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1. 发明申请

WO2011005731A3 PROCESS FOR MAKING CGRP RECEPTOR ANTAGONIST 审中-公开
标题翻译：制备CGRP受体拮抗剂的方法
公开(公告)号：WO2011005731A3
公开(公告)日：2011-05-19
申请号：PCT/US2010041023
申请日：2010-07-06
申请人： MERCK SHARP & DOHME , BELYK KEVIN M , BULGER PAUL G , LINGHU XIN , MALONEY KEVIN M , MCLAUGHLIN MARK , PAN JUN , XIANG BANGPING , XU YINGJU , YIN JINGJUN
发明人： BELYK KEVIN M , BULGER PAUL G , LINGHU XIN , MALONEY KEVIN M , MCLAUGHLIN MARK , PAN JUN , XIANG BANGPING , XU YINGJU , YIN JINGJUN
IPC分类号： C07D241/38 , C07D291/04 , C07D471/04
CPC分类号： C07D471/04 , C07D241/38 , C07D291/04
摘要： The invention encompasses a novel process for making 2-[(8R)-8-(3,5-Difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]acetamide, which is a CGRP receptor antagonist useful for the treatment of migraine, using an asymmetric phase-transfer catalysis route. The invention also encompasses an efficient and practical synthesis of the (R)-acid intermediate, and generates the benzylic stereocenter in an enantioselective manner.
摘要翻译：本发明包括制备2 - [（8R）-8-（3,5-二氟苯基）-10-氧代-6,9-二氮杂螺[4.5]癸-9-基] -N - [（2R） -2'-氧代-1,1'，2'，3-四氢螺[茚-2,3'-吡咯并[2,3-b]吡啶] -5-基]乙酰胺，其为CGRP受体拮抗剂，使用不对称相转移催化途径治疗偏头痛。本发明还包括（R） - 酸中间体的有效和实用的合成，并以对映选择性方式产生苄基立体中心。

2. 发明申请

WO2008006073A2 SYSTEMS AND METHODS FOR DETERMINING PROTECTIVE DEVICE CLEARING TIMES USED FOR PROVIDING REAL-TIME PREDICTIONS ABOUT ARC FLASH EVENTS 审中-公开
标题翻译：用于确定关于ARC闪存事件的实时预测的保护性设备清除时间的系统和方法
公开(公告)号：WO2008006073A2
公开(公告)日：2008-01-10
申请号：PCT/US2007072972
申请日：2007-07-06
申请人： EDSA MICRO CORP , RADIBRATOVIC BRANISLAV , PAN JUN , NASLE ADIB
发明人： RADIBRATOVIC BRANISLAV , PAN JUN , NASLE ADIB
IPC分类号： G06F19/00 , G06F17/10
CPC分类号： G05B17/02
摘要： A system for making real-time predictions about an arc flash event on an electrical system is disclosed. The system includes a data acquisition component, an analytics server and a client terminal. The data acquisition component is communicatively connected to a sensor configured to acquire real-time data output from the electrical system. The analytics server is communicatively connected to the data acquisition component and is comprised of a virtual system modeling engine, an analytics engine and an arc flash simulation engine.
摘要翻译：公开了一种用于对电气系统上的电弧闪光事件进行实时预测的系统。该系统包括数据采集组件，分析服务器和客户终端。数据采集部件通信地连接到被配置为获取从电气系统输出的实时数据的传感器。分析服务器通信地连接到数据采集组件，并且包括虚拟系统建模引擎，分析引擎和电弧闪光模拟引擎。

3. 发明申请

WO0146906A3 INCREMENTAL INTERLACE INTERPOLATION FOR TEXTURE MORPHING 审中-公开
标题翻译：纹理变形的增量间接插值
公开(公告)号：WO0146906A3
公开(公告)日：2002-02-21
申请号：PCT/US0042574
申请日：2000-12-06
申请人： NINTENDO CO LTD , LI XIN , ABOU SAMRA SAMIR , CHAMPAGNE ROBERT , COMAIR CLAUDE , FAM SUN TJEN , GHALI PRASANNA , PAN JUN
发明人： LI XIN , ABOU-SAMRA SAMIR , CHAMPAGNE ROBERT , COMAIR CLAUDE , FAM SUN TJEN , GHALI PRASANNA , PAN JUN
IPC分类号： G06T13/00 , G06T15/04 , G06T15/70
CPC分类号： G06T13/00 , G06T15/04 , G06T2210/44
摘要： A fast, texture morphing algorithm for real-time computer simulation and video games dynamically generates objects "on the fly" by simplifying and reducing the computational load required for a texture morphing/blending process. Incremental interpolation techniques compute a morh parameter based on previous value and morph change rate. Precomputed initial and incremental morph parameter values for each texel component are applied during real-time morphing procedures using integer arithmetic. Approximation errors are reduced by incrementing/decrementing by an extra integer value when the number of morph iterations is a multiple of a frame counter. The frame counter avoids over-runs, and the morphing procedure is "snapped" the texel value to the precise texture target value to prevent under-runs and corresponding artifacts. Interlacing (applying interpolation to a subset of the texels each frame) significantly reduces computational load without introducing significant image artifacts. The morph texture buffer data structure is initially decomposed off-line to reduce the number of real-time calculations required to manipulate texel component data.
摘要翻译：用于实时计算机模拟和视频游戏的快速，纹理变形算法通过简化和减少纹理变形/混合过程所需的计算负荷来“动态地”生成对象。增量插值技术基于先前的值和变形率计算morh参数。使用整数算法在实时变形过程中应用每个纹素分量的预计算初始和渐变变形参数值。当变形迭代次数是帧计数器的倍数时，通过递增/递减额外的整数值来减少近似误差。帧计数器避免过度运行，并且变形过程将纹素值“拍”到精确的纹理目标值，以防止运行不足和相应的伪像。隔行扫描（将插值应用于每个帧的纹素集的子集）可显着降低计算负荷，而不引入显着的图像伪像。变形纹理缓冲器数据结构最初是离线分解的，以减少操纵纹理分量数据所需的实时计算的数量。

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