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1. 发明申请

WO2021257490A1 2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS 审中-公开
公开(公告)号：WO2021257490A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037303
申请日：2021-06-15
申请人： MERCK SHARP & DOHME CORP. , ARASAPPAN, Ashok , BELL, Ian, M. , BUNGARD, Christopher, James , BURGEY, Christopher, S. , COX, Jason, M. , KELLY, Michael, J., III , LAYTON, Mark, E. , LIU, Hong , LIU, Jian , PERKINS, James, J. , SHAH, Akshay, A. , VANHEYST, Michael, David , WU, Zhe
发明人： ARASAPPAN, Ashok , BELL, Ian, M. , BUNGARD, Christopher, James , BURGEY, Christopher, S. , COX, Jason, M. , KELLY, Michael, J., III , LAYTON, Mark, E. , LIU, Hong , LIU, Jian , PERKINS, James, J. , SHAH, Akshay, A. , VANHEYST, Michael, David , WU, Zhe
IPC分类号： C07D233/32 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04 , C07D401/14 , C07D471/08
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

2. 发明申请

WO2021257418A1 2-OXO-OXAZOLIDINE-5-CARBOXAMIDES AS NAV1.8 INHIBITORS 审中-公开
公开(公告)号：WO2021257418A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037157
申请日：2021-06-14
申请人： MERCK SHARP & DOHME CORP. , ARASAPPAN, Ashok , BELL, Ian, M. , BUNGARD, Christopher James , BURGEY, Christopher, S. , COX, Jason, M. , GUIADEEN, Deodial Guy , KELLY, Michael, J., III , LAYTON, Mark, E. , LIU, Hong , LIU, Jian , OLSEN, James, T. , PERKINS, James, J. , SCHUBERT, Jeffrey, W. , SHAH, Akshay, A. , STACHEL, Shawn, J. , VANHEYST, Michael, D. , WU, Zhe
发明人： ARASAPPAN, Ashok , BELL, Ian, M. , BUNGARD, Christopher James , BURGEY, Christopher, S. , COX, Jason, M. , GUIADEEN, Deodial Guy , KELLY, Michael, J., III , LAYTON, Mark, E. , LIU, Hong , LIU, Jian , OLSEN, James, T. , PERKINS, James, J. , SCHUBERT, Jeffrey, W. , SHAH, Akshay, A. , STACHEL, Shawn, J. , VANHEYST, Michael, D. , WU, Zhe
IPC分类号： A61K31/4045 , A61K31/4155 , A61K31/4178
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

3. 发明申请

WO2020092667A1 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS 审中-公开
公开(公告)号：WO2020092667A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058999
申请日：2019-10-31
申请人： MERCK SHARP & DOHME CORP. , ARASAPPAN, Ashok , BELL, Ian, M. , BRESLIN, Michael, J. , BUNGARD, Christopher James , BURGEY, Christopher, S. , CHOBANIAN, Harry, R. , COX, Jason, M. , GINNETTI, Anthony, T. , GUIADEEN, Deodial Guy , JONES, Kristen, L. G. , LAYTON, Mark, E. , LIU, Hong , LIU, Jian , PERKINS, James, J. , STACHEL, Shawn, J. , SUEN-LAI, Linda, M. , WU, Zhe
发明人： ARASAPPAN, Ashok , BELL, Ian, M. , BRESLIN, Michael, J. , BUNGARD, Christopher James , BURGEY, Christopher, S. , CHOBANIAN, Harry, R. , COX, Jason, M. , GINNETTI, Anthony, T. , GUIADEEN, Deodial Guy , JONES, Kristen, L. G. , LAYTON, Mark, E. , LIU, Hong , LIU, Jian , PERKINS, James, J. , STACHEL, Shawn, J. , SUEN-LAI, Linda, M. , WU, Zhe
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/04 , C07D495/04 , A61P29/00 , A61K31/4439 , A61K31/444 , C07D409/14
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

4. 发明申请

WO2020092187A1 2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS 审中-公开
公开(公告)号：WO2020092187A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058251
申请日：2019-10-28
申请人： MERCK SHARP & DOHME CORP. , BRESLIN, Michael, J. , BUNGARD, Christopher James , CHOBANIAN, Harry, R. , JONES, Kristen, L. G. , LAYTON, Mark, E. , LIU, Jian , PERKINS, James, J. , SCHUBERT, Jeffrey William , STACHEL, Shawn, J. , SUEN-LAI, Linda, M. , WU, Zhe
发明人： BRESLIN, Michael, J. , BUNGARD, Christopher James , CHOBANIAN, Harry, R. , JONES, Kristen, L. G. , LAYTON, Mark, E. , LIU, Jian , PERKINS, James, J. , SCHUBERT, Jeffrey William , STACHEL, Shawn, J. , SUEN-LAI, Linda, M. , WU, Zhe
IPC分类号： A61K31/4425 , A61K31/167 , A61K31/44 , C07D213/06 , C07D213/20
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na v 1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Na v 1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

5. 发明申请

WO2022094012A1 MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS 审中-公开
公开(公告)号：WO2022094012A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/056947
申请日：2021-10-28
申请人： MERCK SHARP & DOHME CORP. , ARMACOST, Kira, A. , CHIRIAC, Maria Irina , HURZY, Danielle, M. , KERN, Jeffrey, C. , LIU, Jian , MANLEY, Peter, J. , RADA, Vanessa, L. , RUDD, Michael, T. , STUMP, Craig, A. , WU, Zhe , XIAO, Dong
发明人： ARMACOST, Kira, A. , CHIRIAC, Maria Irina , HURZY, Danielle, M. , KERN, Jeffrey, C. , LIU, Jian , MANLEY, Peter, J. , RADA, Vanessa, L. , RUDD, Michael, T. , STUMP, Craig, A. , WU, Zhe , XIAO, Dong
IPC分类号： A61K31/395 , A61K31/4162 , A61K31/4188 , C07D487/04
摘要： The present invention is directed to macrocyclic urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

8. 发明申请

WO2005109251A3 WEB SERVER FOR MULTI-VERSION WEB DOCUMENTS 审中-公开
公开(公告)号：WO2005109251A3
公开(公告)日：2005-11-17
申请号：PCT/US2005/015700
申请日：2005-05-04
申请人： ORACLE INTERNATIONAL CORPORATION , WU, Zhe
发明人： WU, Zhe
IPC分类号： G06F17/30
摘要： A repository server that makes stored copies of Web-accessible documents available at times when the documents themselves are inaccessible via the Web, because the server the document is located on is unavailable, because the server has removed or renamed the document, or because the server has replaced the version of which the stored copy is a copy with a different version. A client of the repository server may register a document in the repository server. The repository server makes a copy of the registered document and returns a repository URL for the copy to the client. The repository URL may be used to fetch the copy from the repository URL. Registration further relates the stored copy to its document URL, to an identifier for the stored copy, to a fingerprint that is a condensed representation of the stored copy’s content, and to a set of stored copies having similar content. Other operations performed by the repository server include: 1) fetching the content of a document that is registered in the repository server. This is done by receiving a repository URL and determining whether the document corresponding to the stored copy specified by the repository URL is available via the Web; if it is, the client is redirected to the location specified by the document’s document URL; otherwise, the stored copy is fetched. 2) providing the client with a list of a repository URLs for stored copies that are related to the same document URL; and 3) providing the client with a list of repository URLs for stored copies that are similar to the stored copy specified by a given repository URL. The fingerprints are used to compute similarity.

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