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1. 发明申请

WO2010115736A3 DIHYDROOROTATE DEHYDROGENASE INHIBITORS 审中-公开
标题翻译：二氢脱氧核糖核酸酶抑制剂
公开(公告)号：WO2010115736A3
公开(公告)日：2015-10-01
申请号：PCT/EP2010054034
申请日：2010-03-26
申请人： MERCK SERONO SA , THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
发明人： THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
IPC分类号： C07D209/08 , A61K31/33 , A61P35/00 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
CPC分类号： C07D209/08 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
摘要： The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，X 1，X 2，Y，R a，R b，Q具有权利要求1中给出的含义。用于治疗自身免疫性疾病，如多发性硬化症，还用于治疗癌症。

2. 发明申请

WO2010115736A2 DIHYDROOROTATE DEHYDROGENASE INHIBITORS 审中-公开
标题翻译： DIHYDROOROTATE DEHYDROGENASE抑制剂
公开(公告)号：WO2010115736A2
公开(公告)日：2010-10-14
申请号：PCT/EP2010054034
申请日：2010-03-26
申请人： MERCK SERONO SA , THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
发明人： THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
IPC分类号： C07D209/08 , A61K31/33 , A61P35/00 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
CPC分类号： C07D209/08 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
摘要： The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，X 1，X 2，Y，R a，R b，Q具有权利要求1中给出的含义。在治疗自身免疫性疾病如多发性硬化以及治疗癌症中。

3. 发明专利

AU2010233917B2 Dihydroorotate dehydrogenase inhibitors 未知
公开(公告)号：AU2010233917B2
公开(公告)日：2015-07-02
申请号：AU2010233917
申请日：2010-03-26
申请人： MERCK SERONO SA
发明人： THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
IPC分类号： C07D209/08 , A61K31/33 , A61P35/00 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
摘要： The invention relates to compounds of formula (I) wherein R

4. 发明专利

SG10201401169QA DIHYDROOROTATE DEHYDROGENASE INHIBITORS 未知
公开(公告)号：SG10201401169QA
公开(公告)日：2014-05-29
申请号：SG10201401169Q
申请日：2010-03-26
申请人： MERCK SERONO SA
发明人： THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
摘要： The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.

5. 发明专利

ES2882797T3 Inhibidores de dihidroorotato deshidrogenasa 未知
公开(公告)号：ES2882797T3
公开(公告)日：2021-12-02
申请号：ES10711665
申请日：2010-03-26
申请人： MERCK SERONO SA
发明人： THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
IPC分类号： C07D209/08 , A61K31/33 , A61P35/00 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
摘要： Un compuesto de acuerdo con la fórmula I: **(Ver fórmula)** en la que: R1 representa COOH, COOA, COA, CF3, acilo, ciano, Het, tetrazolilo, sulfonilo, CON(R3)2 o CONHA; R2 representa H, Hal, A, O-A, Ar; Ra representa Ar, Het, O-Het, NH-Het, O-Ar, -O-(CH2)m-Het, -NH-(CH2)m-Het, NH-Ar, S(O)2Ar, S(O)Ar, -S-Ar, OCF3; Y representa CRf; X1 y X2 representan cada uno independientemente entre sí NRc o NRd; Rb y Rc representan juntos un enlace químico; Rf y Re representan juntos un enlace químico; Rd representa H, A, -(CH2)m-COOH; Q representa el arileno **(Ver fórmula)** Hal representa F, Cl, Br o I; A es un alquilo ramificado o lineal que tiene de 1 a 12 átomos de C, en donde uno o más, preferentemente de 1 a 7 átomos de H pueden reemplazarse por Hal, OR3, CN o N(R3)2 y en donde uno o más, preferentemente de 1 a 7 grupos CH2 no adyacentes pueden reemplazarse por O o S y/o por grupos -CH=CH- o -C≡C, o representa cicloalquilo o cicloalquilalquileno que tienen 3-7 átomos de C en el anillo; Ar representa un anillo carbocíclico monocíclico o bicíclico, saturado, insaturado o aromático que tiene de 6 a 14 átomos de carbono que pueden estar sin sustituir o sustituidos por un grupo seleccionado de (R4)n y/o (R5)n; Het representa un anillo heterocíclico monocíclico o bicíclico, saturado, insaturado o aromático que tiene de 1 a 4 átomos de N, O y/o S que pueden estar sin sustituir o sustituidos por un grupo seleccionado de (R4)n y/o (R5)n; R3 es H o alquilo; cada uno de R4 y R5 se selecciona independientemente de Hal, hidroxi, alcoxi, carboxi, carboxi-alquilo, perfluoro- alquilo, perfluoro-alquiloxi, acilo, alquilsulfonilo, sulfonilo, ciano, nitro, amino, amido, alquilo opcionalmente sustituido por un carboxi, o Het-alquilo opcionalmente sustituido por un acilo, alquilsulfonilo, -O(CH2)nAr, - O(CH2)nHet, -(CH2)mHet, OA, -NHCO(CH2)mAr, NHCO-(CH2)mHet, CONHA o alquilo; n representa 0, 1, 2, 3, 4, 5; y m representa 0, 1, 2, 3, 4, 5, 6; y derivados, solvatos, tautómeros, sales y estereoisómeros farmacéuticamente aceptables del mismo, incluyendo mezclas de los mismos en todas las relaciones.

6. 发明专利

MY159575A DIHYDROOROTATE DEHYDROGENASE INHIBITORS 未知
公开(公告)号：MY159575A
公开(公告)日：2017-01-13
申请号：MYPI2011004318
申请日：2010-03-26
申请人： MERCK SERONO SA
发明人： THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
IPC分类号： C07D235/18 , A61K31/4184 , C07D209/08 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12
摘要： THE INVENTION RELATES TO COMPOUNDS OF FORMULA (I) WHEREIN R1, R2, X1, X2, Y, Ra, Rb, Q HAVE THE MEANINGS GIVEN IN CLAIM 1. THE COMPOUNDS ARE USEFUL E.G. IN THE TREATMENT OF AUTOIMMUNE DISORDERS, SUCH AS MULTIPLE SCLEROSIS AND ALSO IN THE TREATMENT OF CANCER DISORDERS.

7. 发明专利

NZ595819A DIHYDROOROTATE DEHYDROGENASE INHIBITORS; benzimidazole-4-carboxylic acid 未知
公开(公告)号：NZ595819A
公开(公告)日：2013-02-22
申请号：NZ59581910
申请日：2010-03-26
申请人： MERCK SERONO SA
发明人： THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
IPC分类号： C07D409/10 , A61K31/33 , A61K31/4184 , A61P35/00 , C07D209/08 , C07D235/06 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D413/10 , C07D417/10 , C07D471/04
摘要： Patent No. 595819 Disclosed is a compound of formula I such as 2-biphenyl-4-yl-1H-benzoimidazole-4- carboxylic acid, which is useful for treating dihydroorotate dehydrogenase associated disorders such as multiple sclerosis and rheumatoid arthritis

8. 发明专利

SG174125A1 DIHYDROOROTATE DEHYDROGENASE INHIBITORS 未知
公开(公告)号：SG174125A1
公开(公告)日：2011-10-28
申请号：SG2011055167
申请日：2010-03-26
申请人： MERCK SERONO SA
发明人： THUNUGUNTLA SIVA SANJEEVA RAO , SUBRAMANYA HOSAHALLI , KUNNAM SATISH REDDY , SANIVARU VIJAY SEKHAR REDDY , BINGI CHAKRAPANI , KUSANUR RAVIRAJ , SCHWARZ MATTHIAS , ARLT MICHAEL
摘要： The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.

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