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6. 发明专利

CA2202173A1 USE OF INHIBITORS OF CYCLOOXYGENASE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 未知
公开(公告)号：CA2202173A1
公开(公告)日：1996-04-25
申请号：CA2202173
申请日：1995-10-09
申请人： MERCK SHARP & DOHME , MERCK FROSST CANADA INC
发明人： LEGER SERGE , GAUTHIER JACQUE YVES , WANG ZHAOYIN , PRASIT PETPIBOON , THERIEN MICHEL , DUCHARME YVES , LEBLANC YVES , HILL RAYMOND GEORGE , SIRINATHSINGHJI DALIP JAICARAN
IPC分类号： A61K45/00
摘要： The invention describes a method of treating neurodegenerative disorders such as Alzheimer's Disease by using a COX-2 inhibitor.

7. 发明专利

CA2207650A1 USE OF A TACHYKININ ANTAGONIST AND AN OPIOID ANALGESIC 未知
公开(公告)号：CA2207650A1
公开(公告)日：1996-07-04
申请号：CA2207650
申请日：1995-12-15
申请人： MERCK SHARP & DOHME
发明人： HILL RAYMOND GEORGE
IPC分类号： C07D265/32 , A61K31/535 , A61K31/5375 , A61K45/06 , A61P25/04 , C07D413/06 , C07D417/02 , A61K31/485
摘要： The present invention relates to the use of a tachykinin antagonist and an opioid analgesic for manufacture of a medicament for the treatment or prevention of pain or nociception. There is also provided pharmaceutical compositions and products comprising a tachykinin antagonist and an opioid analgesic.

8. 发明专利

CA2345357A1 BENZIMIDAZOLINYL PIPERIDINES AS CGRP LIGANDS 未知
公开(公告)号：CA2345357A1
公开(公告)日：2000-04-06
申请号：CA2345357
申请日：1999-09-22
申请人： MERCK & CO INC , MERCK SHARP & DOHME
发明人： HILL RAYMOND GEORGE , PATCHETT ARTHUR A , YANG LIHU
IPC分类号： A61K31/4427 , A61K31/4433 , A61K31/454 , A61P3/10 , A61P9/10 , A61P25/04 , A61P25/06 , A61P29/00 , A61P35/00 , C07D401/04 , C07D409/14 , A61K31/415
摘要： A compound of formula I, wherein: R1 is naphthyl or benzothienyl which is unsubstituted or substituted at up to three substitutable positions independently by C1-6 alkyl, halogen, C1-6 alkoxy, CF3, OCF3, NO2, CN, methylenedioxy or ethylenedioxy; R2 is hydrogen, C1-8 alkyl, -(CH2)t-aryl wherein aryl is selected from phenyl, biphenyl and naphthyl, -(CH2)t- heteroaryl wherin heteroaryl is selected from tetrazolyl, oxadiazolyl, thiadiazolyl, triazolyl and pyrazinyl, -(CH2)qC(O)OR6, -(CH2)qOR6, - (CH2)qOC(O)R6, -(CH2)qC(O)R6, -(CH2)qC(O)(CH2)taryl, -(CH2)qN(R6)C(O)R6, - (CH2)qC(O)N(R6)2, -(CH2)qN(R6)SO2R6, -(CH2)qN(R6)C(O)N(R6)2, - (CH2)qOC(O)N(R6)2, -(CH2)qN(R6)C(O)OR6, -(CH2)qN(R6)SO2N(R6)2 and - (CH2)qS(O)mR6; R3 is NH2; R4 is hydrogen, C1-6 alkyl, C1-6 alkoxy, halogen, OCF3 or CF3; R5 is hydrogen, C1-6 alkyl, C1-6 alkoxy, halogen, OCF3 or CF3; R6 is hydrogen, C1-8 alkyl or C3-7 cycloalkyl, and when two R6 groups are prese nt and both represent C1-8 alkyl they may optionally together with the atom to which they are both attached form a C3-8 ring; Q is -(CH2)x-C(R7)(R7a)-(CH2) y- or -(CH2)x-V-(CH2)y-; R7 and R7a are independently chosen from hydrogen, CF3 , halogen, C1-6 alkyl and C1-6 alkoxy; V is a C3-8 non-aromatic cyclic or bicyclic ring or an aromatic ring which is benzene or naphthalene, said ring being unsubstituted or substituted at up to three substitutable positions independently by C1-6 alkyl, C1-6 alkoxy, halogen, OCF3, CF3, CN, NO2, methylenedioxy or ethylenedioxy; m is 0, 1 or 2; q is 0, 1, 2, 3 or 4; t is 0, 1, 2 or 3; x and y are independently 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof; useful as CGRP (calcitonin gene-related peptide) receptor ligands, processes for their preparation, their use in therapy, pharmaceutical compositions comprising them and methods of treatment using them.

9. 发明专利

AU705523B2 Use of a tachykinin antagonist and an opioid analgesic 未知
公开(公告)号：AU705523B2
公开(公告)日：1999-05-27
申请号：AU4185496
申请日：1995-12-15
申请人： MERCK SHARP & DOHME
发明人： HILL RAYMOND GEORGE
IPC分类号： C07D265/32 , A61K31/535 , A61K31/5375 , A61K45/06 , A61P25/04 , C07D413/06 , C07D417/02
摘要： This invention relates to methods and compositions for treating pain and nociception in a patient by administering a combination of a morpholine or thiomorpholine tachykinin antagonist and an opioid analgesic.

10. 发明专利

AU758983B2 Use of a COX-2 inhibitor and a NK-1 receptor antagonist for treating inflammation 未知
公开(公告)号：AU758983B2
公开(公告)日：2003-04-03
申请号：AU3948699
申请日：1999-05-19
申请人： MERCK SHARP & DOHME
发明人： BOYCE SUSAN , HILL RAYMOND GEORGE , RUPNIAK NADIA MELANIE
IPC分类号： A61K31/18 , A61K31/40 , A61K45/06 , A61P19/02 , A61P19/06 , A61P29/00 , A61P43/00

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