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1. 发明申请

WO2017147352A1 ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF 审中-公开
标题翻译：抗过敏性异恶唑啉化合物，包含它们的长效注射制剂，方法和用途
公开(公告)号：WO2017147352A1
公开(公告)日：2017-08-31
申请号：PCT/US2017/019239
申请日：2017-02-24
申请人： MERIAL, INC.
发明人： LE HIR DE FALLOIS, Lois, Patrick , MENG, Charles, Q. , CADY, Susan, Mancini , CHEIFETZ, Peter , GALESKA, Izabela
IPC分类号： A01N43/80 , C07D261/04 , A01P7/04 , A01P7/02 , A01P3/00 , A61K9/00 , A61K47/00 , A61K31/422
CPC分类号： A61K31/415 , A01N43/80 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/107 , A61K31/42 , A61K31/422 , A61K47/10 , A61K47/14 , C07D261/04 , C07D413/04 , C07D471/04 , C07D491/107 , A01N25/02 , A01N25/22
摘要： This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.
摘要翻译：本发明涉及用于防治动物中寄生虫的长效可注射组合物，其包含至少一种异恶唑啉活性剂，液体PEG和/或中性油，任选的助溶剂和任选的药学上可接受的添加剂或赋形剂。本发明还提供了具有对体外寄生虫持久效力的新型异恶唑啉活性剂。本发明还提供了用于根除，控制和预防动物中寄生虫感染和侵染的改进方法，包括将本发明的新型异恶唑啉化合物和长效可注射组合物施用于有此需要的动物。

2. 发明申请

WO2018039508A1 METHOD FOR REDUCING UNWANTED EFFECTS IN PARASITICIDAL TREATMENTS 审中-公开
标题翻译：减少寄生虫治疗中的不利影响的方法
公开(公告)号：WO2018039508A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048527
申请日：2017-08-25
申请人： MERIAL, INC.
发明人： LE HIR DE FALLOIS, Lois, Patrick
IPC分类号： A01N43/80 , A01P7/00
CPC分类号： A01N25/32 , A61K9/0019 , A61K31/42 , A61K47/10 , A61P33/14 , A01N43/80
摘要： The present intention provides for, inter alia, a method for reducing a withdrawal period when treating livestock for parasitic infestations, which comprises administering an effective amount of a parasiticidal composition comprising an (S) enantiomer of an isoxazoline compound of the formula (S)-1 or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein, and an inert carrier or formulation adjuvant; wherein the composition contains less than 10% by weight of an (R) enantiomer of an isoxazoline compound or a pharmaceutically acceptable salt thereof. Moreover, the present invention further provides for method for reducing at least one unwanted effect while treating a non-human animal for a parasitic infestation by administering an effective amount of a parasiticidal composition comprising an (S) enantiomer of an isoxazoline compound of the formula (S)-l or a pharmaceutically acceptable salt thereof and an inert carrier or formulation adjuvant, wherein the composition contains less than 10% by weight of an (R) enantiomer of an isoxazoline compound or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明特别提供了一种用于减少处理家畜寄生虫害时的停药期的方法，该方法包括给予有效量的包含异恶唑啉（S）对映异构体的杀寄生虫组合物式（S）-1化合物或其药学上可接受的盐，其中变量如本文所定义，以及惰性载体或制剂助剂; 其中所述组合物包含小于10重量％的异恶唑啉化合物或其药学上可接受的盐的（R）对映异构体。此外，本发明进一步提供了通过给药有效量的杀虫组合物来减少至少一种不希望的效果，同时治疗非人动物寄生虫侵染的方法，所述组合物包含式（I）的异恶唑啉化合物的（S）对映体 S）-1或其药学上可接受的盐和惰性载体或配制助剂，其中所述组合物包含小于10重量％的异恶唑啉化合物或其药学上可接受的盐的（R）对映体。

3. 发明公开

EP3419424A1 ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF 有权转让
公开(公告)号：EP3419424A1
公开(公告)日：2019-01-02
申请号：EP17709300.2
申请日：2017-02-24
申请人： Merial, Inc.
发明人： LE HIR DE FALLOIS, Lois, Patrick , MENG, Charles, Q. , CADY, Susan, Mancini , CHEIFETZ, Peter , GALESKA, Izabela
IPC分类号： A01N43/80 , C07D261/04 , A01P7/04 , A01P7/02 , A01P3/00 , A61K9/00 , A61K47/00 , A61K31/422

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