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1. 发明专利

JP2007125043A Production of medium chain length polyhydroxyalkanoates from fatty acid biosynthetic pathways 审中-公开
标题翻译：从脂肪酸生产途径生产中链长度聚羟基烷酸
公开(公告)号：JP2007125043A
公开(公告)日：2007-05-24
申请号：JP2007035383
申请日：2007-02-15
申请人： Metabolix Inc , メタボリックス,インコーポレイテッド
发明人： AQUIN STEPHANIE , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： A01H5/00 , C12Q1/44 , A01H1/00 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12P7/64 , C12Q1/02 , C12Q1/25 , C12Q1/48
CPC分类号： C12N9/93 , C12N9/00 , C12N9/10 , C12N9/1029 , C12N9/16 , C12N15/8243
摘要： PROBLEM TO BE SOLVED: To express an acyl CoA synthetase, a PHA synthase and a PhaG in an organism to produce PHA. SOLUTION: A method for producing polyhydroxyalkanoates (PHAs) from fatty acid biosynthetic pathways using a 3-hydroxy acyl ACP thioesterase, a PHA synthase, and an acyl CoA synthetase, is provided. Methodology for enabling PHA production from fatty acid biosynthetic pathways in non-native bacterial PHA producers and plants using an enzyme having the catalytic activity of 3-hydroxy acyl ACP thioesterase, an acyl CoA synthetase (with substrate specificity for medium chain length 3-hydroxy fatty acids), and a medium chain length PHA synthase, is provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：在生物体中表达酰基辅酶A合成酶，PHA合酶和PhaG以产生PHA。解决方案：提供了使用3-羟基酰基ACP硫酯酶，PHA合成酶和酰基辅酶A合成酶从脂肪酸生物合成途径制备聚羟基链烷酸酯（PHA）的方法。使用具有3-羟基酰基ACP硫酯酶（酰基辅酶A合成酶（具有中等链长度3-羟基脂肪酸的底物特异性））的酶的非天然细菌PHA生产者和植物中的脂肪酸生物合成途径的PHA生产的方法酸）和中链长度PHA合酶。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2008194049A Production of medium chain length polyhydroxyalkanoate from fatty acid biosynthetic pathway 审中-公开
标题翻译：从脂肪酸生物路线生产中链长度聚羟基烷酸
公开(公告)号：JP2008194049A
公开(公告)日：2008-08-28
申请号：JP2008061883
申请日：2008-03-11
申请人： Metabolix Inc , メタボリックス,インコーポレイテッド
发明人： AQUIN STEPHANIE , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： A01H5/00 , C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12P7/62 , C12Q1/02 , C12Q1/25 , C12Q1/44 , C12Q1/48
CPC分类号： C12N9/93 , C12N9/00 , C12N9/10 , C12N9/1029 , C12N9/16 , C12N15/8243
摘要： PROBLEM TO BE SOLVED: To express PhaG together with acyl CoA synthetase and PHA synthase in organisms in order to carry out production of PHA. SOLUTION: A method for producing polyhydroxyalkanoates (PHAs) from fatty acid biosynthetic pathways using a 3-hydroxy acyl ACP thioesterase, a PHA synthase, and an acyl CoA synthetase, has been developed. Methodology for enabling PHA production from fatty acid biosynthetic pathways in non-native bacterial PHA producers and plants by using an enzyme having the catalytic activity of 3-hydroxy acyl ACP thioesterase, an acyl CoA synthetase (with substrate specificity for medium chain length 3-hydroxy fatty acids) and a medium chain length PHA synthase has been developed. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：与生物体中的酰基辅酶A合成酶和PHA合酶一起表达PhaG，以进行PHA的生产。解决方案：已经开发了使用3-羟基酰基ACP硫酯酶，PHA合成酶和酰基辅酶A合成酶从脂肪酸生物合成途径制备聚羟基链烷酸酯（PHA）的方法。通过使用具有3-羟基酰基ACP硫酯酶（酰基辅酶A合成酶）（具有中链长度3-羟基的底物特异性）的催化活性的酶，在非天然细菌PHA生产者和植物中通过脂肪酸生物合成途径产生PHA的方法脂肪酸）和中链长度的PHA合酶。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2007222185A Production of medium chain length polyhydroxyalkanoate from fatty acid biosynthetic pathway 有权
标题翻译：从脂肪酸生物路线生产中链长度聚羟基烷酸
公开(公告)号：JP2007222185A
公开(公告)日：2007-09-06
申请号：JP2007153418
申请日：2007-06-08
申请人： Metabolix Inc , メタボリックス,インコーポレイテッド
发明人： AQUIN STEPHANIE , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： A01H5/00 , C12Q1/44 , A01H1/00 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12Q1/02 , C12Q1/25 , C12Q1/48
CPC分类号： C12N9/93 , C12N9/00 , C12N9/10 , C12N9/1029 , C12N9/16 , C12N15/8243
摘要： PROBLEM TO BE SOLVED: To develop a PhaG with an acyl CoA synthetase and a PHA synthase in an organism so as to produce PHA. SOLUTION: Methods for producing polyhydroxyalkanoates (PHAs) from fatty acid biosynthetic pathways by using a 3-hydroxy acyl ACP thioesterase, a PHA synthase, and an acyl CoA synthetase, have been developed. Methodology for enabling PHA production from fatty acid biosynthetic pathways in non-native bacterial PHA producers and plants by using an enzyme having the catalytic activity of 3-hydroxy acyl ACP thioesterase, an acyl CoA synthetase (having substrate specificity for medium chain length 3-hydroxy fatty acids), and a medium chain length PHA synthase, has been developed. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：在生物体中开发具有酰基辅酶A合成酶和PHA合成酶的PhaG，以产生PHA。解决方案：已经开发了通过使用3-羟基酰基ACP硫酯酶，PHA合成酶和酰基辅酶A合成酶从脂肪酸生物合成途径制备聚羟基链烷酸酯（PHA）的方法。通过使用具有3-羟基酰基ACP硫酯酶的催化活性的酶，酰基辅酶A合成酶（具有中链长度3-羟基的底物特异性），使非天然细菌PHA生产者和植物中脂肪酸生物合成途径产生PHA的方法脂肪酸）和中链长度PHA合成酶。版权所有（C）2007，JPO＆INPIT

4. 发明申请

WO0240690A2 PRODUCTION OF MEDIUM CHAIN LENGTH POLYHYDROXYALKANOATES FROM FATTY ACID BIOSYNTHETIC PATHWAYS 审中-公开
标题翻译：从脂肪酸生产途径生产中链长度聚羟基烷酸
公开(公告)号：WO0240690A2
公开(公告)日：2002-05-23
申请号：PCT/US0143686
申请日：2001-11-16
申请人： METABOLIX INC
发明人： AQUIN STEPHANIE , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： A01H5/00 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12Q1/02 , C12Q1/25 , C12Q1/44 , C12Q1/48
CPC分类号： C12N9/93 , C12N9/00 , C12N9/10 , C12N9/1029 , C12N9/16 , C12N15/8243
摘要： Methods for producing polyhydroxyalkanoates (PHAs) from fatty acid biosynthetic pathways using a 3-hydroxy acyl ACP thioesterase, a PHA synthase, and an acyl CoA synthetase, have been developed. Methodology for enabling PHA production from fatty acid biosynthetic pathways in non-native bacterial PHA producers and plants using an enzyme having the catalytic activity of 3-hydroxy acyl ACP thioesterase, an acyl CoA synthetase with substrate specificity for medium chain length 3-hydroxy fatty acids, and a medium chain length PHA synthase, has been developed. Acyl CoA synthetase activity can be supplied either by the endogenous acyl CoA synthetase of the host organism, when sufficiently expressed, or the host organism's activity can be supplemented by the expression of a recombinant acyl CoA synthetase gene. New strategies are described for plant based PHA production in the chloroplasts, cytosol, and peroxisomes of biomass crops as well as the plastids, cytosol, and peroxisomes of oil seed crops.
摘要翻译：已经开发了使用3-羟基酰基ACP硫酯酶，PHA合成酶和酰基辅酶A合成酶从脂肪酸生物合成途径生产聚羟基链烷酸酯（PHA）的方法。使用具有3-羟基酰基ACP硫酯酶的催化活性的酶，非天然细菌PHA生产者和植物中的脂肪酸生物合成途径的PHA生产的方法，具有对于中链长度3-羟基脂肪酸具有底物特异性的酰基辅酶A合成酶，和中链长度PHA合酶。酰基辅酶A合成酶活性可以通过宿主生物体的内源酰基辅酶A合成酶提供，当被充分表达时，或者宿主生物的活性可以通过重组酰基辅酶A合成酶基因的表达补充。描述了用于生物量作物的叶绿体，细胞溶质和过氧化物酶体以及油料种子作物的质体，细胞溶质和过氧化物酶体的基于植物的PHA生产的新策略。

5. 发明申请

WO0240690A9 PRODUCTION OF MEDIUM CHAIN LENGTH POLYHYDROXYALKANOATES FROM FATTY ACID BIOSYNTHETIC PATHWAYS 审中-公开
标题翻译：从脂肪酸生物合成途径生产中链长度聚羟基烷酸酯
公开(公告)号：WO0240690A9
公开(公告)日：2003-11-20
申请号：PCT/US0143686
申请日：2001-11-16
申请人： METABOLIX INC
发明人： AQUIN STEPHANIE , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： A01H5/00 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12Q1/02 , C12Q1/25 , C12Q1/44 , C12Q1/48 , C12N15/52 , C12N15/70
CPC分类号： C12N9/93 , C12N9/00 , C12N9/10 , C12N9/1029 , C12N9/16 , C12N15/8243
摘要： Methods for producing polyhydroxyalkanoates (PHAs) from fatty acid biosynthetic pathways using a 3-hydroxy acyl ACP thioesterase, a PHA synthase, and an acyl CoA synthetase, have been developed. Methodology for enabling PHA production from fatty acid biosynthetic pathways in non-native bacterial PHA producers and plants using an enzyme having the catalytic activity of 3-hydroxy acyl ACP thioesterase, an acyl CoA synthetase with substrate specificity for medium chain length 3-hydroxy fatty acids, and a medium chain length PHA synthase, has been developed. Acyl CoA synthetase activity can be supplied either by the endogenous acyl CoA synthetase of the host organism, when sufficiently expressed, or the host organism's activity can be supplemented by the expression of a recombinant acyl CoA synthetase gene. New strategies are described for plant based PHA production in the chloroplasts, cytosol, and peroxisomes of biomass crops as well as the plastids, cytosol, and peroxisomes of oil seed crops.
摘要翻译：已经开发了使用3-羟基酰基ACP硫酯酶，PHA合酶和酰基CoA合成酶从脂肪酸生物合成途径生产聚羟基链烷酸酯（PHA）的方法。使用具有催化活性的3-羟基酰基ACP硫酯酶的酶，在非天然细菌PHA生产者和植物中从脂肪酸生物合成途径产生PHA的方法，所述酰基CoA合成酶对中等链长3-羟基脂肪酸具有底物特异性，和一个中等链长的PHA合成酶。当充分表达时，酰基辅酶A合成酶活性可以通过宿主生物体的内源性酰基CoA合成酶来提供，或者宿主生物体的活性可以通过表达重组酰基CoA合成酶基因来补充。新的策略描述了基于植物的生物量作物的叶绿体，细胞质和过氧化物酶体以及油籽作物的质体，细胞质和过氧化物酶体的PHA生产。

6. 发明专利

AU3646402A Production of medium chain length polyhydroxyalkanoates from fatty acid biosynthetic pathways 未知
公开(公告)号：AU3646402A
公开(公告)日：2002-05-27
申请号：AU3646402
申请日：2001-11-16
申请人： METABOLIX INC
发明人： AQUIN STEPHANIE , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： A01H5/00 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12Q1/02 , C12Q1/25 , C12Q1/44 , C12Q1/48

7. 发明专利

AU2002236464B2 Production of medium chain length polyhydroxyalkanoates from fatty acid biosynthetic pathways 未知
公开(公告)号：AU2002236464B2
公开(公告)日：2005-09-15
申请号：AU2002236464
申请日：2001-11-16
申请人： METABOLIX INC
发明人： SNELL KRISTI D , PEOPLES OLIVER P , AQUIN STEPHANIE
IPC分类号： A01H5/00 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12Q1/02 , C12Q1/25 , C12Q1/44 , C12Q1/48 , C12N015/82
摘要： Methods for producing polyhydroxyalkanoates (PHAs) from fatty acid biosynthetic pathways using a 3-hydroxy acyl ACP thioesterase, a PHA synthase, and an acyl CoA synthetase, have been developed. Methodology for enabling PHA production from fatty acid biosynthetic pathways in non-native bacterial PHA producers and plants using an enzyme having the catalytic activity of 3-hydroxy acyl ACP thioesterase, an acyl CoA synthetase with substrate specificity for medium chain length 3-hydroxy fatty acids, and a medium chain length PHA synthase, has been developed. Acyl CoA synthetase activity can be supplied either by the endogenous acyl CoA synthetase of the host organism, when sufficiently expressed, or the host organism's activity can be supplemented by the expression of a recombinant acyl CoA synthetase gene. New strategies are described for plant based PHA production in the chloroplasts, cytosol, and peroxisomes of biomass crops as well as the plastids, cytosol, and peroxisomes of oil seed crops.

8. 发明专利

CA2428713A1 PRODUCTION OF MEDIUM CHAIN LENGTH POLYHYDROXYALKANOATES FROMFATTY ACID BIOSYNTHETIC PATHWAYS 未知
公开(公告)号：CA2428713A1
公开(公告)日：2002-05-23
申请号：CA2428713
申请日：2001-11-16
申请人： METABOLIX INC
发明人： SNELL KRISTI D , PEOPLES OLIVER P , AQUIN STEPHANIE
IPC分类号： A01H5/00 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12Q1/02 , C12Q1/25 , C12Q1/44 , C12Q1/48 , C12N15/52 , C12N15/70
摘要： Methods for producing polyhydroxyalkanoates (PHAs) from fatty acid biosynthetic pathways using a 3-hydroxy acyl ACP thioesterase, a PHA synthas e, and an acyl CoA synthetase, have been developed. Methodology for enabling PH A production from fatty acid biosynthetic pathways in non-native bacterial PHA producers and plants using an enzyme having the catalytic activity of 3- hydroxy acyl ACP thioesterase, an acyl CoA synthetase with substrate specificity for medium chain length 3-hydroxy fatty acids, and a medium chai n length PHA synthase, has been developed. Acyl CoA synthetase activity can be supplied either by the endogenous acyl CoA synthetase of the host organism, when sufficiently expressed, or the host organism's activity can be supplemented by the expression of a recombinant acyl CoA synthetase gene. Ne w strategies are described for plant based PHA production in the chloroplasts, cytosol, and peroxisomes of biomass crops as well as the plastids, cytosol, and peroxisomes of oil seed crops.

9. 发明专利

CA2375831A1 PLANT MULTI-GENE EXPRESSION CONSTRUCTS 未知
公开(公告)号：CA2375831A1
公开(公告)日：2000-12-28
申请号：CA2375831
申请日：2000-06-23
申请人： METABOLIX INC
发明人： AQUIN STEPHANIE , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/09 , C12N5/10 , C12N15/67 , C12N15/82 , A01H5/00 , A01K67/027
摘要： Methods and constructs are provided for the introduction of multiple genes into plants using a single transformation event. Coordinated expression of genes in the cassette, producing proteins with native amino acid sequences, is achieved by production of one polycistronic mRNA that contains separate translation initiation signals for each enzyme coding region. Bicistronic constructs contain a single 5' promoter, protein encoding sequence 1, an IRE S, protein encoding sequence 2, and a single 3' polyadenylation sequence. For polycistronic constructs, additional cassettes of protein encoding sequences , in which each coding region is preceded by an IRES, can be inserted between protein encoding sequence 2 and the polyadenylation sequence. The methods an d constructs are useful for creating plants with stacked input traits (e.g., glyphosate tolerant plants producing BT toxin) and/or value added products (e.g., the production of PHAs in plants).

10. 发明专利

DE60141594D1 未知
公开(公告)号：DE60141594D1
公开(公告)日：2010-04-29
申请号：DE60141594
申请日：2001-11-16
申请人： METABOLIX INC
发明人： AQUIN STEPHANIE , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： A01H5/00 , C12N9/10 , C12N1/21 , C12N9/00 , C12N9/16 , C12N15/09 , C12N15/52 , C12N15/54 , C12N15/55 , C12N15/70 , C12N15/82 , C12P7/42 , C12Q1/02 , C12Q1/25 , C12Q1/44 , C12Q1/48

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