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1. 发明申请

WO2010104933A1 INHIBITORS OF AKT ACTIVITY 审中-公开
标题翻译： AKT活动的抑制剂
公开(公告)号：WO2010104933A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/026796
申请日：2010-03-10
申请人： MERCK SHARP & DOHME CORP. , BANYU PHARMACEUTICAL CO., LTD. , FAN, Weiming , HAXELL, Thomas, F. N. , JENKS, Matthew, G. , KAWANISHI, Nobuhiko , LEE, Shuliang , LIU, Hao , MALASKA, Michael, J. , MOORE, Joseph, A., III , OGINO, Yoshio , ONOZAKI, Yu , PANDI, Bharathi , PEEL, Michael, R. , SAKAMOTO, Toshihiro , SIU, Tony
发明人： FAN, Weiming , HAXELL, Thomas, F. N. , JENKS, Matthew, G. , KAWANISHI, Nobuhiko , LEE, Shuliang , LIU, Hao , MALASKA, Michael, J. , MOORE, Joseph, A., III , OGINO, Yoshio , ONOZAKI, Yu , PANDI, Bharathi , PEEL, Michael, R. , SAKAMOTO, Toshihiro , SIU, Tony
IPC分类号： C07D403/00 , C07D413/00
CPC分类号： C07D471/14 , C07D487/14 , C07D519/00
摘要： The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译：本发明提供抑制Akt活性的取代的稠合萘啶衍生物。特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。

2. 发明申请

WO2007127012A1 ANTIFUNGAL AGENTS 审中-公开
标题翻译：反真菌药
公开(公告)号：WO2007127012A1
公开(公告)日：2007-11-08
申请号：PCT/US2007/007856
申请日：2007-03-29
申请人： MERCK & CO., INC. , SCYNEXIS, INC. , BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , TSE, Bruno , DROPINSKI, James , MENG, Dongfang , GREENLEE, Mark, L. , PEEL, Michael , FAN, Weiming , MAMAI, Ahmed , LIU, Hao , LI, Keqaing
发明人： BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , TSE, Bruno , DROPINSKI, James , MENG, Dongfang , GREENLEE, Mark, L. , PEEL, Michael , FAN, Weiming , MAMAI, Ahmed , LIU, Hao , LI, Keqaing
IPC分类号： A61K31/58 , C07J71/00 , A61P31/10
CPC分类号： C07J71/0005
摘要： The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (l,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
摘要翻译：本发明涉及式I的新型烯虫腈衍生物及其药学上可接受的盐，其合成及其作为（1,3）-β-D-葡聚糖合酶抑制剂的用途。本发明化合物及其药学上可接受的盐以及包含本发明化合物及其药学上可接受的盐的药物组合物可用于治疗或预防抗真菌感染和相关疾病和病症。

3. 发明授权

EP2406250B1 INHIBITORS OF AKT ACTIVITY 有权
标题翻译： AKT活性抑制剂
公开(公告)号：EP2406250B1
公开(公告)日：2015-08-12
申请号：EP10751342.6
申请日：2010-03-10
申请人： Merck Sharp & Dohme Corp. , MSD K.K.
发明人： FAN, Weiming , HAXELL, Thomas, F. N. , JENKS, Matthew, G. , KAWANISHI, Nobuhiko , LEE, Shuliang , LIU, Hao , MALASKA, Michael, J. , MOORE, Joseph, A., III , OGINO, Yoshio , ONOZAKI, Yu , PANDI, Bharathi , PEEL, Michael, R. , SAKAMOTO, Toshihiro , SIU, Tony
IPC分类号： C07D403/00 , C07D413/00 , C07D471/14 , C07D487/14 , A61K31/4375 , A61K35/00
CPC分类号： C07D471/14 , C07D487/14 , C07D519/00

4. 发明授权

EP2007396B1 Enfumafungin derivatives as antifungal agents 有权转让
标题翻译： Enfumafungin衍生ALS Antimykotika
公开(公告)号：EP2007396B1
公开(公告)日：2013-02-13
申请号：EP07754382.5
申请日：2007-03-29
申请人： Merck Sharp & Dohme Corp. , Scynexis, Inc.
发明人： BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , TSE, Bruno , DROPINSKI, James , MENG, Dongfang , GREENLEE, Mark, L. , PEEL, Michael , FAN, Weiming , MAMAI, Ahmed , LIU, Hao , LI, Keqaing
IPC分类号： A61K31/58 , C07J71/00 , A61P31/10
CPC分类号： C07J71/0005

5. 发明公开

EP2406250A1 INHIBITORS OF AKT ACTIVITY 有权
标题翻译： AKT活性抑制剂
公开(公告)号：EP2406250A1
公开(公告)日：2012-01-18
申请号：EP10751342.6
申请日：2010-03-10
申请人： Merck Sharp & Dohme Corp. , MSD K.K.
发明人： FAN, Weiming , HAXELL, Thomas, F. N. , JENKS, Matthew, G. , KAWANISHI, Nobuhiko , LEE, Shuliang , LIU, Hao , MALASKA, Michael, J. , MOORE, Joseph, A., III , OGINO, Yoshio , ONOZAKI, Yu , PANDI, Bharathi , PEEL, Michael, R. , SAKAMOTO, Toshihiro , SIU, Tony
IPC分类号： C07D403/00 , C07D413/00
CPC分类号： C07D471/14 , C07D487/14 , C07D519/00
摘要： The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译：本发明提供了抑制Akt活性的取代的稠合萘啶衍生物。特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。本发明还提供了包含此类抑制性化合物的组合物以及通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。

6. 发明申请

WO2012046144A1 METHOD AND APPARATUS FOR SUB-SAMPLING OF A CODEBOOK IN LTE-A SYSTEM 审中-公开
标题翻译：在LTE-A系统中对子代码进行子采样的方法和装置
公开(公告)号：WO2012046144A1
公开(公告)日：2012-04-12
申请号：PCT/IB2011/002828
申请日：2011-10-06
申请人： ALCATEL LUCENT , WU, Lu , YANG, Hongwei , LIU, Hao
发明人： WU, Lu , YANG, Hongwei , LIU, Hao
IPC分类号： H04L25/03
CPC分类号： H04B7/0456 , H04B7/0469 , H04B7/0478 , H04L25/03343 , H04L25/03917 , H04L25/03923
摘要： The embodiments of the present invention disclose a method and an apparatus for sub-sampling of a codebook in the LTE-A system where a precoding matrix W is a product of two matrices W 1 and W 2 , i.e. W=W 1 W 2 , codebooks for W, W 1 and W 2 are denoted as C, C 1 and C 2 respectively, and r indicates a rank. The method includes sub-sampling the codebook C such that the sub-sampled codebook C has a size of equal to or less than 4 bits. In the sub-sampling, codewords evenly distributed in the codebook C are extracted, where some or all of the codewords are in a form of discrete Fourier transform (DFT) vector to be suitable for evenly linear arrays, and the other codewords are suitable for cross-polarized linear arrays.
摘要翻译：本发明的实施例公开了一种在LTE-A系统中对码本进行子采样的方法和装置，其中预编码矩阵W是两个矩阵W1和W2的乘积，即W = W1W2，W，W1的码本 W2分别表示为C，C1，C2，r表示秩。该方法包括对码本C进行子采样，使得子采样码本C具有等于或小于4位的大小。在子采样中，提取均匀分布在码本C中的码字，其中一些或全部码字是离散傅里叶变换（DFT）向量的形式，以适合均匀的线性阵列，其他码字适用于交叉极化线性阵列。

7. 发明申请

WO2012020310A2 METHOD OF TRANSMITTING FEEDBACK INFORMATION IN A MIMO COMMUNICATION SYSTEM AND DEVICE THEREOF 审中-公开
标题翻译：在MIMO通信系统中发送反馈信息的方法及其装置
公开(公告)号：WO2012020310A2
公开(公告)日：2012-02-16
申请号：PCT/IB2011/002065
申请日：2011-07-27
申请人： Alcatel Lucent , LIU, Hao
发明人： LIU, Hao
IPC分类号： H04B7/04
CPC分类号： H04B7/0478 , H04B7/0417 , H04B7/0641 , H04B7/065
摘要： The present invention provides a method of providing feedback information in a user equipment of a communication system based on MIMO, comprising: determining a first latest measured long-term covariance matrix according to a downlink channel matrix model; transmitting the quantization of a first latest estimated long-term covariance matrix corresponding to the first latest measured long-term covariance matrix to the base station; determining a second latest measured long-term covariance matrix according to a downlink channel matrix model; determining the variation information of a second latest estimated long-term covariance matrix with respect to an estimated long-term covariance matrix of the last-time reset point; and transmitting the quantization of the variation information to the base station. With such a solution, overhead during the feedback of long-term covariance matrix is greatly reduced in MIMO scenario.
摘要翻译：本发明提供一种在基于MIMO的通信系统的用户设备中提供反馈信息的方法，包括：根据下行链路信道矩阵模型确定第一最新测量的长期协方差矩阵; 将与所述第一最近测量的长期协方差矩阵相对应的第一最新估计长期协方差矩阵的量化向所述基站发送; 根据下行链路信道矩阵模型确定第二最新测量的长期协方差矩阵; 确定关于最后一次复位点的估计长期协方差矩阵的第二最新估计长期协方差矩阵的变化信息; 以及向所述基站发送所述变化信息的量化。通过这样的解决方案，在MIMO方案中大大减少了长期协方差矩阵反馈期间的开销。

8. 发明申请

WO2010145557A1 SYSTEM AND METHOD FOR DETERMINING PERFORMANCE OF WEARABLE ELECTRODE 审中-公开
标题翻译：用于确定可磨损电极性能的系统和方法
公开(公告)号：WO2010145557A1
公开(公告)日：2010-12-23
申请号：PCT/CN2010/074039
申请日：2010-06-18
申请人： THE HONG KONG POLYTECHNIC UNIVERSITY , TAO, Xiao-ming , WANG, Rong-xin , LI, Xin-sheng , LIU, Hao
发明人： TAO, Xiao-ming , WANG, Rong-xin , LI, Xin-sheng , LIU, Hao
IPC分类号： G06G7/48 , G06G7/62 , H01L21/00
CPC分类号： G01N27/4163
摘要： A system (100) and a method for determining the performance of a wearable electrode are provided. The system (100) includes a container (37) of liquid to simulate a static or dynamic environment for the electrode; a measurement module (2) to analyse and record predetermined properties of the electrode in response to passing an electrical current through the liquid during operation in the simulated environment to determine the performance of the electrode.
摘要翻译：提供一种用于确定耐磨电极的性能的系统（100）和方法。系统（100）包括用于模拟电极的静态或动态环境的液体容器（37）测量模块（2），用于响应于在模拟环境中的操作期间使电流通过液体来分析和记录电极的预定特性，以确定电极的性能。

9. 发明申请

WO2006028421A1 MULTI-DIE IC PACKAGE AND MANUFACTURING METHOD 审中-公开
标题翻译：多芯片封装和制造方法
公开(公告)号：WO2006028421A1
公开(公告)日：2006-03-16
申请号：PCT/SG2005/000310
申请日：2005-09-09
申请人： UNITED TEST AND ASSEMBLY CENTER (S) PTE LTD , WANG, Chuen Khiang , LIU, Hao , TAN, Hien Boon , LAW, Teik Lyk, Clifton , BIDIN, Rahamat , SUN, Yi Sheng, Anthony
发明人： WANG, Chuen Khiang , LIU, Hao , TAN, Hien Boon , LAW, Teik Lyk, Clifton , BIDIN, Rahamat , SUN, Yi Sheng, Anthony
IPC分类号： H01L25/065
CPC分类号： H01L23/49575 , H01L23/4951 , H01L24/48 , H01L24/49 , H01L2224/32245 , H01L2224/48091 , H01L2224/48247 , H01L2224/4826 , H01L2224/49 , H01L2224/73215 , H01L2224/73265 , H01L2225/06562 , H01L2924/00014 , H01L2924/01033 , H01L2924/01078 , H01L2924/01082 , H01L2924/14 , H01L2924/1532 , H01L2924/181 , H01L2224/45099 , H01L2224/05599 , H01L2924/00012
摘要： A method for manufacturing integrated circuit packages (100, 200, 300) and a muli-chip integrated circuit package (100, 200, 300) are disclosed. A first die (110) is attached onto a first side of a set of leads of a leadframe (130), an adhesive (350) is applied onto the set of leads at a second side opposite to the first side. A second die (120) is attached onto the adhesive (350). The adhesive fills into the gaps between the leads. The adhesive is then cured. The adhesive attaching the second die fills the a s between the leads so that to avoid formation of internal cavities in the package
摘要翻译：公开了一种用于制造集成电路封装（100,200,300）和多晶硅集成电路封装（100,200,300）的方法。第一模具（110）附接到引线框架（130）的一组引线的第一侧上，在与第一侧相对的第二侧处将粘合剂（350）施加到引线组上。第二模具（120）附接到粘合剂（350）上。粘合剂填充到引线之间的间隙中。然后将粘合剂固化。附着第二模具的粘合剂在引线之间填充a，以避免在封装中形成内部空腔

10. 发明申请

WO2003027246A2 ANTAGONISTS 审中-公开
标题翻译：拮抗剂
公开(公告)号：WO2003027246A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/030412
申请日：2002-09-24
申请人： NOVO NORDISK A/S , DGI BIOTECHNOLOGIES , PILLUTLA, Renuka , DEDOVA, Olga , BLUME, Arthur, J. , GOLDSTEIN, Neil, I. , BRISSETTE, Renee , WANG, Pinger , LIU, Hao , HSIAO, Ku-chuan , LENNICK, Michael , FLETCHER, Paul
发明人： PILLUTLA, Renuka , DEDOVA, Olga , BLUME, Arthur, J. , GOLDSTEIN, Neil, I. , BRISSETTE, Renee , WANG, Pinger , LIU, Hao , HSIAO, Ku-chuan , LENNICK, Michael , FLETCHER, Paul
IPC分类号： C12N
CPC分类号： C07K14/65 , C07K14/62
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
摘要翻译：公开了能够结合具有激动剂或拮抗剂活性的胰岛素和/或胰岛素样生长因子受体并从各种肽文库鉴定的肽序列。本发明还鉴定至少两个不同的结合位点，其存在于胰岛素和胰岛素样生长因子受体上，并选择性结合本发明的肽。作为激动剂，本发明的肽可用于开发作为补充或替代内源性肽激素的治疗剂。拮抗剂肽也可以开发为治疗剂。

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