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1. 发明申请

WO2004022780A3 METHOD FOR IDENTIFYING SUBSTANCES HAVING A HERBICIDE ACTION 审中-公开
标题翻译：除草剂效应识别物质的方法
公开(公告)号：WO2004022780A3
公开(公告)日：2004-07-01
申请号：PCT/EP0308393
申请日：2003-07-30
申请人： METANOMICS GMBH & CO KGAA , PLESCH GUNNAR , BLAU ASTRID , DAESCHNER KLAUS
发明人： PLESCH GUNNAR , BLAU ASTRID , DAESCHNER KLAUS
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8274
摘要： The invention relates to a method for identifying compounds having a herbicide action. The invention also relates to nucleic acid constructs, to vectors containing said nucleic acid constructs, to transgenic organisms, and to the use of the same. Also disclosed are substances which have been identified by means of the abovementioned method.
摘要翻译：本发明涉及鉴定除草活性化合物的方法。此外，本发明涉及核酸构建体，含有核酸构建体的载体，转基因生物体及其用途。此外，本发明涉及通过上述方法鉴定的物质。

2. 发明申请

WO2004074440A3 PREPARATION OF ORGANISMS WITH FASTER GROWTH AND/OR HIGHER YIELD 审中-公开
标题翻译：具有较快增长和/或较高产量的有机物的制备
公开(公告)号：WO2004074440A3
公开(公告)日：2004-12-23
申请号：PCT/US2004004422
申请日：2004-02-13
申请人： METANOMICS GMBH & CO KGAA , PLESCH GUNNAR , CHARDONNENS AGNES , SCHMITZ OLIVER , PUZIO PIOTR , EBNETH MARCUS , WANG XI-QING
发明人： PLESCH GUNNAR , CHARDONNENS AGNES , SCHMITZ OLIVER , PUZIO PIOTR , EBNETH MARCUS , WANG XI-QING
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C07K14/415 , C12N15/8261 , C12N15/8271 , Y02A40/146
摘要： A method for preparing a nonhuman organism with faster growth and/or increased yield in comparison with a reference organism, which method comprises increasing the activity of L450 in said organism or in one or parts thereof in comparison with a reference organism.
摘要翻译：一种用于制备与参照生物体相比生长更快和/或产量增加的非人生物体的方法，该方法包括与参照生物体相比增加所述生物体或其一个或多个部分中L450的活性。

3. 发明申请

WO2004057003A3 METHOD FOR PRODUCING AMINOACIDS 审中-公开
标题翻译：用于生产环状氨基转基因生物
公开(公告)号：WO2004057003A3
公开(公告)日：2004-10-14
申请号：PCT/EP0314649
申请日：2003-12-19
申请人： METANOMICS GMBH & CO KGAA , SCHMITZ OLIVER , PUZIO PIOTR , BLAU ASTRID , LOOSER RALF , WENDEL BIRGIT , KAMLAGE BEATE , PLESCH GUNNAR
发明人： SCHMITZ OLIVER , PUZIO PIOTR , BLAU ASTRID , LOOSER RALF , WENDEL BIRGIT , KAMLAGE BEATE , PLESCH GUNNAR
IPC分类号： C12N9/10 , C12N9/88 , C12N15/82 , C12P13/12 , C12N9/02 , C12N9/92
CPC分类号： C12P13/12 , C12N9/1014 , C12N9/88 , C12N15/8251 , C12N15/8253
摘要： The invention relates to a method for producing aminoacids in transgenic organisms. The inventive method consists of the following steps: a) introduction of nucleic acids sequence which codes threonine decomposing protein or lysine decomposing protein or codes threonine decomposing protein and lysine decomposing protein, b) introduction of nucleic acids sequence which improves the decomposition of threonine or lysine or the decomposition of threonine and lysine in the transgenic organisms; c) expression of (a) or (b) nucleic acids sequence in a transgenic organism. In a very useful manner, the nucleic acids sequence is introduced in the step a) of the method, said sequence being selected from: i) the nucleic acids sequence with the sequence present in SEQ ID NO: 1, SEQ ID NO:11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 23 and/or SEQ ID NO:25; ii) the nucleic acids sequence which is preserved as a result of a degenerate genetic code by re-recording aminoacids sequence present in SEQ ID NO: 2, SEQ ID NO: 12, SEQ ID NO:14, SEQ ID NO: 16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24 and/or 26; and iii) a derivative of the nucleic acid sequence present in SEQ ID NO: 1, SEQ ID NO:11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 23 and/or SEQ ID NO:25 which codes polypeptides with the nucleic acids sequence present in SEQ ID NO: 2, SEQ ID NO: 12, SEQ ID NO:14, SEQ ID NO: 16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24 and/or 26 and which comprises at least 50 % of homology in terms of aminoacids without reducing the biological activity of polypeptides.
摘要翻译：一种用于生产的在转基因生物的氨基酸的方法，其特征在于该方法包括以下步骤：a）将其编码苏氨酸降解蛋白质或赖氨酸分解蛋白质或编码苏氨酸降解蛋白质和赖氨酸分解蛋白质的核酸序列或b）将增加在转基因生物中的苏氨酸或赖氨酸降解或苏氨酸和赖氨酸降解的核酸序列，和c）表达的下指定的（a）或（b）在所述转基因Organismus.Vorteilhaft的核酸序列是在工艺步骤（a）中从组i选择的核酸序列）与SEQ ID NO的核酸序列：1，SEQ ID NO：11，SEQ ID NO：13，SEQ ID NO：15，SEQ ID NO：17，SEQ ID NO：19，SEQ ID NO：21，SEQ ID NO：所示;: 23和/或SEQ ID NO 25的序列 ⅱ）的核酸序列由于通过在SEQ ID NO回译遗传密码的简并性：2，SEQ ID NO：12，SEQ ID NO：14，SEQ ID NO：16，SEQ ID NO：18，SEQ ID NO：20 ，SEQ ID NO：22，SEQ ID NO：24和/或SEQ ID NO：得到的氨基酸序列示出26和iii）SEQ ID NO的衍生物：1，SEQ ID NO：11，SEQ ID NO：13，SEQ ID NO：15，SEQ ID NO：17，SEQ ID NO：19，SEQ ID NO：21，SEQ ID NO：23和/或SEQ ID NO：核酸序列代表25，与在SEQ ID NO，其编码的多肽：2 ，SEQ ID NO：12，SEQ ID NO：14，SEQ ID NO：16，SEQ ID NO：18，SEQ ID NO：20，SEQ ID NO：22，SEQ ID NO：24和/或SEQ ID NO：26 编码的氨基酸序列示出，并且具有在没有多肽基本上降低的生物活性的氨基酸水平至少50％的同源性; 介绍。

4. 发明申请

WO02066660A3 METHOD FOR IDENTIFYING HERBICIDALLY ACTIVE SUBSTANCES 审中-公开
标题翻译：一种用于识别除草活性物质
公开(公告)号：WO02066660A3
公开(公告)日：2003-08-28
申请号：PCT/EP0201466
申请日：2002-02-13
申请人： METANOMICS GMBH & CO KGAA , PLESCH GUNNAR , BLAU ASTRID , DAESCHNER KLAUS , KLEIN MATHIEU
发明人： PLESCH GUNNAR , BLAU ASTRID , DAESCHNER KLAUS , KLEIN MATHIEU
IPC分类号： C07K14/415 , C12N15/82 , C12Q1/00 , C12Q1/18 , C12Q1/68
CPC分类号： C12N15/8274 , C07K14/415 , C12Q1/00 , C12Q1/18 , C12Q1/6895 , C12Q2600/158 , G01N2500/00
摘要： The invention relates to genes and methods for isolating genes coding for gene products, the lack of said gene products leading to significantly delayed growth and/or completely stunted growth at the embryonic stage of Arabidopsis thaliana. The invention relates to the use of said genes and the gene products coded thereby for discovering novel herbicides. The invention also relates to the use of the genes and gene products identified here for producing plants which are resistant to herbicides. The invention further relates to a method for identifying herbicidally active substances, substances identified according to said method and the use of said substances as herbicides. Furthermore, the invention relates to nucleic acid constructs, vectors, organisms containing said nucleic acid constructs and/or vectors, and especially transgenic plants containing said nucleic acid constructs and/or vectors. Disclosed is also a method for identifying antagonists and the use thereof, antibodies and antisense RNA molecules, and agents containing a herbicide substance which is isolated according to the inventive methods. Finally, the invention relates to compositions containing the antibodies, the antisense nucleic acids and/or the antagonists.
摘要翻译：在本发明中，用于分离基因的基因和方法被描述，即导致无法在拟南芥幼苗水平强延迟生长和/或完全的生长停滞，其编码的基因产物。本发明描述了使用这些基因和基因产物的新的除草剂的发现由其编码的。此外，本发明描述了一种用于对具有抗性的植物的除草剂的制备中的用途本文所鉴定的基因和基因产物的。本发明还涉及一种方法，用于识别除草活性的物质，通过该方法和它们作为除草剂的用途鉴定的物质。本发明还涉及核酸构建体，载体，含有所述核酸构建体和/或载体，含有所述核酸构建体和/或载体尤其是转基因植物的生物。本发明还涉及一种方法，用于鉴定拮抗剂和它们的用途，抗体和反义RNA分子，以及组合物包括通过本发明的方法分离的除草物质。此外，本发明提供了含有组合物涉及的抗体，反义核酸和/或拮抗剂。

5. 发明专利

BR0317537A 未知
公开(公告)号：BR0317537A
公开(公告)日：2005-11-22
申请号：BR0317537
申请日：2003-12-19
申请人： METANOMICS GMBH & CO KGAA
发明人： SCHMITZ OLIVER , PUZIO PIOTR , BLAU ASTRID , WENDEL BIRGIT , LOOSER RALF , KAMLAGE BEATE , PLESCH GUNNAR
IPC分类号： C12N9/10 , C12N9/88 , C12N15/82 , C12P13/12 , C12N9/92 , C12N9/02
摘要： Method for preparing amino acids (AA) in transgenic organisms by introducing and expressing a nucleic acid (I) that: (a) encodes a protein (II) able to degrade Thr and/or Lys; or (b) increases degradation of Thr and/or Lys in the organism, is new. Independent claims are also included for: (1) nucleic acid construct (A) containing (I) functionally linked to one or more regulatory sequences; (2) vector that contains (I) or (A); (3) transgenic prokaryotic or eukaryotic organisms (B) containing at least one (I), (A) or the vector of (2); and (4) eight specified sequences (IIa) of 376, 115, 127, 147, 169, 362, 106 and 104 amino acids (all reproduced).

6. 发明专利

NO20052807D0 未知
公开(公告)号：NO20052807D0
公开(公告)日：2005-06-10
申请号：NO20052807
申请日：2005-06-10
申请人： METANOMICS GMBH & CO KGAA
发明人： PLESCH GUNNAR , SCHMITZ OLIVER , PUZIO PIOTR , BLAU ASTRID , LOOSER RALF , WENDEL BIRGIT , KAMLAGE BEATE
IPC分类号： C12N9/10 , C12N9/88 , C12N15/82 , C12P13/12 , C12N
摘要： Method for preparing amino acids (AA) in transgenic organisms by introducing and expressing a nucleic acid (I) that: (a) encodes a protein (II) able to degrade Thr and/or Lys; or (b) increases degradation of Thr and/or Lys in the organism, is new. Independent claims are also included for: (1) nucleic acid construct (A) containing (I) functionally linked to one or more regulatory sequences; (2) vector that contains (I) or (A); (3) transgenic prokaryotic or eukaryotic organisms (B) containing at least one (I), (A) or the vector of (2); and (4) eight specified sequences (IIa) of 376, 115, 127, 147, 169, 362, 106 and 104 amino acids (all reproduced).

7. 发明专利

NO20052807A 未知
公开(公告)号：NO20052807A
公开(公告)日：2005-09-13
申请号：NO20052807
申请日：2005-06-10
申请人： METANOMICS GMBH & CO KGAA
发明人： PLESCH GUNNAR , SCHMITZ OLIVER , PUZIO PIOTR , BLAU ASTRID , LOOSER RALF , WENDEL BIRGIT , KAMLAGE BEATE
IPC分类号： C12N9/10 , C12N9/88 , C12N15/82 , C12P13/12 , C12N9/02 , C12N9/92
CPC分类号： C12P13/12 , C12N9/1014 , C12N9/88 , C12N15/8251 , C12N15/8253

8. 发明专利

DE10238434A1 未知
公开(公告)号：DE10238434A1
公开(公告)日：2004-04-15
申请号：DE10238434
申请日：2002-08-16
申请人： METANOMICS GMBH & CO KGAA
发明人： PLESCH GUNNAR , BLAU ASTRID , DAESCHNER KLAUS
IPC分类号： C12N15/82 , C07K16/00 , A01H5/00 , C07H21/00 , C07K14/415 , C12Q1/68

9. 发明专利

AR032709A1 PROCEDIMIENTO PARA IDENTIFICAR SUSTANCIAS CON ACCION HERBICIDA 未知
公开(公告)号：AR032709A1
公开(公告)日：2003-11-19
申请号：ARP020100541
申请日：2002-02-15
申请人： METANOMICS GMBH & CO KGAA
发明人： PLESCH GUNNAR , BLAU , DAESCHNER
IPC分类号： C07K14/415 , C12N15/82 , C12Q1/00 , C12Q1/18 , C12Q1/68 , G01N33/50 , C12N15/11 , C12N15/29 , C12N15/52 , C12N9/00 , C12N15/63 , C07K16/00 , C07K14/00 , A01H5/00 , A01N63/02
摘要： Se describen genes y procedimiento para aislar genes que codifican para productos génicos que, en caso de falta, producen un crecimiento muy retardado y/o una detencion total del crecimiento al nivel de los brotes de Arabisopsis thaliana. Se describe la utilizacion de estos genes y los productos génicos codificados para el recubrimiento de nuevos herbicidas. Además, se describe el uso de los genes y productos génicos identificados aquí para la preparacion de plantas resistentes a los herbicidas. Se refiere también a un procedimiento para identificar sustancias con efecto herbicida, sustancias identificadas segun este procedimiento, así como su uso como herbicidas. Se refiere también a las construcciones de ácido nucleico, vectores, organismos que contienen las construcciones de ácido nucleico y/o vectores, especialmente las plantas transgénicas contienen construcciones de ácido nucleico y/o vectores. Por otra parte se refiere a un procedimiento para identificar antagonistas y su uso, anticuerpos y moléculas de ARN antisentido, así como agentes que contienen una sustancias herbicida aislada segun los procedimiento de la invencion. Además, se refiere a las composiciones que contienen el anticuerpo, el ácido nucleico antisentido y/o el antagonista

10. 发明专利

DE10125537A1 Identifying herbicides and plant growth regulators, from ability to inhibit specific genes, also use of these genes to prepare herbicide-resistant transgenic plants 未知
公开(公告)号：DE10125537A1
公开(公告)日：2003-04-24
申请号：DE10125537
申请日：2001-05-23
申请人： METANOMICS GMBH & CO KGAA
发明人： BLAU ASTRID , KLEIN MATHIEU , PLESCH GUNNAR , DAESCHNER KLAUS
IPC分类号： C07K14/415 , C12N15/82 , C12Q1/00 , C12Q1/18 , C12Q1/68 , C12Q1/6895 , A01H5/00 , C07H21/00 , C12N5/10 , C12N15/52
摘要： Identifying compounds (A) with herbicidal activity from ability to reduce or block expression or activity of gene products of specific nucleic acid sequences (I) or amino acid sequences (II) encoded by (I), is new. Identifying compounds (A) with herbicidal activity from ability to reduce or block expression or activity of gene products of specific nucleic acid sequences (I) or amino acid sequences (II) encoded by (I), is new. (I) are: (a) any of 49 552-3435 nucleotide sequences, given in the specification , or their derivatives or fragments with at least 60 % homology; (b) sequences that encode any of 49 183-1144 residue amino acid sequences, (II), given in the specification, or their fragments or derivatives with at least 50% homology, or derivatives with at least 20% homology and equivalent biological activity; (c) sequences that encode a polypeptide fragment or epitope that binds to an antibody specific for a polypeptide encoded by (i); or (d) a nucleic acid encoding a fragment of (i) and having any of about 40 specified enzymatic activities. Independent claims are also included for the following: (1) construct containing (I) linked to at least one regulatory signal; (2) (A) identified by the new method that has molecular weight below 1000, inhibition constant below 1 mM and fewer than 3 hydroxy groups on a carbon-containing ring, or is a protein (especially antibody) or antisense RNA; (3) vectors containing the construct of (1); (4) organism containing at least one construct of (1) or vector of (3); (5) method for identifying antagonists (B) of proteins encoded by (I); (6) method for controlling unwanted plant growth using (A) or (B); (7) producing altered gene products from the sequences of (I); (8) producing transgenic plants that are resistant to (A) or (B) by overexpression of (I); and (9) plants produced by method (8).

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