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1. 发明申请

WO0224666A3 4-AMINO-QUINAZOLINES 审中-公开
标题翻译： 4-氨基喹唑啉
公开(公告)号：WO0224666A3
公开(公告)日：2002-09-26
申请号：PCT/EP0110704
申请日：2001-09-17
申请人： MERCK PATENT GMBH , MEDERSKI WERNER , DEVANT RALF , BARNICKEL GERHARD , BERNOTAT-DANIELOWSKI SABINE , VICKERS JAMES , CEZANNE BERTRAM , DHANOA DALJIT , ZHAO BAO-PING , RINKER JAMES , PLAYER MARK R , JAEGER EDWARD , SOLL RICHARD
发明人： MEDERSKI WERNER , DEVANT RALF , BARNICKEL GERHARD , BERNOTAT-DANIELOWSKI SABINE , VICKERS JAMES , CEZANNE BERTRAM , DHANOA DALJIT , ZHAO BAO-PING , RINKER JAMES , PLAYER MARK R , JAEGER EDWARD , SOLL RICHARD
IPC分类号： A61K31/517 , A61P7/02 , A61P9/10 , A61P43/00 , C07D239/94 , C07D405/12 , C07D409/10 , C07D409/14 , C07D521/00 , C07D403/12
CPC分类号： C07D231/12 , C07D233/56 , C07D239/94 , C07D249/08 , C07D405/12 , C07D409/10 , C07D409/14
摘要： Quinazolines of the formula I, in which R, R , R , R , R and Y have the meaning indicated in Patent Claim 1, and their salts or solvates as glycoprotein IbIX antagonists.
摘要翻译：其中R，R 1，R 2，R 3，R 4和Y具有权利要求1中所述含义的式I的喹唑啉及其盐或溶剂化物作为糖蛋白IbIX拮抗剂。

2. 发明申请

WO2006110678A3 PAWL ASSEMBLY 审中-公开
标题翻译： PAWL装配
公开(公告)号：WO2006110678A3
公开(公告)日：2007-06-07
申请号：PCT/US2006013358
申请日：2006-04-11
申请人： SOUTHCO , ANDERSON GLENN E , LANGKAMP RICHARD B , SCHLACK RICHARD E , TURNER D DALE , VICKERS JAMES , SPATIG STPEHEN K , RIBLETT H ALLEN
发明人： ANDERSON GLENN E , LANGKAMP RICHARD B , SCHLACK RICHARD E , TURNER D DALE , VICKERS JAMES , SPATIG STPEHEN K , RIBLETT H ALLEN
IPC分类号： E05C3/04
CPC分类号： E05B63/0056 , E05B65/02 , E05C3/042 , Y10T292/0886 , Y10T292/0891 , Y10T292/1043 , Y10T292/1083 , Y10T292/1084 , Y10T292/438
摘要： The present invention is directed to a pawl assembly that can be installed to the output shaft of a latch mechanism more easily, and in some embodiments without the use of tools, as compared to prior art pawls.
摘要翻译：本发明涉及一种棘爪组件，其可以与现有技术的棘爪相比更容易地安装到闩锁机构的输出轴上，并且在一些实施例中不使用工具。

3. 发明专利

ZA200303062B 4-amino-quinazolines. 未知
公开(公告)号：ZA200303062B
公开(公告)日：2004-07-19
申请号：ZA200303062
申请日：2003-04-17
申请人： MERCK PATENT GMBH
发明人： MEDERSKI WERNER , DEVANT RALF , BARNICKEL GERHARD , BERNOTAT-DANIELOWSKI SABINE , VICKERS JAMES , CEZANNE BERTRAM , DHANOA DALJIT , ZHAO BAO-PING , RINKER JAMES , PLAYER MARK R , JAEGER EDWARD , SOLL RICHARD
IPC分类号： A61K31/517 , A61K31/5377 , A61P7/02 , A61P9/10 , A61P9/14 , A61P43/00 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D , A61K , A61P
摘要： Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein 1bIX antagonists.

4. 发明专利

AU1392302A 4-amino-quinazolines 未知
公开(公告)号：AU1392302A
公开(公告)日：2002-04-02
申请号：AU1392302
申请日：2001-09-17
申请人： MERCK PATENT GMBH
发明人： MEDERSKI WERNER , DEVANT RALF DR , BARNICKEL GERHARD , BERNOTAT-DANIELOWSKI SABINE , VICKERS JAMES , CEZANNE BERTRAM , DHANOA DALJIT , ZHAO BAOPING , RINKER JAMES , PLAYER MARK R , JAEGER EDWARD , SOLL RICHARD
IPC分类号： A61K31/517 , A61P7/02 , A61P9/10 , A61P43/00 , C07D239/94 , C07D405/12 , C07D409/10 , C07D409/14 , C07D521/00 , C07D403/12
摘要： Quinazolines of the formula I, in which R, R , R , R , R and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

5. 发明专利

BR0114020A 未知
公开(公告)号：BR0114020A
公开(公告)日：2003-07-22
申请号：BR0114020
申请日：2001-09-17
申请人： MERCK PATENT GMBH
发明人： MEDERSKI WERNER , RALF DEVANT , BARNICKEL GERHARD , BERNOTAT-DANIELOWSKI SABINE , VICKERS JAMES , CEZANNE BERTRAM , DHANOA DALJIT , ZHAO BAO-PING , RINKER JAMES , PLAYER MARK R , JAEGER EDWARD , SOLL RICHARD
IPC分类号： A61K31/517 , A61K31/5377 , A61P7/02 , A61P9/10 , A61P9/14 , A61P43/00 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein 1bIX antagonists.

6. 发明专利

HU0300008A2 AMINOSULFONYLBIPHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PREPARATION 未知
公开(公告)号：HU0300008A2
公开(公告)日：2003-06-28
申请号：HU0300008
申请日：2001-02-22
申请人： MERCK PATENT GMBH
发明人： BARNES CHRISTOPHER , BERNOTAT-DANIELOWSKI SABINE , DORSCH DIETER , GLEITZ JOHANNES , JURASZYK HORST , MEDERSKI WERNER , MELZER GUIDO , TSAKLAKIDIS CHRISTOS , VICKERS JAMES
IPC分类号： C07D271/06 , A61K31/18 , A61K31/4245 , A61P7/02 , A61P9/00 , A61P9/10 , A61P29/00 , A61P43/00 , C07C311/29 , C07C311/39 , C07C311/46
摘要： Amidino- or guanidino-aryl substituted aminosulfonyl-biphenyl derivatives (I) are new. Amidino- or guanidino-aryl substituted aminosulfonyl-biphenyl derivatives (I) are new. [Image] R1phenyl or naphthyl (both mono-substituted by Q and optionally further substituted by A, OR5, N(R5)2, NO2, CN, halo, NR5COA, NR5COAr', NR5SO2A, NR5SO2Ar', COOR5, CON(R5)2, CON(R5)Ar', COR6, COAr' or S(O)nA); Q : C(=NH)NH2 (optionally mono-substituted by COA, COC(R6)2Ar', COOA, OH or an amino-protecting group), NHC(=NH)NH2, 5-methyl-1,2,4-oxadiazol-3-yl or 5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl; R2N(R5)2, NR5COA, NR5COAr or NR5COOR5; R3, R4H, A, OR5, N(R5)2, NO2, CN, halo, NR5COA, NR5COAr', NR5SO2A, NR5SO2Ar', COOR5, CON(R5)2, CON(R5)Ar', COR6, COAr' or S(O)nA; R5H, A, -CR6R7-Ar' or -CR6R7-Het; R6, R7H, A or (CH2)rAr'; R8H or A; X : O, NR5, CONR5, N(SO2Ar) or N(SO2Het); W : (CR6R6)n, OCR6R7, 1,3- or 1,4-phenylene or 1,3- or 1,4-phenylene-C(R6)2; V : (C(R6)2)m; A : 1-20C alkyl (optionally having 1 or 2 CH2 replaced by O, S or CH=CH and optionally substituted by 1-7 F); Ar : phenyl or naphthyl (both optionally substituted by 1-3 of A, Ar', Het, OR5, N(R5)2, NO2, CN, halo, NR5COA, NR5COAr', NR5SO2A, NR5SO2Ar', COOR5, CON(R5)2, CON(R5)Ar', COR6, COAr' or S(O)nA); Ar' : phenyl or naphthyl (both optionally substituted by 1-3 of A, OR6, N(R6)2, NO2, CN, halo, NR6COA, NR5SO2A, COOR6, CON(R6)2, COR6, SO2NR6 or S(O)nA); Het : N- or C-bonded, mono- or bicyclic, saturated, unsaturated or aromatic heterocyclyl containing 1-4 of N, O and/or S (optionally substituted by 1-3 of A, OR6, N(R6)2, NO2, CN, halo, NR6COA, NR6SO2A, COOR6, CON(R6)2, COR6, SO2NR6, S(O)nA or =O); r : 0-5; m : 0 or 1, and n : 0-2. - ACTIVITY : Anticoagulant; thrombolytic; cardiant; antiarteriosclerotic; antiinflammatory; cerebroprotective; antianginal; vasotropic. - MECHANISM OF ACTION : Coagulation Factor Xa inhibitor; coagulation Factor VIIa inhibitor; serine protease inhibitor. No biological test data is given.

7. 发明专利

PL359918A1 4-AMINO-QUINAZOLINES 未知
公开(公告)号：PL359918A1
公开(公告)日：2004-09-06
申请号：PL35991801
申请日：2001-09-17
申请人： MERCK PATENT GMBH
发明人： MEDERSKI WERNER , DEVANT RALF , BARNICKEL GERHARD , BERNOTAT-DANIELOWSKI SABINE , VICKERS JAMES , CEZANNE BERTRAM , DHANOA DALJIT , ZHAO BAO-PING , RINKER JAMES , PLAYER MARK R , JAEGER EDWARD , SOLL RICHARD
IPC分类号： A61K31/517 , A61P7/02 , A61P9/10 , A61P43/00 , C07D239/94 , C07D405/12 , C07D409/10 , C07D409/14 , C07D521/00 , C07D403/12
摘要： Quinazolines of the formula I, in which R, R , R , R , R and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

8. 发明专利

PL356565A1 AMINOSULFONYLBIPHENYL DERIVATIVES 未知
公开(公告)号：PL356565A1
公开(公告)日：2004-06-28
申请号：PL35656501
申请日：2001-02-22
申请人： MERCK PATENT GMBH
发明人： DORSCH DIETER , JURASZYK HORST , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , BERNOTAT-DANIELOWSKI SABINE , MELZER GUIDO , GLEITZ JOHANNES , BARNES CHRISTOPHER , VICKERS JAMES
IPC分类号： A61K31/18 , A61K31/4245 , A61P7/02 , C07D271/06 , A61P9/00 , A61P9/10 , A61P29/00 , A61P43/00 , C07C311/29 , C07C311/39 , C07C311/46
摘要： Amidino- or guanidino-aryl substituted aminosulfonyl-biphenyl derivatives (I) are new. Amidino- or guanidino-aryl substituted aminosulfonyl-biphenyl derivatives (I) are new. [Image] R1phenyl or naphthyl (both mono-substituted by Q and optionally further substituted by A, OR5, N(R5)2, NO2, CN, halo, NR5COA, NR5COAr', NR5SO2A, NR5SO2Ar', COOR5, CON(R5)2, CON(R5)Ar', COR6, COAr' or S(O)nA); Q : C(=NH)NH2 (optionally mono-substituted by COA, COC(R6)2Ar', COOA, OH or an amino-protecting group), NHC(=NH)NH2, 5-methyl-1,2,4-oxadiazol-3-yl or 5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl; R2N(R5)2, NR5COA, NR5COAr or NR5COOR5; R3, R4H, A, OR5, N(R5)2, NO2, CN, halo, NR5COA, NR5COAr', NR5SO2A, NR5SO2Ar', COOR5, CON(R5)2, CON(R5)Ar', COR6, COAr' or S(O)nA; R5H, A, -CR6R7-Ar' or -CR6R7-Het; R6, R7H, A or (CH2)rAr'; R8H or A; X : O, NR5, CONR5, N(SO2Ar) or N(SO2Het); W : (CR6R6)n, OCR6R7, 1,3- or 1,4-phenylene or 1,3- or 1,4-phenylene-C(R6)2; V : (C(R6)2)m; A : 1-20C alkyl (optionally having 1 or 2 CH2 replaced by O, S or CH=CH and optionally substituted by 1-7 F); Ar : phenyl or naphthyl (both optionally substituted by 1-3 of A, Ar', Het, OR5, N(R5)2, NO2, CN, halo, NR5COA, NR5COAr', NR5SO2A, NR5SO2Ar', COOR5, CON(R5)2, CON(R5)Ar', COR6, COAr' or S(O)nA); Ar' : phenyl or naphthyl (both optionally substituted by 1-3 of A, OR6, N(R6)2, NO2, CN, halo, NR6COA, NR5SO2A, COOR6, CON(R6)2, COR6, SO2NR6 or S(O)nA); Het : N- or C-bonded, mono- or bicyclic, saturated, unsaturated or aromatic heterocyclyl containing 1-4 of N, O and/or S (optionally substituted by 1-3 of A, OR6, N(R6)2, NO2, CN, halo, NR6COA, NR6SO2A, COOR6, CON(R6)2, COR6, SO2NR6, S(O)nA or =O); r : 0-5; m : 0 or 1, and n : 0-2. - ACTIVITY : Anticoagulant; thrombolytic; cardiant; antiarteriosclerotic; antiinflammatory; cerebroprotective; antianginal; vasotropic. - MECHANISM OF ACTION : Coagulation Factor Xa inhibitor; coagulation Factor VIIa inhibitor; serine protease inhibitor. No biological test data is given.

9. 发明专利

HU0302429A2 4-AMINO-QUINAZOLINES, PROCESS FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE 未知
公开(公告)号：HU0302429A2
公开(公告)日：2003-10-28
申请号：HU0302429
申请日：2001-09-17
申请人： MERCK PATENT GMBH
发明人： BARNICKEL GERHARD , BERNOTAT-DANIELOWSKI SABINE , CEZANNE BERTRAM , DEVANT RALF , DHANOA DALJIT , JAEGER EDWARD , MEDERSKI WERNER , PLAYER MARK R , RINKER JAMES , SOLL RICHARD , VICKERS JAMES , ZHAO BAO-PING
IPC分类号： A61K31/517 , A61P7/02 , A61P9/10 , A61P43/00 , C07D239/94 , C07D405/12 , C07D409/10 , C07D409/14 , C07D521/00
摘要： Quinazolines of the formula I, in which R, R , R , R , R and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

10. 发明专利

BR0114021A 未知
公开(公告)号：BR0114021A
公开(公告)日：2003-08-19
申请号：BR0114021
申请日：2001-09-17
申请人： MERCK PATENT GMBH
发明人： MEDERSKI WERNER , RALF DEVANT , BARNICKEL GERHARD , BERNOTAT-DANIELOWSKI SABINE , VICKERS JAMES , CEZANNE BERTRAM , DHANOA DALJIT , ZHAO BAO-PING , RINKER JAMES , PLAYER MARK R , JAEGER EDWARD , SOLL RICHARD
IPC分类号： A61K31/517 , A61P7/02 , A61P9/10 , A61P43/00 , C07D239/94 , C07D405/12 , C07D409/10 , C07D409/14 , C07D521/00 , C07D403/12
摘要： Quinazolines of the formula I, in which R, R , R , R , R and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

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