的COR 5，COOR 5P或CONR 5P 5 R 5; 和每个R 8是H，（C 1-4烷基），（C 3-6）环烷基或（C 1-4烷基） 1-4）烷基 - （C 3-6 - ）环烷基; 或b）E为CR 8a R 8b其中R 8a和R 8b为H或烷基和J 是CH _{2 ; 或J是CR 8a R 8b和E是CH 2 2，虚线代表单键; 或c）E为C（O）且J为CR 8a R 8b或J为C（O）且E为CR 8a R 并且虚线表示单键;并且虚线表示单键。或d）E和J是CR 8a R 8b并且虚线表示双键。式I化合物具有抗HIV WT和双突变株的活性。}

9. 发明授权

EP2139850B1 INHIBITORS OF HISTONE DEACETYLASE 有权
公开(公告)号：EP2139850B1
公开(公告)日：2018-09-12
申请号：EP08748100.8
申请日：2008-04-09
申请人： MethylGene Inc.
发明人： TESSIER, Pierre , LEIT, Silvana , SMIL, David , DÉZIEL, Robert , AJAMIAN, Alain , CHANTIGNY, Yves, Andre , DOMINGUEZ, Celia
IPC分类号： C07C259/06 , A61K31/16 , A61K31/18 , A61K31/33 , C07C311/19 , C07C323/50 , C07D521/00 , A61P35/00
CPC分类号： C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/088 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.

10. 发明公开

EP2217588A1 INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译： HISTONE DEACETYLASE的抑制剂
公开(公告)号：EP2217588A1
公开(公告)日：2010-08-18
申请号：EP08845130.7
申请日：2008-11-03
申请人： Methylgene, Inc.
发明人： MALLAIS, Tammy , MORADEI, Oscar , AJAMIAN, Alain , TESSIER, Pierre , SMIL, David , FRECHETTE, Sylvie , MACHAALANI, Roger , LEIT, Silvana , BEAULIEU, Patrick , DÉZIEL, Robert , MANCUSO, John
IPC分类号： C07D333/38 , A61K31/16 , A61K31/381 , A61K31/415 , C07C259/10 , C07C311/16 , C07D231/14 , C07D267/18 , C07D277/56 , C07D333/20 , C07D333/70 , C07D413/04 , C07D513/04
CPC分类号： C07D277/593 , C07C259/10 , C07C311/29 , C07D207/327 , C07D207/34 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/14 , C07D235/18 , C07D239/28 , C07D239/38 , C07D261/18 , C07D263/34 , C07D267/20 , C07D277/30 , C07D277/64 , C07D307/85 , C07D307/91 , C07D317/60 , C07D333/24 , C07D333/38 , C07D401/04 , C07D403/10 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
摘要翻译：本发明涉及用于抑制HDAC酶活性的化合物和方法。更具体地说，本发明提供了式（I），（I）化合物和其N-氧化物，水合物，溶剂合物，药学上可接受的盐，前药和复合物，以及其外消旋和局部混合物，非对映异构体和对映异构体，其中L，M ，n，R，W，X和Y如说明书中所定义。

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