专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

AU2007234843B2 Inhibitors of histone deacetylase 未知
公开(公告)号：AU2007234843B2
公开(公告)日：2013-07-11
申请号：AU2007234843
申请日：2007-04-05
申请人： METHYLGENE INC
发明人： MALLAIS TAMMY , VAISBURG ARKADII , ROY SIMON , MORADEI OSCAR , DEZIEL ROBERT , MANCUSO JOHN , MACHAALANI ROGER , PAQUIN ISABELLE , TESSIER PIERRE , LEIT SILVANA , FRECHETTE SYLVIE , BESTERMAN JEFFREY M , SMIL DAVID
IPC分类号： C07D207/32 , C07D213/40 , C07D213/56 , C07D213/61 , C07D295/14 , C07D307/52 , C07D317/58 , C07D333/28 , C07D333/36 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds which are derivatives of benzamide and suitable in methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions .

2. 发明专利

AU2007234843A1 Inhibitors of histone deacetylase 未知
公开(公告)号：AU2007234843A1
公开(公告)日：2007-10-18
申请号：AU2007234843
申请日：2007-04-05
申请人： METHYLGENE INC
发明人： ROY SIMON , FRECHETTE SYLVIE , MACHAALANI ROGER , MORADEI OSCAR , MANCUSO JOHN , LEIT SILVANA , DEZIEL ROBERT , MALLAIS TAMMY , TESSIER PIERRE , PAQUIN ISABELLE , SMIL DAVID , VAISBURG ARKADII , BESTERMAN JEFFREY M
IPC分类号： C07D207/32 , C07D213/40 , C07D213/56 , C07D213/61 , C07D295/14 , C07D307/52 , C07D317/58 , C07D333/28 , C07D333/36 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

3. 发明专利

CA2680467C INHIBITORS OF HISTONE DEACETYLASE 未知
公开(公告)号：CA2680467C
公开(公告)日：2016-11-08
申请号：CA2680467
申请日：2008-03-12
申请人： METHYLGENE INC
发明人： FRECHETTE SYLVIE , ISAKOVIC LUBO , PAQUIN ISABELLE , ROY SIMON , VAISBURG ARKADII , MORADEI OSCAR
IPC分类号： C07D207/14 , A61K31/40 , A61K31/4025 , A61K31/4439 , A61K31/5377 , A61P35/00 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions. One aspect of the invention provides compounds of formula (1): (1), in which T, A and X are as described herein.

4. 发明专利

HK1126769A1 BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE 未知
公开(公告)号：HK1126769A1
公开(公告)日：2009-09-11
申请号：HK09105802
申请日：2009-06-29
申请人： METHYLGENE INC
发明人： MORADEI OSCAR , PAQUIN ISABELLE , FRECHETTE SYLVIE , MALLAIS TAMMY , ROY SIMON , MACHAALANI ROGER , VAISBURG ARKADII , BESTERMAN JEFFREY M , TESSIER PIERRE , MANCUSO JOHN , SMIL DAVID , LEIT SILVANA , DEZIEL ROBERT
IPC分类号： C07D20060101
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

5. 发明专利

CA2680467A1 INHIBITORS OF HISTONE DEACETYLASE 未知
公开(公告)号：CA2680467A1
公开(公告)日：2008-09-18
申请号：CA2680467
申请日：2008-03-12
申请人： METHYLGENE INC
发明人： PAQUIN ISABELLE , MORADEL OSCAR , ROY SIMON , VAISBURG ARKADII , ISAKOVIC LUBO , FRECHETTE SYLVIE
IPC分类号： C07D207/14 , A61K31/40 , A61K31/4025 , A61K31/4439 , A61K31/5377 , A61P35/00 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12
摘要： The invention relates to the inhibition of histone deacetylase. The inven tion provides compounds and methods for inhibiting histone deacetylase enzym atic activity. The invention also provides compositions and methods for trea ting cell proliferative diseases and conditions. One aspect of the invention provides compounds of formula (1): (1), in which T, A and X are as describe d herein.

6. 发明专利

ES2452820T3 Derivados de benzamida como inhibidores de histona desacetilasa 未知
公开(公告)号：ES2452820T3
公开(公告)日：2014-04-02
申请号：ES07760170
申请日：2007-04-05
申请人： METHYLGENE INC
发明人： MORADEI OSCAR , PAQUIN ISABELLE , FRECHETTE SYLVIE , MALLAIS TAMMY , ROY SIMON , MACHAALANI ROGER , VAISBURG ARKADII , BESTERMAN JEFFREY M , TESSIER PIERRE , MANCUSO JOHN , SMIL DAVID , LEIT SILVANA , DEZIEL ROBERT
IPC分类号： C07D207/32 , C07D213/40 , C07D213/56 , C07D213/61 , C07D295/14 , C07D307/52 , C07D317/58 , C07D333/28 , C07D333/36 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compuesto de fórmula IK:**Fórmula** y N-óxidos, hidratos, solvatos, sales farmacéuticamente aceptables o complejos del mismo y mezclas racémicas yescalémicas, diastereómeros y enantiómeros del mismo, en la que X es arilo opcionalmente sustituido con uno, doso tres hidroxilo, -O-alquilo C1-C3, amino, -NR3R4, -CN, -CF3, -alquilo C1-C4, -S(O)0-2R5,-O-CF3 o halo seleccionadosindependientemente, Y es -NH2 u -OH; Ra es H o F; Z es fenilo, heteroarilo, heterociclilo o cicloalquilo; R es R9-(alquil C0-6)N-C(O)-N(H)-(CH2)t-, alquil C0-6-S(O)2-N(H)-fenil-C(O)-N(H)-(CH2)t-, R9-O-C(O)-N(H)-(CH2)t- o R9-O-C(O)-(CH2)t- en el que t es 0-2; y R9 es R10-alquil-C0-C2-, en el que R10 es arilo, heterociclilo o heteroarilo de 5 ó 6 miembros o N(X1)(X2)-alquil C0-3-, y en el que X1 y X2 son independientemente H, alquilo C1-C4 o heteroarilo de 5 ó 6 miembros, siempre que cuando R10es heterociclilo unido a través de los átomos de N, entonces R9 es R10-C2-alquil-; y en el que R3 y R4 se seleccionan independientemente del grupo que consiste en -alquil C2-C3-OR5, -C(O)-arilo, -alcoxi C1-C3-alquilo C1-C3, -alquil C2-C3-O-alquilo C1-C3, -alquil C2-C3-NR5R6,-CH2-C(CH3)2-NR5R6, en los que arilo y heteroariloestán opcionalmente sustituidos con uno, dos o tres amino, metoxilo, hidroxilo, -S-CH2-heteroarilo, -NR3S(O)2-alquiloC1-C3.

7. 发明专利

CA2648804A1 BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE 未知
公开(公告)号：CA2648804A1
公开(公告)日：2007-10-18
申请号：CA2648804
申请日：2007-04-05
申请人： METHYLGENE INC
发明人： PAQUIN ISABELLE , MALLAIS TAMMY C , MORADEL OSCAR , ROY SIMON , MACHAALANI ROGER , VAISBURG ARKADII , BESTERMAN JEFFREY M , FRECHETTE SYLVIE , TESSIER PIERRE , DEZIEL ROBERT , SMIL DAVID , MANCUSO JOHN , LEIT SILVANA
IPC分类号： C07D207/32 , C07D213/40 , C07D213/56 , C07D213/61 , C07D295/14 , C07D307/52 , C07D317/58 , C07D333/28 , C07D333/36 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

8. 发明公开

EP2134680A4 INHIBITORS OF HISTONE DEACETYLASE 有权
标题翻译：组蛋白去乙酰化酶抑制剂
公开(公告)号：EP2134680A4
公开(公告)日：2012-03-07
申请号：EP08733559
申请日：2008-03-12
申请人： METHYLGENE INC
发明人： FRECHETTE SYLVIE , ISAKOVIC LUBO , PAQUIN ISABELLE , ROY SIMON , MORADEI OSCAR , VAISBURG ARKADII
IPC分类号： C07D207/14 , A61K31/40 , A61K31/4025 , A61K31/4439 , A61K31/5377 , A61P35/00 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12
CPC分类号： C07D401/12 , C07D207/14 , C07D401/04 , C07D403/04 , C07D405/12

9. 发明专利

ES2565243T3 Inhibidores de histona desacetilasa 未知
公开(公告)号：ES2565243T3
公开(公告)日：2016-04-01
申请号：ES08733559
申请日：2008-03-12
申请人： METHYLGENE INC
发明人： FRECHETTE SYLVIE , ISAKOVIC LUBO , PAQUIN ISABELLE , ROY SIMON , MORADEI OSCAR , VAISBURG ARKADII
IPC分类号： C07D207/14 , A61K31/40 , A61K31/4025 , A61K31/4439 , A61K31/5377 , A61P35/00 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12
摘要： Un compuesto de la fórmula (1):**Fórmula** o un N-óxido, hidrato, solvato, sal farmacéuticamente aceptable del mismo, o una mezcla racémica o escalémica, diastereómero, enantiómero o tautómero del mismo, en el que T es NH2 u OH; A es arileno, que está opcionalmente sustituido; y X es en el que Y >= N, n1 >= 1 y Z1 se selecciona de entre el grupo que consiste en R12-O-C(O)-N(R2), (hidrocarbilo C1-C6)-O-(hidrocarbilo C1-C6)-OC( O)-N(R2)-, (hidrocarbilo C1-C6)-O-C(O)NR2)- o R16-O-C(O)-N(R2)-, en el que R16 20 se selecciona de entre el grupo que consiste en (hidro carbilo C1-C6)-, Ar-(hidrocarbilo C1-C2)-, Het- (hidrocarbilo C1-C2)-, Hca-(hidrocarbilo C0-C2)- o Cak-(hidrocarbilo C0-C2)-; en donde cada R2 se selecciona independientemente de entre el grupo que consiste en hidrógeno, (alquilo C1-C5)-, Hca- (alquilo C0-C4)-, Cak-(alquilo C0-C4)-, R14-CO-, R14-SO2-, R14-CO-NH- y R14-CO-O-, en donde cada alquilo está opcionalmente sustituido; cada R12 se selecciona independientemente de entre el grupo que consiste en (hidrocarbilo C1-C6)-, Ar- (hidrocarbilo C1-C6)-, Het-(hidrocarbilo C1-C6)-, Hca-(hidrocarbilo C0-C6)-, Cak-(hidrocarbilo C0-C6)- opcionalmente sustituido; y cada R14 se selecciona independientemente de entre el grupo que consiste en Ar- e (hidrocarbilo C1-C6)- opcionalmente sustituido; en donde cualquier resto (hidrocarbilo C1-C6)- está opcionalmente sustituido, y cada Ar es independientemente un arilo opcionalmente sustituido, cada Het es independientemente un heteroarilo opcionalmente sustituido, cada Hca es independientemente un heterocicloalquilo opcionalmente sustituido, y cada Cak es independientemente un cicloalquilo opcionalmente sustituido.

10. 发明专利

CA2648804C BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE 未知
公开(公告)号：CA2648804C
公开(公告)日：2014-05-27
申请号：CA2648804
申请日：2007-04-05
申请人： METHYLGENE INC
发明人： MORADEI OSCAR , PAQUIN ISABELLE , FRECHETTE SYLVIE , MALLAIS TAMMY C , ROY SIMON , MACHAALANI ROGER , VAISBURG ARKADII , BESTERMAN JEFFREY M , TESSIER PIERRE , MANCUSO JOHN , SMIL DAVID , LEIT SILVANA , DEZIEL ROBERT
IPC分类号： C07D207/32 , C07D213/40 , C07D213/56 , C07D213/61 , C07D295/14 , C07D307/52 , C07D317/58 , C07D333/28 , C07D333/36 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds which are derivatives of benzamide and suitable in methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions .

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式