专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012058210A1 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) 审中-公开
标题翻译： RNA干扰介导的使用短暂干扰核酸的基因表达的抑制（siNA）
公开(公告)号：WO2012058210A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057663
申请日：2011-10-25
申请人： MERCK SHARP & DOHME CORP. , CANCILLA, Mark , CUNNINGHAM, James, J. , FLANAGAN, W. Michael , HARINGSMA, Henry, J. , KENSKI, Denise , STANTON, Matthew, G. , STIRDIVANT, Steven, M. , WILLINGHAM, Aarron
发明人： CANCILLA, Mark , CUNNINGHAM, James, J. , FLANAGAN, W. Michael , HARINGSMA, Henry, J. , KENSKI, Denise , STANTON, Matthew, G. , STIRDIVANT, Steven, M. , WILLINGHAM, Aarron
IPC分类号： A61K31/713 , C07H21/02
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/331 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2320/32 , C12N2320/51 , C12N2310/3527 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
摘要翻译：本发明涉及用于研究，诊断和治疗响应于基因表达和/或活性的调节和/或调节基因表达途径的性状，疾病和病症的化合物，组合物和方法。具体地说，本发明涉及包括小核酸分子的双链核酸分子，例如能够介导或介导针对靶基因表达的RNA干扰（RNAi）的短干扰核酸（siNA）分子。

2. 发明申请

WO2019241178A1 COMPLEX MOLECULE SUBSTRUCTURE IDENTIFICATION SYSTEMS, APPARATUSES AND METHODS 审中-公开
公开(公告)号：WO2019241178A1
公开(公告)日：2019-12-19
申请号：PCT/US2019/036449
申请日：2019-06-11
申请人： MERCK SHARP & DOHME CORP.
发明人： FRIDMAN, Arthur , BAGCHI, Ansuman , YU, Xiang , CANCILLA, Mark
IPC分类号： G16B50/00 , G16B45/00
摘要： Embodiments of the present invention provide a computer-implemented system and method for generating and searching a database containing all of the potential substructures (e.g., metabolites) of a chosen complex molecule based on minimum cleavable units (MCUs) of the chosen complex molecule, wherein each record in the generated database suitably defines the molecular weight and physical arrangement of each substructure. Embodiments of the invention also provide a user interface and a search engine for searching the database based on a query molecular weight (or query molecular weight range) to identify all of the substructures having a total molecular weight matching the query molecular weight or range. Embodiments of the invention are also capable of transmitting to a display device operated by an end user a description and/or a graphical representation of every identified substructure of the chosen complex molecule.

3. 发明申请

WO2019241191A1 CUT VERTEX METHOD FOR IDENTIFYING COMPLEX MOLECULE SUBSTRUCTURES 审中-公开
公开(公告)号：WO2019241191A1
公开(公告)日：2019-12-19
申请号：PCT/US2019/036467
申请日：2019-06-11
申请人： MERCK SHARP & DOHME CORP.
发明人： FRIDMAN, Arthur , BAGCHI, Ansuman , YU, Xiang , CANCILLA, Mark
IPC分类号： G16C20/20
摘要： Embodiments of the present invention avoid the processing problems associated with using conventional computer systems for identifying and characterizing all of the substructures (e.g., metabolites) of large complex molecules by using a defined minimum cleavable unit (MCU) and an MCU graph for a chosen molecule, as well as a "cut vertex" in the MCU graph for the chosen molecule. The system splits the MCU graph of the chosen molecule at the specified cut vertex to produce two separate MCU graph components (i.e., a first MCU subgraph and a second MCU subgraph) of the chosen molecule, and generates and traverses a first line graph component and a second line graph component, respectively, for the two MCU subgraph components with a graph traversing algorithm to generate and store in memory a first database of substructures and molecular weights for the first component, and a second database of substructures and molecular weights for the second line graph component. Subsequently, embodiments of the present invention can perform binary searches on the two databases (or the two subsections of a single database) to identify and produce graphic representations of all of the substructures of the chosen molecule that have molecular weights that match the query molecular weight (or range of query molecular weights), including the substructures of the chosen molecule that straddle (i.e., include) the cut vertex.

4. 发明公开

EP3794599A1 CUT VERTEX METHOD FOR IDENTIFYING COMPLEX MOLECULE SUBSTRUCTURES 审中-公开
公开(公告)号：EP3794599A1
公开(公告)日：2021-03-24
申请号：EP19820431.5
申请日：2019-06-11
申请人： MERCK SHARP & DOHME CORP.
发明人： FRIDMAN, Arthur , BAGCHI, Ansuman , YU, Xiang , CANCILLA, Mark
IPC分类号： G16C20/20

5. 发明公开

EP2632472A1 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) 有权转让
标题翻译：通过RNA干扰介导的抑制使用短干扰核酸（新浪网）的基因表达
公开(公告)号：EP2632472A1
公开(公告)日：2013-09-04
申请号：EP11836946.1
申请日：2011-10-25
申请人： Merck Sharp & Dohme Corp.
发明人： CANCILLA, Mark , CUNNINGHAM, James, J. , FLANAGAN, W. Michael , HARINGSMA, Henry, J. , KENSKI, Denise , STANTON, Matthew, G. , STIRDIVANT, Steven, M. , WILLINGHAM, Aarron
IPC分类号： A61K31/713 , C07H21/02
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/331 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2320/32 , C12N2320/51 , C12N2310/3527 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
摘要翻译：本发明涉及化合物，组合物，以及用于研究，诊断和治疗的性状，疾病和状况没有对基因表达和/或活性的调节有反应的，和/或调节基因表达的途径的方法。具体地说，本发明涉及一种包括小核酸分子，：如短干扰核酸双链核酸分子（的siNA）分子确实能够介导的或没有介导针对靶基因表达的RNA干扰（RNAi）。

6. 发明公开

EP3794597A1 COMPLEX MOLECULE SUBSTRUCTURE IDENTIFICATION SYSTEMS, APPARATUSES AND METHODS 审中-公开
公开(公告)号：EP3794597A1
公开(公告)日：2021-03-24
申请号：EP19819375.7
申请日：2019-06-11
申请人： MERCK SHARP & DOHME CORP.
发明人： FRIDMAN, Arthur , BAGCHI, Ansuman , YU, Xiang , CANCILLA, Mark
IPC分类号： G16B50/00 , G16B45/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式