专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP1603901B1 TETRAHYDROPYRAN COMPOUNDS AS TACHYKININ ANTAGONISTS 有权
标题翻译： TETRAHYDROPYRANVERBINDUNGEN速激肽
公开(公告)号：EP1603901B1
公开(公告)日：2008-10-15
申请号：EP04717163.2
申请日：2004-03-04
申请人： MERCK SHARP & DOHME LTD.
发明人： DIRAT, Olivier , ELLIOTT, Jason Matthew , HUSCROFT, Ian Thomas , JELLEY, Richard Alexander , KULAGOWSKI, Janusz Jozef , RAUBO, Piotr Antoni , SHAW, Duncan Edward , STERNFELD, Francine , SWAIN, Christopher John
IPC分类号： C07D405/04 , C07D405/06 , C07D407/12 , C07D417/04 , C07D491/10 , C07D498/04 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/54 , A61P25/00 , A61P29/00
CPC分类号： C07D405/04 , C07D405/06 , C07D407/12 , C07D417/04 , C07D491/10
摘要： The present invention relates to the compounds of the formula (I), wherein R?1, R2, R3, R4, R5, R6, R7, R8, R9¿ and W are as defined herein, and pharmaceutically acceptable salts thereof; the compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

2. 发明授权

EP0929554B1 SPIRO-AZACYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TACHYKININ ANTAGONISTS 失效
标题翻译：螺氮杂衍生物，生产与应用，速激肽拮抗剂
公开(公告)号：EP0929554B1
公开(公告)日：2006-03-15
申请号：EP97919167.3
申请日：1997-09-18
申请人： MERCK SHARP & DOHME LTD.
发明人： HAWORTH, Karen Elizabeth , SEWARD, Eileen Mary , SWAIN, Christopher John
IPC分类号： C07D491/107 , A61K31/445 , C07D307/00 , C07D221/00
CPC分类号： C07D491/10
摘要： Substituted spiro-azacyclic derivatives of structural formula (I), wherein R1 represents hydrogen, hydroxy, C¿1-6?alkyl, C2-6alkenyl, C3-7cycloalkyl optionally substituted alkyl, optionally substituted alkoxy, C2-6alkenyloxy, C3-7cycloalkoxy, phenoxy, benzyloxy, cyano, halogen, NR?11COR14, NRaRb, SRa, SORa, SO¿2Ra or OSO¿2R?a; R2 represents hydrogen, halogen, C¿1-6?alkyl or C1-6alkoxy; or when R?2¿ is adjacent to R1, they may be joined together such that there is formed a 5- or 6-membered saturated or unsaturated ring containing one or two oxygen atoms; R3 represents an optionally substituted 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms, selected from nitrogen, oxygen and sulphur; R4 represents hydrogen, halogen, C¿1-6?alkyl, C1-6alkoxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SR?a, SORa, SO¿2Ra, CO2R?a, CONRaRb, C¿2-6alkenyl, C2-6alkynyl or C1-4alkyl substituted by C1-4alkoxy; R5 represents hydrogen, halogen, C¿1-6?alkyl, trifluoromethyl or C1-6alkoxy substituted by C1-4alkoxy; R?6¿ represents hydrogen, CORa, CO2Ra, COCONRaRb, COCO¿2R?a, optionally substituted C¿1-6?alkyl; or R?6¿ represents a group of the formula -CH¿2?C CCH2NR?7R8; or R6¿ represents C¿1-6?alkyl, optionally substituted by oxo, substituted by a 5-membered or 6-membered heterocyclic ring containing 1, 2 or 3 nitrogen atoms optionally substituted by =O or =S and optionally substituted by a group of the formula ZNR?7R8; R9 and R10¿ each independently represents hydrogen, halogen, C¿1-6?alkyl, CH2OR?d¿, oxo, CO¿2R?a or CONRaRb; p is zero or 1; q is 1 or 2; and X represents -CH¿2?- or -CH2CH2-; Y represents -CH=, -CH2-, -CH2CH= or -CH2CH2-, with the proviso that the sum total of carbon atoms in X+Y is 2 or 3; and when X is -CH2- and Y is -CH= or -CH2CH=, the broken line represents a double bond; or a pharmaceutically acceptable salt thereof, are tachykinin receptor antagonists of use, for example, in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.

3. 发明公开

EP0942734A1 USE OF NK-1 RECEPTOR ANTAGONISTS FOR TREATING SEVERE ANXIETY DISORDERS 失效
标题翻译： NK-1受体拮抗剂的严重关注问题的药物中的用途
公开(公告)号：EP0942734A1
公开(公告)日：1999-09-22
申请号：EP97953721.0
申请日：1997-11-25
申请人： MERCK SHARP & DOHME LTD.
发明人： BAKER, Raymond, BBSRC , CURTIS, Neil Roy , ELLIOTT, Jason Matthew , HARRISON, Timothy , HOLLINGWORTH, Gregory John , JACKSON, Philip Stephen , KULAGOWSKI, Janusz Jozef , RUPNIAK, Nadia Melanie , SEWARD, Eileen Mary , SWAIN, Christopher John , WILLIAMS, Brian John
IPC分类号： A61K31 , A61K45 , A61P25 , C07D211 , C07D265 , C07D413 , C07D491
CPC分类号： A61K31/661 , A61K31/395 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/5375 , A61K31/5377 , A61K31/675 , C07D211/56 , C07D491/10
摘要： The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist in a medicament adapted for oral administration for the treatment or prevention of severe anxiety disorders without concomitant therapy with other anti-anxiety agents, methods of treatment using such an NK-1 receptor antagonist and pharmaceutical compositions comprising it.

4. 发明授权

EP0652866B1 AZACYCLIC COMPOUNDS 失效
标题翻译： AZACYCLIC化合物
公开(公告)号：EP0652866B1
公开(公告)日：1998-11-25
申请号：EP93917877.8
申请日：1993-07-20
申请人： MERCK SHARP & DOHME LTD.
发明人： SEWARD, Eileen Mary , SWAIN, Christopher John
IPC分类号： C07D211/42 , C07D401/12 , C07D207/12 , C07D211/54 , A61K31/445 , A61K31/40
CPC分类号： C07D401/12 , C07D207/12 , C07D211/42 , C07D211/54 , C07D405/12
摘要： Compounds of Formula (I), and salts and prodrugs thereof, wherein n is 1, 2 or 3; X represents O or S; R1 is optionally substituted phenyl; R2 is aryl or heteroaryl; R?4 and R5¿ are independently H, halo, C¿1-6?alkyl, oxo, CH2OR?a, CO¿2Ra or CONRaRb; R8 represents C(COORa)2, C(CONRaRb)2 or C1-6alkyl substituted by C(=NR?a)NRbNRcCO¿2Rd, CONHNRaRb, C(S)NR?aRb, CONRaC¿1-6alkylR?12, CONR13C¿2-6alkynyl, CONR13C2-6alkenyl, COCONR?aRb, CONRaC(NRb)NRcRd, CONR13SO¿2Ra, SO2NR?13CORa, CONRa¿heteroaryl or COR?q; Ra, Rb, Rc and Rd¿ are each H, C¿1-6?alkyl, phenyl or trifluoromethyl. R?12¿ represents OR?a, CONRaRb¿ or heteroaryl; R13 represents H or C¿1-6?alkyl; and R?q¿ represents a group (a) where Q represents the residue of a non-aromatic azacyclic or azabicyclic ring system; are tachykinin antagonists useful in therapy.
摘要翻译：式（I）化合物及其盐和前药，其中n为1,2或3; X代表O或S; R1是任选取代的苯基; R2是芳基或杂芳基; R 4和R 5独立地为H，卤素，C 1-6烷基，氧代，CH 2 OR a，CO 2 R a或CONR a R b; R 8代表C（COOR a）2，C（CONR a R b）2或被C（= NR a）NR b NR c CO 2 R d，CONHNR a R b，C（S）NR a R b，CONR a C 1-6烷基R 12，CONR 13 C CONR a C（NR b）NR c R d，CONR 13 SO 2 R a，SO 2 NR 13 R 13 R a，CONR a杂芳基或COR 2 q; Ra，Rb，Rc和Rd分别为H，C1-6烷基，苯基或三氟甲基。 R 12'代表OR'a，CONR a R b或杂芳基; R13代表H或C1-6烷基; R a表示基团（a），其中Q表示非芳族氮杂环或氮杂双环体系的残基; 是用于治疗的速激肽拮抗剂。

5. 发明公开

EP1286978A1 CYCLOHEXYL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开
标题翻译： CYROHEXYLDERIVATE UND IHRE ANWENDUNG ALS NEUROKININ-1（NK-1）REZEPTOR ANTAGONISTEN
公开(公告)号：EP1286978A1
公开(公告)日：2003-03-05
申请号：EP01929825.6
申请日：2001-05-16
申请人： MERCK SHARP & DOHME LTD. , Merck & Co., Inc.
发明人： CASTRO PINEIRO, Jose Luis , DINNELL, Kevin , ELLIOTT, Jason Matthew , HOLLINGWORTH, Gregory John , SHAW, Duncan Edward , SWAIN, Christopher John , YANG, Lihu
IPC分类号： C07D295/16 , A61K31/495 , A61K31/44 , A61K31/4427 , A61K31/16 , A61P25/24 , A61P25/04 , A61P1/08 , C07D295/12 , C07D211/58 , C07D471/10 , C07D401/06 , C07C217/52 , C07C237/06 , C07D295/14
CPC分类号： C07D295/185 , C07B2200/09 , C07C45/29 , C07C49/697 , C07C49/747 , C07C49/753 , C07C217/52 , C07C233/23 , C07C233/31 , C07C233/58 , C07C233/59 , C07C235/40 , C07C235/82 , C07C237/04 , C07C237/24 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/48 , C07D211/58 , C07D213/38 , C07D241/08 , C07D295/096 , C07D295/15 , C07D295/155 , C07D295/192 , C07D295/205 , C07D401/06 , C07C47/228
摘要： The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R?1, R2, R3,R4, R5, R6, R7, R13, R14, R15, R16, R17, R?18, R19, R21a and R21b¿ are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
摘要翻译：本发明涉及式（I）的化合物：其中环A是苯基或吡啶环; X代表选自（a），（b），（c），（d），（e），（f），（g），（h），（i），（j），（k），（l）和R 1，R 2，R 3，R 4，R R 5，R 6，R 7，R 13，R 14，R 14， R 16，R 16，R 17，R 18，R 19，R 21a， SUP＆gt;和R＆lt; 21b＆gt;如本文所定义。这些化合物特别用于治疗或预防抑郁，焦虑，疼痛，炎症，偏头痛，呕吐或带状疱疹后神经痛。

6. 发明公开

EP0652866A1 AZACYCLIC COMPOUNDS 失效
标题翻译：氮杂联系*。
公开(公告)号：EP0652866A1
公开(公告)日：1995-05-17
申请号：EP93917877.0
申请日：1993-07-20
申请人： MERCK SHARP & DOHME LTD.
发明人： SEWARD, Eileen Mary , SWAIN, Christopher John
IPC分类号： A61K31 , A61P11 , A61P25 , A61P29 , A61P43 , C07D207 , C07D211 , C07D401 , C07D405
CPC分类号： C07D401/12 , C07D207/12 , C07D211/42 , C07D211/54 , C07D405/12
摘要： Compounds of Formula (I), and salts and prodrugs thereof, wherein n is 1, 2 or 3; X represents O or S; R1 is optionally substituted phenyl; R2 is aryl or heteroaryl; R?4 and R5¿ are independently H, halo, C¿1-6?alkyl, oxo, CH2OR?a, CO¿2Ra or CONRaRb; R8 represents C(COORa)2, C(CONRaRb)2 or C1-6alkyl substituted by C(=NR?a)NRbNRcCO¿2Rd, CONHNRaRb, C(S)NR?aRb, CONRaC¿1-6alkylR?12, CONR13C¿2-6alkynyl, CONR13C2-6alkenyl, COCONR?aRb, CONRaC(NRb)NRcRd, CONR13SO¿2Ra, SO2NR?13CORa, CONRa¿heteroaryl or COR?q; Ra, Rb, Rc and Rd¿ are each H, C¿1-6?alkyl, phenyl or trifluoromethyl. R?12¿ represents OR?a, CONRaRb¿ or heteroaryl; R13 represents H or C¿1-6?alkyl; and R?q¿ represents a group (a) where Q represents the residue of a non-aromatic azacyclic or azabicyclic ring system; are tachykinin antagonists useful in therapy.

7. 发明公开

EP0636130A1 AZACYCLIC COMPOUNDS 失效
标题翻译： AZACYCLIC化合物
公开(公告)号：EP0636130A1
公开(公告)日：1995-02-01
申请号：EP93910151.0
申请日：1993-04-14
申请人： MERCK SHARP & DOHME LTD.
发明人： BAKER, Raymond , LADDHWAHETTY, Tamara , SEWARD, Eileen Mary , SWAIN, Christopher John
IPC分类号： C07D211 , A61K31 , A61P11 , C07D207 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417
CPC分类号： C07D401/06 , C07D207/12 , C07D211/54 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D417/06
摘要： Compounds of formula (I), and salts and prodrugs thereof wherein n is 1, 2 or 3; X represents O or S; Y represents a hydrocarbon chain of 1, 2, 3 or 4 carbon atoms optionally substituted by oxo; R1 is phenyl optionally substituted by 1, 2 or 3 of C¿1-6?alkyl, C2-6alkenyl, C2-6alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, -OR?a, SRa, SORa, SO¿2R?a, -NRaRb, -NRaCORb, -NRaCO¿2Rb, -CO2Ra or -CONRaRb; R2 is phenyl, indazolyl, thienyl, furyl, pyridyl, thiazolyl, tetrazolyl, quinolyl, benzhydryl, or benzyl; R?4 and R5¿ each independently represent H, halo, C¿1-6?alkyl, oxo, CH2OR?a, CO¿2Ra or CONRaRb; R8 represents an optionally substituted aromatic heterocycle; and R?a and Rb¿ are H, trifluoromethyl, C¿1-6?alkyl or phenyl optionally substituted by C1-6alkyl, halo or trifluoromethyl; are tachykinin antagonists useful in medecine.
摘要翻译：式（I）化合物及其盐或前体药物，其中n为1,2或3; X代表O或S; Y代表任选被氧代取代的1,2,3或4个碳原子的烃链; R1是任选被1,2或3个C1-6烷基，C2-6链烯基，C2-6炔基，卤素，氰基，硝基，三氟甲基，三甲基甲硅烷基，-OR3a，SRa，SORa，SO2R -NR a R b，-NR a COR b，-NR a CO 2 R b，-CO 2 R a或-CONR a R b; R2为苯基，吲唑基，噻吩基，呋喃基，吡啶基，噻唑基，四唑基，喹啉基，二苯甲基或苄基; R 4和R 5各自独立地代表H，卤素，C 1-6烷基，氧代，CH 2 OR a，CO 2 R a或CONR a R b; R8表示任选取代的芳族杂环; R 3a和R b为H，三氟甲基，C 1-6烷基或任选被C 1-6烷基，卤素或三氟甲基取代的苯基; 是速激肽拮抗剂，可用于糖尿病。

8. 发明公开

EP0942735A1 USE OF NK-1 RECEPTOR ANTAGONISTS FOR TREATING SCHIZOPHRENIC DISORDERS 失效
标题翻译： NK-1受体拮抗剂的FOR病症精神分裂症的药物中的用途
公开(公告)号：EP0942735A1
公开(公告)日：1999-09-22
申请号：EP97953724.0
申请日：1997-11-25
申请人： MERCK SHARP & DOHME LTD.
发明人： BAKER, Raymond, BBSRC , CURTIS, Neil Roy , ELLIOTT, Jason Matthew , HARRISON, Timothy , HOLLINGWORTH, Gregory John , JACKSON, Philip Stephen , KULAGOWSKI, Janusz Jozef , RUPNIAK, Nadia Melanie , SEWARD, Eileen Mary , SWAIN, Christopher John , WILLIAMS, Brian John
IPC分类号： C07D491 , A61K31 , A61K45 , A61P25 , A61P43 , C07D211 , C07D401
CPC分类号： A61K31/661 , A61K31/395 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/5375 , A61K31/5377 , A61K31/675 , C07D211/56 , C07D491/10
摘要： The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist for the manufacture of a medicament adapted for oral administration for the treatment or prevention of schizophrenic disorders, methods of treatment using such a NK-1 receptor antagonist and pharmaceutical compositions comprising it.

9. 发明公开

EP0929554A1 SPIRO-AZACYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TACHYKININ ANTAGONISTS 失效
标题翻译：螺氮杂衍生物，生产与应用，速激肽拮抗剂
公开(公告)号：EP0929554A1
公开(公告)日：1999-07-21
申请号：EP97919167.0
申请日：1997-09-18
申请人： MERCK SHARP & DOHME LTD.
发明人： HAWORTH, Karen Elizabeth , SEWARD, Eileen Mary , SWAIN, Christopher John
IPC分类号： A61P25 , A61K31 , A61P1 , A61P9 , A61P11 , A61P13 , A61P15 , A61P17 , A61P19 , A61P27 , A61P29 , A61P35 , A61P37 , A61P43 , C07D491
CPC分类号： C07D491/10
摘要： Substituted spiro-azacyclic derivatives of structural formula (I), wherein R1 represents hydrogen, hydroxy, C¿1-6?alkyl, C2-6alkenyl, C3-7cycloalkyl optionally substituted alkyl, optionally substituted alkoxy, C2-6alkenyloxy, C3-7cycloalkoxy, phenoxy, benzyloxy, cyano, halogen, NR?11COR14, NRaRb, SRa, SORa, SO¿2Ra or OSO¿2R?a; R2 represents hydrogen, halogen, C¿1-6?alkyl or C1-6alkoxy; or when R?2¿ is adjacent to R1, they may be joined together such that there is formed a 5- or 6-membered saturated or unsaturated ring containing one or two oxygen atoms; R3 represents an optionally substituted 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms, selected from nitrogen, oxygen and sulphur; R4 represents hydrogen, halogen, C¿1-6?alkyl, C1-6alkoxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SR?a, SORa, SO¿2Ra, CO2R?a, CONRaRb, C¿2-6alkenyl, C2-6alkynyl or C1-4alkyl substituted by C1-4alkoxy; R5 represents hydrogen, halogen, C¿1-6?alkyl, trifluoromethyl or C1-6alkoxy substituted by C1-4alkoxy; R?6¿ represents hydrogen, CORa, CO2Ra, COCONRaRb, COCO¿2R?a, optionally substituted C¿1-6?alkyl; or R?6¿ represents a group of the formula -CH¿2?C CCH2NR?7R8; or R6¿ represents C¿1-6?alkyl, optionally substituted by oxo, substituted by a 5-membered or 6-membered heterocyclic ring containing 1, 2 or 3 nitrogen atoms optionally substituted by =O or =S and optionally substituted by a group of the formula ZNR?7R8; R9 and R10¿ each independently represents hydrogen, halogen, C¿1-6?alkyl, CH2OR?d¿, oxo, CO¿2R?a or CONRaRb; p is zero or 1; q is 1 or 2; and X represents -CH¿2?- or -CH2CH2-; Y represents -CH=, -CH2-, -CH2CH= or -CH2CH2-, with the proviso that the sum total of carbon atoms in X+Y is 2 or 3; and when X is -CH2- and Y is -CH= or -CH2CH=, the broken line represents a double bond; or a pharmaceutically acceptable salt thereof, are tachykinin receptor antagonists of use, for example, in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.

10. 发明授权

EP0593557B1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY 失效
标题翻译：芳烃含药物组合物及其治疗应用
公开(公告)号：EP0593557B1
公开(公告)日：1996-01-31
申请号：EP92914055.6
申请日：1992-07-03
申请人： MERCK SHARP & DOHME LTD.
发明人： SWAIN, Christopher John , TEALL, Martin Richard , WILLIAMS, Brian John
IPC分类号： C07C217/48 , C07C271/20 , C07C237/20 , C07C229/36 , C07D295/092 , C07C229/14 , C07C237/08 , C07C233/18
CPC分类号： C07D295/185 , A61K38/00 , C07C211/29 , C07C217/48 , C07C217/64 , C07C229/14 , C07C229/36 , C07C233/18 , C07C233/22 , C07C233/73 , C07C237/06 , C07C237/08 , C07C237/20 , C07C255/13 , C07C255/54 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/10 , C07C275/24 , C07C275/28 , C07C311/04 , C07C2601/02 , C07D207/28 , C07D241/08 , C07D295/092 , C07K5/06026 , Y10S514/886
摘要： Compounds of formula (I), and salts and prodrugs thereof, wherein Q is R?9CR10R11¿ or CH¿2?R?9CR10R11¿ where R9 is H or OH and R?10 and R11¿ are optionally substituted phenyl, optionally substituted benzyl, C¿5-7?cycloalkyl or (C5-7cycloalkyl)methyl; R?1 and R2¿ are H, optionally substituted C¿1-6? alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkenyl, C2-6 alkynyl, COR?a, COORa¿, COC¿1-6?alkylhalo, COC1-6alkylNR?aRb, CONR12C¿1-6alkylCONR?aRb, CONRaRb¿, or SO¿2?R?a, or R1 and R2¿ together form a chain (CH¿2?)q optionally substituted by oxo where one methylene group may optionally be replaced by O or NR?x; R3¿ is H, C¿1-6? alkyl or C2-6alkenyl; R?4¿ is optionally substituted phenyl(C¿1-3? alkyl); X and Y are H, or X and Y together are =O; and Z is O, S, or NR?7¿; are tachykinin antagonists. They and compositions thereof are useful in therapy.
摘要翻译：式（I）的化合物及其盐和药物前体： worin Q是 - [R <9> CR <1> <0> - [R <1> <1>或CH 2 <9> CR <1> <0>ř <1> <1>，其中R <9>是H或OH并且R <1> <0>和R <1> <1>是任选取代的苯基，任选取代的苄基，C 5-7环烷基或（5-7环烷基基）甲基; [R <1>和R <2>是H，任选substituiertem C 1-6烷基，取代的苯基（C 1-4烷基），C 2-6烯基，C 2-6炔基任选地，COR ，COOR COC1 -6alkylhalo，COC 1-6-alkylNR 中ř的，CONR <1> <2> C1-6alkylCONR - [R的，CONR 中ř的，或SO 2 R ，或 [R <1>和R <2>一起形成链（CH 2）由氧代q OPTIONALLY substituiertem其中一个亚甲基可被O任选地替换或NR ; [R <3>为H，C 1-6烷基或C 2-6烯基; [R <4>任选substituiertem苯基（C 1-3烷基）; X和Y是H，或X和Y一起为= O; 并且Z为O，S，或NR <7>; 是速激肽拮抗剂。他们及其组合物可用于治疗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式