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1. 发明专利

ES2402659T3 Derivados de enfumafungina como agentes antifúngicos 未知
公开(公告)号：ES2402659T3
公开(公告)日：2013-05-07
申请号：ES07754382
申请日：2007-03-29
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： BALKOVEC JAMES , BOUFFARD FRANCES , TSE BRUNO , DROPINSKI JAMES , MENG DONGFANG , GREENLEE MARK , PEEL MICHAEL , FAN WEIMING , MAMAI AHMED , LIU HAO , LI KEQAING
IPC分类号： A61K31/58 , A61P31/10 , C07J71/00
摘要： Un compuesto de Fórmula I: **Fórmul** o una sal faUn compuesto de Fórmula I: **Fórmul** o una sal faUn compuesto de Fórmula I: **Fórmul** o una sal farmacéuticamente aceptable del mismo, en la que: X rmacéuticamente aceptable del mismo, en la que: X rmacéuticamente aceptable del mismo, en la que: X es O o H,H; 5 R1 es a) OH; b) OC(O)alquilo C1-C12,es O o H,H; 5 R1 es a) OH; b) OC(O)alquilo C1-C12,es O o H,H; 5 R1 es a) OH; b) OC(O)alquilo C1-C12, sin sustituir o sustituido con 1 o 2 sustituyente sin sustituir o sustituido con 1 o 2 sustituyente sin sustituir o sustituido con 1 o 2 sustituyentes seleccionados entre OR0, N(R0)2 y CO2R0; c) OC(Os seleccionados entre OR0, N(R0)2 y CO2R0; c) OC(Os seleccionados entre OR0, N(R0)2 y CO2R0; c) OC(O)haloalquilo C1-C6; d) OC(O)cicloalquilo C3-C8; e))haloalquilo C1-C6; d) OC(O)cicloalquilo C3-C8; e))haloalquilo C1-C6; d) OC(O)cicloalquilo C3-C8; e) O-alquilo C1-C6, sin sustituir o sustituido con 1 O-alquilo C1-C6, sin sustituir o sustituido con 1 O-alquilo C1-C6, sin sustituir o sustituido con 1 o 2 sustituyentes seleccionados entre OR0 y N(R0) o 2 sustituyentes seleccionados entre OR0 y N(R0) o 2 sustituyentes seleccionados entre OR0 y N(R0)2; f) OC(O)NH-alquilo C1-C6, sin sustituir o susti2; f) OC(O)NH-alquilo C1-C6, sin sustituir o susti2; f) OC(O)NH-alquilo C1-C6, sin sustituir o sustituido con fenilo; g) OC(O)O-alquilo C1-C6; h) NHC(tuido con fenilo; g) OC(O)O-alquilo C1-C6; h) NHC(tuido con fenilo; g) OC(O)O-alquilo C1-C6; h) NHC(O)alquilo C1-C6, sin sustituir o sustituido con feO)alquilo C1-C6, sin sustituir o sustituido con feO)alquilo C1-C6, sin sustituir o sustituido con fenilo; o i) (O)nCH2C(O)-alquilo C1-C6. nilo; o i) (O)nCH2C(O)-alquilo C1-C6. nilo; o i) (O)nCH2C(O)-alquilo C1-C6.

2. 发明专利

DK2007396T3 Enfumafungin-derivat som antimykotika 未知
公开(公告)号：DK2007396T3
公开(公告)日：2013-03-18
申请号：DK07754382
申请日：2007-03-29
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： BALKOVEC JAMES M , BOUFFARD FRANCES AILEEN , TSE BRUNO , DROPINSKI JAMES , MENG DONGFANG , GREENLEE MARK L , PEEL MICHAEL , FAN WEIMING , MAMAI AHMED , LIU HAO , LI KEQAING
IPC分类号： A61K31/58 , A61P31/10 , C07J71/00

3. 发明专利

CA2731941A1 ANTIFUNGAL AGENTS 未知
公开(公告)号：CA2731941A1
公开(公告)日：2010-02-18
申请号：CA2731941
申请日：2009-08-07
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： GREENLEE MARK L , WILKENING ROBERT , APGAR JAMES , SPERBECK DONALD , WILDONGER KENNETH JAMES , MENG DONGFANG , PARKER DANN L , PACOFSKY GREGORY JAMES , HEASLEY BRIAN HAID , MAMAI AHMED , NELSON KINGSLEY
IPC分类号： A01N43/64 , A61K31/21 , A61K31/41
摘要： Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (l,3)-ß-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs,,as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

4. 发明专利

AU2009282476A1 Antifungal agents 未知
公开(公告)号：AU2009282476A1
公开(公告)日：2010-02-18
申请号：AU2009282476
申请日：2009-08-10
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： GREENLEE MARK L , WILKENING ROBERT , APGAR JAMES , SPERBECK DONALD , WILDONGER KENNETH JAMES , MENG DONGFANG , PARKER DANN L JR , MAMAI AHMED
IPC分类号： A01N43/64 , A61K31/21 , A61K31/41
摘要： Novel derivatives of enfumafungin are disclosed herein, along with' their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and method of using such compounds as antifungal agents and/or inhibitors of (1,3)-&bgr;-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

5. 发明专利

AU2009282474A1 Antifungal agents 未知
公开(公告)号：AU2009282474A1
公开(公告)日：2010-02-18
申请号：AU2009282474
申请日：2009-08-07
申请人： SCYNEXIS INC , MERCK SHARP & DOHME
发明人： GREENLEE MARK L , WILKENING ROBERT , APGAR JAMES , SPERBECK DONALD , WILDONGER KENNETH JAMES , MENG DONGFANG , PARKER DANN L JR , PACOFSKY GREGORY JAMES , HEASLEY BRIAN HAID , MAMAI AHMED , NELSON KINGSLEY
IPC分类号： A01N43/64 , A61K31/21 , A61K31/41

6. 发明专利

CA2731696A1 ANTIFUNGAL AGENTS 未知
公开(公告)号：CA2731696A1
公开(公告)日：2010-02-18
申请号：CA2731696
申请日：2009-08-10
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： GREENLEE MARK L , WILKENING ROBERT , APGAR JAMES , SPERBECK DONALD , WILDONGER KENNETH JAMES , MENG DONGFANG , PARKER DANN L JR , MAMAI AHMED
IPC分类号： A01N43/64 , A61K31/21 , A61K31/41
摘要： Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and method of using such compounds as antifungal agents and/or inhibitors of (1,3)-.beta.-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

7. 发明专利

CA2731941C DERIVATIVES OF ENFUMAFUNGIN AS INHIBITORS OF(1,3)-BETA.-D-GLUCAN SYNTHASE 未知
公开(公告)号：CA2731941C
公开(公告)日：2016-09-27
申请号：CA2731941
申请日：2009-08-07
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： GREENLEE MARK L , WILKENING ROBERT , APGAR JAMES , SPERBECK DONALD , WILDONGER KENNETH JAMES , MENG DONGFANG , PARKER DANN L , PACOFSKY GREGORY JAMES , HEASLEY BRIAN HAID , MAMAI AHMED , NELSON KINGSLEY
IPC分类号： C07J71/00 , A01N43/64 , A61K31/58 , A61P31/10 , C07J63/00
摘要： Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as inhibitors of (1,3)-.beta.-D-glucan synthase.

8. 发明专利

AU2009282476B2 Antifungal agents 未知
公开(公告)号：AU2009282476B2
公开(公告)日：2015-04-09
申请号：AU2009282476
申请日：2009-08-10
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： GREENLEE MARK L , WILKENING ROBERT , APGAR JAMES , SPERBECK DONALD , WILDONGER KENNETH JAMES , MENG DONGFANG , PARKER JR DANN L , MAMAI AHMED
IPC分类号： C07J63/00 , A01N43/64 , A61K31/21 , A61K31/41 , C07D405/04
摘要： Novel derivatives of enfumafungin are disclosed herein, along with' their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and method of using such compounds as antifungal agents and/or inhibitors of (l,3)-&bgr;-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

9. 发明专利

CA2731696C ANTIFUNGAL AGENTS 未知
公开(公告)号：CA2731696C
公开(公告)日：2016-10-11
申请号：CA2731696
申请日：2009-08-10
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： GREENLEE MARK L , WILKENING ROBERT , APGAR JAMES , SPERBECK DONALD , WILDONGER KENNETH JAMES , MENG DONGFANG , PARKER DANN L JR , MAMAI AHMED
IPC分类号： C07J71/00 , A61K31/58 , A61P31/10 , C07J63/00
摘要： Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and method of using such compounds as antifungal agents and/or inhibitors of (1,3)-.beta.-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

10. 发明公开

EP2326181A4 ANTIFUNGAL AGENTS 审中-公开
标题翻译： ANTIMYKOTIKA
公开(公告)号：EP2326181A4
公开(公告)日：2012-11-28
申请号：EP09806945
申请日：2009-08-07
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： GREENLEE MARK L , WILKENING ROBERT , APGAR JAMES , SPERBECK DONALD , WILDONGER KENNETH JAMES , MENG DONGFANG , PARKER DANN L JR , PACOFSKY GREGORY JAMES , HEASLEY BRIAN HAID , MAMAI AHMED , NELSON KINGSLEY
IPC分类号： A01N43/64 , A61K31/21 , A61K31/41
CPC分类号： A61K31/343 , A01N43/653 , A61K31/21 , A61K31/41 , C07D493/08 , C07D519/00

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