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1. 发明申请

WO2010068953A3 GREEN PROCESS AND COMPOSITIONS FOR PRODUCING POLY(5HV) AND 5 CARBON CHEMICALS 审中-公开
标题翻译：用于生产聚（5HV）和5碳化合物的绿色方法和组合物
公开(公告)号：WO2010068953A3
公开(公告)日：2010-08-05
申请号：PCT/US2009067943
申请日：2009-12-14
申请人： METABOLIX INC , FARMER WILLIAM R , BICKMEIER JEFF , LU CHENFENG , CHANG DONG-EUN , SKRALY FRANK , RAMSEIER THOMAS MARTIN
发明人： FARMER WILLIAM R , BICKMEIER JEFF , LU CHENFENG , CHANG DONG-EUN , SKRALY FRANK , RAMSEIER THOMAS MARTIN
IPC分类号： C12N1/21 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/80 , C12N9/88 , C12N15/52 , C12P7/04 , C12P7/18 , C12P7/42 , C12P7/44 , C12P7/62
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/0069 , C12N9/10 , C12N9/1029 , C12N9/1096 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/42 , C12P7/44 , C12P7/625
摘要： Recombinant hosts for producing polyhydroxyalkanoates and methods of producing polyhydroxyalkanoates from renewable carbon substrates are provided. Certain recombinant hosts that produce 5 carbon chemicals such as 5-amino?entanoate (5AP), 5 -hydroxy valerate (5HV), glutarate, and 1,5 pentanediol (PDO) are also provided. One embodiment provides a recombinant host expressing a gene encoding a heterologous enzyme selected from the group consisting of a polyhydroxyalkanoate synthase and a 5-hydroxyvalerate-CoA (5HV-CoA) transferase, wherein the host produces a polymer containing 5-hydroxyvalerate. Preferably, the host expresses both a polyhydroxyalkanoate synthase and a 5HV-CoA transferase. The host can be prokaryotic or eukaryotic. A preferred prokaryotic host is E. coli. The polymers produced by the recombinant hosts can be homopolymers or copolymers of 5-hydroxyvalerate. A preferred copolymer is poly(3-hydroxybutyrate-co-5-hydroxyvalerate).
摘要翻译：提供了用于生产聚羟基链烷酸酯的重组宿主和从可再生碳底物生产聚羟基链烷酸酯的方法。还提供了产生5种碳化学物质的某些重组宿主，如5-氨基蓖麻酸酯（5AP），5-羟基戊酸酯（5HV），戊二酸酯和1,5-戊二醇（PDO）。一个实施方案提供了表达编码选自聚羟基链烷酸酯合酶和5-羟基戊酸酯-CoA（5HV-CoA）转移酶的异源酶的基因的重组宿主，其中所述宿主产生含有5-羟基戊酸酯的聚合物。优选地，宿主表达聚羟基链烷酸酯合成酶和5HV-CoA转移酶。宿主可以是原核生物或真核生物。优选的原核宿主是大肠杆菌。由重组宿主产生的聚合物可以是5-羟基戊酸酯的均聚物或共聚物。优选的共聚物是聚（3-羟基丁酸酯 - 共-5-羟基戊酸酯）。

2. 发明申请

WO2011034946A1 GENERATION OF HIGH POLYHYDROXYBUTRATE PRODUCING OILSEEDS 审中-公开
标题翻译：高聚羟基丁酸酯生产油脂的生成
公开(公告)号：WO2011034946A1
公开(公告)日：2011-03-24
申请号：PCT/US2010048963
申请日：2010-09-15
申请人： METABOLIX INC , PATTERSON NII , TANG JIHONG , HAN JIXIANG , TAVVA VENKATA , HERTIG ANDREW , ZHANG ZHIGANG , RAMSEIER THOMAS MARTIN , BOHMERT-TATAREV KAREN , PEOPLES OLIVER P , SNELL KRISTI D
发明人： PATTERSON NII , TANG JIHONG , HAN JIXIANG , TAVVA VENKATA , HERTIG ANDREW , ZHANG ZHIGANG , RAMSEIER THOMAS MARTIN , BOHMERT-TATAREV KAREN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62
CPC分类号： C12N15/8214 , C12N15/8257
摘要： Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates ("PHA") are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate ("PHB"). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.
摘要翻译：提供了用于合成生物聚合物的转基因植物，植物材料，植物细胞和遗传构建体，例如聚羟基链烷酸酯（“PHA”）。在一个实施方案中，转基因植物合成聚羟基丁酸酯（“PHB”）。在一个实施方案中，转基因植物编码一种或多种编码产生PHA的酶的基因的siRNA。在更优选的实施方案中，siRNA表达处于诱导型调节元件的控制下。在另一个实施方案中，转基因植物含有编码会降解聚合物的表达酶的转基因。在一个优选的实施方案中，这些酶的表达处于发芽特异性，诱导型或最小启动子的控制下。在另一个实施方案中，转基因植物含有编码增加聚合物合成碳流量的酶的转基因。在一个优选的实施方案中，这些转基因编码增加卡尔文循环中碳流量的酶。

3. 发明申请

WO2005089093A3 IMPROVED EXPRESSION SYSTEMS WITH SEC-SYSTEM SECRETION 审中-公开
标题翻译：改进的表达系统与SEC系统分泌
公开(公告)号：WO2005089093A3
公开(公告)日：2006-03-02
申请号：PCT/US2004039316
申请日：2004-11-22
申请人： DOW GLOBAL TECHNOLOGIES INC , RETALLACK DIANE M , SCHNEIDER JANE C , RAMSEIER THOMAS MARTIN
发明人： RETALLACK DIANE M , SCHNEIDER JANE C , RAMSEIER THOMAS MARTIN
IPC分类号： C07K14/21 , C07K14/61 , C07K16/00 , C07K16/16 , C12N15/62 , C12N15/78 , C07H21/04 , C07H7/00 , C07H19/00 , C12N1/21 , C12N15/10 , C12N15/63 , C12N15/64 , C12N15/72 , C07H14/21
CPC分类号： C07K14/21 , C07K14/61 , C07K16/00 , C07K16/16 , C07K2317/622 , C07K2319/036 , C12N15/625 , C12N15/78
摘要： Improved methods and prokaryotic expression systems for producing recombinant proteins using Sec-system secretion signal peptides are described using Pseudomonas fluorescens Sec secretion systems. Specific novel Sec-system secretion signal peptides are described, as are fusion proteins and coding sequences for improved secretion of recombinant proteins and peptides.
摘要翻译：使用荧光假单胞菌分泌系统描述了使用Sec系统分泌信号肽生产重组蛋白质的改进方法和原核表达系统。描述了特异性新型Sec系统分泌信号肽，融合蛋白和用于改善重组蛋白和肽分泌的编码序列也是如此。

4. 发明申请

WO2014058655A8 POLYHYDROXYALKANOATE COPOLYMER COMPOSITIONS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：聚羟基烷基酯共聚物组合物及其制备方法
公开(公告)号：WO2014058655A8
公开(公告)日：2015-05-14
申请号：PCT/US2013062812
申请日：2013-10-01
申请人： METABOLIX INC
发明人： RAMSEIER THOMAS MARTIN , BICKMEIER JEFFREY A , FARMER WILLIAM R , MORSE CATHERINE , CHINNAPEN HIMANI , PEOPLES OLIVER P , SHABTAI YOSSEF
IPC分类号： C12P7/62 , C08L67/04
CPC分类号： C12P7/625 , C08G63/06 , C08L67/04 , C08L2201/06
摘要： A polyhydroxyalkanoate copolymer composition is provided. The composition comprises a plurality of polyhydroxyalkanoate copolymer molecules. The polyhydroxyalkanoate copolymer molecules (i) comprise 3-hydroxybutyrate monomers and 4-hydroxybutyrate monomers, (ii) have a monomeric molar percentage of 4-hydroxybutyrate monomers of 23.5 to 75%, and (iii) have a biobased content of ≥ 80%. Also provided is a method of making a polyhydroxyalkanoate copolymer composition. The method comprises culturing an organism in the presence of one or more carbon raw materials under conditions under which (a) the one or more carbon raw materials are converted to 3- hydroxybutyryl-CoA and 44iydroxybutyryl-CoA and (b) the 34iydroxybutyryl-CoA and the 4- hydroxybutyryl-CoA are polymerized to form the polyhydroxyalkanoate copolymer molecules, thereby forming the composition. The organism has been genetically engineered to comprise particular enzymatic activities, and to not comprise other particular enzymatic activities. The one or more carbon raw materials, taken together, have a biobased content of ≥80%.
摘要翻译：提供聚羟基链烷酸酯共聚物组合物。组合物包含多种聚羟基链烷酸酯共聚物分子。聚羟基链烷酸酯共聚物分子（i）包含3-羟基丁酸酯单体和4-羟基丁酸酯单体，（ii）具有23.5-75％的4-羟基丁酸酯单体的单体摩尔百分数，和（iii）生物基含量≥80％。还提供了制备聚羟基链烷酸酯共聚物组合物的方法。该方法包括在（a）一种或多种碳原料转化为3-羟基丁酰辅酶A和44羟基丁酰辅酶A的条件下，在一种或多种碳原料存在下培养生物体，和（b）34-羟基丁酰辅酶A 并且使4-羟基丁酰辅酶A聚合以形成聚羟基链烷酸酯共聚物分子，从而形成组合物。生物体已被遗传工程化以包含特定的酶活性，并且不包含其它特定的酶活性。一种或多种碳原料合计，生物基含量≥80％。

5. 发明专利

AU2010295638A1 Generation of high polyhydroxybutrate producing oilseeds 未知
公开(公告)号：AU2010295638A1
公开(公告)日：2012-04-26
申请号：AU2010295638
申请日：2010-09-15
申请人： METABOLIX INC
发明人： PATTERSON NII , TANG JIHONG , HAN JIXIANG , TAVVA VENKATA , HERTIG ANDREW , ZHANG ZHIGANG , RAMSEIER THOMAS MARTIN , BOHMERT-TATAREV KAREN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62
摘要： Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates ("PHA") are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate ("PHB"). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.

6. 发明专利

BR112012005591A2 Geração de sementes oleaginosas produzindo alto poliidroxibutirato. 未知
公开(公告)号：BR112012005591A2
公开(公告)日：2015-09-01
申请号：BR112012005591
申请日：2010-09-15
申请人： METABOLIX INC
发明人： PATTERSON NII , TANG JIHONG , HAN JIXIANG , TAVVA VENKATA , HERTIG ANDREW , ZHANG ZHIGANG , RAMSEIER THOMAS MARTIN , BOHMERT-TATAREV KAREN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62

8. 发明专利

CA2773707A1 GENERATION OF HIGH POLYHYDROXYBUTRATE PRODUCING OILSEEDS WITH IMPROVED GERMINATION AND SEEDLING ESTABLISHMENT 未知
公开(公告)号：CA2773707A1
公开(公告)日：2011-03-24
申请号：CA2773707
申请日：2010-09-15
申请人： METABOLIX INC
发明人： PATTERSON NII , TANG JIHONG , HAN JIXIANG , TAVVA VENKATA , HERTIG ANDREW , ZHANG ZHIGANG , RAMSEIER THOMAS MARTIN , BOHMERT-TATAREV KAREN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62
摘要： Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates ("PHA") are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate ("PHB"). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.

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