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1. 发明公开

KR20180070697A ROR감마T 저해제로서의 치환된 인다졸 화합물 및 이의 용도 审中-公开
公开(公告)号：KR20180070697A
公开(公告)日：2018-06-26
申请号：KR20187014954
申请日：2016-10-27
申请人： MERCK SHARP & DOHME
发明人： LAPOINTE BLAIR T , FULLER PETER H , GUNAYDIN HAKAN , LIU KUN , SCOTT MARK E , TROTTER B WESLEY , ZHANG HONGJUN
IPC分类号： C07D491/107 , A61K31/416 , A61P17/06 , A61P19/02 , A61P29/00 , C07D403/06 , C07D403/12 , C07D405/12
CPC分类号： C07D491/107 , C07D231/56 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D487/04 , C07D487/10 , C07D491/048
摘要： 본발명은화학식 I에따른화합물및 이의약제학적으로허용가능한염에관한것이다. 이와같은화합물은 ROR감마T-매개질병또는질환의치료에사용될수 있다. [화학식 I]

2. 发明申请

WO2012054364A3 BICYCLIC DIAMINES AS JANUS KINASE INHIBITORS 审中-公开
标题翻译：作为JANUS KINASE INHIBITORS的双相DIAMINES
公开(公告)号：WO2012054364A3
公开(公告)日：2014-04-10
申请号：PCT/US2011056498
申请日：2011-10-17
申请人： MERCK SHARP & DOHME , GUERIN DAVID JOSEPH , BRUBAKER JASON D , MARTINEZ MICHELLE , JUNG JOON O , ANTHONY NEVILLE J , SCOTT MARK E , CAMMARANO CAROLYN MICHELE , HOFFMAN DAWN MARIE MAMPREIAN , WOO HYUN CHONG , DINSMORE CHRISTOPHER J , JONES PHILIP
发明人： GUERIN DAVID JOSEPH , BRUBAKER JASON D , MARTINEZ MICHELLE , JUNG JOON O , ANTHONY NEVILLE J , SCOTT MARK E , CAMMARANO CAROLYN MICHELE , HOFFMAN DAWN MARIE MAMPREIAN , WOO HYUN CHONG , DINSMORE CHRISTOPHER J , JONES PHILIP
IPC分类号： A61K31/34 , A61K31/44
CPC分类号： C07D471/04 , A61K31/519 , C07D519/00
摘要： The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译：本发明提供了作为Jak抑制剂的式I化合物，因此可用于治疗Jak介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

3. 发明专利

AU2014234906B2 Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors 未知
公开(公告)号：AU2014234906B2
公开(公告)日：2017-11-16
申请号：AU2014234906
申请日：2014-03-19
申请人： MERCK SHARP & DOHME
发明人： CHILDERS MATTHEW LLOYD , DINSMORE CHRISTOPHER , FULLER PETER , GUERIN DAVID , KATZ JASON DAVID , PU QINGLIN , SCOTT MARK E , THOMPSON CHRISTOPHER F , ZHANG HONGJUN , FALCONE DANIELLE , TORRES LUIS , BRUBAKER JASON , ZENG HONGBO , CAI JIAQIANG , DU XIAOXING , WANG CHONGGANG , BAI YUNFENG , KONG NORMAN , LIU YUMEI , ZHENG ZHIXIANG
IPC分类号： C07D487/04 , A61K31/437 , A61K31/4375 , A61P25/00 , A61P35/00 , A61P37/00 , C07D487/08 , C07D487/14
摘要： Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

4. 发明专利

AU2014234906A1 Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors 未知
公开(公告)号：AU2014234906A1
公开(公告)日：2015-08-13
申请号：AU2014234906
申请日：2014-03-19
申请人： MERCK SHARP & DOHME
发明人： CHILDERS MATTHEW LLOYD , DINSMORE CHRISTOPHER , FULLER PETER , GUERIN DAVID , KATZ JASON DAVID , PU QINGLIN , SCOTT MARK E , THOMPSON CHRISTOPHER F , ZHANG HONGJUN , FALCONE DANIELLE , TORRES LUIS , BRUBAKER JASON , ZENG HONGBO , CAI JIAQIANG , DU XIAOXING , WANG CHONGGANG , BAI YUNFENG , KONG NORMAN , LIU YUMEI , ZHENG ZHIXIANG
IPC分类号： C07D487/04 , A61K31/437 , A61K31/4375 , A61P25/00 , A61P35/00 , A61P37/00 , C07D487/08 , C07D487/14
摘要： Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

5. 发明专利

CA2901766A1 N-(2-CYANO HETEROCYCLYL)PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 未知
公开(公告)号：CA2901766A1
公开(公告)日：2014-09-25
申请号：CA2901766
申请日：2014-03-19
申请人： MERCK SHARP & DOHME
发明人： DINSMORE CHRISTOPHER , FULLER PETER , GUERIN DAVID , THOMPSON CHRISTOPHER F , PU QINGLIN , SCOTT MARK E , KATZ JASON DAVID , KURUKULASURIYA RAVI , CLOSE JOSHUA T , FALCONE DANIELLE , BRUBAKER JASON , ZENG HONGBO , BAI YUNFENG , FU JIANMIN , KONG NORMAN , LIU YUMEI , ZHENG ZHIXIANG
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.

6. 发明专利

ES2683309T3 Cicloalquilnitrilpirazolpiridonas como inhibidores de janus cinasa 未知
公开(公告)号：ES2683309T3
公开(公告)日：2018-09-26
申请号：ES14767371
申请日：2014-03-19
申请人： MERCK SHARP & DOHME
发明人： CHILDERS MATTHEW LLOYD , DINSMORE CHRISTOPHER , FULLER PETER , GUERIN DAVID , KATZ JASON DAVID , PU QINGLIN , SCOTT MARK E , THOMPSON CHRISTOPHER F , ZHANG HONGJUN , FALCONE DANIELLE , TORRES LUIS , BRUBAKER JASON , ZENG HONGBO , CAI JIAQIANG , DU XIAOXING , WANG CHONGGANG , BAI YUNFENG , KONG NORMAN , LIU YUMEI , ZHENG ZHIXIANG
IPC分类号： C07D487/04 , A61K31/437 , A61K31/4375 , A61P25/00 , A61P35/00 , A61P37/00 , C07D487/08 , C07D487/14
摘要： Un compuesto de fórmula I o una sal farmacéuticamente aceptable o un estereoisómero del mismo: **Fórmula** A se selecciona entre arilo y heteroarilo; n es 0, 1, 2, 3 o 4; m es 0, 1, 2, 3 o 4; p es 0, 1, 2, 3 o 4; R1 se selecciona entre: halógeno, Oxo (>=O), alquil C1-10(oxi)0-1(carbonil)0-1alquilo C0-10, heteroalquil C1-10(oxi)0-1(carbonil)0-1alquilo C0-10, alquenil C2-10(oxi)0-1(carbonil)0-1alquilo C0-10, arilalquil C0-10(oxi)0-1(carbonil)0-1alquilo C0-10, cicloalquil C3-12alquil C0-10(oxi)0-1(carbonil)0-1alquilo C0-10, heteroariloalquil C0-10(oxi)0-1(carbonil)0-1 alquilo C0-10, heterocicloalquil (C3-12)alquil C0-10(oxi)0-1(carbonil)0-1alquilo C0-10, alquil C0-10(oxi)0-1(carbonil)0-1aminoalquilo C0-10, heteroalquil (C1-10) (oxi)0-1(carbonil)0-1aminoalquilo C0-10, cicloalquil C3-12alquil C0-10(oxi)0-1(carbonil)0-1aminoalquilo C0-10, arilalquil C0-10(oxi)0-1(carbonil)0-1aminoalquilo C0-10, heteroarilalquil C0-10(oxi)0-1(carbonil)0-1aminalquilo C0-10, heterocicloalquil (C3-12)alquil C0-10(oxi)0-1(carbonil)0-1aminoalquilo C0-10, alquilamino C0-10 (carbonil)0-1 alquilo C0-10, heteroalquilamino (C1-10) (carbonil)0-1alquilo C0-10, cicloalquilamino C3-12(carbonil)0-1alquilo C0-10, arilalquil C0-10aminoamino(carbonil)0-1 alquilo C0-10, heteroarilo C0-10alquilamino(carbonil)0-1alquilo C0-10, heterocicloalquil (C3-12)amino(carbonil)0-1alquilo C0-10, alquil C0-10sulfonilalquilo C0-10, heteroalquil C1-10sulfonilalquilo C0-10, cicloalquil (C3-12)alquil C0-10sulfonilalquilo C0-10, cicloheteroalquil (C3-12)alquil C0-10sulfonilalquilo C0-10, heteroarilalquil C0-10 sulfonilalquilo C0-10, arilalquil C0-10sulfonilalquilo C0-10, alquil C1-10sulfamoilalquilo C0-10, heteroalquil C1-10sulfamoilalquilo C0-10, cicloalquil (C3-12)alquil C0-10sulfamoilalquilo C0-10, cicloheteroalquil (C3-12)alquil C0-10sulfamoilalquilo C0-10, heteroarilalquil C0-10sulfamoilalquilo C0-10, arilalquil C0-10sulfamoilalquilo C0-10, alquil C1-10sulfonimidoilalquilo C0-10, heteroalquil C1-10sulfonimidoilalquilo C0-10, cicloalquil (C3-12)alquil C0-10sulfonimidoilalquilo C0-10, cicloheteroalquil (C3-12)alquil C0-10sulfonimidoilalquilo C0-10, heteroarilalquil C0-10sulfonimidoilalquilo C0-10, arilalquil C0-10sulfonimidoilalquilo C0-10, alquil C1-10tioalquilo C0-10, (alquil C0-10)1-2amino, -CO2(alquilo C0-10), -(alquil C0-10)CO2H,

7. 发明专利

MX2015013418A CICLOALQUIL NITRILO PIRAZOLO PIRIDONAS COMO INHIBIDORES DE JANUS QUINASA. 未知
公开(公告)号：MX2015013418A
公开(公告)日：2016-06-24
申请号：MX2015013418
申请日：2014-03-19
申请人： MERCK SHARP & DOHME
发明人： THOMPSON CHRISTOPHER F , SCOTT MARK E , ZHANG HONGJUN , BRUBAKER JASON , FALCONE DANIELLE , CHILDERS MATTHEW LLOYD , FULLER PETER , GUERIN DAVID , KATZ JASON DAVID , TORRES LUIS , BAI YUNFENG , KONG NORMAN , LIU YUMEI , ZHENG ZHIXIANG , DINSMORE CHRISTOPHER , PU QINGLIN , CAI JIAQIANG , DU XIAOXING , WANG CHONGGANG , HONGBO ZENG
IPC分类号： C07D487/04 , A61K31/437 , A61K31/4375 , A61P25/00 , A61P35/00 , A61P37/00 , C07D487/08 , C07D487/14
摘要： Se proveen compuestos de fórmula I, (Ver Formula) que son inhibidores de JAK y son útiles para el tratamiento de enfermedades mediadas por JAK tales como artritis reumatoide asma, COPD y cáncer.

8. 发明专利

CA2964375A1 ETHYL N-BOC PIPERIDINYL PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 未知
公开(公告)号：CA2964375A1
公开(公告)日：2016-04-28
申请号：CA2964375
申请日：2015-10-21
申请人： MERCK SHARP & DOHME
发明人： SCOTT MARK E , GUERIN DAVID , MOLINARI DANIELLE , KATTAR SAM , FULLER PETER , DINSMORE CHRISTOPHER , KONG NORMAN , BAI YUNFENG , FU JIAMIN , LIU YUMEI , ZHENG ZHIXIANG
IPC分类号： A61K31/437
摘要： The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.

10. 发明专利

CA2901770A1 ACYCLIC CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 未知
公开(公告)号：CA2901770A1
公开(公告)日：2014-09-25
申请号：CA2901770
申请日：2014-03-19
申请人： MERCK SHARP & DOHME
发明人： DINSMORE CHRISTOPHER , FULLER PETER , GUERIN DAVID , KATZ JASON DAVID , THOMPSON CHRISTOPHER F , FALCONE DANIELLE , DENG WEI , TORRES LUIS , ZENG HONGBO , BAI YUNFENG , FU JIANMIN , KONG NORMAN , LIU YUMEI , ZHENG ZHIXIANG , SCOTT MARK E
IPC分类号： C07D487/04 , A61K31/437 , A61K31/4375 , A61P25/00 , A61P35/00 , A61P37/00 , C07D487/08 , C07D487/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

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